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All Journal Nexus Pendidikan Kedokteran dan Kesehatan Nexus Kedokteran Klinik Nexus Biomedika Nexus Kedokteran Translasional Journal of Epidemiology and Public Health Indonesian Journal of Medicine Jurnal Respirasi (JR) Jurnal Epidemiologi Kesehatan Indonesia
Leli Saptawati
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Uji Efektivitas Prosedur Disinfeksi Tingkat Tinggi Endoskopi Saluran Cerna RSUD Dr. Moewardi Aviaddina Ramadhani; . Marwoto; Leli Saptawati
Nexus Biomedika Vol 2, No 1 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

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Background: The risk of infection associated with gastrointestinal endoscope remains a topic of interest. This vexation may be related to reliability of the disinfecting techniques or the compliances with the guideline laid down for high-level disinfection. Gastrointestinal endoscope disinfecting techniques may vary from site to site. This study was to examine the effectiveness of gastrointestinal endoscope high-level disinfection at Rumah Sakit Umum Daerah (RSUD) Dr. Moewardi. Methods: An observational study using cross sectional design was conducted at RSUD Dr. Moewardi. Thirty samples from gastrointestinal endoscope swab after high-level disinfection process with 24 hours storage and without storage was sampled with convenience sampling technique. Data from this research were analyzed descriptively and tested using Chi square test. Results: Microorganism were detected in 11/14 samples of gastrointestinal endoscope after 24 hours storage and 3/16 samples of gastrointestinal endoscope without storage process. The microorganisms were Bacillus sp, Staphylococcus aureus, Staphylococcus non-aureus, and Clostridium sp. Significant relationship was detected between storage processes after gastrointestinal endoscope high-level disinfection with microorganism contamination. Conclusions: High-level disinfection of gastrointestinal endoscopes RSUD Dr. Moewardi was not yet effective. There was a significant relationship between gastrointestinal endoscopy storage for 24 hours with the effectiveness of high-level disinfection of gastrointestinal endoscopes. Keywords: high-level disinfection, gastrointestinal endoscope, 24 hours storage, without 24 hours storage.
Screening The Effectiveness of Menirans Leaf Extract (Phyllanthus niruri L.), Pepaya (Carica papaya L.), and Kunyit (Curcuma longa L.) as Antidengue In Vitro Hutami Sri Ummiyati; Ratih Puspita Febrinasari; Leli Saptawati
Nexus Biomedika Vol 5, No 1 (2016): Nexus Biomedika
Publisher : Nexus Biomedika

