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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Cardiology Jurnal Respirologi Indonesia JK Unila (Jurnal Kedokteran Universitas Lampung) Respiratory Science Cerdika: Jurnal Ilmiah Indonesia
Budhi Antariksa
Departemen Pulmonologi Dan Kedokteran Respirasi, Fakultas Kedokteran Universitas Indonesia, RSUP Persahabatan, Jakarta
Agriculture, Biological Sciences & Forestry Humanities Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Osteoporosis Prevalence In Stable Patients With Chronic Obstructive Pulmonary Disease Dwi Handoko; Faisal Yunus; Budhi Antariksa; Rochsismandoko Rochsismandoko
Respiratory Science Vol. 1 No. 2 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v1i2.19

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality in the world. Comorbid diseases in COPD contributing to low health status, affecting the duration of treatment and even death. Osteoporosis is a quite often comorbid that found in COPD. In Indonesia, there are no data of prevalence on osteoporosis in patient with stable COPD. The aim this research to get the data of osteoporosis in patients with stable COPD at Persahabatan Hospital. Method: The studie’s design was cross-sectional. Patients with stable COPD who came to the Asthma/COPD policlinic at Persahabatan Hospital who meet the criteria of inclusion and exclusion. Subjects had an examined of bone mineral density using dual energy x-ray absorptiometry (DXA) and had an examined of vitamin D blood level. At the time of visit, conducted anamnesis of symptoms, exacerbations, history of smoking, used of corticosteroid (oral or inhaled), comorbid, assessment of nutritional status. Results: Subjects were dominated with male (90.6%) in the age group 65-75 years old (53.1%), and smoking history (84.4%). The most degree of COPD were GOLD II (46.9%) and group B (50%) that using corticosteroid (65.7%). Prevalence of osteoporosis was 37.5%. There were no statistically significant between COPD group, the degree of COPD, sex, smoking history, history of corticosteroid, age, levels of 25-OHD, pulmonary function with the occurrence of osteoporosis in patients with stable COPD. There were a statistically significant on low BMI as a risk factor for osteoporosis in stable COPD. Conclusion: The prevalence of osteoporosis in patients with stable COPD in the Persahabatan Hospital is 37.5%. There are a statistically significant relationship between BMI with osteoporosis in patients with stable COPD.
Chest Wall Syndrome Isti Mardiana Soetartio; Agus Dwi Susanto; Dicky Soehardiman; Budhi Antariksa
Respiratory Science Vol. 2 No. 1 (2021): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i1.34

Abstract

Chest wall syndrome is the most frequent cause of chest pain complained by patients admitted to the physician’s office, in outward as well as in emergency department. It may affect all ages with sex ratio of 1:1 between man and woman. History of illness and sensibility to palpation or tenderness were the keys to the diagnostic approach. Pain was generally moderate, well localized, continuous or intermittent over a number of hours to days or weeks and was amplified by position or movement that was commonly located on the left side of the chest. Chest wall syndrome is usually a common and benign condition, but it leads to anxiety and frequent recurrence. Definitive treatment is not yet confirmed and treatment for the different condition causing isolated musculoskeletal chest pain is poor. Therefore, some options to avoid aggravating physical activities, stretching, and simple analgesics as needed are the best choices of current management.
Preoperative Assessment Prior to Lung Resection: How to Eliminate the Risk Dian Megawati; Menaldi Rasmin; Budhi Antariksa; Faisal Yunus
Respiratory Science Vol. 2 No. 3 (2022): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v2i3.48

