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All Journal JURNAL PENGABDIAN KEPADA MASYARAKAT Global Health Management Journal Manuju : Malahayati Nursing Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Ners Science Midwifery Borneo Journal Of Pharmascientech Tunas Medika Jurnal Kedokteran & Kesehatan Indonesian Journal of Applied Research (IJAR) JPM: JURNAL PENGABDIAN MASYARAKAT International Journal of Health and Pharmaceutical (IJHP) Jurnal Sehat Indonesia (JUSINDO) KOLONI Riwayat: Educational Journal of History and Humanities Medical Sains : Jurnal Ilmiah Kefarmasian InaBHS (Indonesian Journal of Biomedicine and Health Science)
Sri Marfuati
Universitas Swadaya Gunung Jati
Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary Other

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Pola Penggunaan Antibiotik pada Pasien Demam Tifoid di Instalasi Rawat Inap Rsud Waled Tahun 2023 Bagas Dharma Utama; Sri Marfuati; Rama Samara Brajawikalpa
KOLONI Vol. 5 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i2.828

Abstract

Typhoid fever remains a significant public health problem in developing countries, including Indonesia, with high morbidity rates. Antibiotics are the main therapy for typhoid fever; however, irrational use may lead to antimicrobial resistance, increased treatment costs, and adverse effects. Therefore, evaluating the pattern of antibiotic use is essential to ensure rational therapy and improve patient outcomes. This study aimed to determine the pattern of antibiotic use among typhoid fever patients in the inpatient installation of RSUD Waled in 2023.This study employed a descriptive observational design with a retrospective approach using medical record data. A total sampling technique was applied, resulting in 88 patients who met the inclusion criteria. Variables observed included patient characteristics, types of antibiotics, dosage forms, duration of use, side effects, and allergic responses.The results showed that all patients were confirmed cases (100%), with the majority aged 6–11 years (40.9%) and predominantly male (51.1%). Most patients used BPJS health insurance (96.6%). Cephalosporins were the most frequently prescribed antibiotics (88.6%), mainly administered in parenteral form (77.3%). All patients received antibiotic therapy with appropriate duration according to guidelines (100%), and no side effects or allergic reactions were reported (100%). In conclusion, the pattern of antibiotic use in typhoid fever patients at RSUD Waled in 2023 was consistent with clinical guidelines, dominated by cephalosporin use, and showed no adverse effects or allergic reactions. These findings are important to support rational antibiotic use and to prevent the development of antimicrobial resistance.*
Comparison of the Effectiveness of Antihypertensive Drugs Captopril 25 mg and Amlodipine 5 mg in Lowering Blood Pressure in Hypertensive Patients Ichlasul Amal; Sri Marfuati; Rini Istisakinah
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.455

Abstract

Hypertension is a major global health problem with increasing prevalence and significant risks of complications. This study aims to compare the effectiveness of Captopril 25 mg and Amlodipine 5 mg in lowering blood pressure among hypertensive patients. An analytical observational study with a cross-sectional design was conducted at Waruroyom Community Health Center, involving 70 patients divided equally into two groups. Data were collected using structured questionnaires, medication adherence sheets, and calibrated digital blood pressure monitors. Univariate and bivariate analyses were performed, including paired T-tests and Mann-Whitney tests. The results showed that both Captopril and Amlodipine effectively reduced systolic and diastolic blood pressure. However, Amlodipine 5 mg demonstrated a significantly greater reduction in diastolic blood pressure compared to Captopril 25 mg, while both drugs had similar effects on systolic blood pressure. The conclusion is that Amlodipine may be preferred for patients requiring greater diastolic blood pressure control, although both drugs are effective for systolic reduction.
The Antibacterial Activity Test using Ethyl Acetate Fraction from Kersen Leaves (Muntingia calabura L.) against the Staphylococcus aureus Mutiara Fadilah; Mustika Weni; Sri Marfuati
GHMJ (Global Health Management Journal) Vol. 9 No. 1 (2026)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-911232