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Introduction: Dengue Haemorrhagic Fever (DHF) is an infectious disease that is caused by dengue virus. There were 71.668 DHF cases with 641 mortalities in Indonesia which was recorded from early January to mid-December 2014. Recently, DHF doesnt have a specific therapy. The aim of this study was screening about natural extracts in Indonesia as antidengue. Methods: This study was a laboratory experimental research with dengue virus serotype 2 strain New guinea C (DENV2 NGC) as a subject. This virus was infected into Huh-7 cell line. The study was conducted in 2 parts. First, dengue virus solution was mixed with natural extract and then this solution was infected to Huh-7 cell monolayer to obtain percent infectivity by FFU assay. Second,the natural extract was exposed to Huh-7 cell monolayer to obtain percent viability by MTT assay. The effective extract was selected if the extract had average percent infectivity 20% and average percent viability > 50%. Results: The percentage of viability of menirans leaf extract (Phyllanthus niruri L.), papaya (Carica papaya L.), and turmeric (Curcuma longa L.) were 96.2%, 97.5%, and 88.7% respectively. While their average percentage of infectivity were 63.9%, 10.5%, and 53.6%. Conclusion: The papayas leaf extract (Carica papaya L.) was effective as antidengue in vitro. Keywords: DENV2 NGC,dengue, meniran, papayas leaf, turmeric
The Effectiveness of the Leaf Extract of Jati Belanda (Guazuma ulmifolia Lamk) as Dengue Antiviral In Vitro Yani Dwi Pratiwi; Leli Saptawati; Siti Marufah
Nexus Kedokteran Translasional Vol 6, No 1 (2017): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Introduction: Dengue Haemorrhagic Fever is one of a serious disease in the world because it can cause death. During all these years, DHF in Indonesia only treated by symptomatic and supportive therapy. The purpose of this study was to determine the effectiveness of Jati Belanda leafs extracts as antiviral dengue in vitro. Methods: The method used is pure experimental research and the research design method is post test only control group design. The subject is dengue virus serotype 2 strain New GuineaC (DENV2 NGC) obtained from the Laboratory of Virology and Molecular Biology Department of Microbiology, Faculty of Medicine, University of Indonesiaand this research was started from June until November 2016. The independent variables in this study is the concentration of Jati Belanda leafs extracts obtained from Pharmaceutical Laboratory of Faculty Pharmacy, Gadjah Mada University and dependent variable are infectivity value and viability value. The collected data are presented in tables. Results:In concentration 40 g/ml, the infectivity value is 12.6% and the viability value is 91.4%. Conclusions: The leaf extracts of Jati Belanda is potentially effective as antiviral dengue. Keywords: dengue, Jati Belanda extract, antivirus, DHF
Hubungan antara Hipoglikemi dengan Kejadian Hipotermi pada Neonatus Rujukan di RSUD Dr. Moewardi Dio Dara Virgiansari; Dwi Hidayah; Leli Saptawati
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Neonatal hypoglycaemia is an avoidable cause of mortality and neurodevelopmental impairment. Hypoglicemia may develop to hypothermia as a result of metabolic thermogenesis disturbance. Hypothermia during the newborns period is widely regarded as a major contributory cause of significant morbidity and mortality in developing countries including Indonesia, about 7% prevalence of hypothermia has been reported happens on newborns. The objective of this study was to determine the association between hypoglicemia and hypotermia in newborns. An analytic observational using cross sectional approach was used in this study. A total of eighty one newborns was selected by fixed-disease sampling. Sample of this study were the newborns who referred to Dr. Moewardi Hospital. The data were collected by the measurement of blood glucose concentration and axillary temperature of newborns. The data was analyzed using multiple logistic regression test on SPSS 16 for Windows. Hypoglycemic newborns have a risk of hypothermia 2.381 times higher than non hypoglicemic newborns after controlling some confounding factors, such as: age, birth weight, gestational age, and status of asphyxia, altough it was statistically not significant (OR = 1.98; CI = 95%; 0.54, 7.73; p = 0.305). Early neonatal age (0-7 days), low birth weight (< 2.500 gram), early gestational age (< 37 weeks), asphyxia status were also risk factors of hypothermia in newborns. There was a moderate association between hypoglicemia and hypothermia on referral newborns, altough it was statistically not significant. Hypoglycemic newborns have a higher risk of hypothermia than non hypoglicemic newborns after controlling some confounding factors, such as: age, birth weight, gestational age, and status of asphyxia. Keywords: newborns, referral, hypoglicemia, hypothermia
Hubungan antara Syok Berkepanjangan (Prolonged Shock) dengan Kematian Anak Penderita Dengue Shock Syndrome di PICU/NICU RSUD Dr.Moewardi Rizka Solehah; . Pudjiastuti; Leli Saptawati
Nexus Kedokteran Klinik Vol 2, No 1 (2013): Nexus Kedokteran Klinik
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

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Dengue Shock Syndrome (DSS) is severe type of dengue infection which is the major cause of mortality. In Indonesia, DSS cases increase until 53%, the number of incidence are 500.000 cases every year, and its mortality is 1-5%. DSS is caused by plasma leakage which can leading to tissue hypoperfusion. If proper and timely management of DSS had delayed, DSS may result in multiple organ dysfunction syndrome (MODS) even death. The purpose of this research is to find out whether there is the relationship between prolonged shock and mortality of children with Dengue Shock Syndrome at PICU/NICU of RSUD Dr. Moewardi. This was an analytic observational study with cross sectional approach and purposive sampling technique. A sample of 61 study subject was selected by purposive sampling technique from children who aged 0-18 years, children who suffered Dengue Shock Syndrome and treated at PICU/NICU RSUD Dr. Moewardi in June 2006 - December 2011. The data obtained from PICU/NICU and medical records section of RSUD Dr. Moewardi. Statistical analysis was using chi square test and continued by using contingency coefficient test. Patients of prolonged shock DSS have higher mortality than patients of non-prolonged shock DSS, although the relation between them is low (p = 0.005; contingency coefficient = 0,335). The mortality risk were five times greater (OR= 5; CI 95%; 1,536 16,273). In this study, DSS was much found in girl (59,02%), children aged 6-12 years old (52,46%), and usually who had weak condition (67,21%), and good nutritional status because this study was done at area with good nutritional status was majority in children. There were significant relationship between prolonged shock and mortality of children with Dengue Shock Syndrome at PICU/NICU of RSUD Dr. Moewardi with low rate relation. Patients with prolonged shock DSS have higher risk of mortality than patients with non-prolonged shock DSS.
Effectivity of NS1 Antigen Test for Early Detection of Dengue Fever in Surakarta and Surrounding Areas Arina Setyaningrum; Leli Saptawati; Yulia Sari
Nexus Biomedika Vol 4, No 1 (2015): Nexus Biomedika
Publisher : Nexus Biomedika

