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All Journal CAKRA KIMIA (Indonesian E-Journal of Applied Chemistry) Jurnal Biologi Tropis Indonesian Journal of Pure and Applied Chemistry Justek : Jurnal Sains Dan Teknologi Acta Chimica Asiana Indonesian Journal of Global Health research Jurnal Ilmiah Medicamento Journal of Pharmaceutical and Health Research Jurnal Pengabdian Masyarakat Formosa (JPMF) Jurnal Sains dan Teknologi Jurnal Pengabdian Inovasi Masyarakat Indonesia Sinergi dan Harmoni Masyarakat MIPA
Diah Miftahul Aini
University Of Mataram
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Pengenalan dan Demonstrasi Berbagai Teknik Pemisahan untuk Meningkatkan Pemahaman Siswa SMA Negeri 1 Batukliang Lombok Tengah Pada Mata Pelajaran Kimia Kelas XI Gunawan, Erin Ryantin; Suhendra, Dedy; Handayani, Sri Seno; Aini, Diah Miftahul; Adiguna, Sya’ban Putra; Yanti, Sepia Dwi; Usiana, Shilan; Rischia, Amida
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 4 No. 2 (2025): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v4i2.7903

Abstract

This Community Service activity was conducted at SMA Negeri 1 Batukliang, Central Lombok, a senior high school offering a science (IPA) program and supported by the availability of a chemistry laboratory. The school faces several challenges, including a curriculum that has yet to incorporate real-life applications of chemistry, limited student understanding of chemical separation techniques, and inadequate laboratory facilities and infrastructure. This community service program aimed to introduce and demonstrate various separation techniques including extraction, distillation, and chromatography through interactive lectures, educational videos, and simple hands-on experiments, including processes like extraction, Soxhletation, and distillation. Through this activity, students not only gained theoretical knowledge but also practical experience in applying separation techniques and observing the products generated from these processes. This initiative aligns with the Sustainable Development Goals (SDGs), particularly in supporting quality education. The program is expected to enhance students’ scientific literacy and serve as an initial step toward raising awareness of the importance of chemistry in everyday life.
The Unique Properties of Moringa Oleifera Extract in Soap Optimization: A Scientific Approach Aini, Diah Miftahul; Ratnasari, Baiq Desy
Indonesian Journal of Global Health Research Vol 6 No S6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS6.4799

Abstract

Moringa leaves (Moringa oleifera), a valuable source of bioactive compounds, including flavonoids, phenolic acids, tannin, and terpenoids. These compounds provide significant benefits to the skin, due to their antioxidant, anti-inflammatory, and antimicrobial properties. The chemical composition of these leaves has been demonstrated to enhance dermal hydration and provide protection against environmental stressors. By balancing Moringa with other natural ingredients such as coconut, olive, and palm oil, the efficacy of skincare formulation can be optimized, resulting in improved texture, stability, and consumer appeal. This research aims to optimize the soap's effectiveness by enhancing its properties, such as cleansing, moisturizing, and antimicrobial functions, using the unique characteristics of Moringa oleifera. The initial step involved of an ethanol extract of Moringa leaves, which was then subjected to analysis using Gas Chromatography-Mass Spectrometry (GC-MS). The analysis revealed that Moringa leaves contain eight key compounds, including 2.4(1H,3H)-pyrimidineodione, glycerol, 2,3-dihydro-3,5-dihydroxy-6-methyl-, 4,3-allyl-6-methoxyphenol, epoxylinalool, 1H-pyrrole, 2-(2,4,6-heptatrienyl), tetradecanoics acid, and hexadecanoic acid. The aforementioned compounds were used to formulate a soap base containing Moringa leaves. The resulting soap exhibit a pleasant fragrance, a dense texture, yellow slightly white in color, and a pH of 10, as confirmed by organoleptic and pH test. The recent focus resulting in the development of Moringa-based skincare product that are not only effective but also eco-friendly. Present study represents a promising approach to natural solution that cater to diverse skin types and consumer preferences.
IN SILICO INVESTIGATION OF MOLECULAR INTERACTIONS BETWEEN INULOSUCRASE DERIVED FROM Aspergillus awamori AND EPE COMPOUNDS Aini, Diah Miftahul; Fajriati, Elza Kamila; Yuanita, Emmy; Antari, Gladeva Yugi; Ratnasari, Baiq Desy; Damayanti, Eva Hikmatul
Indonesian Journal of Pure and Applied Chemistry Vol 8, No 2 (2025)
Publisher : Tanjungpura University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26418/indonesian.v8i2.96978

