Article Per Year (5 Year)
p-Index From 2021 - 2026
1.881
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Journal of Mathematical and Fundamental Sciences Jurnal Sains dan Teknologi Farmasi JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Jurnal Penelitian Pendidikan IPA (JPPIPA) JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Pembelajaran dan Biologi Nukleus Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Journal of Multidisciplinary Applied Natural Science
Friardi Ismed
Faculty Of Pharmacy, Universitas Andalas, Padang, West Sumatra, Indonesia. Sumatran Biota Laboratory, Universitas Andalas, Padang, West Sumatra, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

Published : 23 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 23 Documents
Search

 1   2   3 
Aktivitas Penghambatan Enzim α-Glukosidase dari Ekstrak Hasil Fermentasi Bakteri Endofit dari Tapak Dara (Catharanthus roseus (L.) G. Don) Daun Huda, Ulfa Rosiatul; Ismed, Friardi; Arifah, Nurwahidatul; Sardy, Valdy Filando; Rustini
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.9178

Abstract

Catharanthus roseus (L.) G. Don contain bioactive compounds that act as inhibitors against the α-glucosidase enzyme. This study aims to test the α-glucosidase enzyme inhibitor activity of fermented extract of endophytic bacteria from tapak dara leaves and identify the bacterial species. Endophytic bacteria were isolated using a direct planting method, resulting in eight isolates. The bacteria were fermented for 24-72 hours in nutrient broth media. Ethyl acetate was used to extract the fermented bacteria. Screening for α-glucosidase enzyme inhibitory activity was conducted using the TLC bioautography method. Four bacterial isolates (TD 1, TD 3, TD 4, TD 7) produced clear zones, qualitatively indicating that the isolates have inhibitory activity against the α-glucosidase enzyme. The IC50 results from the eight isolates showed that three isolates provided strong IC50 values: isolate TD 1 at 19.93 µg/ml, isolate TD 2 at 92.34 µg/ml, and isolate TD 4 at 13.94 µg/ml, compared to acarbose at 48.85 µg/ml). Molecular identification showed that isolate TD 1 was Pseudomonas oryzihabitans and isolate TD 4 was Staphylococcus warneri. This study concluded that endophytic bacteria from tapak dara leaves have the potential as a source of α-glucosidase enzyme inhibitor compounds for the development of antidiabetic drugs.
Isolasi dan Pengujian Aktivitas Penghambat Enzim Alfa Glukosidase dari Bakteri Endofit Daun Kumis Kucing (Orthosiphon aristatus (Blume) Miq.) Putri, Indah Tamara Herman; Rustini; Ismed, Friardi; Sardi, Valdy F; Arifah, Nurwahidatul
Jurnal Penelitian Pendidikan IPA Vol 10 No 10 (2024): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i10.9264

Abstract

Orthosiphon aristatus (Blume) Miq., commonly known as kumis kucing, is frequently used in traditional Indonesian medicine to treat diabetes, hypertension, rheumatism, gout, and as a diuretic. However, large-scale production of medicinal products from natural sources requires significant raw material and land, creating a need for alternative methods. This study explores the potential of isolating endophytic bacteria from kumis kucing leaves to serve as α-glucosidase enzyme inhibitors, offering a more sustainable approach. Eight bacterial endophytes were isolated and tested using bioautography assays and IC50 measurements to assess their inhibitory activity. Four isolates—KK 1, KK 3, KK 4, and KK 5—demonstrated significant α-glucosidase inhibition, with IC50 values of 41.35 µg/mL, 57.04 µg/mL, 56.70 µg/mL, and 164.16 µg/mL, respectively. Molecular testing identified KK 1 as Priestia aryabhattai, while KK 3 and KK 5 were identified as Priestia megaterium. These findings suggest that endophytic bacteria isolated from Orthosiphon aristatus leaves have the potential to be developed as natural sources of α-glucosidase inhibitors, which are beneficial for diabetes management.
Phytochemical Constituents of Cinnamomum burmannii (Ness & T.Nees) Blume: A Systematic Review Rahwal, Sultan; Agung, Yoki Permana; Ramadani, Suci Indah; Ismed, Friardi; Arifa, Nurwahidatul
JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS Vol 11, No 4: Jurnal Pembelajaran Dan Biologi Nukleus December 2025
Publisher : Universitas Labuhanbatu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36987/jpbn.v11i4.8264

Abstract

Background: Cinnamomum burmannii is an Indonesian native cinnamon species with significant potential for developing pharmaceutical and functional food products. Methodology: This study aims to identify and analyze the phytochemical constituents of C. Burmannii through a systematic literature review using PRISMA databases such as PubMed, Scopus, and Science Direct,were searched from 2015-2025. Findings: The findings reveal that C. Burmannii contains diverse bioactive compounds, including aromatic aldehydes, phenolics, flavonoids, terpenoids, coumarins, aromatic alcohols, organic acids, and aromatic esters. Dominant compounds such as cinnamaldehyde, quercetin, catechin, and eugenol exhibit strong antimicrobial, antioxidant, antidiabetic, anti-inflammatory, and analgesic activities. Quantitative analysis shows total phenolic content ranging from 31–89 mg GAE/100 g, total flavonoid 15–80 mg QE/100 g, and total tannin 89–217 mg CE/g, with ethanol extraction yielding optimal results. Several novel pure compounds, including Burmanoside, Burmafuranic acid, Burmannic acid, and o-hydroxycinnamic acid, have been isolated and demonstrate antiproliferative and photoprotective activities. Contribution: This systematic review highlights the diversity of phytochemical constituents in C. Burmannii and emphasizes the influence of plants parts and extraction methods on phytochemicals profiles.
Co-Authors AA Sudharmawan, AA Agung, Yoki Permana Amri Bakhtiar Annisa Nur Salasa Arif Setiawansyah Arifa, Nurwahidatul Arifah, Nurwahidatul Armenia, Armenia Asmah Indrawaty Clegg, Jack K. DAYAR ARBAIN DEDDI P PUTRA Deddi Prima Putra Dévéhat, Françoise L. Dian Handayani Erizal Zaini Fakhriadi, Athallah Gina Sasha Nabila Gita Susanti HANIF ERONI PUTRA Huda, Ulfa Rosiatul Junaidin Junaidin Maria Dona Octavia Meiridha Mutiara Andania Muhammad Taher Nabila, Gina Sasha Nadhifa Putri NAURA PRIMA VIDIAN Nissa, Mentari Q. Nofrizal Nofrizal Nova Syafni Orue, Analia IC. Putra, Deddi P. Putri, Indah Tamara Herman Putri, Nadhifa Rafky Putra Rahmi Yosmar Rahmi Yosmar Rahwal, Sultan RAMA MULYADI Ramadani, Suci Indah Regina Handayani Handayani, Regina Handayani Rini Agustin Rini Agustin Risma Rahmatunisa Rouaud, Isabelle Rustini Rustini Rustini Rustini Rustini Saafrida Saafrida Saafrida Saafrida Sardi, Valdy F Sardy, Valdy Filando Solachuddin Jauhari Arief Ichwan SRI HARTATI Surya Sumantri Abdullah Suswati . Try Andy Sahputra Try Andy Sahputra Uswatul Hasanah Vike Zulia Putri Yeni Novita Sari Yori Yuliandra Yufri Aldi