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Background:.The first time of dengue virus infection can give symptoms as dengue fever. Dengue fever disease has symptoms that are not typical and may manifest as Dengue Hemorrhagic Fever and can progress to Dengue Shock Syndrome which can cause death if patients get treatment too late. Therefore, it is important to anticipate the delay in treatment so that requires a device to detection of dengue fever which is faster and more accurate. One is NS1 antigen detection methods. This study aimed to determine the effectiveness the NS1 antigen test for early detection of dengue fever in the region of Surakarta and surrounding areas. Method:.This study was a diagnostic test study using a community-based cross-sectional design. Sample size was 49 patients taken with consecutive techniques. Each samples performed detection of dengue NS1 antigen by Rapid strips test of immunochromatography and detection of genetic material of dengue virus by RT-PCR. Both of the data were tested with a diagnostic test. Result:.Diagnostic test results gave 67% of sensitivity, 89% of specificity, 67% of positive predictive value, 89% of negative predictive value, 6.09 of positive likelihood ratio, and 0.37 of negative likelihood ratio. The presence of a major change of the value of pretest probability (24%) to the value of the Post Test Probability (66%) indicated that the dengue NS1 antigen test device could provide diagnostic results which were important and useful. Conclusion:The NS1 antigen test is effective as diagnostic kit of Dengue virus infection due to its well specificity Keywords: Dengue Virus, Dengue NS1 antigen test, early detection of Dengue fever
Factors Associated with the Outcomes of Patients with Hospital-Acquired Pneumonia (HAP) at Dr. Moewardi General Hospital, Surakarta Nawanindha, Natasha; Saptawati, Leli; Widyaningsih, Vitri
Jurnal Respirasi Vol. 10 No. 3 (2024): September 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.3.2024.186-194

Abstract

Introduction: Hospital-acquired pneumonia (HAP) is a common infection with a poor prognosis. Previous studies on factors influencing HAP outcomes have yielded inconsistent findings. Therefore, further research is needed to determine risk factors that affect HAP outcomes. This study evaluated the factors associated with HAP outcomes to enable timely interventions to reduce mortality, costs, and length of stay (LOS). Methods: This cross-sectional study was conducted at Dr. Moewardi General Hospital, Surakarta, using medical record data from January to December 2022. The data included age, gender, malnutrition, anemia, level of consciousness, comorbidities, bacterial culture, and multidrug-resistant organisms (MDROs). The analyses were performed using the Chi-squared and Mann-Whitney U tests, followed by multiple logistic and linear regression tests to determine the correlation between risk factors and outcomes (recovery, death, and LOS). Results: This study included 102 patients with HAP, the majority being males (64.7%) aged 60 years old and above. Additionally, most patients did not exhibit malnutrition (87.3%) or anemia (96.1%), had normal levels of consciousness (67.6%) and mild comorbidities (60.8%), were not infected with MDROs (66.7%), and were predominantly infected by Klebsiella pneumoniae (21.6%). The multiple logistic regression test revealed that decreased consciousness was significantly associated with increased mortality (p < 0.001). Meanwhile, age 60 years old and above was significantly associated with a shorter LOS (p = 0.05). Conclusion: The majority of HAP cases occurred in men aged 60 years and above. Furthermore, there was a significant relationship between decreased consciousness and increased mortality, as well as between the age of 60 years and above and a shorter LOS.
Risk Factors and Prognosis of Nontuberculous Mycobacteria Infection in a High Prevalence of Tuberculosis Setting Saptawati, Leli; Mashuri, Yusuf Ari; Suryawati, Betty; Harsono, Harsono; Pradiptakirana, Riska
Journal of Epidemiology and Public Health Vol. 5 No. 1 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: The prevalence and incidence of Non
The Agreement of Immunoglobulin Gamma Release Assay (IGRA)/ T-SPOT Tuberculosis and Tuberculin Skin Test to Detect Latent TB Infection in Diabetes Mellitus Patients Reviono, Reviono; Sutanto, Yusup Subagio; Harsini, Harsini; Saptawati, Leli; Marwoto, Marwoto; Suryawati, Betty; Redhono, Dhani; Sebayang, Pribadi M
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Background: WHO identifies diabetes mellitus (DM) as a neglected risk factor for tuberculosis (TB). Currently, there is no gold standard test for latent TB infection (LTBI). Centers for Disease Control and Prevention (CDC) recommends using Tuberculin Skin Test (TST) and Immunoglobulin Gamma Release Assay (IGRA) to diagnose LTBI. TST is an LTBI classic diagnostic tool that has low sensitivity and specificity. But it is still preferred in diagnosing LTBI due to its lower price, and more health facilities can perform the examination compared to IGRA (T-SPOT.TB). The study aimed to measure the agreement of TST and T-SPOT.TB testing in detecting LBTI in DM and the correlation of HbA1c with TST and T-SPOT.TB.Subjects and Method: Subjects were DM patients who underwent TST and T-SPOT.TB testing. If the results of TST and T-SPOT.TB was positive, the test would be continued with Xpert MTB/RIF microbiological testing. TST used PPD RT23 2TU. T-SPOT.TB was performed toward peripheral blood mononuclear cells. The degree of agreement between TST and T-SPOT.TB testing was calculated using the Test of Agreement (Kappa Cohen). The degree of correlation between the two variables was calculated by using Pearson correlation.Results: The selected 30 study subjects with DM undergoing antidiabetic therapy showed 6 (20%) detected LTBI and 24 (80%) without LTBI using TST and T-SPOT.TB test. There was a substantial agreement level between TST and T-SPOT.TB testing in detecting LTBI among diabetes mellitus patients undergoing anti-diabetic therapy with kappa value= 0.62 (p<0.001). HbA1c increased T-SPOT (r= 0.07; p= 0.716) and TST (r= 0.11; p= 0.956).Conclusion: TST testing may substitute T-SPOT.TB to detect LTBI among diabetes patients undergoing antidiabetic therapy.Keywords: latent tuberculosis infection, diabetes mellitus, TST, Immunoglobulin Gamma Release Assay (IGRA), T-SPOT.TBCorrespondence: Reviono. Department of Pulmonology and Medical Respiratory, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Indonesia. Email: reviono@staff.uns.ac.id.Indonesian Journal of Medicine (2021), 06(03): 298-306https://doi.­org/10.26911­/theijmed.2021.06.03.07
Factors Associated with Outcomes of Acinetobacter baumannii Infection in Ventilator-Associated Pneumonia in the ICU of Dr. Moewardi General Hospital, Surakarta Putra, Lutfi Lafil Cahya; Saptawati, Leli; Setijanto, Eko; Maryani, Maryani; Maarif, Athok Shofiudin
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.201-207

