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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN PROSIDING SEMINAR NASIONAL Jurnal Kedokteran Diponegoro Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kedokteran Muhammadiyah Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Mutiara Medika: Jurnal Kedokteran dan Kesehatan Biomedika Jurnal Farmasi Sains dan Komunitas Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati South East Asia Nursing Research Medica Arteriana (Med-Art) JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Indonesian Journal of Dentistry Prosiding Seminar Nasional Unimus Indonesian Journal of Pharmacology and Therapy Journal of Community Empowerment
Maya Dian Rakhmawatie
Departement Of Biomedical Sciences, Faculty Of Medicine, Universitas Muhammadiyah Semarang, Semarang, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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In Vitro Effect of Alfa Mangostin on Multiresistant Uropathogenic Escherichia Coli Rakhmawatie, Maya Dian; Rohmani, Afiana; Ahyar, Fariz Wafaul
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2017): June 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (761.141 KB) | DOI: 10.30659/sainsmed.v8i1.1002

Abstract

Introduction: In Indonesia, the most commom uropatogen E. coli resistance has been to ampicillin (91.9%), ciprof loxacin (83.7%) and cefixime (67.6%). α-mangostin, a chemical compound, has been developed as a new antibiotics isolaated from herbal Garcinia mangostana L, but its effectiveness against multiresistant uropathogenic E. Coli has not been established.Objective: This study examined the effect of α-mangostin on growth of multiresistant E. coliMethods: α-mangostin Treatment of E. coli uropatogen bacteria was administered in vitro, using 14 levels of concentration 14; 28,13; 56.25; 112.5;225; And 450 μg/mL with 4 times replication at each concentration. The antibacterial activity of α-mangostin was determined by evaluating bacterial growth at each concentration using the indirect method by sample absorbance reading. The Samples of uropatogen of E. coli treated with various doses of α-mangostin were incubated for 18-20 hours and then subjected to the absorbance reading using a UV-Vis spectrophotometer λ 625 nm.Results: Minimum inhibitory concentration (MIC) in this study was 450 mg/mL. Based on linear regression (STATA 13.1) relationship betweenα-mangostin concentrations and bacterial growth inhibition activity showed 0.0001 <0.05 showing that all concentrations of α-mangostin simultaneously had a significant effect on the growth of uropathogenic E. coli.Conclusion: α-mangostin has not been effective to inhibit the growth of multiresistent uropathogentic E. coli due to a relatively high MIC (450 mcg/mL).a Potentially relevant activity in the clinical setting will occur if the value of the MIC of a substance in vitro <100 μg /mL. Even the pharmaceutical industry prefers the development of antibiotics with in vitro MIC value of ≤ 2 μg/mL.
Pembuatan Simplisia dan Teknik Penyiapan Obat Tradisional Jahe Merah dan Daun Pepaya untuk Standardisasi Dosis Maya Dian Rakhmawatie; Nanik Marfu&#039;ati
Berdikari: Jurnal Inovasi dan Penerapan Ipteks Vol 11, No 1 (2023): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/berdikari.v11i1.16717

Abstract

Many Family Welfare Empowerment Groups (PKK) developed a family medicinal plant garden (TOGA) whose results can be used for traditional medicine for residents in their area. Medicinal plants are usually prepared from the decoction of fresh ingredients obtained from the TOGA garden. Medicinal plant products must be used immediately to avoid the risk of spoilage, especially when the yield is abundant. One of the technologies to reduce the spoilage of medicinal plant products needs to be made in the form of Simplicia. The dry form of Simplicia can make it easier for the public to standardize the doses of medicinal plants and prepare standardized decoctions using the infusion and decoct methods. The service program aims to increase knowledge and skills in making Simplicia and preparation techniques for traditional red ginger and papaya leaf medicines according to standard dosages. The methods used in implementing the program were tutorials and practices. The results of the service program were as follows: 1) Knowledge of PKK partner women in the Sambiroto and Sendang Mulyo areas, Semarang, quantitatively increased significantly by 13.83% as shown by the results of the pre-test vs. post-test, 69.5 vs. 83.33, p-value 0.034; 2) Knowledge and technical skills for preparing traditional medicines using the infusion and decoct methods also increased significantly.
Secondary Metabolites Production of Bacillus spp. Isolated from Sea Cucumbers (Holothuria scabra) and their Activity against Mycobacterium smegmatis Maya Dian Rakhmawatie; Aida Zakiyatul Fikriyah; Ika Dyah Kurniati; Nanik Marfu&#039;ati; Stalis Norma Ethica
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 2 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004843

