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All Journal Jurnal Keperawatan BALI MEDICAL JOURNAL (BMJ) Jurnal Kedokteran Syiah Kuala Journal of the Indonesian Tropical Animal Agriculture Indonesian Journal of Tropical and Infectious Disease Jurnal Penelitian Kesehatan Suara Forikes Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Respirologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Respirasi (JR) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) APTEK Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Kesmas Asclepius Indian Journal of Forensic Medicine & Toxicology Jurnal Cahaya Mandalika Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Scientech Research and Development Hang Tuah Medical Journal Journal of Clinical Microbiology and Infectious Diseases Multidisciplinary Indonesian Center Journal
S. Soedarsono
Department Of Pulmonology, Faculty Of Medicine, Hang Tuah University
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Mutant vary region of pncA gene sequence of pyrazinamide resistance among multidrug resistant Mycobacterium tuberculosis isolates Titiek sulistyowati; Soedarsono; Ni Made Mertaniasih
Journal of Clinical Microbiology and Infectious Diseases Vol. 2 No. 1 (2022): Availabel Online: June 2022
Publisher : Indonesian Society for Clinical Microbiology (Perhimpunan Dokter Spesialis Mikrobiologi Klinik Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/jcmid.v2i1.18

Abstract

ABSTRACT Introduction: Pyrazinamide (PZA) is one of the potent front-line drugs that act as antituberculosis (antiTB) for nonresistant or resistant Mycobacterium tuberculosis. Mutation of pncA gene is considered to be main target of PZA resistance mechanism. This study aims to determine the mutant gene sequences, location, and correlation of pncA gene mutations with PZA resistance in MDR Mycobacterium tuberculosis as a base for the rapid molecular examination. Objective: This study aims to determine the mutant gene sequence and location of pncA gene with PZA resistance in multidrug resistant (MDR) Mycobacterium tuberculosis need a rapid molecular examination for consideration of MDR TB therapy management in Indonesia. Methods: MDR Mycobacterium tuberculosis were identified and tested for PZA resistance with BACTEC MGIT 960 as a gold standard, followed by DNA extraction, PCR amplification and pncA gene sequencing. Results: An analysis of 561 bp sequence of nucleotides was performed to determine type and location of mutations. A total of 35 isolates of this study showed 14 isolates of pncA gene mutation (40%), and revealed in 13 resistant and 1 sensitive isolate. The correlation analysis of pncA gene mutation to PZA resistance was significant (p = 0,003 and r = 0,452). Mutations in 3 (three) specific regions of pncA gene are 1 isolate at codons 51-76, 1 isolate at codons 130-142, and 3 isolates at codons 163-180. Conclusion: Types of mutations in the pncA gene include substitution of 11 isolates, insertion of 2 isolates, and no deletion. Insertion of 178 CGCGCTGGAGGAGATGCGCACCGCC and multiple mutations in one isolate.
Karakteristik Pasien Tuberkulosis Paru Dengan HIV di Rumah Sakit Umum Daerah Dr Harjono Ponorogo Periode Januari 2018 - Desember 2022 Anindya Zalfaa Kusuma Dewi; Ronald Pratama A.; Dody Taruna; Irmawati M. Dikman; Soedarsono Soedarsono; Yelvi Levani
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21666

Abstract

Tuberculosis (TB) is the most common opportunistic infection in people living with HIV/AIDS in Indonesia, and HIV infection promotes Mycobacterium tuberculosis infection. In ODHIV, the probability of contracting TB is 10% per year. According to the Indonesian Ministry of Health, East Java is in second place with 71,909 cases and has the second highest number of AIDS patients and 824,000 TB cases in Indonesia. This study aims to determine the characteristics of pulmonary tuberculosis patients with HIV at DR Harjono Ponorogo Hospital for the period January 2018 - December 2022. This study applied descriptive research methodology with quantitative techniques with secondary data from medical records of pulmonary TB patients with HIV at Dr. Harjono Ponorogo Hospital for the period January 2018 - December 2022.  The results showed a total sample of 130 medical records, there were several characteristics of TB patients with HIV, namely the highest age group of 30-39 years by 29.2%, more in male gender 73%. More patients had last high school education 38.5%, more treatment duration in patients who did for 9 months 61.5% and the results showed more patients with poor prognosis 56%. In conclusion, the characteristics of TB patients with HIV with the highest group at the age of 3-39 years, having male gender, more high school education, with more treatment duration of 9 months, and the results showed a poor prognosis.
Predictive Positive Value Xpert MTB/RIF in Detecting Mycobacterium tuberculosis on Adult Pulmonary Tuberculosis Patients in Dr. Soetomo Referral Hospital Surabaya Indonesia Akirasena, Mayoori; Mertaniasih, Ni Made; Soedarsono; Permatasari, Ariani
Indonesian Journal of Tropical and Infectious Disease Vol. 12 No. 2 (2024)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v12i2.52755

