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AKTIVITAS ANTIOKSIDAN, TOTAL FENOL DAN TOTAL FLAVONOID TANAMAN KEDONDONG (Spondias dulcis Soland ex Park) Veni Haqiqotun Najihah; Eko Mugiyanto; Yulian Wahyu Permadi
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 5 No. 2 (2018)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Upaya peningkatan dalam pemanfaatan antioksidan alami telah dilakukan melalui uji aktivitas antioksidan serta penentuan total fenolik dan flavonoid dari tanaman kedondong (Spondias dulcis Soland ex Park). Tujuan dari penelitian ini adalah untuk menentukan aktivitas antioksidan, total fenolik dan flavonoid dari ekstrak daun, kulit batang dan daging buah kedondong. Ekstraksi telah dilakukan menggunakan pelarut etanol 96% dengan metode maserasi. Analisis spektrofotometri UV-VIS menunjukkan kandungan total fenolik dan flavonoid daun, kulit batang, dan daging buah kedondong sebesar: (37,400 mg GAE/g ekstrak; 9,145 mg QE/g ekstrak), (85,067 mg GAE/g ekstrak; 6,829 mg QE/g ekstrak) dan (4,067 mg GAE/g ekstrak; 4,597 mg QE/g ekstrak). Hasil menunjukkan bahwa ekstrak daun memiliki aktivitas antioksidan tertinggi dengan nilai IC50 13,687 µg/mL..

PENGARUH PENAMBAHAN EKSTRAK DAUN SIRSAK (Annona muricata L.)TERHADAP PROFIL FARMAKOKINETIKA PIROKSIKAM Setyo Tri Raharjo; Dwi Bagus Pambudi; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Piroxicam is one of the NSAID drug that common used in inflammation. Utilizing of herbal medicine along with synthetic drugs can lead to certain interactions, especially the occurrence of pharmacokinetic drug profile changes. The aim of this study is to determine the effect of addition of soursop leaf extract againt pharmacokinetic piroxicam profile. The method used was cross sectional using 6 rabbits, the data were analyzed statistically with t-test using SPSS version 21 program. The results showed that the piroxicam treatment had Cmax = 0.650 μg / ml, tmax = 3 hours, t ½ = 0.693 hours, and AUC = 0.597 hours.μg / ml, while on treatment of combination of piroksikam with soursop leaf extract have value of Cmax = 0,683 μg / ml, tmax = 1 hour, t ½ = 0,693 hours, and AUC = 0,652 jam.μg / ml. The result of data analysis using T test showed that there was significant difference in AUC value (p <0,05). These results suggest that the addition of soursop leaf extract may affect the piroxicam pharmacokinetic profile.

SINTESIS PREKURSOR SENYAWA 2-AMINOBUTYRIC ACID (ABA) DENGAN STARTING MATERIAL MONOSODIUM GLUTAMATE (MSG) Dewi Syarifah; Slamet Slamet; Wirasti Wirasti; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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The aim of the research is to synthesize the compound of Precursor of ABA from MSG the starting material by structural modification as well as to determine the characteristics and physical properties of the synthesis compound. It was done by modification of chemical structure starting with glutamic acid isolation from MSG. Then it isolate reacted with AlCl3 to obtain the ABA compound precursor. The rendemen was 18.5%, of synthesis identification obtained of white powder, odorless, dissolves in hot water and melt at a temperature of 187-189 0C. The UV-Vis spectrophotometry showed that the synthesis process formed a new compound. Confirm with HPLC analysis.

PERBEDAAN AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN, DAGING BUAH, DAN BIJI MENGKUDU (Morinda citrifolia L.) DENGAN METODE DPPH (1,1–DIPHENYL-2-PICRYLHYDRAZYL) Muhammad Syifaul Qulub; W Wirasti; Eko Mugiyanto
Prosiding University Research Colloquium Proceeding of The 8th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Antioksidan adalah senyawa yang menghambat efek negatif dari radikal bebas, Noni (Morinda citrifolia L) memiliki senyawa fenolik seperti itu. Tujuan dari penelitian ini adalah untuk mengevaluasi perbedaan aktivitas antioksidan daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. dengan metode pembilasan radikal bebas DPPH. Uji aktivitas antioksidan diukur dengan spektrofotometri UV-Vis dan data dianalisis dengan ANOVA. Hasil penelitian menunjukkan bahwa daun, daging buah dan ekstrak etanol biji noni Morinda citrifolia L. memiliki total fenolik 47.10 ± 1.73, 18.10 ± 0.00 dan 108.43 ± 1.52 mg GAE / g ekstrak, flavonoid total 15.97 ± 0.03, 3.83 ± 0.15 dan 6.18 ± 0,21 mgQE / g ekstrak., Sementara nilai IC50 374,29 ± 4,14, 442,40 ± 5,78, dan 59,22 ± 0,68 μg / mL, masing-masing. Analisis ANOVA memiliki perbedaan dengan nilai signifikansi (p-value) <0,05.