Abstract

New anti-tuberculosis agents are very important due to Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis problems. Mycobacterium smegmatis can be used to replace Mycobacterium tuberculosis as bacteria test to increase the velocity of anti-tuberculosis screening. To answer the need for new drugs, exploration of secondary metabolites from Bacillus spp. can be conducted. Bacillus spp. are known to produce antimicrobials, including discovery of iturins, fengycins, and pumilacidins. This study explored the Bacillus spp. isolated from fermented intestines of Holothuria scabra. The production of Bacillus sp. Holothuria scabra Fermented Intestine (HSFI) secondary metabolites was done using culture media containing starch as a carbon source, as well as yeast and peptone as a nitrogen source. Production capacity of secondary metabolites of Bacillus sp. HSFI was calculated, to determine its potential as an antibacterial producer. Inhibition testing of secondary metabolites of Bacillus sp. HSFI against M. smegmatis was performed using the Kirby-Bauer disk diffusion method. Based on the results of the inhibition test, it was concluded that Bacillus sp. HSFI-9 has the greatest potential to inhibit the growth of M. smegmatis, with a moderate inhibition (7.67 mm). Production of secondary metabolites from Bacillus sp. HSFI-9 is exceptionally good with an extract production capacity of 24.6 mg/L.
In Vitro Antifungal Activity of Papaya Leaf Extract (Carica papaya L.) AGAINST Trichophyton rubrum Putri, Jasmin Athaya Hayuning; Arfiyanti, Mega Pandu; Rakhmawatie, Maya Dian
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 8 (2024): Volume 11 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i8.15354

Abstract

Trichophytom rubrummerupakan spesies penyebab tinea pedis dan infeksi dermatofitosis pada kuku. Sementara itu, penggunaan obat antijamur untuk terapi dalam jangka panjang dapat menyebabkan efek samping. Oleh sebab itu, dapat dikembangkan obat dari bahan alam seperti daun papaya (Carica papaya L.), yang diketahui memiliki aktivitas farmakologi karena adanya kandungan senyawa aktif seperti alkaloid, triterpenoid, steroid, flavonoid, saponin, dan tanin. Penelitian ini bertujuan membuktikan efektivitas ekstrak etanol daun pepaya (C. papaya L.) dalam menghambat pertumbuhan dan membunuh T. rubrum secara in vitro. Uji aktivitas daya hambat antijamur ekstrak etanol daun pepaya dilakukan menggunakan metode two-fold mikrodilusi pewarnaan resazurin dengan rentang konsentrasi 4000 – 31,25 µg/mL. Untuk uji daya bunuh ekstrak etanol daun pepaya dilakukan menggunakan penilaian jumlah koloni T. rubrum di media Potato Dextrose Agar. Hubungan antara konsentrasi ekstrak etanol dan pepaya dengan jumlah koloni T. rubrum dianalisis menggunakan uji regresi linier. Konsentrasi minimal ekstrak etanol daun papaya untuk menghambat dan membunuh T. rubrum adalah 2000 µg/mL. Dari hasil analisis regresi linear, didapatkan persamaan y = -0,001x + 4,221, R2 0,569 dan koefisien korelasi 0,755. Ekstrak etanol daun pepaya (Carica papaya L.) dapat membunuh dan menghambat pertumbuhan T. rubrum. Selain itu, terdapat hubungan yang kuat antara peningkatan konsentrasi ekstrak daun pepaya dengan aktivitasnya untuk membunuh T. rubrum.
Skrining Diabetes Mellitus Melalui Pemeriksaan dan Konsultasi Hasil Gula Darah di Rumah Pelayanan Sosial Purnamasari, Rina; Rakhmawatie, Maya Dian; Diatri, Devita; Rohmani, Afiana
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 2 No 4 (2023): Oktober
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jipmi.v2i4.161

