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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences journal of internal medicine Jurnal Kedokteran Brawijaya JAM : Jurnal Aplikasi Manajemen Acta Biochimica Indonesiana Heart Science Journal CRJIM (Clinical and Research Journal in Internal Medicine) Narra J Journal of Community Health and Preventive Medicine (JOCHAPM) Jurnal Penyakit Dalam Indonesia
Achmad Rudijanto
Magister Manajemen Rumah Sakit Fakultas Kedokteran Universitas Barawijaya Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Prolonged-heated High-Fat Diet Increase the Serum LDL Cholesterol Level and Induce the Early Atherosclerotic Plaque Development in Wistar Rats Yurina, Valentina; Yunita, Ema Pristi; Raras, Tri Yudani Mardining; Rudijanto, Achmad; Handono, Kusworini
Journal of Tropical Life Science Vol 9, No 1 (2019)
Publisher : Journal of Tropical Life Science

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Abstract

Rats are one of the most widely used animal models in health research. However, since rats are relatively resistant to atherosclerosis, the transgenic rats often used to study atherosclerosis in rats. Our study suggests a prolonged-heated lipid to induce atherosclerosis in rats, therefore provide a more low-cost option to study atherosclerosis in rats. Aims of this study is to compare the effect of heated high-fat diet (HFD) to the LDL and HDL cholesterol level and foam cell formation in the Wistar rat animal model. Rats were divided into three groups, control group was given with the normal diet, and the other two treated groups received oxidized HFD (heated HFD) and HFD, respectively. The heated HFD contain lard that was previously heated at 190°C for 24 h. Diet was given for 8 weeks. The serum LDL and HDL cholesterol level were measured before and 4th and 8th weeks after treatment with help of colorimetric measurement. The aorta analyzed for the foam cell formation after HE staining using the light microscope.  The prolonged- heated HFD significantly increased the LDL cholesterol from the 4th week of the treatment (p = 0.023). The rats aortic from HFD and heated HFD treated groups showed a mononuclear cells infiltration and the early foam cell formation. The heating process of the lipid caused lipid oxidation which significantly increased the LDL cholesterol level of the animal model and foam cells formation. This study suggests that Wistar rats with heated HFD could demonstrated early atherosclerosis plaque development.
Co-Authors Anditri Weningtyas Andreas Budi Wijaya Arief Alamsyah N, Arief Alamsyah Asti Melani Astari Aulanniam Budianto, Mochamad Bachtiar Chomsy, Indah Nur Dewi Santosaningsih Dian Handayani Dian Nugrahenny Em Yunir, Em Ema Pristi Yunita, Ema Pristi Endang S. Rahayu Fachrureza, Mochamad Gatya, Mifta Handono Kalim Heru Iskandar Hose, Victor Alvianoes Guterez Jonny K. Fajar Kumala, Poppy Kusworini Handono Leny Budhi Harti Mandang, Veny VV Mariyatun Mariyatun, Mariyatun Mohammad Saifur Rohman Nasution, Annio Indah Lestari Ni Luh Tantri Nur Samsu Pramesi, Putrika C. Purbaningroom, Dian Laila Puteri, Happy HS Rahmawati, Anna Riza, Mochamad Faishal Rulli Rosandi Saraswati, Made R Sasiarini, Laksmi Syifa Mustika Tri Yudani Mardining Raras VALENTINA YURINA Viera Wardhani Wahjoe Harijanto Wardhana wardhana Wursito, Wursito