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All Journal Medicina journal of internal medicine E-Jurnal Medika Udayana E-Jurnal Udayana Medica Berkala Kedokteran The Indonesian Biomedical Journal Jurnal Penyakit Dalam Udayana ISM (Intisari Sains Medis) : Jurnal Kedokteran Bioscientia Medicina : Journal of Biomedicine and Translational Research Medical and Health Science Journal Neurologico Spinale Medico Chirurgico Bioscientia Medicina : Journal of Biomedicine and Translational Research GANESHA MEDICINA MEDICINUS Jurnal Indonesia Sosial Sains Journal of Global Pharma Technology Asian Journal of Social and Humanities Jurnal Ekonomi Kesehatan Indonesia Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
MADE RATNA SARASWATI .
Bagian Ilmu Penyakit Dalam RSUP Sanglah, Fakultas Kedokteran Universitas Udayana
Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences

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Journal : MEDICINUS

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The Association between Thyroid Function with Bone Mineral Density in Hyperthyroid Patients at The Diabetic Center Clinic of RSUP Prof. dr. I.G.N.G. Ngoerah, Denpasar Katrin Wilentina Siahaan; Made Ratna Saraswati
MEDICINUS Vol. 39 No. 1 (2026): MEDICINUS
Publisher : PT Dexa Medica

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56951/6h1hgs76

Abstract

Hyperthyroidism is a pathological condition caused by an excess of thyroid hormones synthesized and secreted by thyroid gland. The prevalence of hyperthyroidism remains significant worldwide. Hyperthyroidism affect both the resorption and formation phases by stimulating the activity of osteoblasts and osteoclast, shortening the bone remodeling time, and consequently leading to bone loss characterized by a decrease in bone mineral density (BMD). Identifying the risk of osteoporosis and fractures in the hyperthyroid population requires research on the phenomenon of low bone mineral density values in hyperthyroid patients. Therefore, this study seeks to examine the association between thyroid function (TSHs and FT4) with BMD values in hyperthyroid patients. The observational analytic study with a cross-sectional design was conducted on hyperthyroid patients undergoing outpatient treatment at the Diabetic Center Clinic at Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, from January to May 2024, based on the inclusion and exclusion criteria, aged 18-50 years. This study evaluated TSHs and FT4 levels against BMD using dual-energy x-ray absorptiometry (DEXA) bone scans on the femur and lumbar regions, expressed in Z-scores. Data were analyzed using SPSS v.23.0 through univariate and bivariate analysis. The analysis used Spearman correlation with p<0.05 considered significant. The median age of hyperthyroid patients in this study was 34 years (19-50) years, with 84.4% being women. The TSHs level was 0.22 ± 0.45 mIU/L and the FT4 level was 3.22 ± 3.16 ng/dL. Spearman correlation showed no correlation between TSHs levels (r=0.138; p=0.452) and a negative correlation between FT4 levels (r=-0.426; p=0.015) with the average BMD (Z-score), indicating that the higher FT4 levels, then the bone mineral density value gets lower in hyperthyroid patients. This study demonstrates association between FT4 levels and bone mineral density in hyperthyroid patients, while TSHs levels showed no association with BMD in hyperthyroid patients.
Co-Authors A.A Sagung Ika Nuriska A.A.Gde Budhiarta Agus Santosa Ake, Anselmus Anak Agung Gde Budhiarta Anak Agung Gde Budhiarta Anak Agung Gede Ari Nanda Bhaswara Anak Agung Gede Budhiarta Anak Agung Gede Mahaindra Putra Andika Budiartha, Putu Gede Azizah, Norma Nur Azizah Bondan Winarno Budhiarta, Anak Agung Gde Budi Ratna Aryani David Dharmawan Harjanto Devinta, Made Ratih Santi Dewa Ayu Sri Agung Suandewi Dewi, Putu Feby Miswari Dumilah Ayuningtyas Eti Kurniaty Gautama M, Putu Gizha Satrya Gede Agung Widya Iswara Gede Andrewartha Gozali, Theodorus Onesiforus Herawati Sudoyo I Gde Raka Widiana I Gde Suranaya Pandit I Gusti Ayu Sri Mahendra Dewi I Gusti Ngurah Kade Mahardika I Gusti Putu Suka Aryana I Ketut Suastika I Ketut Sustika I Made Ady Wirawan I Made Bagiada I Made Pande Dwipayana I Made Siswadi Semadi I Made Siswadi Semadi I Made Siswadi Semadi I Made Yoga Prabawa I Wayan Eka Satriawibawa I Wayan Hartadi Noor I Wayan Losen Adnyana I Wayan Putu Sutirta Yasa I Wayan Sudhana I Wayan Sumardika I. K. Suastika Ida Bagus Aditya Nugraha Ida Bagus Yorky Brahmantya Isabella Soerjanto Putri K Suastika Kadek Dina Puspitasari Kartadinata, Sarah Levina Katrin Wilentina Siahaan Ketut Suega Komang Agus Wira Nugraha Laksmi, Putu Pradnyasanti Made Ayu Devi Pita Loka Made Yogi Krisnanda Malik, Safarina G. Marisye Christantia Mayura, I Gusti Ngurah Mochtar, Fransiska Muhammad Aris Sugiharso Ni Ketut Rai Purnami Ni Luh Made Novi Ratnasari Ni Luh Putri Kresnasari Ni Made Sintia Anggia Sari Nym Astika Nyoman Arya Shridewi Abhigamika Oktavianthi, Suksma Pande Ayu Naya Kasih Permatananda Parastan, Rovie Hikari Prichilia Sarah Permadi R. Prawira Bayu Putra Dewa Ratih Pradnyandari Pemayun Rena, Ni Made Renny Anggreni Rheza Priyadi Rooseno, Ratna Rayeni Natasha Rusditha, Sarah - S., Hantono Safarina G. Malik Saraswati, Putu Ayu Indah Savitri, Putu Dian Hermawati Sari Sukma Oktavianthi Surya Sanjaya Funistera Susy Purnawati Tuty Kuswardani Wan Muhamad Syafiq Wardana, Rr. Cattleya Allayka Wimpie I Pangkahila Wira Gotera ¬Ni Putu Ade Tiwi Tyastarini Tyastarini