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All Journal Majalah Kedokteran Bandung Jurnal Riset Kesehatan Indonesian Journal of Biotechnology Smart Medical Journal Syntax Literate: Jurnal Ilmiah Indonesia Indonesian Journal of Medicine Smart Society Empowerment Journal Plexus Medical Journal Cermin Dunia Kedokteran
Jarot Subandono
Biochemistry Laboratory, Faculty Of Medicine Sebelas Maret University
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Effect of Ethanolic Extract of Moringa (Moringa oleifera, Lam.) Leaf on Seminiferous Tubules of Wistar Rats (Rattus norvegicus) Model of Metabolic Syndrome Devitasari, Sade; Pesik, Riza Novierta; Subandono, Jarot; Setyawan, Novan Adi
Smart Medical Journal Vol 6, No 2 (2023): August
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i2.69345

Abstract

Introduction: Metabolic syndrome define as symptoms of body abnormalities that increased reactive oxygen species and cause disturbances of the germ cell layer thickness in seminiferous tubules. The content of Moringa oleifera has anti-diabetic, anti-dyslipidemia, and hypotensive effects. This study aimed to find out the effect of ethanolic extract of moringa leaves (Moringa oleifera, Lam.) on the histopathology of seminiferous tubules of Wistar rats (Rattus norvegicus) induced metabolic syndrome with Streptozotocin-Nicotinamide and high-fat diet.Methods: This research was experimental post-only control group design. The subjects were 30 male Rattus norvegicus grouped into normal group (K1), metabolic syndrome group (K2), and 3 metabolic syndrome groups with ethanolic extract of moringa leaf at doses of 150 mg/kg (K3), 250 mg/kg (K4) and 350 mg/kg   of body weight (K5).Results: Thickness of tubules (µm) of group K1 (107.48±10.74), K2 (53.87±25.09), K3 (80.52±3.50), K4 (81.94±9.40), K5 (94.04±8.66). Average number of cell layers of group K1 (8.00±1.09), K2 (3.65±1.35), K3 (5.99±0.36), K4 (6.57±0.36), K5 (6.72±0.20). There was a significant difference in tubule wall thickness and the number of cell layers between the five groups (p<0.05). The K3, K4, and K5 differed significantly from the K2 (p<0.05). K5 has value closest to K1. Conclusion: Ethanolic extract of moringa (Moringa oleifera, Lam.) leaf increased the wall thickness and number of cell layers of seminiferous tubules of Wistar rats (Rattus norvegicus) model of metabolic syndrome with ethanolic extract of moringa leaf at doses of 350 mg/kg of body weight most effectively improved the histopathological of the seminiferous tubules.
Effect of Red Dragon Fruit Extract (Hylocereus polyrhizus) on Total Cholesterol Levels in Wistar Rats Model of Metabolic Syndrome Apriliani, Devina; Subandono, Jarot; Budiastuti, Veronika Ika; Hermawan, Danus
Smart Medical Journal Vol 7, No 1 (2024): April
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v7i1.80973

Abstract

Introduction: The consumption of high fat and sugar can increase the risk of metabolic syndrome. Hylocereus polyrhizus is known to be able to lower total cholesterol levels in the blood. This study aims to determine the effect of Hylocereus polyrhizus extract on total cholesterol levels in Wistar rats with the metabolic syndrome model.Methods: This study used laboratory experimental research using a pretest and posttest with a control group design. The sample consisted of 30 Wistar rats according to the inclusion criteria which were divided into 5 groups: K1 (positive control), K2 (negative control), K3, K4, and K5 (treatment group). The treatment group was given Hylocereus polyrhizus extract with doses of 60, 120, and 180 mg/200grW. Total cholesterol levels were measured on the 8th, 36th, and 64th day. The data were analyzed using the parameterized One-way ANOVA test followed by Tukey's HSD posthoc test, paired T-test, and Pearson's correlation test.Results: The average total cholesterol after being given by Hylocereus polyrhizus extract in K3 (137 ± 2.82 mg/dL), K4 (109 ± 2.31 mg/dL), and K5 (100 ± 2.38 mg/dL) was lower than the negative control group. Data analysis showed significant differences (p<0.05) in total cholesterol levels before and after treatment in all groups. The Pearson correlation test explained that the variation dosage of Hylocereus polyrhizus extract had a very strong correlation with a positive correlation with total cholesterol levels.Conclusion: Induction of Hylocereus polyrhizus extract at doses of 60, 120, and 180 mg/200grW was able to significantly reduce total cholesterol levels.
The Effect of Butterfly Pea Extract on Blood Glucose Levels in White Rats with Metabolic Syndrome Model Gunawan, Olivia; Andri Putranto, R. Prihandjojo; Subandono, Jarot; Ika Budiastuti, Veronika
Smart Medical Journal Vol 6, No 1 (2023): April
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i1.67934