Abstract

Latar belakang: Diabetes mellitus (DM) adalah penyakit tidak menular yang ditandai dengan kadar gula darah melebihi normal. Cara mudah untuk mendeteksi apakah terdapat potensi mengalami diabetes yaitu dengan pengecekan kadar gula darah. Tujuan: Kegiatan ini bertujuan untuk melakukan screening DM melalui pemeriksaan kadar glukosa darah dan konsultasi hasil gula darah sewaktu di Rumah Pelayanan Sosial Pucang Gading, Semarang. Metode: Sasaran kegiatan ini adalah lansia yang berjumlah 50 orang. Waktu pelaksanaan yaitu pada Rabu, 31 Mei 2023. Kegiatan meliputi pemeriksaan cek gula darah sewaktu (GDS) dilanjutkan dengan konsultasi hasil gula darah. Hasil: Sebanyak 50 lansia yang ikut berpartisipasi dalam kegiatan ini sebagian besar adalah perempuan (62%), laki – laki (28%). Dari hasil pemeriksan GDS didapatkan rerata kadar GDS 152.12 gr/dl. Lansia yang tidak menderita DM (91%). Kesimpulan: Sebagian besar lansia memiliki kadar GDS yang normal. Namun, tetap perlu dilakukan upaya deteksi dini supaya tidak terjadi komplikasi Diabetes Mellitus. Kata kunci: diabetes mellitus, gula darah sewaktu, lansia __________________________________________________________________________________ Background: Diabetes Mellitus (DM) is a non-communicable disease characterized by abnormal blood sugar levels. An easy way to detect whether there is potential for diabetes is to check blood sugar levels. Objective: This activity aims to screen for DM by checking blood glucose levels and consulting blood sugar results. Method: The target of this activity is the 50 elderly in the Rumah Pelayanan Sosial Pucang Gading, Semarang City. This activity was carried out on Wednesday, 31st of May, 2023. After implementation, random blood sugar examination then continued with consultation on blood sugar results. Result: A total of 50 elderly who participated in this activity were mostly women (62%), and men (28%). From the random blood sugar examination results, the average random blood sugar level was 152.12 gr/dl. Elderly who did not suffer from DM (91%). Conclusion: Most of the elderly have normal random blood sugar levels. However, early prevention is still needed to prevent complications of Diabetes Mellitus.  Keywords: diabetes mellitus, elderly, random blood sugar level
Impact of Single vs Combination Anti-Hyperglycemic Drug Therapy on HbA1c Levels: A Cross-Sectional Study Diatri, Devita; Rakhmawatie, Maya Dian
South East Asia Nursing Research Vol 6, No 2 (2024)
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/seanr.6.2.2024.79-83

Abstract

Diabetes Mellitus (DM) is a long-term medical condition characterized by increased blood glucose levels caused by abnormalities in the insulin metabolism process. Various types of antihyperglycemic drugs are available, both as single and combination therapy. Recent research shows that single or combination therapy can impact glycemic control differently, especially when looking at changes in HbA1C levels.  This research is descriptive-analytical with a cross-sectional design using medical record data from Type 2 DM patients in the 2022-2023 period.  Data was analyzed using SPSS. In this study, there was a significant relation between single and combination anti-hyperglycemic drug therapy. Bivariate analysis showed that both single and combination therapy were associated with a reduction in HbA1C levels, with a p-value of 0.019. There is a correlation between HbA1C levels and single and combination therapy in type 2 DM patients at the Prolanis Clinic.
EFFICACY OF BASIL LEAF EXTRACT (OCIMUM Spp.) AGAINST MICROBES THAT CAUSES DENTAL AND ORAL DISEASES: A LITERATURE REVIEW Nusantara, Muhammad Vegisa; Sulistyorini, Ratna; Rakhmawatie, Maya Dian
Indonesian Journal of Dentistry Vol 4, No 1 (2024): February 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/ijd.v4i1.13414