Abstract

Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis (Mtb) and transmitted via droplets. Southeast Asia is the largest contributor of TB, and Indonesia itself has the second-highest number in the world with an incidence of approximately 824000 cases. The most common symptoms of active TB are cough, fever, weight loss, and night sweats. The diagnosis can be established upon the confirmation that one of the specimens contains M. tuberculosis. Xpert MTB/RIF provides results in less than 2 hours, whereas culture takes approximately 2-6 weeks. This research aims to evaluate the characteristics and determine the Predictive Positive Value (PPV) percentage of GeneXpert MTB/RIF, utilizing parameters derived from the gold standard examination results, namely culture. This research method is descriptive- analytic based on secondary data extracted from medical records of patients receiving care at the multi-drug resistant TB (MDR-TB) Outpatient Management at Dr. Soetomo Referral Hospital Surabaya from the period January 2019 – April 2022. The results showed that the PPV level of GeneXpert MTB/RIF in detecting the presence of M. tuberculosis is 90%. The diagnosis of pulmonary TB is also supported by the chest X-ray infiltrate's appearance and clinical symptoms of cough, weight loss, fever, and night sweats. Smoking and diabetes are the most common comorbid and risk factors in TB. The conclusion of this study is that the PPV for diagnosing adult pulmonary TB using the Xpert MTB/RIF is relatively high. This suggests the potential use of this method as a diagnosing tool for accurately diagnosing pulmonary tuberculosis.
RE-ENGINEERING PADA PROYEK KONSTRUKSI BANGUNAN GEDUNG (STUDI KASUS: PROYEK PEMBANGUNAN GEDUNG LABORATORIUM KLINIK PRODIA PALEMBANG) Farah Nurul Rakhima; Kartono Wibowo; Soedarsono
Journal of Scientech Research and Development Vol 6 No 2 (2024): JSRD, December 2024
Publisher : Ikatan Dosen Menulis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56670/jsrd.v6i2.586

Abstract

Teknologi konstruksi di Indonesia terus berkembang, terutama dalam desain dan metode kerja. Pada Proyek Pembangunan Gedung Laboratorium Klinik Prodia Palembang, dilakukan re-engineering untuk mengatasi kendala waktu yang ketat dengan membandingkan dua metode pengecoran beton (ready mix dan ready mix dengan aditif Sika Viscocrete 8007) serta dua jenis bekisting (semi sistem dan sistem penuh). Hasil penelitian menunjukkan bahwa metode beton dengan Sika Viscocrete 8007 lebih efisien, menghemat waktu 28 hari, sementara bekisting sistem penuh mengurangi waktu pengerjaan hingga 24 hari meski biayanya lebih tinggi. Kombinasi beton dengan Sika Viscocrete 8007 dan bekisting semi sistem menjadi pilihan optimal, menghemat biaya Rp 45.608.342,48 dan waktu 28 hari. Temuan ini menegaskan pentingnya metode konstruksi yang tepat untuk efisiensi waktu dan biaya proyek.
Efek Teripang Terung (Phyllophorus Sp.) Terhadap Kadar HDL Dan LDL Tikus Dengan Diet Tinggi Lemak ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI; LESTARI DEWI; SOEDARSONO; INDRI NGESTI RAHAYU
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.576

