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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

SEXUAL ABSTINENCE AND IMMOBILISATION STRESS DECREASED NITRATE + NITRITE CONCENTRATION AND INCREASED NECROTIC OF PENILE CORPUS CAVERNOSUM SMOOTH MUSCLE AND ENDOTHELIAL CELLS OF ADULT MALE MICE Karmaya, I.N. Mangku; I. Pangkahila, Wimpie; Pangkahila, J. Alex
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 4, No. 1 Januari 2010
Publisher : Udayana University

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Abstract

Sexual intercourse in adult people is not only related to reproduction,recreation and better relation but also for maintaining good health. Regular andfrequent sexual intercourse has protective role for cardiovascular disease, malignancyand often related with longevity. On the contrary less frequent sexual intercourse isoften correlated to early death and reproductive organ disorders. One main factorwhich involve in any process related to sexual intercourse is nitric oxide. Thisresearch aims to know the declination of total nitrate and nitrite concentration as themain oxidation product of nitric oxide and necrosis of the endothelial and smoothmuscles of corpus cavernosum after three month sexual intercourse abstinence andstress immobilization.By randomized pretest-posttest control group design, the research wasconducted in adult male mice (Mus musculus) which were divided into four groups.each consisted of seven mice. One group as a control and the other three wereexposed to sexual abstinence, immobilization stress and the combination of sexualabstinence and immobilization stress in three months period. The investigation wascarried out to the penile total nitrate and nitrite concentration and the histologicalchanges of the middle part of the penile shaft. To know the degree of lesion then thecalculation of the histologic features was done in five view fields of every preparat.The result was compared to control group.In this research, the mean of total nitrate and nitrite decline and the lowest wasfound in the combine intervention groups with significance level p < 0,005. Thecorpus cavernosum in the intervention groups showed multifocal necrosis onendothelial and smooth muscle cells of corpus cavernosum with picnotic nuclei,irregular form and dark colour. Some muscle cells are lysis. These features werefound in three among seven samples in sexual abstinence group, two among sevensamples in immobilization stress group and in all samples of combined interventiongroup.Conclusions can be drawn from this research are that the sexual abstinence,immobilization stress and the combine interventions decline the nitrate and nitriteconcentrations and induce endothelial and smooth muscle cells necrosis of the copuscavernosum.
PHOTOCHEMOPROTECTION OF CAULERA SPP ACTIVE COMPONENT ON RAT MODEL SKIN Wiraguna, A. A. G. P.; Pangkahila, W.; Mantik-Astawa, and N.
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol 7 No 2 (2013): IJBS Vol2 No2
Publisher : Udayana University

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Abstract

Caulerpa spp. including seaweed and macro-algae can be found in a large number at Coastal Serangan, Bali-Indonesia. Caulerpa spp was historically used for food and vegetable. However, in our today life, this plant was applied as material for skin care products, especially for UV protection. The aim of this study is to know the active component of caulerpa spp extract and its inhibition of premature skin aging induced by UV-B radiation through collagen expression. This was descriptive and experimental research applying a randomized posttest only control group design. Active component contained in the caulerpa spp extract are carotenoid, vitamin A, C, and E, polyphenols, minerals and amino acids. Topical application of caulerpa spp can suppress the UV-B radiation induced collagen damage. Increased of collagen expression in all groups of caulerpa spp. just as good as astaxanthin group in improving collagen expression and 0.2% of caulerpa spp. extract is the most effective dose in improving collagen expression.
Co-Authors ., Nuriyah ., Yulyani ., Zenitalia A. A. G. P. Wiraguna A.A. Gede Budhiarta A.A. Gede Budhiarta A.A. Gede Budhiarta A.A.G.P Wiraguna A.A.G.P. Wiraguna A.A.G.P. Wiraguna A.A.G.P. Wiraguna AAGP Wiraguna AAGP Wiraguna AAGP Wiraguna AAGP. Wiraguna Agung Wiwiek Indrayani Agus Eka Darwinata Akpriyanti, DG Ika Aman, I G M Anak Agung Ayu Ngurah Susraini Anak Agung Gde Budhiarta Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Gede Budhiarta Anak Agung Gede Budhiarta Anak Agung Gede Putra Wiraguna Andrew Lie Angelia Ongko Prabowo Anne Carolina Kencanawati Anshori, Ahmad M. Aprilany Stella peng Astried Haryanto Augus Venty Azizah, Norma Nur Azizah Bagus Komang Satriyasa Balqis Wasliati Balqis Wasliati Bissi Herliane Budhiarta, Anak A.G. Chandra, Aji B. Chynthia Friama Delly Dahlia Dessy Indriana Hatta Dewi, Dian Andriani Ratna Dian Andriani Dumaria, Corazon H. Dwindi Saptania Efrida Sumawati Erwin Sugito Eveline Margo Feily Sari Moelyono Fenni Liem Ferbian M. Siswanto, Ferbian M. Fiter, Joni Gde Ngurah Idraguna Pinatih Gina Septivani Hendrik Danico Heny Widiyowati S Hery Widijanto Huda, Siti M. N. I Gede Made Aman I Gede Widhiantara I Gusti Ayu Sri Mahendra Dewi I Gusti Made Aman I Ketut Suada I Ketut Tunas I Nyoman Adiputra I Nyoman Mangku Karmaya I NYOMAN MANTIK ASTAWA I Wayan Weta Ida Sri Iswari Indah Mira Tiaraputri Wijaya Ingrid Rotinsulu J. A. Pangkahila Junivan Lindra Kandy Rosa Ismalia Larasati, Veny Laura Indriana Liliana, Nize Lis Widodo Peni Liya Rosdiana Luh Putu Iin Indrayani Maker Made Ayu Mirah Wulandari Made Oka Negara MADE RATNA SARASWATI . Manus, Widya Christine Maulidha Suzi Annisa Maya Cesarya Simangunsong Meiny Linda Setiawan Meiyati Panambunan Melanie Maria Magdalena Ratulangi Mery Merysia Milhanah Milhanah Mochtar, Fransiska Muhammad Rahmatullah Ni Luh Putri Astini Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Putu Sriwidyani Nina Marini Nining Triyana Darise Nurwiyanti, . Palumpun, Eva F. Periskila Abigail Phery Candres Putri Puspitasari R. A.T. Kuswardhani Rafiah Sirikit Saenong Riliani, Marisa Romy Kamaluddin Ronald Suryaprawira Rusmiatik Rusmiatik Sabella Setia Wardani Siahaan, Eva R. Siahaan, Marintan S. Y. Sofiana, Rahmi Suarni . Sulaiman, Yogie Susianingsih Murni Hartati Syafii, Corry P. Tambor Tiur Marlina Tamon, Oktavian Tarnajaya, Karnia Thomas Eko Purwata Trisna Yuliharti Tersinanda Ursula Sulistiani Vany Novanty Vashti Saraswati Vitia Tandy Widhayanthi, Trisna A. Wiraguna AAGP Wiraguna, A A G P Wiraguna, A AGP Wiraguna, AAG Wiraguna, Anak A.G.P. Yuziana Yuziana