Abstract

Background: Infection is one of the most common dental and oral health problems experienced by the community. Most infections in the oral cavity are caused by Candida albicans and bacteria such as Streptococcus mutans. Currently, there is a tendency to use natural ingredients that are believed to be antifungal and antibacterial as a substitute for chemicals. One of the natural ingredients that have the potential as antifungal and antibacterial that is easily obtained by the community is basil leaves (Ocimum spp.). Objective: This study aims to determine the efficacy of basil leaf extract (Ocimum spp.) on the growth of C. albicans and S. mutans in vitro. Methods: A systematic literature review study using the Preferred Reporting Items for Systematic Review and Meta-Analyses (PRISMA) method was conducted to find scientific evidence of the efficacy of basil leaves (Ocimum spp). Result: Extracts from the majority of basil leaf species (Ocimum spp.) contain flavonoids, alkaloids, saponins, tannins, steroids, triterpenoids, which are expected to have activity as antifungal and antibacterial agents. The minimum inhibitory concentration (MIC) of basil leaf extract from various species, solvents and extraction methods varied with a range of 0.0025 – 25% w/v. Conclusion: The most effective basil leaf species in inhibiting the growth of C. albicans was Ocimum basilicum which was extracted using maceration method with methanol solvent (MIC 0.01%). Meanwhile, the most effective basil leaf species in inhibiting the growth of S. mutans was Ocimum sanctum L. which was extracted using the soxhletation method with 96% ethanol solvent (MIC 0.0025%).
Potensi Ekstrak Etanol Biji Melon (Cucumis melo L.) sebagai Antibakteri terhadap Streptococcus mutans Penyebab Karies Gigi Adisty Yasmin, Kamila Zalfa; Sulistyorini, Ratna; Rakhmawatie, Maya Dian
Medica Arteriana (Med-Art) Vol 6, No 1 (2024): Juni 2024
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/medart.6.1.2024.19-26

Abstract

Latar Belakang: Karies disebabkan oleh demineralisasi pada jaringan gigi yang mempermudah invasi mikroorganisme seperti Streptococcus mutans. Karies dapat dikontrol dengan obat kumur. Untuk meningkatkan keamanan, dapat digunakan bahan alam sebagai zat untuk obat kumur, seperti melon yang telah diteliti memiliki aktivitas antibakteri. Penelitian ini bertujuan mengetahui aktivitas antibakteri ekstrak etanol biji melon (Cucumis melo L.) dalam menghambat S. mutans.Metode: Biji melon dipersiapkan untuk ekstraksi dengan pelarut etanol meng-gunakan metode maserasi. Uji kualitatif fitokimia dilakukan untuk me-ngetahui kandungan senyawa aktif antibakteri. Uji daya hambat antibakteri dari ekstrak biji melon dilakukan dengan metode difusi cakram, dan untuk penentukan kadar hambat minimal dilakukan dengan metode mikrodilusi. Konsentrasi ekstrak etanol biji melon yang digunakan adalah 100; 50; 25; 12,5  dan 6,25 µg/mL. Ampisilin digunakan sebagai kontrol obat dan aquades sebagai kontrol negatif.Hasil: Hasil pemeriksaan fitokimia mendeteksi adanya senyawa flavonoid, saponin, dan alkaloid dari ekstrak etanol biji melon. Ekstrak etanol biji melon konsentrasi 100 dan 50 µg/mL dapat menghambat pertumbuhan S. mutans dengan kategori hambatan sedang (zona hambat secara berurutan 19,9 mm, 16,7 mm). Hambatan dari ekstrak lebih kecil dibandingkan kontrol positif ampisilin yang mencapai 21,2 mm (kategori kuat). Untuk nilai kadar hambat minimal ekstrak etanol biji melon dapat ditentukan sebesar 12,5 µg/mL. Kesimpulan: Aktivitas antibakteri ekstrak etanol biji melon dapat dipengaruhi adanya senyawa aktif dari golongan flavonoid, saponin, dan alkaloid. Ekstrak etanol biji melon (Cucumis melo L.) memiliki potensi dikembangkan sebagai antibakteri terhadap bakteri penyebab karies gigi S. mutans. 
Efek Pemberian Kombinasi Siprofloksasin dan A-Mangostin Secara In Vitro Terhadap Eradikasi Uropatogen Escherichia Coli Rakhmawatie, Maya Dian; Rohmani, Afiana
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.8 KB) | DOI: 10.26714/magnamed.1.2.2015.191-199

