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Platelet Profile in Patients with Status Asmaticus in Kebumen Juwariyah, Juwariyah; Arjana, Adika Zhulhi; Rahayu, Ester Tri; Rosita, Linda; Irfan, Mohammad Rozan
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (2017): December 2017
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

BACKGROUND: Asthma has been considered as type 1 hypersensitivity disease, but actually asthma involves a variety of inf lammatory factors.Based on pro-inf lammatory cells, asthma is classified into eosinophilic, non-eosinophilic, neutrophilic, and non-neutrophilic. Platelet plays a role inÂ pathophysiology of asthma through inf lammation. However, platelet profile in patients with asthma have not been established.OBJECTIVE: to determine the platelet indices of patients with status asmaticus of different phenotypes.METHODS: a cross-sectional study was conducted among a minimum sample size of 67 patients. Data were collected from medical records of patients in RSUD Kebumen. Platelet indices included mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT).RESULTS: There was no significant difference in the value of MPV and PDW in patients with eosinophilic and neutrophilic asthma (p> 0.05). But,there was a significant difference in PCT between the two groups (P <0.05)CONCLUSION: There was difference only in plateletcrit (PCT) between patients with eosinophilic and netrophilic asthma.

Stability of classification performance on an adaptive neuro fuzzy inference system for disease complication prediction Sri Kusumadewi; Linda Rosita; Elyza Gustri Wahyuni
IAES International Journal of Artificial Intelligence (IJ-AI) Vol 12, No 2: June 2023
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijai.v12.i2.pp532-542

It is crucial to detect disease complications caused by metabolic syndromes early. High cholesterol, high glucose, and high blood pressure are indicators of metabolic syndrome. The aim of this study is to use adaptive neuro fuzzy inference system (ANFIS) to predict potential complications and compare its performance to other classifiers, namely random forest (RF), C4.5, and naïve Bayesian classification (NBC) algorithms. Fuzzy subtractive clustering is used to construct membership functions and fuzzy rules throughout the clustering process. This study analyzed 148 different data sets. Cholesterol, random glucose, systolic, and diastolic blood pressure are all included in the data collection. This learning process was conducted using a hybrid algorithm. The consequent parameters are adjusted forward using the leastsquare approach, while the premise parameters are adjusted backward using the gradient-descent process. The performance of a system is determined by the following indicators: accuracy, sensitivity, specification, precision, area under the curve (AUC), and root mean squared error (RMSE). The results of the training prove that ANFIS is an "excellent classification" classifier. ANFIS has proven to have very good stability across the six performance parameters. The adaptive properties used in ANFIS training and the implementation of fuzzy subtractive clustering strongly support this stability.

Performance of Fuzzy C-Means (FCM) and Fuzzy Subtractive Clustering (FSC) on Medical Data Imputation Sri Kusumadewi; Linda Rosita; Elyza Gustri Wahyuni
ComTech: Computer, Mathematics and Engineering Applications Vol. 15 No. 1 (2024): ComTech
Publisher : Bina Nusantara University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21512/comtech.v15i1.11002

Missing values or incomplete data are frequently encountered in medical records. These issues will be a serious problem if the data must be provided completely for analysis. The research aimed to prove the performance of the Fuzzy Subtractive Clustering (FSC) and Fuzzy C-Means (FCM) methods for solving imputation problems. Both methods were implemented using medical data. It had been conducted using K-Means as a crisp clustering approach for imputation. In the research, fuzzy clustering—a distinct methodology—was applied. The primary research contribution was the suggested fuzzy logic imputation method, which took uncertainty under consideration. The data sample consisted of patients who were at least 40 years old and had a history of hypertension, diabetes, heart disease, stroke, or chronic kidney disease. The test was carried out by taking random portions of data from the entire medical record. The randomization technique used a probability of 10%–50%. The results of the ANOVA test show that the p-value is greater than ∝(=0.05). It means that the imputed value does not differ from the original value, whether implemented in the FSC or FCM method. The algorithm’s performance is evaluated using the Pearson correlation coefficient. According to the t-test results, the FCM method has a higher correlation coefficient than the FSC method. It implies that FCM is superior to FSC.

