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All Journal Statistika Jurnal Peluang Proceedings of Annual International Conference Syiah Kuala University - Social Sciences Chapter Jurnal Gaussian Jurnal Pengajaran MIPA Jurnal Statistika Universitas Muhammadiyah Semarang Jurnal Didaktik Matematika Jurnal Pengajaran Matematika dan Ilmu Pengetahuan Alam Jurnal Riset Pendidikan Matematika Jurnal Elemen Eduma : Mathematics Education Learning and Teaching Jurnal Informatika Upgris Jurnal Penelitian Pendidikan IPA (JPPIPA) Numeracy : Jurnal Ilmiah Pendidikan Matematika International Journal for Educational and Vocational Studies JP2M (Jurnal Pendidikan dan Pembelajaran Matematika) ESTIMASI: Journal of Statistics and Its Application Narra J International Journal of Education and Digital Learning (IJEDL) Jurnal Natural Jurnal Pendidikan Sains Indonesia (Indonesian Journal of Science Education) Heca Journal of Applied Sciences Journal of Educational Management and Learning Infolitika Journal of Data Science PESARE: Science and Engineering Service Journal
Muhammad Subianto
Department Of Statistics, Faculty Of Mathematics And Natural Science, Universitas Syiah Kuala, Banda Aceh 23111, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Journal : Jurnal Penelitian Pendidikan IPA (JPPIPA)

 1 
Identification and Analysis of Potential Breast Anticancer Agents in Pogostemon Cablin through Network Pharmacology Azzahra, Syarifah Fathimah; Harnelly, Essy; Subianto, Muhammad; Kusuma, Wisnu Ananta; Sari, Widya
Jurnal Penelitian Pendidikan IPA Vol 10 No SpecialIssue (2024): Science Education, Ecotourism, Health Science
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10iSpecialIssue.7049

Abstract

Breast cancer is one of the highest known causes of death in Indonesia, especially for women. Pogostemon cablin Benth is one of the Aceh's endemic herbal plants that has been studied to have potential such as anti-inflammatory, antiproliferative, antioxidant, antimicrobial, and proapoptotic. Network pharmacology approach was conducted to explore and analyze the potential of P. cablin as an anti-breast cancer. P. cablin plant compounds were obtained from GCMS and breast cancer genes data were obtained from OMIM, GeneCard, and DisGeNet databases. Target proteins and pathways involved were identified using STRING-DB and Metascape. Network analysis was performed using Cytoscape. A total of 65 plant compounds with 554 target proteins and 1854 disease genes were obtained. Based on the results of combining protein targets using Venn diagrams, 138 overlapping proteins between drug compounds and breast cancer disease targets were identified. Based on KEGG and GO analysis, P. cablin is known to have potential in breast cancer treatment/therapeutic mechanisms. Based on the "compound-protein target-pathway" multi-target mechanism, pogostol; 1H-Cycloprop[e]azulen-7-ol, decahydro-1,1,7-trimethyl-4-methylene-, [1ar-(1aα,4aα,7β,7aβ,7bα)]-; 3-Hexen-1-ol, 2,5-dimethyl-, acetate, (Z)-, 5β,7βH,10α-Eudesm-11-en-1α-ol; Acetic acid, 3-hydroxy-6-isopropenyl-4,8a-dimethyl 1,2,3,5,6,7,8,8a-octahydronaphthalen-2-yl ester; and Humulenol-II interacts with proteins that play a significant role in breast cancer, which are MAPK1, EGFR, TNF, AKT1, and JAK2. Hence, it can be concluded that P. cablin has good potential to be a source of therapeutic treatment against breast cancer. However, it needs to be tested clinically to further determine the effects of this P. cablin compound.
Design and Development of Website and Android-Based Aceh Biodiversity Applications Subianto, Muhammad; Harnelly, Essy; Misbullah, Alim; Afidh, Razief Perucha Fauzie; Akhyar, Fikrul; Irfan, Muhammad; Dharma, Wira; Nazaruddin; Zulfan
Jurnal Penelitian Pendidikan IPA Vol 11 No 4 (2025): April
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i4.10535

Abstract

Aceh is an exceptional region in Indonesia characterized by significant biodiversity and abundant natural wealth. Despite these numerous benefits, there is limited information regarding the potential of biodiversity in this region. Therefore, this research aimed to design and develop Website and Android-based applications to facilitate access to information regarding biodiversity in Aceh. In the development process, the Waterfall method was used, and the applications consisted of two main components, namely the back-end and the front-end. The users were divided into three categories, including contributors, verificators, and admins. After the development was complete, functionality testing was conducted using the black box method, and usability was examined using the Post-Study System Usability Questionnaire (PSSUQ). The results of functionality testing showed that both applications operate efficiently, thereby providing users with a satisfying experience when accessing information about Aceh biodiversity. The usability score was approximately 7 for Website-based and 6 for Android-based applications, showing a high level of usability.
Co-Authors . Zulfan Afidh, Razief Perucha Fauzie Ahmad, Noor Atinah Ainal Mardhiah Akhyar, Fikrul ALFIAN FUTUHUL HADI Almunir Sihotang Azzahra, Syarifah Fathimah Bagus Sartono Cut Morina Zubainur Cut Mulyawati Cut Rina Rossalina Dwi Fadhiliani Earlia, Nanda Essy Harnelly EVI RAMADHANI Farsiah, Laina Fitriana AR Ghazi Mauer Idroes Hijriyana P., Meildha Hizir Sofyan Husdayanti, Noviana Idroes, Ghalieb Mutig Idroes, Ghazi M. Idroes, Ghifari M. INA YATUL ULYA Indah Manfaati Nur Irnanda , Irnanda, Irnanda Irvanizam, Irvanizam Kairupan, Tara S. Kurniadinur, Kurniadinur M. Ikhsan M. Ikhsan M. Ikhsan Maulana, Aga Miftahuddin Miftahuddin Miftahuddin Miftahuddin Miftahuddin Mikyal Bulqiah, Mikyal Misbullah, Alim Muhammad Al Agani Muhammad Iqbal Muhammad Irfan Mukhamad Najib Mursyida, Waliam Nazaruddin Niode, Nurdjannah Jane Nisya Fajri Noviandy, Teuku R. Nurbaiti Nurbaiti Nurdjannah J. Niode Nurjani Nurjani Nurjannah Nurjannah Nurleila, Nurleila Prakoeswa, Cita RS. Purnama Mulia Farib Rahmah Johar Razief Perucha Fauzie Afidh Reza Wafdan Rika Fitriani Rika Siviani Rinaldi Idroes Rizal Munadi RR. Ella Evrita Hestiandari S.Pd. M Kes I Ketut Sudiana . Salmawaty Salmawati Salmawaty Salmawaty Sasmita, Novi Reandy sufriani, sufriani Sugara, Dimas Rendy Suhartono Suhendra, Rivansyah Suryadi Suryadi Teuku Rizky Noviandy Tuti Asmiati Vivi Dina Melani Vivi Dina Melani Vivi Dina Melani Widya Sari Wira Dharma Wisnu Ananta Kusuma Yusrizal Yusrizal Zahriah, Zahriah Zainal Abidin Zainal Abidin Zhilalmuhana, Teuku Zulfan