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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences journal of internal medicine Jurnal Kedokteran Brawijaya JAM : Jurnal Aplikasi Manajemen Jurnal Penelitian Pendidikan IPA (JPPIPA) Acta Biochimica Indonesiana CRJIM (Clinical and Research Journal in Internal Medicine) Narra J Journal of Community Health and Preventive Medicine (JOCHAPM) Jurnal Penyakit Dalam Indonesia
Achmad Rudijanto
Magister Manajemen Rumah Sakit Fakultas Kedokteran Universitas Barawijaya Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Other

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Prolonged-heated High-Fat Diet Increase the Serum LDL Cholesterol Level and Induce the Early Atherosclerotic Plaque Development in Wistar Rats Yurina, Valentina; Yunita, Ema Pristi; Raras, Tri Yudani Mardining; Rudijanto, Achmad; Handono, Kusworini
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

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Abstract

Rats are one of the most widely used animal models in health research. However, since rats are relatively resistant to atherosclerosis, the transgenic rats often used to study atherosclerosis in rats. Our study suggests a prolonged-heated lipid to induce atherosclerosis in rats, therefore provide a more low-cost option to study atherosclerosis in rats. Aims of this study is to compare the effect of heated high-fat diet (HFD) to the LDL and HDL cholesterol level and foam cell formation in the Wistar rat animal model. Rats were divided into three groups, control group was given with the normal diet, and the other two treated groups received oxidized HFD (heated HFD) and HFD, respectively. The heated HFD contain lard that was previously heated at 190°C for 24 h. Diet was given for 8 weeks. The serum LDL and HDL cholesterol level were measured before and 4th and 8th weeks after treatment with help of colorimetric measurement. The aorta analyzed for the foam cell formation after HE staining using the light microscope.  The prolonged- heated HFD significantly increased the LDL cholesterol from the 4th week of the treatment (p = 0.023). The rats aortic from HFD and heated HFD treated groups showed a mononuclear cells infiltration and the early foam cell formation. The heating process of the lipid caused lipid oxidation which significantly increased the LDL cholesterol level of the animal model and foam cells formation. This study suggests that Wistar rats with heated HFD could demonstrated early atherosclerosis plaque development.
Co-Authors Andreas Budi Wijaya Arie Srihardyastutie Arief Alamsyah N, Arief Alamsyah Asti Melani Astari Aulanni'am, Aulanni'am Aulanniam Budianto, Mochamad Bachtiar Dewi Santosaningsih Dian Handayani Em Yunir, Em Ema Pristi Yunita, Ema Pristi Endang S. Rahayu Fachrureza, Mochamad Gatya, Mifta Handono Kalim Heru Iskandar Jonny K. Fajar Kumala, Poppy Kusworini Handono Leny Budhi Harti Mandang, Veny VV Mariyatun Mariyatun, Mariyatun Nasution, Annio Indah Lestari Ni Luh Tantri Nur Samsu Pramesi, Putrika C. Puteri, Happy HS Rahmawati, Anna Ramadani, Devi Rulli Rosandi Saraswati, Made R Sasiarini, Laksmi Syifa Mustika Tri Yudani Mardining Raras VALENTINA YURINA Viera Wardhani Wahjoe Harijanto Wardhana wardhana Wuragil, Dyah Kinasih Wursito, Wursito