Implementation of Problem Based Learning (PBL) Electronic Module Teaching Materials to Increase Student Interest and Learning Outcomes in Reaction Rate Material Siregar, Raudatul Hasanah; Rosita, Linda; Jwitaningsih, Tita
Jurnal Pendidikan dan Pembelajaran Kimia Vol 13, No 1 (2024): Jurnal Pendidikan dan Pembelajaran Kimia
Publisher : Universitas Lampung

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This implementation research is to determine the comparison of the improvement of learning outcomes and interest of students taught by using electronic module teaching materials based on Problem Based Learning and students taught by using high school chemistry textbook teaching materials and to determine the relationship between interest and the improvement of student learning outcomes in reaction rate material class XI at SMA Negeri 14 Medan. This research is a pure experimental research with pretest-posttest control group desaign design. Samples in the study were taken 2 classes using random sampling technique, namely class XI IPA 5 as an experimental class taught using PBL-based electronic module teaching materials and class XI IPA 2 as a control class taught using high school chemistry textbook teaching materials. The application of electronic module teaching materials is measured through the difference in the average n-Gain of student learning outcomes and interest, both in the experimental and control classes. The results showed that the increase in student learning outcomes and interest in the experimental class was higher than in the control class. The average increase in learning outcomes in the experimental class was 0.71 with an increase in interest of 0.54 and an increase in learning outcomes in the control class was 0.478 with an increase in interest of 0.31. Then, there is a correlation between interest and the improvement of student learning outcomes taught using PBL-based electronic module teaching materials of 0.764 with a high category.Keywords: PBL-based electronic modules, learning outcomes, learning interestDOI: 10.23960/jppk.v13.i1.2024.06

Pemodelan Sistem Urinalisis Mikroskopik Untuk Kristal Amorf Sebagai Solusi Pada Laboratorium Rositasari, Annisa; Muhimmah, Izzati; Rosita, Linda
Jurnal Sains, Nalar, dan Aplikasi Teknologi Informasi Vol. 4 No. 2 (2025)
Publisher : Department of Informatics Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/snati.v4.i2.40734

Dalam penelitian ini mikroskop berfungsi untuk melihat objek terkecil yang ada di dalam kandungan urin. Ahli Tenaga Laboratorium Medis (ATLM) merupakan tenaga kesehatan yang menggunakan mikroskop untuk pengamatan. Penelitian dilaksanakan dengan mengambil data dari Rumah Sakit Islam Yogyakarta PDHI dan mendapat 153 data pemeriksaan urin dari pasien yang datang ke Unit Gawat Darurat (UGD), rawat jalan, dan rawat inap. Dari 153 data yang diperoleh, di mana 53 di antaranya menunjukkan adanya urin dengan enam jenis kristal yang terdeteksi. Keenam jenis kristal tersebut meliputi kristal kalsium oksalat, kristal fosfat triple, fosfat amorf, kalsium karbonat, kristal amonium biurat, dan kristal asam urat. Sistem yang dikembangkan menggunakan bahasa pemrograman Python ini fokus pada identifikasi jenis kristal amorf. Dalam sistem tersebut, hasil marking yang dilakukan oleh ahli pada objek kristal berhasil dikenali oleh sistem. Sistem sudah sesuai dengan hasil yang diperoleh dari pakar. Pengujian ini menggunakan Single Decision Threshold dan memperoleh hasil nilai sensitivity sebesar 0.63 atau dalam bentuk persen yaitu 63%. Sistem mendapatkan hasil nilai specificity sebesar 0.17 atau 17%. Sistem mendapatkan hasil nilai accuracy sebesar 0.36 atau 36% dan sistem mendapatkan hasil nilai precision sebesar 0.35 atau 35%. Kinerja sistem sebesar 26%.

