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FORMULASI FILM FORMING SPRAY DARI KLORAMFENIKOL UNTUK LUKA Rusdiati Helmidanora; Siti Jubaidah; Is alukal Fauziah A.A
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 8 No 2 (2023): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v8i2.1517

The wound healing process should be short so as not to interfere with productivity and reduce costs. SFFS (spray film forming system) is a combination of transdermal preparations in which a polymer solution is sprayed onto the skin and will form an almost transparent film by evaporation of the solvent. Film-forming solutions are particularly advantageous for transporting the active substance to the site of action by the shortest route in cases of dermal or lower tissue infections. Chloramphenicol is a lipophilic drug so it penetrates the skin well because the stratum corneum matrix is also lipophilic. The purpose of this study was to make a formulation of a sprayed chloramphenicol film-forming solution in order to obtain the best formula and increase effectiveness. The research was carried out on an experimental basis and three formulas were prepared with different polymer concentrations. The results of the study obtained a film-forming spray for each formula with a film formed that was flexible and adhered well to the skin, with a pH of 6. The time needed to make the film layer in skin is 0.87-1.19 minutes with an average dose weight of spray is 61.33-85.33 mg.

Effect of Infusion Buas-Buas Leaf (Premna serratifolia Linn.) on Decreasing Blood Glucose Level of Alloxan-Induced White Mice Marliana, Anis; Helmidanora, Rusdiati
Jurnal Ilmu Kesehatan Vol 11 No 2 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i2.3786

The prevalence of diabetes is incresing year by year, indicates that there is a need for diabetes treatment. One alternavite treatment for diabetes melitus uses traditional medicine which has relatively small effect when compared to synthetic diabetes melitus drugs use the long term. One plant buas-buas which is utilized a natural therapy to blood glucose levels leaves buas-buas (Premna serratifolia Linn). that are believe have antiabetic effect. The study was to determine infusion of buas-buas leaves can decreas blood glucose levels in alloxan-induced mice. The research is experimental using purposive sampling. Method collection sample, make simplisia of buas-buas leaves, extracing buas-buas leaves and antidiabetic test on 25 male white mice. The test was conducted by divid into 5 treatments groups, namely positive control (metformin), negative control (aquadest), and control treatment preparations with concentrations of 10, 20, and 40 %. Mice were induced alloxan with dose of 200 mg/kg BB intraperitoneally and give after blood glucose levels 200 mg/dL, then measurd blood glucose levels of mice on day 7 and day 14. The data result were analyzed using Kruskall Wallis Test. The results of study indicate that infusion of wild buas leaves can decreas blood glucose levels. A dose of wild buas leaf infusion with a concentration of 20 % is effective in decreasing blood glucose levels.

Evaluasi Rasionalitas Penggunaan Favipiravir pada Pasien COVID-19 di Rumah Sakit Dirgahayu Samarinda Tahun 2022 Yason Lukius; Rusdiati Helmidanora; Heri Wijaya
Jurnal Farmasi Komunitas Vol. 11 No. 2 (2024): JURNAL FARMASI KOMUNITAS
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfk.v11i2.56599

Favipiravir merupakan antivirus yang dapat digunakan sebagai terapi pengobatan pada pasien COVID-19 apabila digunakan secara tepat. Tujuan dari penelitian ini untuk mengetahui rasionalitas penggunaan Favipiravir pada pasien COVID-19 di Rumah Sakit Dirgahayu Samarinda pada tahun 2022 berdasarkan kriteria tepat pasien, tepat diagnosis, tepat obat, tepat dosis, tepat interval waktu pemberian, tepat lama pemberian, dan waspada efek samping obat. Penelitian ini merupakan penelitian non eksperimental yang dilakukan dengan observasional deskriptif, teknik pengambilan sampel menggunakan metode total sampling secara retrospektif. Karakteristik pasien COVID-19 pada 53 sampel dalam penelitian ini sebesar 62,3% berusia 26-45 tahun, dengan dominasi pasien berjenis kelamin perempuan sebesar 71,7%, dan komorbid terbanyak adalah diabetes melitus yaitu sebesar 7,5%. Penentuan rasionalitas penggunaan Favipiravir dinilai berdasarkan pada literatur Informatorium Obat COVID-19 di Indonesia Edisi 4 dengan hasil tepat pasien (100,0%), tepat diagnosis (100,0%), tepat obat (100,0%), tepat dosis (83,0%), tepat interval waktu pemberian (100,0%), tepat lama pemberian (100,0%), dan telah waspada efek samping obat. Hasil penelitian ini menunjukkan bahwa penggunaan Favipiravir pada pasien COVID-19 di Rumah Sakit Dirgahayu Samarinda tahun 2022 telah rasional berdasarkan data rekam medis dan kriteria tepat pasien, tepat diagnosis, tepat obat, tepat dosis, tepat interval waktu pemberian, tepat lama pemberian dan waspada efek samping obat (6T1W).