Abstract

Fructooligosaccharides (FOS) are important prebiotics synthesized by the enzymatic activity of inulosucrase, and understanding their molecular interactions is essential for exploring potential modulators. This study examined the interaction between inulosucrase from Aspergillus awamori (PDB ID: 1Y4W) and the compound EPE (4-(2-hydroxyethyl)-1-piperazine ethanesulfonic acid) using an in silico molecular docking approach. Since the 1Y4W structure lacks a co-crystallized ligand, EPE was selected as a surrogate ligand derived from PDB ID: 3SC7 and prepared for docking simulations. Docking with AutoDock Vina produced a best binding affinity of "“5.6 kcal/mol, with the strongest hydrogen bond observed with TRP305 (1.92 Ã…) and additional interactions with TYR279 (3.75 Ã…). These results indicate a moderate but stable interaction, weaker than the native substrate fructose reported in crystallographic studies. Overall, EPE shows potential as a modulatory compound of inulosucrase activity and provides a basis for further enzymological and biotechnological research.
Pemberdayaan Kader Kesehatan Ibu-Ibu Di Lingkungan Monjok Kebon Jaya Barat Melalui Pelatihan Pembuatan Sabun Herbal Daun Kelor (Moringa Oleifera) Aini, Diah Miftahul; Antari, Gladeva Yugi; Ratnasari, Baiq Desy
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.5919

Abstract

Monjok Kebon Jaya Barat, Mataram, has rich natural resource potential, including the Moringa plant (Moringa oleifera) which is known for its skin health benefits. Although the local community has utilised moringa leaves in daily consumption, the great potential for further processing, such as making herbal soap, has not been maximised. Herbal soap made from moringa leaves can be a safer alternative to cleaning products, reduce dependence on harmful chemicals, and support a green economy. This programme aims to empower women health cadres in Monjok Kebon Jaya Barat through skills training in making herbal soap made from moringa leaves. The method used involved three main stages: activity preparation, soap-making training, and sustainability evaluation. In the training, participants were given theoretical and practical knowledge on the benefits of moringa leaves, the saponification process, and herbal soap making. The evaluation showed that most participants were able to follow the training well, although there were some technical constraints related to ingredient measurement and temperature control. The programme had a positive impact on skills enhancement and economic empowerment. The training is effective in introducing herbal soap making and can be a sustainable business opportunity. It is recommended to provide continuous assistance in marketing and the formation of joint business groups to improve the sustainability and welfare of the local community.
Pelatihan Pembuatan Minuman Herbal Daun Pecut Kuda di SMA Darul Hikmah Mataram Rahman, Suburi; Dwiani, Afe; Yuniartini, Ni Luh Putu Sherly; Nugrahani, Rizki; Arini, Laili Azmiati; Patmawati, Patmawati; Salsabila, Riska Dia Salma; Riani, Riani; Maulana, Harpan; Aini, Diah Miftahul
Jurnal Pengabdian Inovasi Masyarakat Indonesia Vol. 3 No. 2 (2024): Edisi Agustus
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpimi.v3i2.5999

Abstract

SMA Darul Hikmah Mataram is one of the private secondary education institutions in the city of Mataram with the existence of a school that is still beautiful and surrounded by many medicinal plants. The existence of horse whip leaves (Stachytarpheta jamaicensis) in this school is very abundant and still underutilised. Horse whip leaves are useful as antioxidants and anti-inflammatories. Chemical compounds contained in horse whip leaves are flavonoids, terpenoids, alkaloids, tannins, steroids, and saponins. Herbal drinks are one of the practical products that can be processed into antioxidant-rich drinks using very cheap and easy packaging. This activity aims to increase the knowledge of teachers and students at SMA Darul Hikmah Mataram about making drinks, educate and increase the use of horse whip leaves as herbal drinks at SMA Darul Hikmah Mataram, show training participants the processing of horse whip leaves as herbal drinks, and increase product value related to packaging and processing of horse whip leaves as herbal drinks. The methods used were preparation, processing of horse whip leaves into powder, and evaluation. Evaluation is carried out through direct interviews and questions and answers. The results of this service are that the participants follow the entire series of activities well and are able to make pecut kuda herbal drinks in powder form and packaging with pouches, this activity is expected to be a government initiation for the development of local agricultural products in the form of herbs that have high selling value.
Inovasi Pangan Lokal Berbasis Pisang: Strategi Pemberdayaan Masyarakat Pemenang Lombok Utara menuju Produk Berdaya Saing Aini, Diah Miftahul; Antari, Gladeva Yugi; Isnaeni, Sri Laela; Jumadil, Jumadil; Saputra, Firman Abadi
Sinergi dan Harmoni Masyarakat MIPA Vol. 2 No. 1 (2025): Oktober
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sinonim.v2i1.6654