Abstract

Introduction: Metabolic syndrome is an accumulation of several disorders, one of which is hyperglycemia. Clitoria ternatea is a plant that contains lots of flavonoids and is known to reduce blood glucose levels in metabolic syndrome. This study aimed to determine the effect of butterfly pea extract (Clitoria ternatea) on blood glucose levels in white rats with metabolic syndrome models.Methods: This research is an experimental study using animal models with pre and post-test control group design method. The number of samples was 30 male white rats which were divided into 5 groups: group 1–negative control group; group 2–positive control group; group 3, group 4, and group 5 were the metabolic syndrome group which was given Clitoria ternatea extract with doses of 100, 200, and 400 mg/kgBW, respectively for 28 days. Measurement of blood glucose levels for all groups was carried out on the 36th day as the pre-test and the 64th day as the post-test. Blood glucose levels were obtained through retroorbital venous blood which was analyzed with the Easy Touch blood glucose stick meter. One-way ANOVA was used to analyze data, followed by post-hoc LSD test, and paired T-test.Results: The average post-test random blood glucose levels decreased by 135.16 mg/dl, 163.18 mg/dl, and 168.35 mg/dl. There was a significant difference (p<0.05) between the pre-test and post-test blood glucose levels along with the average blood glucose level amongst groups.Conclusion: Butterfly pea (Clitoria ternatea) could decrease blood glucose levels and cause further decrease with higher doses.
Edukasi dan Aplikasi Loci pada Guru SD di Wilayah Kecamatan Kerjo Karanganyar Muthmainah, Muthmainah; Nurwati, Ida; Subandono, Jarot; Hermawan, Danus; Budiani, Dyah Ratna; Hakim, Fikar Arsyad; Handayani, Selfi; Pakha, Dyonisa Nasirochmi; Sunggoro, Agus Jati
Smart Society Empowerment Journal Vol 3, No 3 (2023): November
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v3i3.79482

Abstract

Pendahuluan: Fakta di lapangan menunjukkan sebagian besar guru SD di Kecamatan Kerjo, Karanganyar belum pernah mendengar atau mengetahui metode Loci. Metode Loci merupakan salah satu cara untuk meningkatkan daya ingat dengan mengoptimalkan keseimbangan fungsi otak kiri dan kanan. Tujuan pengabdian masyarakat ini adalah melakukan edukasi dan aplikasi metode Loci melalui penyuluhan kepada para guru SD tersebut untuk meningkatkan daya ingat.Metode: Penyuluhan dilakukan pada Selasa, 23 Mei 2023 jam 08.00-12.30, di aula kantor Korwilcam Bidang Pendidikan Kecamatan Kerjo, Karanganyar. Peserta penyuluhan adalah para guru SD dalam wilayah Kecamatan Kerjo, Karanganyar sebanyak 50 orang. Di Kecamatan Kerjo terdapat 29 SD, dari tiap-tiap SD mewakilkan 1-2 orang guru. Tahap-tahap kegiatan pengabdian masyarakat meliputi persiapan, pelaksanaan, dan pelaporan kegiatan. Penyuluhan diberikan melalui ceramah interaktif dan mempraktekkan cara menghafal dengan metode Loci. Peserta menjalani pretes sebelum dan postes sesudah penyuluhan. Nilai pretes dan postes dibandingkan menggunakan uji statistik Wilcoxon (α=0,05). Hasil dan pembahasan: Kegiatan pengabdian masyarakat yang berupa penyuluhan metode Loci telah dilaksanakan sesuai rencana dan diikuti oleh 50 orang guru SD dari 29 SD yang ada di wilayah Kecamatan Kerjo, Karanganyar. Rerata nilai pretes peserta 42,56±21,04 dan nilai postes 62,56±28,11 dengan nilai signifikansi p<0,001. Hal ini berarti bahwa penyuluhan yang berupa ceramah interaktif dan praktek aplikasi metode Loci, selain dapat memberikan pemahaman mengenai pengetahuan metode Loci, juga berpengaruh dalam meningkatkan daya ingat peserta.Kesimpulan: Edukasi dan aplikasi metode Loci yang diberikan melalui penyuluhan dapat memberikan pemahaman mengenai metode Loci dan dapat meningkatkan daya ingat pada para guru SD di Kecamatan Kerjo, Karanganyar.
Self-disclosure (Keterbukaan Diri) dan Quarter-life Crisis (Krisis Seperempat Abad) Mahasiswa Psikologi Afifah Ulva Zein; Yuliadi, Istar; Subandono, Jarot; Septiawan, Debree
Plexus Medical Journal Vol. 2 No. 1 (2023): Februari
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i1.416