EFEK HIPOTENSIF DARI ACEi DAN ARB PADA PASIEN DIABETES MELLITUS DAN HIPERTENSI DI RSUD. ABDUL WAHAB SYAHRANIE SAMARINDA Rusdiati Helmidanora; Triswanto Sentat
Jurnal Ilmiah Manuntung Vol 3 No 2 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v3i2.126

More than two-thirds of patients with type 2 diabetes also experience hypertension whose development coincides with hyperglycemia, where each disease has a tendency to influence the increased risk of other diseases. Sundry new guidelines, such as the National Joint Committee 8, the American Diabetes Association recommend blood pressure targets in the diabetic population of <140/90 mmHg to reduce cardiovascular risk and prevent the progression of nephropathy. This study aims to determine whether there is a difference in achieving blood pressure target < 140/90 mmHg according to Join National Committee 8 between ACEi and ARB in patients with type 2 diabetes with hypertension. This research was conducted using a retrospective at internist clinic of Abdul Wahab Syahranie hospital, by taking secondary data from the medical record from blood pressure o 49 outpatients received a single antihypertensive either drug ACEi 29 people or ARB 34 people. This study showed that the achievement of target blood pressure by <140/90 mmHg (JNC 8 guideline) between ACEi 7 (28%) and ARB 5 (20,8%) group and it can be concluded that between ACEi and ARB drugs(P=0.5) there was no differsignificantly in achievement blood pressure target on type 2 diabetes with hypertension.

DRPs (DRUG RELATED PROBLEMS) PADA PENDERITA DIABETES MELLITUS DENGAN KOMPLIKASI GAGAL GINJAL DI RUMAH SAKIT UMUM DAERAH ‘X’ DI SAMARINDA PERIODE OKTOBER-DESEMBER 2016 Rusdiati Helmidanora; Muhammad Reza; Yullia Sukawaty
Jurnal Ilmiah Manuntung Vol 4 No 2 (2018): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v4i2.197

Drug Related Problems (DRPs) is an unexpected event from the patient's experience because drug therapy can interfere with the success of healing. Patients with chronic disease for a long time have a chance of developing DRP. One chronic disease is diabetes mellitus which is a metabolic disorder due to lack of insulin production produced by the pancreas gland. Diabetic nephropathy is a microvascular complication that often occurs in type 1 and type 2 diabetes, due to high blood sugar levels that can cause kidney structure to change and impaired function. The aim of this study was to determine DRP in patients with diabetes with kidney failure. Research conducted was non-experimental research with data collection retrospectively. The data were analyzed by using standard reference books, Drug Information Handbooks. Based on the results of the study found DRPs in patients with DM with kidney failure in the inpatient installation of RSUD 'X' Samarinda in the period October-December 2016 who needed drugs but did not receive it (24%), received drugs without appropriate indications (11%), received wrong drugs (3%), dose was too low (0%), dose was too high (5%), the patient has ADR (13%), and compliance (0%).