Abstract

Banana is an abundant commodity in Lombok, and its processing into value-added products requires community empowerment strategies to ensure the production of high-quality products.This community service activity aims to empower the community in Pemenang, North Lombok, by developing banana-based processed product innovations, especially banana chips, to improve the welfare and competitiveness of local products. The problems faced by the community include the low added value of banana agricultural products, non-standard processing techniques, and limited understanding of food safety, packaging, and certifications such as halal and Good Manufacturing Practice (GMP). This activity was carried out through technical training on banana chip processing, attractive packaging design, and the socialization of food safety standards and certification processes. The results showed increased production skills, awareness of the importance of legality and food safety, and community readiness to develop a competitive local processed-based business. This activity is the first step to building community economic independence based on local potential integrated with industry standards.
Molecular docking study of mutant levansucrase (E342A) from Bacillus subtilis as a receptor for D-glucopyranose and β-D-fructofuranose ligands: Molecular docking study of mutant levansucrase Diah Miftahul Aini; Firda Ade Irmayanti; Emmy Yuanita; Maulida Septiyana; Baiq Desy Ratnasari
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.262

Abstract

Molecular docking is a widely applied computational approach for predicting the binding modes of small-molecule ligands within the active site of a target protein. This research investigated the interactions of mutant levansucrase E342A from Bacillus subtilis (PDB ID: 1PT2) for β-D-fructofuranose and D-glucopyranose ligands. Using AutoDock Vina, the docking results indicated that β-D-fructofuranose exhibited a higher binding energy of –5.6 kcal/mol, compared to D-glucopyranose with a value of –5.4 kcal/mol, suggesting a more stable interaction. It was supported by the binding interaction analysis of β-D-fructofuranose, which established five hydrogen bonds, including direct interactions with the key catalytic residues Asp86 (2.76 Å) and Asp247 (2.64 Å) that are essential for the enzymatic reaction. In contrast, D-glucopyranose formed four hydrogen bonds, involving Arg360 (3.07 Å) and Glu340 (2.64 Å), with most residues contributing to structural stabilization rather than direct catalysis. These results confirm that β-D-fructofuranose plays a crucial role as a determinant of levansucrase activity in the biosynthesis of levan-type FOS, which are known to exhibit strong prebiotic activity.
In silico comparative study of substituted xanthone derivatives with hydrazone, ester, and ether groups as antituberculosis agents M. Ibnu Sabil; Anggi Wilian Namira; Naufalika Dzahabiyyaa; Diah Miftahul Aini; Emmy Yuanita
Acta Chimica Asiana Vol. 9 No. 1 (2026)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v9i1.281

Abstract

Tuberculosis (TB) remains a major global health challenge, particularly due to the increasing emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis. The discovery of novel antituberculosis agents with new mechanisms of action is therefore urgently needed. Xanthone derivatives have attracted considerable attention due to their broad range of biological activities, including antibacterial and antituberculosis effects. This study aimed to evaluate the potential of xanthone derivatives as inhibitors of serine/threonine protein kinase (PknG) of M. tuberculosis through an in silico molecular docking approach. The crystal structure of the target protein (PDB ID: 4Y0X) was obtained from the Protein Data Bank and prepared using Chimera and Discovery Studio. Ligand structures were designed and optimized using ChemDraw, HyperChem, and GaussView, and molecular docking was performed using AutoDock Vina. The binding interactions were analyzed using LigPlot+ to identify key amino acid residues involved in ligand–protein interactions. The docking results showed that Hydrazone-Xhantone exhibited the highest binding affinity toward PknG as a value of –8.9 kcal/mol, which was slightly better than native ligand (–8.8 kcal/mol). Hydrazone-Xhantone formed stable hydrogen bonds with key active site residues, including SER106, GLY131, and ASP191, with bond lengths ranging from 2.06 to 2.16 Å. Other candidates showed lower binding affinities and fewer stabilizing interactions. The results indicate that Hydrazone-Xhantone has promising potential as a PknG inhibitor and may serve as a lead compound for further antituberculosis drug development. This study highlights the usefulness of molecular docking as a preliminary screening tool in the rational design of new antituberculosis agents.
Co-Authors Abdul Muin Adiguna, Sya’ban Putra Anggi Wilian Namira Antari, Gladeva Yugi Arini, Laili Azmiati Baiq Desy Ratnasari Baiq Desy Ratnasari Baiq Desy Ratnasari Baiq Desy Ratnasri Balqis, Solina Damayanti, Eva Hikmatul Dedy Suhendra Dwiani, Afe Emmy Yuanita Emmy Yuanita Emmy Yuanita Erin Ryantin Gunawan Faelga Sara Rosiana Fajriati, Elza Kamila Firda Ade Irmayanti Imam Syahputra Yamin Isnaeni, Sri Laela Jumadil, Jumadil Khairul Pahmi Rahmawati M. Ibnu Sabil Maulana, Harpan Maulida Septiyana Naufalika Dzahabiyyaa Patmawati Patmawati, Patmawati Rahman, Suburi Ratnasari, Baiq Desy Riani Riani, Riani Rischia, Amida Rizki Nugrahani, Rizki Salsabila, Riska Dia Salma Saputra, Firman Abadi Sri Seno Handayani Surya Hadi Usiana, Shilan Winda Harnianti Yanti, Sepia Dwi Yuniartini, Ni Luh Putu Sherly Zul Hendry