Abstract

Background: Staphylococcus aureus is a common cause of skin and soft tissue infections (pyoderma) and has developed resistance to multiple antibiotics. Kersen (Muntingia calabura L.) leaves contain bioactive compounds such as flavonoids, triterpenoids, steroids, tannins, and saponins, which have been reported to possess antibacterial properties. Aim: This study aimed to evaluate the in vitro antibacterial activity of the ethyl acetate fraction of M. calabura leaves against S. aureus. Methods: An experimental study with a post-test-only control group design was conducted. Phytochemical screening was performed to identify the secondary metabolites present in the fraction. Antibacterial testing was done using the well diffusion method on Mueller-Hinton Agar (MHA). Five treatment groups (ethyl acetate fractions at concentrations of 100%, 60%, 20%, 10%, and 1%) were compared to a negative control (10% DMSO) and a positive control (doxycycline). Inhibition zones were measured manually in millimeters and analyzed using one-way ANOVA (p < 0.05). Results: The ethyl acetate fraction demonstrated a concentration-dependent antibacterial effect. Mean ± SD inhibition zones were 17.20 ± 1.92 mm (100%), 12.94 ± 1.13 mm (60%), 7.99 ± 0.70 mm (20%), 7.34 ± 0.35 mm (10%), and 6.71 ± 0.85 mm (1%). The positive control showed a significantly higher inhibition zone (33.82 ± 1.62 mm), while the negative control showed no inhibition. Phytochemical screening of the kersen leaf ethyl acetate fraction includes tannins, saponins, steroids, triterpenoids, and phenolics. Conclusion: The ethyl acetate fraction of M. calabura leaves exhibited antibacterial activity against S. aureus. These findings support its potential development as a plant-based antibacterial agent, although further in vivo studies are needed.
In vitro study the effect of flavonoid routine in cassava leaves (manihot esculenta c.) on the replication of dengue virus serotype 1 strain new guinea C Dery Handaiana Putra Galuh Pangestu; Dadan Ramadhan Apriyanto; Sri Marfuati; Beti Ernawati Dewi
Science Midwifery Vol 14 No 2 (2026): June: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i2.2381

Abstract

Dengue hemorrhagic fever (DHF) is an infectious disease caused by the dengue virus with clinical manifestations of fever, muscle pain and joint pain accompanied by leukopenia, rash, lymphadenopathy and thrombocytopenia. According to WHO, DHF is still a major health problem in Indonesia, while dengue antiviral therapy does not yet exist, but several studies have found the potential of cassava leaves because they contain routine flavonoid compounds that function as antivirals. Objective: To determine the effect of routine flavonoids from cassava leaves (Manihot esculenta C.) on the replication of Dengue virus serotype 1 strain New Guinea C in Vitro by analyzing the 50% inhibitory concentration (IC50), 50% cytotoxic concentration (CC50), and selectivity index. Method: The research was experimental with a post-test control group design. This study used 7 groups, namely 1 control group and 6 treatment groups. The treatment group consisted of routine administration of Flavonoids from cassava leaves (Manihot esculenta C.) with concentrations of 50 µg/ml, 25 µg/ml, 12.5 µg/ml, 6.25 µg/ml, 3.125 µg/ml and 1.5 µg/ml. The control group (K) was given 0.2% Dimethyl sulfoxide (DMSO). Data were tested using the Kruskal Wallis test. Results: In the Kruskal Wallis test, there was an effect of routine Flavonoids on dengue virus replication (p value = 0.006). The IC50 value obtained at a concentration of 3.36 µg/ml was declared very strong inhibition, and the CC50 at a concentration of 17.48 µg/ml was declared toxic, for the Selectivity Index obtained a value of 5.2 declared safe in its use. Conclusion: Routine flavonoids in cassava leaves (Manihot esculenta C.) have an effect on the replication of Dengue virus Serotype 1 Strain New Guinea C in Vitro.
The Relationship between Characteristics with Medication Adherence and Quality of Life among the Pulmonary Tuberculosis Patients at the Cirebon City Community Lung Health Center, Indonesia Asri Permata Dewi; Niklah Zaidah; Sri Marfuati
GHMJ (Global Health Management Journal) Vol. 8 No. 3 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-831245

Abstract

Background: Tuberculosis (TB) is one of the top ten causes of death worldwide, caused by the Mycobacterium tuberculosis germ. Adherence to medication is a key factor in successful treatment and efforts to improve the quality of life of TB patients. Aims: Analyzing the relationship between characteristics with medication adherence and quality of life of pulmonary TB patients at the Cirebon City Community Lung Health Center. Methods: This study used an analytic observation method with a Cross Sectional design. The measuring instruments used were medical records and questionnaires that had been tested for validity and reliability, with a total of 131 respondents of pulmonary TB patients at the Cirebon City Community Lung Health Center (BKPM). Results : The most common characteristics were adult age 90.8%, female gender 56.5%, secondary education 50.4%, student 28.2%, length of treatment at the advanced stage 59.5%, adherent to taking medication 87.0%, good quality of life 54.2%. Based on the Chi-Square test, the relationship between characteristics and drug compliance from age p-value=0.189, gender p-value=0.320, education p-value=0.447, occupation p-value=0.594, length of treatment p-value=0.014. The relationship between characteristics and quality of life from age p-value=0.688, gender p-value=0.550, education p-value=0.838, occupation p-value=0.519, length of treatment p-value=0.604. Based on the logistic regression test, the relationship between characteristics and drug compliance from age p-value=0.058, length of treatment p-value=0.006. Conclusion: There is no relationship between age, gender, education, and occupation with medication adherence (p>0.05). Whereas in the length of treatment there is a relationship with adherence to taking medication. There is no relationship between characteristics and quality of life of pulmonary TB patients (p>0.05). The characteristic most associated with adherence to taking medication is length of treatment (p=0.006). Future researchers are advised to explore other factors that may be related to medication adherence and quality of life in patients with pulmonary TB.
Hubungan Dukungan Keluarga dengan Kepatuhan Minum Obat pada Pasien Hipertensi di Puskesmas Karangsembung Novan Ibrahim; Sri Marfuati; Nanang Ruhyana
KOLONI Vol. 5 No. 2 (2026): JUNI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/koloni.v5i2.900