UJI AKTIVITAS ANTIBAKTERI EKSTRAK BUNGA KECOMBRANG (Etlingera elatior (Jack) R. M.Sm.) TERHADAP BAKTERI Staphylococcus aureus Sp. Helmidanora, Rusdiati; Yullia Sukawaty; Divya Miranti; Tria Prayoga; Nia Lisnawati
Jurnal Ilmiah Manuntung Vol 10 No 1 (2024): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v10i1.769

Kecombrang plant contains essential oils which are bioactive, including 0.0735% in the leaves. in flowers 0.0334%, in stems 0.0029% and in rhizomes 0.0021%. Combrang flowers (Etlingera elatior (Jack)) have effective antibacterial activity. The aim of this research was to determine the level of ethanol extract of kecombrang flowers from Pampang village (100-500 masl), East Kalimantan in inhibiting Staphylococcus aureus bacteria. The object studied was the inhibitory zone of kecombrang flower extract against Staphylococcus aureus bacteria. Extract preparation was carried out using the maceration method using 96% ethanol solvent, antibacterial activity testing was carried out using the well method with extract concentrations of 10%, 20%, 40%, 60% and positive control chloramphenicol and negative control DMSO. The results of this study were that 96% ethanol extract of kecombrang flowers had antibacterial activity against Staphylococcus aureus bacteria with a maximum concentration of 60% and had a medium category inhibitory power of 5.933 mm.

A Quantitative Study Assessment of Public Knowledge Regarding Self-Medication with Ibuprofen In Marang Kayu District: A Quantitative Study Sentat, Triswanto; Nurjannah, Ika; Jubaidah, Siti; Wijaya, Heri; Helmidanora, Rusdiati
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 1 (2025): J Sains Farm Klin 12(1), April 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.1.72-80.2025

Self-medication is an approach widely used by the public to treat mild pain symptom by using over-the-counter medications without a prescription from physician. One of the medications that can be used for self-medication is Ibuprofen. Ibuprofen is a drug that can be used for self-medication; however, its use should be under the supervision and guidance of healthcare professionals. This study aims to determine the level of public knowledge regarding the self-medication use of ibuprofen in Marang Kayu District. This research uses a quantitative design with a descriptive approach. Data were collected through questionnaires distributed to 369 respondents selected using purposive sampling. The questionnaire included questions about knowledge aspects regarding ibuprofen and self-medication patterns. The study results showed that the level of public knowledge in Marang Kayu District about Ibuprofen for self-medication was 14.5% (49 respondents) with a high level of knowledge, 31.3% (106 respondents) with a moderate level of knowledge, and the majority, 54.3% (184 respondents), with a low level of knowledge. The results underscore the urgent need for targeted health education programs to improve public awareness and promote safe self-medication practices. Enhancing community knowledge is essential to minimize the risks associated with improper ibuprofen use and to encourage responsible drug consumption

Effect of Infusion Buas-Buas Leaf (Premna serratifolia Linn.) on Decreasing Blood Glucose Level of Alloxan-Induced White Mice Marliana, Anis; Helmidanora, Rusdiati
Jurnal Ilmu Kesehatan Vol 11 No 2 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i2.3786

The prevalence of diabetes is incresing year by year, indicates that there is a need for diabetes treatment. One alternavite treatment for diabetes melitus uses traditional medicine which has relatively small effect when compared to synthetic diabetes melitus drugs use the long term. One plant buas-buas which is utilized a natural therapy to blood glucose levels leaves buas-buas (Premna serratifolia Linn). that are believe have antiabetic effect. The study was to determine infusion of buas-buas leaves can decreas blood glucose levels in alloxan-induced mice. The research is experimental using purposive sampling. Method collection sample, make simplisia of buas-buas leaves, extracing buas-buas leaves and antidiabetic test on 25 male white mice. The test was conducted by divid into 5 treatments groups, namely positive control (metformin), negative control (aquadest), and control treatment preparations with concentrations of 10, 20, and 40 %. Mice were induced alloxan with dose of 200 mg/kg BB intraperitoneally and give after blood glucose levels 200 mg/dL, then measurd blood glucose levels of mice on day 7 and day 14. The data result were analyzed using Kruskall Wallis Test. The results of study indicate that infusion of wild buas leaves can decreas blood glucose levels. A dose of wild buas leaf infusion with a concentration of 20 % is effective in decreasing blood glucose levels.

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