Hubungan Ureum dan Kreatinin Serum dengan Lamanya Terapi Hemodialisis pada Pasien Penyakit Ginjal Kronis (PGK) di RS PKU Bantul Malfica, Muhammad Joddy; Rosita, Linda; Yuantari, Rahma
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 1 No. 1 (2023)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol1.iss1.art2

Latar Belakang: Penurunan fungsi ginjal yang cukup berat dilihat dari peningkatan dua substansi kimia darah yaitu ureum dan kreatinin serum. Hemodialisis sebagai pengganti ginjal sementara dapat menurunkan kadar ureum dan kreatinin serum yang meningkat pada pasien Penyakit Ginjal Kronik (PGK). Semakin lamanya hemodialisis pada penyakit ginjal kronik diharapkan semakin terkontrol pula kadar ureum dan kreatinin pasien.Tujuan: Mengetahui apakah terdapat hubungan ureum dan kreatinin serum dengan lamanya hemodialisis pada pasien penyakit ginjal kronik di Rumah Sakit PKU Bantul D.I. Yogyakarta.Metode: Penelitian ini merupakan penelitian kuantitatif korelasi dengan pendekatan cross sectional. analisis data menggunakan analisis univariat dan bivariat dilakukan pada bulan November–Desember 2020 dengan sampel sebesar 50 orang yang menggunakan teknik consecutive sampling. Hasil: Nilai ureum dan kreatinin serum pada 50 subjek penelitian ditemukan berada pada kadar tinggi baik laki-laki maupun perempuan dengan nilai rerata ureum masing-masing (40,06 mg/dL & 35,59 mg/dL) dan nilai median kreatinin serum (3,05 mg/dL dan 2,28 mg/dL). Hubungan antara kadar ureum dan kreatinin serum dengan lamanya hemodialisis masing-masing didapatkan p = 0,980 dan p = 0,665.Simpulan: Tidak terdapat adanya hubungan yang bermakna antara ureum dan kreatinin serum dengan lamanya hemodialisis pada pasien penyakit ginjal kronik di RS PKU Bantul. Kata kunci : Ureum; kreatinin; lama hemodialisis; pasien penyakit ginjal kronis

Efek Kombinasi Kurkumin dan Simvastatin Terhadap Kolesterol Total pada Tikus Wistar yang Diinduksi Kuning Telur Puyuh Permana, I Gede Surya; Hendrawati, Asri; Rosita, Linda
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 3 No. 1 (2025)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/bikkm.vol3.iss1.art4

Latar Belakang:Hiperlipidemia disebabkan oleh konsumsi tinggi lemak dan merupakan faktor risiko penyakit kardiovaskular. Statin merupakan obat pilihan dalam menurunkan kadar kolesterol tinggi, namun menimbulkan beberapa efek samping. Oleh karena itu diperlukan suatu senyawa yang dapat menurunkan kadar kolesterol total tanpa memberikan efek samping. Kurkumin memiliki efek antioksidan sekaligus penghambat peroksidasi lipid. Tujuan:Penelitian ini bertujuan untuk mengetahui efek pemberian kombinasi kurkumin dan simvastatin terhadap kadar kolesterol total pada tikus yang diinduksi kuning telur puyuh. Metode: Penelitian ini merupakan penelitian eksperimental dengan desain post-test only control group design. Dua puluh ekor tikus dibagi menjadi 4 kelompok, terdiri atas: K1 yaitu tikus hiperlipidemia yang diberi plasebo, K2 yaitu tikus hiperlipidemia yang diberi simvastatin dosis 0,18 mg/200gBB/hari, K3 yaitu tikus hiperlipidemia yang diberi kurkumin dosis 80 mg/kggBB/hari, K4 yaitu tikus hiperlipidemia yang diberi simvastatin 0,18 mg/200gBB/hari dengan kurkumin dosis 80 mg/kgBB/hari. Perlakuan diberikan selama 4 minggu. Pengukuran kadar kolesterol total menggunakan metode CHOD-PAP (Cholesterol Oxidase Method). Data kolesterol total dianalisis menggunakan one way ANOVA. Hasil: Penelitian ini menunjukkan rata-rata kadar kolesterol total pada kelompok kelompok K1 sebesar 75,00 ± 3,26 mg/dL, K2 sebesar 71,40 ± 14,467 mg/dL, K3 sebesar 73,80 ± 31,14 mg/dL dan K4 sebesar 77,80 ± 39,21 mg/dL. Tidak ada perbedaan yang signifikan antar kelompok K1-K4 (p=0,953). Simpulan:Pemberian kombinasi kurkumin dan simvastatin tidak memiliki efek terhadap kadar kolesterol total pada tikus hiperlipidemia. Kata Kunci: Kurcumin; simvastatin; hiperlipidemia; kolesterol total; kombinasi