Abstract

Cholesterol is divided into two different forms, including HDL (high-density lipoprotein, also referred to as "good fat". LDL (low-density lipoprotein), sometimes known as "bad fat". A buildup of cholesterol levels in the blood that can lead to cardiovascular disease. Sea cucumbers contain flavonoids which are a class of phenolic compounds. Flavonoids have properties as antioxidants. This study was conducted to determine the effect of ethanol extract of sea cucumber (Phyllophorus sp.) on HDL and LDL levels in wistar strain white rats induced by high fat diet. This study was conducted in the biochemistry laboratory of the Faculty of Medicine, Hang Tuah University using 30 white rats (Rattus norvegicus) male wistar strain. The rats were divided into 5 groups, namely, groups of animals that did not receive treatment, groups of animals fed a high-fat diet, groups of animals fed a high-fat diet and sea cucumber ethanol extract 8.5mg/kgBB, groups of animals fed a high-fat diet and sea cucumber ethanol extract at a dose of 17mg/kgBB, groups of animals fed a high-fat diet and simvastatin. On the 35th day, HDL and LDL levels were examined in all groups. The conclusion of the results of this study is that the administration of sea cucumber ethanol extract can increase HDL levels even though it is not significant, and can significantly reduce LDL levels. Keywords: Sea cucumber ethanol extract (Phyllophorus sp.), HDL, LDL, Wistar white rat, high fat diet
Penerapan Sistem Manajemen Keselamatan Dan Kesehatan Kerja (SMK3)  Pada Proyek Pembangunan Jalan Shelly Puspita Ayu Wardhani; Kartono Wibowo; Soedarsono
Jurnal Kesmas Asclepius Vol. 7 No. 2 (2025): Jurnal Kesmas Asclepius
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/21ffpv62

Abstract

This study aims to evaluate the implementation and success rate of the Occupational Safety and Health Management System “SMK3” in construction projects, referring to Government Regulation (PP) Number 50 of 2012. The method used is descriptive qualitative. The results of the analysis show that the level of implementation of “SMK3” reached 90.96% with the predicate “Satisfactory”. This indicates that the contractor has carried out the duties and functions of “SMK3” well and in accordance with regulations. The implementation of “SMK3” in this project includes several regulations, such as the use of Personal Protective Equipment (PPE) according to the type of work, calls to obey signs, maintain cleanliness, and report emergencies. In addition, this regulation also regulates hazard identification and risk assessment. Overall, it can be concluded that the implementation of “SMK3” in this project is in accordance with PP No. 50 of 2012. The satisfactory implementation of “SMK3” is able to create a safe and productive work environment. Keywords: Identification, Implementation of “SMK3”, PP No. 50 of 2012, Success Rate of SMK3.
Pengaruh Aspek Sanitasi Terhadap Kualitas Kenyamanan Tinggal di Rusunawa Kraton Kota Tegal Tejowati, Rr Putri Tejowati; M. Faiqun Ni'am; Soedarsono
Aptek Jurnal Apliksai Teknologi (APTEK): Volume 16, No. 02, Juni 2024
Publisher : Fakultas Teknik Universitas Pasir Pengaraian

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30606/aptek.v16i2.2413

Abstract

Pembangunan rumah susun sederhana sewa di perkotaan berperanan untuk meminimalisir penggunaan lahan di perkotaan, menyediakan hunian masyarakat tidak mampu dengan lingkungan yang bersih dan sehat. Sanitasi bangunan rusunawa meliputi ketersediaan air bersih, pengolahan air limbah, pengelolaan sampah penting disediakan agar bangunan dan lingkungan bersih, sehat, nyaman sehingga kesehatan penghuni terjamin serta terhindar dari penyakit. Permasalahan timbul berkaitan dengan ketersediaan sarana dan sistem sanitansi semakin dirasakan kurang nyaman oleh penghuni. Tujuan penelitian mengidentifikasi, menganalisis kondisi eksisting sanitasi serta pengaruhnya terhadap penurunan kualitas bangunan dan lingkungan. Analisis dilakukan supaya mendapat rekomendasi perbaikan untuk kenyamanan penghuni. Metode penelitian survey kondisi eksisting, wawancara, kuesioner, analisis deskriptif kuantitatif. Obyek penelitian kondisi sanitasi bangunan dan lingkungan serta hasil kuesioner terhadap penghuni dan pengelola. Hasil penelitian sistim air bersih sangat layak, sistim air limbah sangat tidak layak, sistim sampah layak. Terdapat pengaruh secara silmultan sistim air bersih, air kotor dan air limbah terhadap kualitas bangunan dan lingkungan.
DAMPAK PEMBANGUNAN JALAN KERETA API LAYANG DI RUAS PERSIMPANGAN PALANG JOGLO SURAKARTA Sondang Kuncoro; Rachmat Mudiyono; Soedarsono
Jurnal Cahaya Mandalika ISSN 2721-4796 (online) Vol. 3 No. 1 (2022)
Publisher : Institut Penelitian Dan Pengambangan Mandalika Indonesia (IP2MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/jcm.v3i1.2091