Abstract

Introduction: Acinetobacter baumannii is a nosocomial pathogen with high mortality rates in intensive care units (ICUs) and is commonly associated with ventilator-associated pneumonia (VAP). Due to declines in physiological and immune functions, A. baumannii can trigger septic shock complications, thereby increasing mortality risk. This study aimed to identify the risk factors associated with outcomes in VAP patients in the ICU of Dr. Moewardi General Hospital, Surakarta. Methods: This retrospective cohort study was conducted at Dr. Moewardi General Hospital, Surakarta, using patient medical records. Data were analyzed with Chi-square and Mann-Whitney U tests, followed by multiple logistic and linear regression to determine correlations between risk factors and outcomes (recovery, mortality, length of stay/LOS). Results: This study included 80 patients with VAP caused by A. baumannii. Most patients were under 60 years old (52.5%), had good nutritional status (75%), were on ventilators for less than 10 days (63.75%), and had mild comorbidities (51.25%). Moderate-severe comorbidities (p=0.001) and malnutrition (p=0.005) were significantly associated with increased mortality. In addition, ventilator use ≥10 days was significantly associated with LOS (p<0.001). Conclusion: Moderate-severe comorbidities and malnutrition were risk factors for mortality in patients with A. baumannii-related VAP, while ventilator use ≥10 days was a risk factor for prolonged hospitalization. Identifying these factors can help medical personnel manage conditions that worsen VAP outcomes and reduce the risk of A. baumannii-related mortality.
Co-Authors . Marwoto . Marwoto . Pudjiastuti . Pudjiastuti Arina Setyaningrum Aviaddina Ramadhani Dhani Redhono, Dhani Dio Dara Virgiansari Dwi Hidayah Dwi Hidayah Eko Setijanto Harsono Harsono Henrikus Jeffrey F .L Hutami Sri Ummiyati Kusmadewi Eka Damayanti Larasati, Riska Maarif, Athok Shofiudin Marufah, Siti marwoto marwoto Maryani Maryani Mashuri, Yusuf Ari Mochammad Imron Awalludin Nawanindha, Natasha Pradiptakirana, Riska Pratiwi, Yani Dwi Putra, Lutfi Lafil Cahya Ratih Dewi Yudhani Ratih Puspita Febrinasari Reviono Reviono Rizka Solehah Sarah Luthfiani Sebayang, Pribadi M Sheilla Elfira San Pambayun Siti Marufah SURYAWATI, BETTY SURYAWATI, BETTY Suyatmi . Tri Nugraha Susilawati Vitri Widyaningsih Yani Dwi Pratiwi Yulia Sari Yusup Subagio Sutanto