Abstract

Hypertension is a non-communicable disease requiring long-term treatment and is one of the leading causes of cardiovascular complications. Adherence to antihypertensive medication is essential to maintain stable blood pressure and prevent complications. One of the factors influencing medication adherence is family support. This study aimed to determine the relationship between family support and medication adherence among hypertensive patients at Karangsembung Health Center, Cirebon Regency, in 2024. This study used an analytic observational design with a cross-sectional approach. The population consisted of hypertensive patients in the working area of Karangsembung Health Center, with a sample of 96 respondents selected using consecutive sampling technique. The independent variable was family support, while the dependent variable was medication adherence. Data were collected using a family support questionnaire, the Morisky Medication Adherence Scale (MMAS), and medical records. Data analysis was performed using the Spearman Rank correlation test. The results showed that most respondents had good family support, namely 63 respondents (65.6%), and the majority were adherent to medication, namely 73 respondents (76.0%). The Spearman Rank test showed a p-value of 0.000 (≤0.05) with a correlation coefficient of 0.550, indicating a positive relationship with moderate correlation strength. In conclusion, there is a significant relationship between family support and medication adherence among hypertensive patients at Karangsembung Health Center, where better family support is associated with higher medication adherence.
Efektivitas Ekstrak Tunggal dan Kombinasi Kulit Mangga Gedong Gincu (Mangifera indica L.) dan Belimbing Wuluh (Averrhoa bilimbi L.) terhadap Staphylococcus aureus Farras Fida Yumna; Sri Marfuati; Dadan Ramadhan Apriyanto
Jurnal Ners Vol. 10 No. 4 (2026): OKTOBER 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i4.63748

Abstract

Staphylococcus aureus merupakan patogen penyebab berbagai infeksi pada manusia. Mangga gedong gincu (Mangifera indica L.) dan belimbing wuluh (Averrhoa bilimbi L.), yang banyak tumbuh di Indonesia, berpotensi sebagai alternatif pengobatan tradisional untuk infeksi bakteri. Mengetahui kandungan fitokimia dan efektivitas ekstrak tunggal serta kombinasi kulit mangga gedong gincu dan buah belimbing wuluh terhadap Staphylococcus aureus. Penelitian eksperimental dengan desain post-test only control group menggunakan metode difusi sumuran. Terdapat 10 kelompok perlakuan: ekstrak kulit mangga 10% dan 25%, buah belimbing 10% dan 25%, enam kombinasi konsentrasi berbeda, serta kontrol positif dan negatif. Zona hambat diukur dengan jangka sorong dan dianalisis menggunakan uji Shapiro-Wilk, One Way ANOVA, dan LSD. Kandungan metabolit sekunder pada ekstrak kulit buah mangga dan buah belimbing yaitu alkaloid, flavonoid, tanin, saponin, dan fenol. Ekstrak kulit mangga 25% menghasilkan zona hambat 9,47 mm, lebih besar dari 10% (6,50 mm). Ekstrak buah belimbing 25% menghasilkan hambatan 3,35 mm, lebih tinggi dari 10% (1,38 mm). Kombinasi kulit mangga 25% dan buah belimbing 25% menunjukkan zona hambat terbesar (11,25 mm). Ekstrak kulit buah mangga gedong gincu memiliki daya hambat sedang, dan buah belimbing wuluh memiliki daya hambat lemah terhadap Staphylococcus aureus. Kombinasi konsentrasi tinggi keduanya menunjukkan daya hambat kuat.
Co-Authors Amalia Dwi Ayu Pitaloka Apriyanto, Dadan Ramadhan Arthur Ulil Albab Asri Permata Dewi Bagas Dharma Utama Beti Ernawati Dewi Catur Setiya Sulistiyana Dadan Ramadhan Apriyanto Dadan Ramadhan Apriyanto Dery Handaiana Putra Galuh Pangestu Emallia Fitriani Emilia Putri Agustin Esa Giri Rahayu Farras Fida Yumna Fathunnisa, Firda Fauzah, Shofa Nur Hery Widijanto Hikmah Fitriani Hikmah Fitriani Ichlasul Amal Ignatius Hapsoro Wirandoko Januar, Henny Sholihat Like Efriani Lola kemala dewi Loren, Azzahro Maharani Menik Herdwiyanti Mustika Weni Mutiara Fadilah Nanang Ruhyana Nasution, Aulia Ananta Niklah Zaidah Novan Ibrahim Nurbaiti Putri, Inayati Diana Rafsanjani, Ali Rafi Rama Samara Brajawikalpa Riawan, Firanda Putri Rini Istisakinah Ruri Eka Maryam Mulyaningsih Thysa Thysmelia Affandi Uswatun Khasanah Witri Pratiwi