Abstract

The Joglo intersection is a confluence of two national roads, namely Jl. Ki Mangunsarkoro and Jl. Youth Pledge. Then two provincial roads namely Jl. Colonel Sugiono who headed towards Purwodadi and Jl. Pierre Tendean. The traffic flow at the Joglo intersection is getting denser. This study aims to determine the level of service at level crossings at Joglo Crossings. Data collection was carried out by means of a direct survey at the intersection of the joglo cross section during peak hours in the morning, afternoon and evening from 06.00 - 18.00 WIB. From the survey results, grouping was carried out on each segment at the intersection and presented in the form of a vehicle table. In calculating the intersection analysis using the 1997 Indonesian Road Capacity Manual. The performance results of the Surakarta joglo intersection before construction showed that the degree of saturation in the morning was 0.612, the degree of saturation during the day was 0.474 indicating the level of class C road service. The degree of saturation in the afternoon was 0.969 indicating the level of class E road service, while the degree of saturation at construction shows the morning of 0.620, the degree of saturation during the day is 0.634 which indicates the level of class C road service. The degree of saturation in the afternoon is 1.064 which indicates the level of class F road service. In the Elevated Railway Development Project there will be narrowing on certain sections due to With this development, traffic engineering management was carried out while construction was in progress.
CLINICAL PROFILE OF DRUG-RESISTANT TUBERCULOSIS (DR-TB) PATIENTS DURING THE COVID-19 PANDEMIC AT RSUD DR. SOETOMO (JANUARY 2021 - DECEMBER 2021) (TITLE) Valentina Alfianti Herdy Tamyn; Rebekah J. Setiabudi; Soedarsono; Ibrahim Syamsuri; Shofiuddin Al Mufid
Multidisciplinary Indonesian Center Journal (MICJO) Vol. 3 No. 1 (2026): Vol. 3 No. 1 Edisi Januari 2026
Publisher : PT. Jurnal Center Indonesia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62567/micjo.v3i1.1608

Abstract

The emergence of the COVID-19 pandemic in 2019 has had an impact on all aspects of life, particularly global health. Indonesia is one of the affected countries. The Indonesian government has responded to the conditions of this pandemic, one of which is by imposing access restrictions to prevent the pandemic from spreading. This policy indirectly affects the community's activities, including the utilization of existing healthcare services. Meanwhile, available data show that one of the major issues that the Indonesian state is still dealing with is its status as the third country with the greatest number of TB (Tuberculosis) cases in the world, with some of the TB cases being classified as Drug-Resistant Tuberculosis (DR-TB).
DEVELOPMENT OF E-TIBI+ AS EARLY DETECTION AND SYSTEMATIC MANAGEMENT OF TUBERCULOSIS CASES IN PLHIV Erwin Astha Triyono; Feriawan Tan; Lilis Masyfufah; Sulvy Dwi Anggraini; Maria Lucia Inge Lucida; Soedarsono; Merita Arini; Tri Pudy Asmarawati; Ariani Permatasari; Rosita Dwi Yuliandari
Journal of Vocational Health Studies Vol. 9 No. 3 (2026): March 2026 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V9.I3.2026.199-207

