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All Journal Medula JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Hendra Tarigan Sibero
Bagian Ilmu Kesehatan Kulit dan Kelamin, Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Journal : Medula

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Faktor-Faktor yang Mempengaruhi Derajat Kecacatan Kusta Fauziani, Andra Nabila; Anggraini, Dwi Indria; Hanriko, Rizki; Sibero, Hendra Tarigan
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.936

Abstract

Morbus Hansen, also known as leprosy, is an infectious disease that is chronic or chronic. This disease is caused by the acid-fast bacillus (BTA) Mycobacterium leprae which is obligate intracellular. This disease can attack various body systems, including the peripheral nervous system, skin, mucosa, upper respiratory tract, reticuloendothelial system, eyes, muscles and bones. Based on WHO data for 2021, globally there were 133,781 cases of leprosy, with Indonesia ranking third highest in the world with 10,976 new cases after India and Brazil. Leprosy that is not treated properly can cause disability. There are two types of disability in leprosy, namely primary and secondary disability. Primary disability is caused directly by the Mycobacterium leprae bacteria, while secondary disability is a disorder that arises because the primary disability is not treated properly. The level of disability in leprosy is classified based on symptoms of damage to the eyes, hands and feet with levels 0, 1 and 2. Factors that influence the degree of disability in leprosy are grouped into demographic factors, internal factors and external factors. Demographic factors include age, gender, socio-economic status, occupation, and education level. Internal factors include the type of leprosy, length of suffering, number of nerves affected, and leprosy reaction. External factors include compliance with taking medication, delays in treatment, and self-care.
Faktor-faktor yang Mempengaruhi Keberhasilan Terapi Pasien Kusta Sagia, Nabilla Alsa; Anggraini, Dwi Indria; Wulan, Anggraeni Janar; Sibero, Hendra Tarigan
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.937

Abstract

Leprosy is a chronic granulomatous infectious disease caused by the obligate intracellular bacterium Mycobacterium leprae (M. leprae). This disease comes from the Latin word "lepros" which means scale. M. Leprae bacteria enter the human body through 2 main routes, namely through the skin and the upper respiratory tract. Leprosy bacilli enter the human body through direct contact with the skin or nasal mucosa originating from droplets. Bacteria from droplets will survive for 2 days in a dry environment, even up to 10 days in a humid environment and low temperatures. The success of therapy for Morbus Hansen patients is expressed by RFT (Release from Treatment). RFT can be stated after the dose is fulfilled without having to undergo laboratory examination. PB (paucibacillary) patients who have received 6 doses (blister) of treatment within 6-9 months are declared RFT, without having to undergo a laboratory examination. MB (multibacillary) patients who have received 12 doses (blister) of MDT treatment within 12-18 months are declared RFT, without having to undergo a laboratory examination. The factors that play a role in the success of therapy for leprosy patients are age, gender, education, employment, knowledge, compliance with taking medication, and family support.
Deteksi Dini dan Tatalaksana Rheumatoid Arthritis Farhry Alvini Rahmania; Sibero, Hendra Tarigan; Ramadhian, Muhammad Ricky
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.967

Abstract

Rheumatoid arthritis (RA) is a long-term progressive inflammatory autoimmune disorder that can caused damage to the joints into disability, if it isn’t handled appropriately. There are 1.4 million people in Indonesia that have been found to suffer from rheumatoid arthritis. In the early stages of rheumatoid arthritis, there are symptoms such as fatigue, flu-like syndromes, swollen joints and pain, and morning stiffness; and also increased levels of C-reactive protein (CRP) and increased sedimentation rate of erythorisite (ESR). In contrast, untreated rheumatoid arthritis displays severe systemic manifestations such as pleural effusion, pulmonary nodules and interstitial lung disease, IMF, vasculitis in small and medium arteries, re-evolution, cartilage damage, rheumatic nodules and others. Diagnosis of rheumatoid arthritis is established after assessing symptoms, physical examination, risk factor, family history, assessment along with ultrasound, and lab marker assessment such as increased levels of CRP and ESR in serum and detection of RA-specific autoantibodies. Rheumatoid arthritis is incurable, but it can be controlled with appropriate medication and prognosis monitoring. The prognosis of rheumatoid arthritis is based on clinical evidence and laboratory examination. Early detection and appropriate management of rheumatoid arthritis are key to better prognosis. This article therefore discusses the importance of early diagnosis and treatment of rheumatoid arthritis.
Hubungan Usia, Jenis Kelamin, Dan Pekerjaan Dengan Kejadian Dermatofitosis di Rumah Sakit Umum Daerah Dr. H. Abdul Moeloek Provinsi Lampung Periode 2017- 2021 Graceciela, Yohana Eva; Anggraini, Dwi Indria; Himayani, Rani; Sibero, Hendra Tarigan
Medula Vol 14 No 6 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i6.1097