Implementation of Problem Based Learning (PBL) Electronic Module Teaching Materials to Increase Student Interest and Learning Outcomes in Reaction Rate Material Siregar, Raudatul Hasanah; Rosita, Linda; Jwitaningsih, Tita
Jurnal Pendidikan dan Pembelajaran Kimia Vol 13, No 1 (2024): Jurnal Pendidikan dan Pembelajaran Kimia
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

This implementation research is to determine the comparison of the improvement of learning outcomes and interest of students taught by using electronic module teaching materials based on Problem Based Learning and students taught by using high school chemistry textbook teaching materials and to determine the relationship between interest and the improvement of student learning outcomes in reaction rate material class XI at SMA Negeri 14 Medan. This research is a pure experimental research with pretest-posttest control group desaign design. Samples in the study were taken 2 classes using random sampling technique, namely class XI IPA 5 as an experimental class taught using PBL-based electronic module teaching materials and class XI IPA 2 as a control class taught using high school chemistry textbook teaching materials. The application of electronic module teaching materials is measured through the difference in the average n-Gain of student learning outcomes and interest, both in the experimental and control classes. The results showed that the increase in student learning outcomes and interest in the experimental class was higher than in the control class. The average increase in learning outcomes in the experimental class was 0.71 with an increase in interest of 0.54 and an increase in learning outcomes in the control class was 0.478 with an increase in interest of 0.31. Then, there is a correlation between interest and the improvement of student learning outcomes taught using PBL-based electronic module teaching materials of 0.764 with a high category.Keywords: PBL-based electronic modules, learning outcomes, learning interestDOI: 10.23960/jppk.v13.i1.2024.06

Diagnosis dan Tatalaksana Demam Tifoid pada Pasien Lansia dengan Komorbiditas Hipertensi dan Diabetes Melitus Tipe 2: Sebuah Laporan Kasus Maryani Saputri, Eka; Rosita, Linda; Rais, Andri
Berkala Ilmiah Kedokteran dan Kesehatan Masyarakat Vol. 4 No. 1 (2026)
Publisher : Fakultas Kedokteran, Universitas Islam Indonesia

