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All Journal JURNAL FARMASIMED (JFM) Best Journal (Biology Education, Sains and Technology) Jurnal Penelitian Farmasi dan Herbal International Journal Of Science, Technology & Management (IJSTM) Jurnal Pengabdian Masyarakat Putri Hijau PCJN Pharmaceutical and Clinical Journal of Nusantara Jurnal Pengabdian Kepada Masyarakat Meambo
Sanjaya, Angga Nugraha
Institut Kesehatan Deli Husada
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Transportation Veterinary

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Phytochemical Screening and Antibacterial Potential Ethanol Extract of Kemangi Leaves (Ocimum basilicum L.) Towards Staphylococcus aureus Sanjaya, Angga Nugraha; Harahap, Urip; Dalimunthe, Aminah
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.630

Abstract

An infectious disease is a disease with the highest prevalence in the world, with a great risk of transmission. Staphylococcus aureus is a pathogen that can cause several infectious diseases. The use of kemangi leaves as vegetables can be used as an invention in treating infections caused by bacteria. The purpose of this study was a phytochemical screening test to determine what metabolites are contained and their potential activity against Staphylococcus aureus. The research method is to carry out a qualitative phytochemical screening test using reagents and an antibacterial potential test against Staphylococcus aureus using the Kirby-Bauer method (diffusion agar) with varying concentrations. The results showed that kemangi leaves extract showed positive results on the secondary metabolite compounds, were alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The diameter of the inhibition zone at a concentration of 500 mg/mL showed the diameter of the inhibition zone was 11.93 ± 0.25 mm with the strong category group. The conclusion is that the ethanolic extract of kemangi leaves shows the ethanolic extract of kemangi leaves has potential as an antibacterial.
TESTING THE EFFECTIVENESS OF BIDARA LEAF ETHANOL EXTRACT (Ziziphus mauritiana L.) IN GEL PREPARATIONS FOR BURN WOUNDS IN MALE RABBIT (Oryctolapus cuniculus) Sulasmi, Sulasmi; Sanjaya, Angga Nugraha; Bangun, Sofia Elia Sari; Cahaya, Cucu Arum Dwi
PCJN: Pharmaceutical and Clinical Journal of Nusantara Vol. 1 No. 01 (2022): PCJN: Pharmaceutical and Clinical Journal of Nusantara
Publisher : CV. Nusantara Scientific Medical

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.99 KB) | DOI: 10.58549/pcjn.v1i01.2

Abstract

Abstract Bidara plants have many benefits in the treatment of sore skin, ulcers, and burns. Burns are a form of tissue damage or loss caused by contact with a heat source such as fire, hot water, electricity, radiation, or corrosive substances. This study aims to determine the effectiveness of the ethanol extract of bidara leaf in healing burns in male rabbits compared to bioplacenta. This study used an experimental method of maceration extraction using 96% ethanol. To test the effect of burns, 15 test animals were grouped into five groups, each of which used three test animals. The treatment group was a gel-based negative control group, a positive bioplacenta control group, and a treatment group with bidara leaf ethanol extract at concentrations of 5%, 10%, and 15%. The results of the research on the effectiveness of healing burns in the three formulations, namely a concentration of 15%, showed faster healing of wound diameter in male rabbits compared to concentrations of 5% and 10% but were not more effective when compared to bioplacenta ointment. Keywords: Bidara leaf ethanol extract, burns, ointment and bioplacenton
UJI EFEKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL RIMPANG JAHE (Zingiber officinale Roscoe) PADA TIKUS PUTIH JANTAN Hengki Frengki Manullang; Angga Nugraha Sanjaya; Tresia Angelina
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.12255