Abstract

Effect of In Vitro Combination of Ciprofloxacin and A-Mangostin on Eradication of Uropathogen Escherichia ColiBackground: The percentage of resistance Escherichia coli (E. coli) in patients with UTI to ciprofloxacin reached 73.04%. Various attempts to maximize the use of antibiotics have been done, including optimizing the parameters pharmacokinetics/pharmacodynamics (PK / PD) of each antibiotic. Another effort is needed to optimize the use of antibiotic treatment that has been available, one of which combines the use of compounds derived from herbs, eg active compounds a-mangostin.Objective: The purpose of this study is to find the effect of the combination of á-mangostin and ciprofloxacin on uropathogen E. coli (UPEC) eradication.Methods: This research was carried out by treating the bacteria uropathogenE. coli (UPEC) in vitro. Treatment is divided into (a) treatment groups using ciprofloxacin concentration Cmax at 500 mg dose (2,4 μg/mL), (b) treatment groups using ciprofloxacin concentration Cmax at 750 mg dose (4,3 μg/mL), (c) treatment groups using ciprofloxacin concentration 2,4 μg/mL and a-mangostin concentration 0,18 μg/mL, (d) treatment groups using ciprofloxacin concentration 4,3 μg/mL and a-mangostin concentration 0,18 μg/mL.Result: states that a combination of á-mangostin and ciprofloxacin can prevent the growth of uropathogen E. coli ciprofloxacin-resistant strains (MIC value of 128 μg/mL) compared to administration of ciprofloxacin alone, but the effect was not significant. On uropathogen E coli sensitive to ciprofloxacin (MIC 0,008 μg/mL) and intermediate (MIC 0,5 μg/mL), there was no difference effect of decreasing the number of colonies between awarding a combination of ciprofloxacin and á-mangostin compared administering ciprofloxacin only.Conclusion: Provision of á-mangostin grading 0,18 μg/mL combined with ciprofloxacin had no real benefit in eradicating uropathogen E. coli, which is tested in vitro.
The Cytoxic Effects Of Forest Honey (Apis dorsata) On T47D Breast Cancer Cells Adnan, Malik Hisyam; Rakhmawatie, Maya Dian; Tursinawati, Yanuarita
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 11, No 2 (2024): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.11.2.2024.181-188

Abstract

Background: In 2018, an estimated 2 million people had breast cancer. Forest honey (Apis dorsata) can have antioxidant activity due to the presence of flavonoid saponin, alkaloid, and tannin compound, therefore can be used as anticancer through the induction of apoptosis.Objective: To determine the IC50 of forest honey (Apis dorsata) on T47D breast cancer cells and see the morphology of T47D cells after administration of forest honey.Methods: This study is an in vitro test of the cytotoxic activity of forest honey against T47D breast cancer cells using the MTT assay method. The concentration of forest honey was prepared by the two-fold microdilution method in the range of 1000 - 31.25 µg/mL. Doxorubicin was used as a control drug with a concentration of 20 - 0.675 µg/mL. The morphology of T47D cells after treatment was observed with an inverted microscope with 400x magnification.Results: Forest honey (Apis dorsata) from any concentration did not show any inhibition of growth of T47D breast cancer cells. Meanwhile, doxorubicin had an IC50 of 3.746 µg/mL. The morphology of T47D cells with honey administration showed many live cells with formazan crystals.Conclusion: Forest honey has no cytotoxic activity against T47D breast cancer cells.
Co-Authors - Gilang - Rihadini Abdillah, Rifqi Adisty Yasmin, Kamila Zalfa Adnan, Malik Hisyam Afiana Rohmani Aida Zakiyatul Fikriyah Andra Novitasari Arfiyanti, Mega Pandu Arief Tajally Adhiatma Bintang Tatius Darmono SS Dendiana, M Belraka Khazhadhia’ Kun Dewi Seswita Zilda Diatri, Devita Dyah Kurnia Fitri Erwin Kukuh Widhianto Eti Nurwening Sholikhah Fariz Wafaul Ahyar, Fariz Wafaul Febrina Dwi Haryani Fiska Rahmawati Harsoyo Notoatmodjo Ika Dyah Kurniati Joharlina, Lourensya Berta Kanti Ratnaningrum Kurniawan, Dwi Agus Merry Tiyas Anggraini Muhammad Adzanta Al Afghani Mustofa Mustofa Nanik Marfu&#039;ati Nanik Marfuati Nanik Marfu’ati Nur Rakhma Akmalia Nurkomariah Zulhijjah Nusantara, Muhammad Vegisa Purnamasari, Rina Putri, Jasmin Athaya Hayuning Putri, Zata Amani Fahdina Ransidelenta Vistaprila Elmarda Ratna Sulistyorini, Ratna Retno Indrastiti Samiroh Samiroh, Samiroh Stalis Norma Ethica Tefia Riswanda Lumban Gaol Ulya, Rohmatul Yanuarita Tursinawati, Yanuarita Zulizar, Alif Adlan