Abstract

Dermatophytosis is a dermatophyte fungal infection that attacks keratinized tissues. This disease can be caused by various internal and external factors. The internal risk factors causing dermatophytosis include age, gender, and occupation. In addition to that, this study aimed at determining the relationship between age, gender, and occupation toward dermatophytosis cases. This study used an analytical observational design with a cross-sectional approach. The sample in this study consisted of 114 patients with dermatophytosis sourced from the secondary data in the form of medical records. The research data were conducted by using total sampling technique in RSUD Dr. H. Abdul Moeloek Lampung Province. The recorded data included the patients’ age, gender, occupational, and diagnosis. Then, the data were analysed using chi-square test presented in tabular form. The results showed that the majority of dermatophytosis patients were adults, female, and employees who worked in government/private institutions. The results of the chi-square test showed a significant value for the age variable (p = 0.035) and the gender variable (p = 0.041), while for the work variable there was no significant relationship (p = 0.615). There is a significant relationship between age and gender with the dermatophytosis cases and there is no significant relationship between occupation and the dermatophytosis cases.
Pengaruh Waktu Inkubasi Terhadap Daya Hambat Ekstrak Daun Binahong Pada Cutibacterium Acnes Alvista, Valentina Nancy; Sibero, Hendra Tarigan; Aditya, Muhammad; Apriliana, Ety
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1272

Abstract

Acne (Acne vulgaris) is a common skin disorder often caused by the bacterium Cutibacterium acnes. Bacterial resistance to antibiotics used in acne treatment has become a significant concern. This study evaluated the effect of incubation time on the diameter of the inhibition zone produced by binahong (Anredera cordifolia) leaf extract in inhibiting the growth of C. acnes. The well diffusion method was employed using extract concentrations of 25%, 50%, 75%, and 100%. Data analysis was conducted using a paired t-test. The results showed a significant difference (p < 0.001) in the inhibition zones formed based on variations in incubation time. The findings indicated that longer incubation times resulted in larger inhibition zones. Binahong leaf extract was found to be effective in inhibiting the growth of C. acnes, particularly at higher concentrations and with longer incubation durations. These results demonstrate the potential of binahong leaf extract as an effective acne treatment to address antibiotic resistance.
Identifikasi Kandungan Senyawa Aktif Antibakteri Ekstrak Bawang Putih dalam Menghambat Pertumbuhan Bakteri Cutibacterium acnes Penyebab Acne Vulgaris Aprianti, Shervia Dwi; Sibero, Hendra Tarigan; Aditya, Muhammad; Himayani, Rani
Medula Vol 14 No 12 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i12.1302

Abstract

Introduction: The cases of antibiotic resistance in the treatment of acne vulgaris have been steadily increasing. A study conducted by the Dermatology Clinic of Hanyang University Hospital, South Korea, showed an increase in antibiotic resistance cases in the management of acne vulgaris, with resistance rates of 30% for clindamycin and 26.7% for erythromycin. One adjunctive therapy believed to be a breakthrough in anticipating the increase in antibiotic resistance causing acne vulgaris is the use of garlic extract. This study aims to conduct antibacterial phytochemical screening of garlic extract in inhibiting the growth of Cutibacterium acnes. Methods: The antibacterial active compounds in garlic plants were identified through phytochemical screening. Meanwhile, the antibacterial test was conducted using the well diffusion method with garlic extract concentrations of 25%, 50%, 75%, and 100%. Clindamycin was used as the positive control. Results: The phytochemical screening results of garlic extract in this study revealed the presence of flavonoids, alkaloids, tannins, phenols, and terpenoids. In the antibacterial test using the well diffusion method, the largest inhibition zone was observed with clindamycin treatment, while the smallest inhibition zone diameter was recorded with 25% garlic extract concentration. Discussion: The active antibacterial compounds found in garlic extract, including flavonoids, alkaloids, tannins, phenols, and terpenoids, have been proven to inhibit the growth of Cutibacterium acnes, as indicated by the formation of inhibition zone diameters in the antibacterial test.
Hubungan Daerah Tempat Tinggal dengan Kejadian Dermatitis Atopik Izdihar, Adinda Fairuz; Sibero, Hendra Tarigan; Graharti, Risti; Carolia, Novita
Medula Vol 14 No 8 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i8.1311