Abstract

Peradangan merupakan respons biologis alami tubuh terhadap cedera atau infeksi, yang ditandai dengan gejala seperti nyeri, panas, kemerahan, dan pembengkakan. Penggunaan obat antiinflamasi sintetis jangka panjang seringkali menimbulkan efek samping, terutama pada sistem pencernaan dan kardiovaskular. Salah satu alternatif potensial adalah penggunaan tanaman obat, seperti rimpang jahe (Zingiber officinale Roscoe), yang mengandung senyawa aktif termasuk flavonoid, alkaloid, dan gingerol, yang dikenal karena sifat antiinflamasinya. Penelitian ini bertujuan untuk mengevaluasi efektivitas ekstrak etanol 96% rimpang jahe dalam mengurangi peradangan yang diinduksi karagenan pada tikus putih jantan (Rattus norvegicus L.). Metode eksperimental dengan rancangan acak lengkap digunakan. Subjek dibagi menjadi lima kelompok: kelompok kontrol negatif (1% Na CMC), kelompok kontrol positif (natrium diklofenak), dan tiga kelompok perlakuan yang menerima ekstrak jahe dengan dosis 300, 400, dan 500 mg/kgBB. Data dianalisis menggunakan ANOVA Satu Arah dan dilanjutkan dengan uji post-hoc Tukey HSD. Semua kelompok perlakuan menunjukkan penurunan tingkat inflamasi, dengan dosis 500 mg/kgBB menunjukkan efek paling signifikan, sangat mirip dengan efek natrium diklofenak. Uji statistik menunjukkan perbedaan yang signifikan antara kelompok kontrol negatif dan kelompok perlakuan. Ekstrak etanol rimpang jahe menunjukkan potensi sebagai agen antiinflamasi alami yang efektif, terutama pada dosis 500 mg/kgBB
PENINGKATAN KESIAPSIAGAAN TANGGAP DARURAT KEBAKARAN MELALUI PELATIHAN DAN SIMULASI PENGGUNAAN ALAT PEMADAM API RINGAN (APAR) BAGI GURU DAN SISWA DI SMA NEGERI 15 MEDAN Ira Risnawati; Viktor Edyward Marbun; Angga Nugraha Sanjaya; Johannes Sembiring; Rizqi Nanda Putri
BEST Journal (Biology Education, Sains and Technology) Vol 9, No 1 (2026): Juni 2026
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v9i1.13997

Abstract

Kebakaran merupakan salah satu bencana yang dapat terjadi kapan saja dan menimbulkan kerugian material maupun korban jiwa apabila tidak ditangani dengan baik. Lingkungan sekolah memiliki potensi risiko kebakaran yang berasal dari instalasi listrik, laboratorium, kantin, maupun aktivitas pembelajaran yang melibatkan penggunaan peralatan elektronik. Rendahnya pengetahuan dan keterampilan warga sekolah dalam menghadapi keadaan darurat kebakaran dapat meningkatkan risiko terjadinya korban dan kerugian yang lebih besar. Oleh karena itu, diperlukan upaya peningkatan kesiapsiagaan melalui pelatihan dan simulasi penggunaan Alat Pemadam Api Ringan (APAR). Kegiatan ini bertujuan untuk meningkatkan pengetahuan, sikap, dan keterampilan guru serta siswa SMA Negeri 15 Medan dalam menghadapi keadaan darurat kebakaran melalui pelatihan dan simulasi penggunaan APAR. Metode yang digunakan meliputi penyuluhan, demonstrasi, praktik langsung, dan simulasi tanggap darurat kebakaran. Peserta kegiatan terdiri atas guru dan siswa yang diberikan materi mengenai teori dasar kebakaran, klasifikasi kebakaran, jenis-jenis APAR, prosedur penggunaan APAR, serta langkah-langkah evakuasi saat terjadi kebakaran. Hasil kegiatan menunjukkan adanya peningkatan pemahaman peserta mengenai bahaya kebakaran dan prosedur penggunaan APAR. Peserta mampu mempraktikkan teknik penggunaan APAR dengan metode PASS (Pull, Aim, Squeeze, Sweep) secara benar. Simulasi tanggap darurat juga meningkatkan kemampuan koordinasi dan respons peserta dalam menghadapi situasi kebakaran. Kegiatan ini diharapkan dapat mendukung terciptanya budaya keselamatan dan kesiapsiagaan bencana di lingkungan sekolah.
Penyuluhan Keamanan, Efektivitas, Interaksi Obat Tradisional dan Obat Moderen Pada Hipertensi di Desa Sudirejo, Kabupaten Deli Serdang Sofia Rahmi; Angga Nugraha Sanjaya; Pintata Sembiring; Herviani Sari; Debby Astri; Yosy Silalahi
Jurnal Pengabdian Meambo Vol. 4 No. 1 (2025): Jurnal Pengabdian Kepada Masyarakat MEAMBO
Publisher : PROMISE

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56742/jpm.v4i1.131

Abstract

Penyakit hipertensi merupakan penyakit yang tidak dapat disembuhkan, tetapi dapat dikendalikan, sehingga pasien dengan diagnosa hipertensi harus mengkonsumsi obat seumur hidup. Pengobatan tradisional sebagai alternatif terapi hipertensi semakin meningkat setiap tahunnya. Tujuan dari kegiatan pengabdian ini yaitu memberikan penyuluhan keamanan, efektivitas dan interaksi obat tradisional dan obat moderen di Desa Sudirejo, Kabupaten Deli Serdang. Metode yang dilakukan pada kegiatan pengabdian ini yaitu metode penyuluhan interaktif, diskusi kelompok, pendampingan konsultasi langsung dan penyebaran leaflet. Hasil yang diperoleh yaitu beberapa masyarakat berpendapat bahwa selain mengkonsumsi obat antihipertensi, masyarakat juga mengkonsumsi rebusan obat tradisional. Kesimpulan dari kegiatan pengabdian ini yaitu pengobatan tradisional lebih diminati oleh masyarakat lansia karena usia lansia umumnya memiliki pengalaman atau kepercayaan yang lebih kuat terhadappengobatan tradisional dibanding kelompok usia muda..
Testing the Activity of Nanochitosan Hydrogel Containing Earthworm (Lumbricus rubellus) Extract as a Future Anti-Aging Candidate Nina Irmayanti Harahap; Nurul Dahlia Harahap; Angga Nugraha Sanjaya
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.3820