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Diagnosis dan Tatalaksana Demam Tifoid pada Pasien Lansia disertai Hipertensi dan Diabetes Melitus Tipe 2 Background: Typhoid fever is a systemic infectious disease that remains prevalent in developing countries, including Indonesia. In elderly patients with comorbidities such as hypertension and type 2 diabetes mellitus, typhoid fever may present with atypical clinical manifestations and an increased risk of complications, requiring accurate diagnosis and comprehensive management. Objective: This paper aims to describe the diagnosis and management of typhoid fever in an elderly patient with concomitant hypertension and type 2 diabetes mellitus. Methods: This study is presented as a case report. Data were collected through history taking, physical examination, laboratory investigations, and evaluation of the management provided during the patient’s hospitalization. Results: The elderly patient exhibited atypical clinical features of typhoid fever, supported by positive serological findings. The patient received appropriate antibiotic therapy according to current guidelines, along with optimal management of hypertension and type 2 diabetes mellitus, resulting in clinical improvement during treatment. Conclusion: The diagnosis of typhoid fever in elderly patients with comorbid hypertension and type 2 diabetes mellitus requires a high index of clinical suspicion. Appropriate and integrated management of both the infection and comorbid conditions can lead to favorable clinical outcomes. Keywords: Typhoid fever; Elderly; Hypertension; Type 2 diabetes mellitus; Management Latar Belakang: Demam tifoid merupakan penyakit infeksi sistemik yang masih menjadi masalah kesehatan endemik di negara berkembang, termasuk Indonesia. Pada populasi pasien lanjut usia (lansia) dengan komorbiditas seperti hipertensi dan diabetes melitus tipe 2, penyakit ini sering kali bermanifestasi dengan gejala klinis yang atipikal serta memiliki risiko komplikasi yang lebih tinggi. Kondisi ini menuntut ketajaman diagnosis dan pendekatan tata laksana yang komprehensif. Deskripsi Kasus: Kami melaporkan kasus seorang pasien lansia yang menunjukkan gambaran klinis demam tifoid yang tidak khas. Penegakan diagnosis dilakukan melalui anamnesis mendalam, pemeriksaan fisik, serta dikonfirmasi dengan temuan serologis positif. Pasien mendapatkan terapi antibiotik yang sesuai dengan pedoman terkini, bersamaan dengan manajemen optimal untuk mengontrol hipertensi dan diabetes melitus tipe 2 yang dideritanya. Evaluasi selama perawatan menunjukkan adanya perbaikan klinis yang signifikan. Simpulan: Penegakan diagnosis demam tifoid pada pasien lansia dengan multipatologi memerlukan indeks kecurigaan klinis yang tinggi mengingat manifestasinya yang sering tersamar. Tata laksana yang tepat dan terintegrasi antara penanganan infeksi akut serta kontrol kondisi komorbid terbukti mampu menghasilkan luaran klinis yang baik. Kata kunci: demam tifoid; lansia; hipertensi; diabetes melitus tipe 2; tata laksana terintegrasi.

DIAGNOSTIC TEST OF NEUTROPHIL LYMPHOCYTE RATIO IN CONFIRMED COVID-19 POSITIVE PATIENT AT RSUD WONOSARI Arofiq, Muhammad Ariq Naufal; Linda Rosita; Mulyaningrum, Utami
Biomedika Vol 18, No 1 (2026): Biomedika February 2026
Publisher : Universitas Muhammadiyah Surakarta

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Coronavirus Disease 2019 (Covid-19) is an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The neutrophil lymphocyte ratio (NLR) biomarker is used as a parameter of inflammatory reactions which is also frequently evaluated in Covid-19. In Covid-19 patients, there is often an increase in NLR through the mechanism of lymphocyte exhaustion. This research to identify the performance of NLR in a diagnostic test for confirmed Covid-19 patients at RSUD Wonosari. This study is analytical observational through a cross-sectional approach. Sampling used a consecutive sampling technique. The target population was suspected Covid-19 patients. Data were analyzed by univariate, ROC curve, and diagnostic tests. A total of 75 suspected Covid-19 patients were found 33 male patients (44%), 42 female patients (66%), and the most aged> 55 years were 52 patients (69.3%). RT-PCR results found 57 patients were positive for Covid-19 (76%) and 18 patients were negative for Covid-19 (24%). ROC curve obtained AUC value 0.785 (p<0.05; 95% CI 0.662-0.907) with cut-off point NLR≥ 2.33, sensitivity 91.2%, specificity 50%, NPV 64.3%, PPV 85.2%, LR+ 1.81, and LR- 0.17. NLR can be an initial diagnostic tool for Covid-19.

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