Abstract

Background: HIV and TBC combinations have received global public attention in recent years. Current collaborative tuberculosis and HIV elimination strategy is not enough to eradicate these two infectious diseases. Therefore, an innovative elimination approach leveraging advancements in digital technology is urgently needed. Purpose: To evaluate the tuberculosis elimination by optimizing case finding and monitoring treatment completion through the Early Detection and Management of Tuberculosis Application System + (E-TIBI+) application based on self-assessment in the HIV population. Method: This observational cohort study was conducted in Surabaya city, East Java Province, Indonesia in the period of September - October 2024. The study population consisted of adult PLHIV who completed the E-TIBI+ self-assessment. The E-TIBI+ application is a web-based platform. Data analysis included univariate analysis in the form of frequencies for each variable and crosstab analysis with the Kendall tau-b test in E-TIBI+ application acceptance data. Result: From a total of 386 patients screened, 61 (15.80%) PLHIV were suspected of having TBC. From the 61 patients, there were 17 patients who sought diagnosis at the health facility of their choice. User acceptance of the E-TIBI+ application by PLHIV patients tends to be positive and statistically significant. Conclusion: The E-TIBI+ application demonstrates strong potential to enhance early detection and systematic monitoring of tuberculosis case management among PLHIV through digital technology.
Co-Authors Abdul Rahman Bahmid Agnes Dwi Sis Perwitasari, Agnes Dwi Sis Agung Dewi Sekar Agustinus Rizki Wirawan Riadi Akirasena, Mayoori Alvin Hartanto Kurniawan, Alvin Hartanto Amelia Lorensia ANAK AGUNG ISTRI AGUNG, SRILA NATASWARI Andri Dwi Wahyudi Andy Sulaiman Siregar Anindya Zalfaa Kusuma Dewi Anita Dewi Anggraini Anita Widyoningroem Ariani Permatasari Asmarawati, Tri Pudy Bendrong Moediarso Budi Suprapti Budiono Budiono D. Sunarti Deby Kusumaningrum Diana, Adawiyah Putri Dody Taruna Eko Budi Koendhori, Eko Budi Elisabeth Tri Wahyuni Widoretno Erwin Astha Triyono Farah Nurul Rakhima Feriawan Tan H. Haryono Ibrahim Syamsuri Indri Ngesti Rahayu Irmawati M. Dikman Isa Ansori Jusak Nugraha Kartono Wibowo Kuntaman Kuntaman Kusmiati, Tutik Laily Hidayati Lestari Dewi Lulus Handayani M. Faiqun Ni'am M. Yamin S. S Makhfudli Makhfudli ManikRetno Wahyunitisari Maria Lucia Inge Lucida Masyfufah, Lilis Merita Arini Mohammad Yamin Sunaryo Suwandi Monica Dyah Puspitasari Muhammad Bagus Fidiandra Ni Made Mertaniasih Ni Putu Anggita Medyantari Nurul Wiqoyah, Nurul Nuswantoro, Djohar Pepy Dwi Endraswari, Pepy Dwi Permatasari, Ariani Pramanindyah Bekti Anjani Prasetya, Hanung Purwoko, Agus Putra, Oki Nugraha Putranto, J.Nugroho Eko Rachmat Mudiyono Rebekah Setiabudi, Rebekah Retno Budiarti Ricky Septafianty Rivan Virlando Suryadinata Ronald Pratama A. Ronald Pratama Adiwinoto Rosantia Sarassari Rosita Dwi Yuliandari Rudi Hariyono Safira Nur Ainiyah Setiawati, Rosy Sheila Gerhana Darmayanti Shelly Puspita Ayu Wardhani Shofiuddin Al Mufid Siti Ermawati Sondang Kuncoro Stephanie Christina Sulaiman Sulvy Dwi Anggraini Tejowati, Rr Putri Tejowati Titiek sulistyowati Tri Puji Astuti Umiastuti, Pirlina Valentina Alfianti Herdy Tamyn Wahyu Agung Purnomo Wahyu Setiani Wibowo Wahyu Setiani Wibowo Wayan Tunas Artama Yelvi Levani