Abstract

Background: Premature aging is a skin problem influenced by exposure to solar radiation and the formation of Reactive Oxygen Species (ROS). Accumulation of ROS can cause oxidative stress, leading to skin damage such as dryness, loss of elasticity, and wrinkles. Earthworm (Lumbricus rubellus) extract contains flavonoids, alkaloids, and tannins, which have potential antioxidant activity. Formulation in the form of a nanitosan hydrogel is expected to support the delivery of active compounds into the skin. Objective: This study aimed to analyze the antioxidant activity of Lumbricus rubellus extract and evaluate the physical characteristics and stability of nanitosan hydrogel as an anti-aging candidate. Methods: The extract was obtained by maceration using 70% ethanol. Phytochemical screening was conducted for flavonoids, alkaloids, and tannins. Antioxidant activity was evaluated using the DPPH method at concentrations of 20–100 µg/mL and determined based on the IC₅₀ value. The extract was then formulated into nanitosan hydrogel at concentrations of 2.5%, 5%, and 7.5%, followed by evaluation of organoleptic properties, homogeneity, pH, spreadability, viscosity, and irritation. Results: The extract yield was 34.3% and contained flavonoids, alkaloids, and tannins. The IC₅₀ value of the extract was 95.44 ppm, indicating strong antioxidant activity. The preparations showed good homogeneity and organoleptic stability, with a pH range of 6.6–6.8 and viscosity of 28,000–32,000 cps. Visual observation showed no apparent signs of irritation. Conclusion: Lumbricus rubellus extract demonstrated strong antioxidant activity and could be formulated into nanitosan hydrogel with good physical characteristics, indicating its potential for further development as an anti-aging preparation.
UJI AKTIVITAS ANTIBAKTERI SEDIAAN SALEP EKSTRAK BUNGA BELIMBING WULUH (Averrhoa bilimbi L.) TERHADAP BAKTERI PENYEBAB JERAWAT Propionibacterium Acnes DAN Staphylococcus Epidermidis TIO RANTI SARI SEMBIRING; Masria Phetheresia Sianipar; Anggun Syafitri; angga nugraha sanjaya
Jurnal Penelitian Farmasi & Herbal Vol. 9 No. 1 (2026): Jurnal Penelitian Farmasi dan Herbal
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/kzz03w83

Abstract

Acne is a skin disease often caused by infection with the bacteria Propionibacterium acnes and Staphylococcus epidermidis. Long-term use of antibiotics can lead to bacterial resistance, necessitating alternative treatments derived from natural ingredients. Starfruit flowers (Averrhoa bilimbi L.) are known to contain secondary metabolites such as flavonoids, saponins, tannins, terpenoids, and polyphenols, which have antibacterial potential. This study aimed to formulate an ethanol extract of starfruit flowers into an ointment, evaluate the physical characteristics of the preparation, and determine its antibacterial activity against Propionibacterium acnes and Staphylococcus epidermidis. This was an experimental study. Starfruit flower samples were processed into crude drugs, then characterized and phytochemically screened. Extraction was carried out using a maceration method with 96% ethanol as a solvent. The resulting extract was formulated into ointment preparations at concentrations of 10%, 15%, and 20%. The ointment preparations were then evaluated for organoleptic properties, homogeneity, pH, spreadability, and irritation. It is recommended that future research conduct antibacterial testing on different formulations of the ethanolic extract of (Averrhoa bilimbi L). flowers.
Co-Authors Aminah Dalimunthe Angelina, Tresia Anggun Syahfitri Bangun, Sofia Elia Sari Bunga Rimta Barus Cahaya, Cucu Arum Dwi Debby Astri Delisma Marsauli Simorangkir Dian Ika Perbina Meliala Evi Deviana Gultom Hengki Frengki Manullang Hengki Frengki Manullang, Hengki Frengki Herviani Sari Johannes Sembiring Linta Meliala MARBUN, VIKTOR EDYWARD Masria Phetheresia Sianipar Nina Irmayanti Harahap Nurul Dahlia Harahap Palas Tarigan Pintata Sembiring Puji Lestari PUJI LESTARI Puspita, Rika Rika Puspita Sari Risnawati, Ira Rizqi Nanda Putri SEMBIRING, TIO RANTI SARI Sofia Rahmi Sulasmi Sulasmi TIO RANTI SARI SEMBIRING Tresia Angelina Urip Harahap Wahyudi Wahyudi Yosy Silalahi