Abstract

Introduction: Quarter-life crisis is an individual who enters the period of emerging adulthood without stopping questioning the future, confused in dealing with problems, and reflecting a lot on the past to see whether his life up to now is in accordance with the life he dreamed of. This crisis is most intense in their twenties and often occurs in someone who is in the transition phase from education to the next career level, for example, a final year student. Therefore, it is necessary to find a way to reduce the negative impacts that arise, which is by knowing more about the situation that being experienced by self disclosure. This study aimed to determine whether there is a relationship between self-disclosure and quarter-life crisis in final year students. Methods:This research was observasional analytics with cross-sectional design. Subject in this research was psychology student at UNS in year 2018, amounted to 46 people who met the inclusion and exclusion criteria. Sampling was done by pusposive sampling technique. The level of self-disclosure was measured by filling out the Self-disclosure questionnaire, while the degree of quarter-life crisis was measured by the Quarter-life Crisis questionnaire. The data obtained were then analyzed by spearman rank correlation test. Results: This study showed a significant and negative relationship between the level of self-disclosure with quarter-life crisis (sig f=0,049) Conclusions: Based on the results of this study, there was a moderate relationship between the level of self-disclosure and quarter-life crisis on psychology students Universitas Sebelas Maret year 2018, where the higher level of self-disclosure, the lower level of quarter-life crisis.  
Pengaruh Ekstrak Buah Naga Merah (Hylocereus polyrhizus) Terhadap Kadar LDL pada Tikus Wistar Model Sindrom Metabolik Bernarda, Clarisca Calcafiorentina; Hermawan, Danus; Subandono, Jarot; Andri Putranto, R Prihandjojo
Plexus Medical Journal Vol. 2 No. 5 (2023): Oktober
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v2i5.872

Abstract

Pendahuluan: Sindrom metabolik didefinisikan sebagai kumpulan gejala abnormal metabolik meliputi resistensi insulin, hipertensi, dislipidemia, dan obesitas sentral. Dislipidemia ditandai dengan adanya penurunan kadar LDL dan peningkatan kadar HDL. Buah naga merah (Hylocereus polyrhizus) diketahui dapat menurunkan kadar LDL sehingga mampu memperbaiki kondisi sindrom metabolik. Penelitian ini bertujuan untuk mengetahui pengaruh ekstrak buah naga merah (Hylocereus polyrhizus) terhadap kadar LDL pada tikus Wistar model sindrom metabolik. Metode: Penelitian ini bersifat eksperimental laboratorik dengan pretest dan posttest control group design. Jumlah sampel terdiri atas tikus Wistar berkelamin jantan dengan jumlah 30 ekor dan dibagi menjadi 5 kelompok: K1 (kelompok kontrol negatif); K2 (kelompok kontrol positif); K3, K4, dan K5 sebagai kelompok sindrom metabolik yang diberi ekstrak Hylocereus polyrhizus dengan dosis berturut-turut 60 mg/200gBB/hari, 120 mg/200gBB/hari, 180 mg/200gBB/hari. Pengukuran kadar LDL pada semua kelompok dilakukan pada hari ke-8, 36, dan 64. Data dianalisis menggunakan uji normalitas Shapiro-Wilk, dilanjutkan dengan uji homogenitas Levene, uji one-way ANOVA, uji post-hoc Tukey HSD, uji T berpasangan, serta uji korelasi Pearson. Hasil: Kadar LDL terendah pasca pemberian ekstrak buah naga merah (Hylocereus polyrhizus) diperoleh pada K1, sedangkan kadar LDL tertinggi pada K2. Berdasarkan analisis statistik, didapatkan perbedaan kadar LDL sebelum dan setelah perlakuan yang signifikan (p<0,05) pada semua kelompok. Uji korelasi Pearson menunjukkan bahwa dosis ekstrak buah naga merah (Hylocereus polyrhizus) memiliki hubungan yang sangat kuat dengan arah hubungan negatif terhadap kadar LDL. Simpulan: Pemberian ekstrak buah naga merah (Hylocereus polyrhizus) dengan dosis 60 mg/200gBB/hari, 120 mg/200gBB/hari, dan 180 mg/200gBB/hari dapat menurunkan kadar LDL secara signifikan.  
Pelatihan Kader Kesehatan dalam Pemberdayaan Poskestren di Pondok Pesantren Al Amaanah Karanganyar Selfi Handayani; Ida Nurwati; Jarot Subandono; Muthmainah Muthmainah; Danus Hermawan; Dyah Ratna Budiani; Fikar Arsyad Hakim; Dyonisa Nasirochmi Pakha; Agus Jati Sunggoro
Smart Society Empowerment Journal Vol 5, No 2 (2025): Juli
Publisher : Faculty of Medicine, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/ssej.v5i2.94068