Abstract

Atopic dermatitis is a frequently occurring skin inflammation characterized by pruritus and lesions in specific areas such as the face and extremities. The majority of cases manifest during the first year of life, with a high prevalence among children under five years of age. In Europe, 118 million cases were recorded in 2023, whereas in Indonesia, the prevalence reached 10-20% among children and 1-3% among adults. This condition involves an interplay of exogenous and endogenous factors, including environmental exposure, genetic predisposition, immunological mechanisms, and colonization by Staphylococcus aureus. Environmental factors contributing to the incidence of atopic dermatitis include exposure to pollutants such as carbon monoxide, nitrogen dioxide, PM2.5, PM10, and volatile organic compounds (formaldehyde). Such exposure is a significant risk factor for atopic dermatitis in urban areas. This study aimed to analyze the correlation between residential areas and the incidence of atopic dermatitis at RSUD Dr. H. Abdul Moeloek during the period of January 2022 to July 2024. Data were collected from medical records, encompassing a total sample size of 82 patients. The chi-square test revealed a statistically significant relationship between residential area and the occurrence of atopic dermatitis, with individuals residing in urban areas being 0.23 times more likely to develop atopic dermatitis compared to those living in non-urban areas (p=0.02; OR=0.23)
Dermatitis Seboroik: Etiologi & Faktor Risiko, Patofisiologi, Diagnosis, dan Tatalaksana Sudarmanto, Syifa Hasna; Sibero, Hendra Tarigan; Ratna, Maya Ganda; Darwis, Iswandi
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1327

Abstract

Seborrheic dermatitis is a type of chronic skin inflammation caused by the fungus Malassezia sp. which is often found among patients. The prevalence reaches 4.38% on a global scale and 2% - 30% in Asia. Often found in infantile (self-limited) and adult (chronic) patients. This disease is considered to reduce the patient's quality of life. The high number of cases and the rate of decline in patient quality of life due to seborrheic dermatitis became the basis for conducting this research. Research was conducted to collect and analyze articles that raise topics related to clinical aspects of seborrheic dermatitis. The research design used was a literature review. Article collection was carried out using relevant article search applications such as Google Scholar, PubMed, and Prospero. The articles used have a range of publication criteria in 2013-2024. Based on the articles collected, results were obtained in the form of risk factors, pathophysiology, diagnosis and management of seborrheic dermatitis. Risk factors that are considered to trigger seborrheic dermatitis include high sebaceous gland activity, low body immunity, physical environmental factors in the form of humidity and temperature, and a history of poor personal hygiene. The appearance of the disease is in the form of reddish lesions covering fine colored scales, sometimes accompanied by oil or white powder. The severity of the disease is determined through the SDASI score or Seborrhoeic Dermatitis Area Severity Index. Healing therapy aims to reduce symptoms and improve skin function. The type of therapy given is based on the lesion severity index and the patient's response to therapy.
Co-Authors Agustyas Tjiptaningrum Alvista, Valentina Nancy Anggraeni Janar Wulan, Anggraeni Janar Aprianti, Shervia Dwi Asep Sukohar Dwi Indria Anggraini Ety Apriliana Farhry Alvini Rahmania Fauzi Ahmad Muda Fauziani, Andra Nabila Graceciela, Yohana Eva Iswandi Darwis Izdihar, Adinda Fairuz Karima, Nisa Muhammad Aditya, Muhammad Muhammad Ricky Ramadhian Muhammad Yusran Novita Carolia Putra, I Wayan Ardana Rahmayani, Fidha Rani Himayani Ratna, Maya Ganda Risti Graharti Rizki Hanriko Sagia, Nabilla Alsa Sari, Mahala Ramah Sudarmanto, Syifa Hasna Yisran, Muhammad