Abstract

Lung resection is part of the treatment of various lung diseases, both malignancy and infection. Although it has great benefits, lung resection can result in a variety of functional disorders that can affect the whole cardiopulmonary system. The mortality of these procedures is 2-4% in segmentectomy and 6-8% in lobectomy, while the mortality of pneumonectomy in the world is 11%. Good preoperative assessment of patients has been reported to have reduced mortality and morbidity after lung resection. Things that need to be considered to assess preoperative eligibility include age, lung function, cardiovascular fitness, nutrition, and performance status. The preoperative pulmonary tolerance assessment is divided into three stages: the first stage is the assessment of lung function and blood gas analysis, the second stage is to assess postoperative prediction of pulmonary function, and the third stage is to assess the maximum oxygen consumption per minute by doing a cardiopulmonary exercise test. Patients who have a good tolerance for lung resection are patients who have predictive postoperative force expiration volume one second (ppoFEV1) values more than 40%, predictive postoperative diffusion capacity of the lung for carbon monoxide (ppoDLCO) more than 50%, and maximum oxygen consumption (VO2 max) more than 15ml/kg/min.
Exploring Epigenetic Landscapes in COPD: Therapeutic Implications and Recent Insights Wirawan, Aditya; Kinasih, Tutug; Imaniar, Rania; Baskoro, Hario; Antariksa, Budhi; Matsumoto, Naohisa
Respiratory Science Vol. 5 No. 2 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i2.166

Abstract

Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of global mortality, primarily driven by an abnormal inflammatory response to harmful particles and gases. This review explores the epigenetic mechanisms underlying COPD pathogenesis and their therapeutic implications. A comprehensive literature review was conducted, analyzing recent findings on DNA methylation, histone modifications, and noncoding RNAs (ncRNAs) in COPD. Key studies highlighting the impact of these epigenetic changes on inflammation, cellular responses, and disease progression were evaluated. Our review highlights that epigenetic modifications, such as DNA methylation and histone modifications, significantly impact gene expression without altering the DNA sequence. Cigarette smoking has been shown to influence both DNA methylation and histone acetylation, leading to inflammatory responses and the the exacerbation of COPD. These modifications contribute to chronic inflammation and disease progression, with alterations in histone acetylation, methylation, and phosphorylation playing critical roles in COPD pathogenesis. The interplay between epigenetic changes and environmental factors, particularly tobacco smoke, reveals a complex mechanism driving COPD progression. Aberrant gene expression linked to these epigenetic modifications suggests potential disease severity and progression biomarkers. Targeting these alterations offers novel therapeutic strategies. Emerging treatments, such as quercetin and theophylline, promise to restore normal cellular functions and effectively manage COPD. Future research should focus on elucidating these mechanisms further and developing targeted therapies to mitigate the impact of epigenetic modifications on COPD.
Co-Authors Aditya Wirawan, Aditya Agus Dwi Susanto Agustin, Heidy Andika Chandra Putra Aniwidyaningsih, Wahju Aria Kekalih Astari Pranindya Sari Audita, Fatira R. Bambang Budi Siswanto Baskoro, Hario Damayanti, Triya Debi Febriani Dewantoro, Luhur Dewi Yenita Dewi Yennita Sari Dian Megawati Diana Septiyanti Dianiati Kusumo Sutoyo Dwi Handoko Elhidsi, Mia Erlina Burhan Faisal Yunus Faisal Yunus Faisal Yunus Faisal Yunus Faisal Yunus Fanny Fachrucha Hananto Andrianto Harris Abdullah Helda Helda Hera Afidjati Ibrahim Nur Insan Putra Darmawan Isbaniah, Fathiyah Isep Supriyana Isti Mardiana Soetartio Kinasih, Tutug Kirana Anggarani, Sekar M. Arsyad M. Arsyad, M. Matsumoto, Naohisa Menaldi Rasmin Mirza Purwitasari Mohamad Fahmi Alatas Muhammad Alkaff Mulkan Azhary Prihartono, Nurhayati Adnan Purbasari, Utami Raden Rara Diah Handayani Rania Imaniar Ratnawati Ratnawati Retno A S Soemarwoto Riliani, Marisa Rita Rogayah Rochsismandoko Rochsismandoko Samoedro, Erlang Sekar Kirana Anggarani Sita Laksmi Andarini Soehardiman, Dicky Steven Jonathan Syazili Mustofa Taufik, Feni Fitriani Tomu Juliani Wahyu Aniwidyaningsih Wiwien Heru Wiyono Zaini, Jamal