Abstract

Pendahuluan: Pos Kesehatan Pesantren (Poskestren) adalah suatu bentuk upaya untuk meningkatkan kesehatan warga pesantren. Para kader poskestren, yang meliputi para santri, perlu memiliki pengetahuan dan keterampilan dalam pemeriksaan vital sign (VS), antropometri, serta perilaku hidup bersih dan sehat (PHBS). Tujuan dari kegiatan pengabdian ini adalah memberikan pengetahuan, pemahaman dan keterampilan pelatihan VS, antropometri, dan PHBS kepada kader kesehatan di pos kesehatan pesantren.Metode: Sosialisasi dan pelatihan keterampilan pemeriksaan VS, antropometri, dan PHBS dilaksanakan pada bulan Juli 2024. Terdapat 30 orang kader kesehatan poskestren beserta 10 pamong yang mengikuti acara ini. Pemateri dan instruktur memberikan materi menggunakan media presentasi, pamflet, dan tanya-jawab. Kemudian kegiatan dilanjutkan dengan melatih keterampilan kader secara langsung. Sebelum dilakukan sosialisasi dan pelatihan, peserta melaksanakan pre-test, dan kemudian diikuti dengan post-test setelah mendapatkan pelatihan.Hasil dan pembahasan: Hasil evaluasi terhadap pengetahuan tentang PHBS pada kader Kesehatan memperlihatkan bahwa 80% (24 kader) telah mengalami peningkatan pengetahuan dari yang awalnya hanya 24% (7 kader). Nilai pretest dan post-test keterampilan VS dan antropometri memperlihatkan perbedaan, yaitu terjadi peningkatan pengetahuan tentang vital sign dan antropometri. Setelah dilakukan pelatihan pemeriksaan vital sign dan antropometri, semua kader sudah dapat melakukan pemeriksaan dengan baik.Kesimpulan: Sosialisasi dan pelatihan keterampilan dapat meningkatkan pengetahuan tentang PHBS, pemeriksaan VS, dan antropometri. Semua kader kesehatan yang dilatih sudah dapat melaksanakan pemeriksaan VS dan antropometri dengan baik.
Co-Authors . Darto . Darto . Kustiwinarni . Widiastuti Afifah Ulva Zein Agus Jati Sunggoro Andri Putranto, R Prihandjojo Andri Putranto, R. Prihandjojo Aphridasari, Jatu Apriliani, Devina Bernarda, Clarisca Calcafiorentina Betty Saptiwi Bhisma Murti Budiastuti, Veronika Ika Daniel Satyo Nurcahyo Danus Hermawan Danus Hermawan Danus Hermawan Darmawan, Muhammad Dzaki Devi Purnamasari Sasongko Devitasari, Sade Didik Tulus Subekti Diding H P Diding Heri Prasetyo Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Dyah Ratna Budiani Dyonisa Nasirochmi Pakha Dyonisa Nasirochmi Pakha ENDANG LISTYANINGSIH Endang Listyaningsih Erma Sulistyaningsih Fernando Feliz Christyan Fikar Arsyad Hakim Ginong Pratidina Wijnaputri Hakim, Fikar Arsyad Hermawan, Danus Ida Nurwati Ida Nurwati Ika Budiastuti, Veronika Istar Yuliadi Ivan Aristo Suprapto Putra Jusup, Sinu Andhi Lilik Wijayanti Mahendra, Fadia Yuda Martini . Martini Martini Milana Phangadi Muhammad Samhan Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Muthmainah Nabila Haningtyas Novan Adi Setyawan Nurcahyo, Daniel Satyo OLIVIA GUNAWAN Prihandjojo Andri Putranto Putranto, R. Prihandjojo Andri Putri Melliana, Valensia Risya Cilmiaty AR Riza Novierta Pesik Salamatun Umma Sarsono Sarsono Sarsono - Sarsono Sarsono Selfi Handayani Selfi Handayani Selfi Handayani Septiawan, Debree SETYO SRI RAHARJO Siska Dewi Agustina Siti Aisyah Soenarwan Hery Poerwanto, Soenarwan Hery Sri Hartati Hadinoto Sukarti Moeljopawiro Sukarti Moeljopawiro Sunggoro, Agus Jati Tamaulina Br Sembiring Valensia Putri Melliana Vivienne Tjung Wayan T. Artama Wayan T. Artama Wijayanti, Lilik Witjaksana, Risnu Ardian Yohana Trissya Anggraeni