PENGENALAN OBAT ANTIBIOTIKA PADA PENGURUS CABANG AISYAH BLIGO KABUPATEN PEKALONGAN Slamet Slamet; Wulan Agustin Ningrum; Eko Mugiyanto
Jurnal Bakti untuk Negeri Vol 2 No 2 (2022): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

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Antibiotics are drugs used by doctors for the treatment of infections caused by microbes such as bacteria. Problems arise in the use of antibiotics that are not correct. Inappropriate use of antibiotics. The use of antibiotics that do not kill bacteria so that bacteria are resistant and antibiotic treatment does not work. The purpose of this community service is to remind you of the correct use of drugs and the consequences if antibiotic treatment is not correct. The method used is a lecture about antibiotics and infectious diseases that often occur in the community. The result of this service is that knowledge about antibiotic drugs and how to use them by Aisyah's caretakers is getting better which is reinforced by a high posttest score compared to the pretest value. The conclusion of the community service to the management of Aisyah's mothers is that their knowledge of antibiotics is getting better and those who have forgotten are reminded of their knowledge of antibiotics and their use.

PENGENALAN OBAT ANTIBIOTIKA PADA PENGURUS CABANG AISYAH BLIGO KABUPATEN PEKALONGAN Slamet Slamet; Wulan Agustin Ningrum; Eko Mugiyanto
Jurnal Bakti untuk Negeri Vol 2 No 2 (2022): JBN
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jbn.v2i2.1107

Antibiotics are drugs used by doctors for the treatment of infections caused by microbes such as bacteria. Problems arise in the use of antibiotics that are not correct. Inappropriate use of antibiotics. The use of antibiotics that do not kill bacteria so that bacteria are resistant and antibiotic treatment does not work. The purpose of this community service is to remind you of the correct use of drugs and the consequences if antibiotic treatment is not correct. The method used is a lecture about antibiotics and infectious diseases that often occur in the community. The result of this service is that knowledge about antibiotic drugs and how to use them by Aisyah's caretakers is getting better which is reinforced by a high posttest score compared to the pretest value. The conclusion of the community service to the management of Aisyah's mothers is that their knowledge of antibiotics is getting better and those who have forgotten are reminded of their knowledge of antibiotics and their use.

Identifikasi Variasi Gen yang Bersifat Missense/Nonsense Pada Dermatomyositis Dengan Memanfaatkan Database Genomik Dan Bioinformatik Lalu Muhammad Irham; Anisa Nova Puspitaningrum; Wirawan Adikusuma; Eko Mugiyanto; Ageng Brahmadhi; Gina Noor Djalilah; Rahmat Dani Satria; Firdayani; Abdi Wira Septama
Majalah Farmasi dan Farmakologi Vol. 27 No. 1 (2023): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v27i01.22185

Dermatomyositis merupakan penyakit autoimun yang termasuk jenis idiopatik inflamasi miopati (IIM), penyakit ini dapat mempengaruhi kulit dan otot manusia. Gejala klinis Dermatomyositis pada sebagian besar pasien adalah kelemahan otot tubuh, ruam kulit dan kulit bersisik. Salah satu faktor penyebab Dermatomyositis yang sering dilaporkan adalah faktor genetik. Hingga kini, penelitian terkait Dermatomyositis masih terbatas pada identifikasi jenis variasi gen yang mempengaruhi, namun tidak melaporkan variasi gen mana yang paling berkontribusi pada Dermatomyositis khususnya yang bersifat missense/nonsense. Sehingga pada penelitian ini kami memanfaatkan database genomik dan analisis bioinformatik untuk mengidentifikasi variasi gen yang paling berhubungan dengan penyakit Dermatomyositis. Penelitian ini menggunakan beberapa database, termasuk GWAS catalog, PheWAS catalog, HaploReg (v41.), dan GTEx portal. Hasil dari penelitian ini ditemukan bahwa gen ZBP1 berkaitan erat dengan penyakit Dermatomyositis dan menunjukkan ekpresi yang tinggi pada beberapa jaringan seperti paru-paru, lambung, esophagus, kulit, jantung dan otot. Variasi gen berdasarkan frekuensi varian alel (rs59626664, rs60542959, rs2066807, rs1048661, rs745400, rs2305480, rs2305479) terkait Dermatomyositis menunjukkan ekspresi jaringan tertinggi di kulit suprapubic, kulit dibawah lengan, otot rangka, dan esofagus. Penelitian ini menekankan bahwa integrasi database genomik dan analisis bioinformatik menunjukkan variasi gen yang berperan dalam patogenesis Dermatomyositis khususnya yang bersifat missense/nonsense. Kami menyarankan untuk peneliti selanjutnya untuk fokus pada variasi gen tersebut untuk divalidasi di fase klinis khusunya di populasi Indonesia.

Indonesian anti-inflammation herbs mechanism: mini review Nuniek Nizmah. F Mochtar; Eko Mugiyanto; Wirasti wirasti; Vanesa Maharani; Novel Umarella; Hilda Fitria Wulandari; St. Rahmatullah; Widyastuti Handayani; Dwi Bagus Pambudi; Riska Kurnia Oktaviani; Achmad Vandian Nur; Yuliah Wahyu Permadi; Ainun Muthoharoh; Thanh-Hoa Vo; Muh. Nur Khoiru Wihadi
Jurnal Ilmiah Kesehatan Vol. 16 No. 2 (2023): Jurnal Ilmiah Kesehatan
Publisher : Universitas Muhammadiyah Pekajangan Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48144/jiks.v16i2.1453

This mini-review aims to provide an overview of some commonly used anti-inflammatory herbs in Indonesia. Inflammation is a complex physiological response that plays a role in various diseases, and herbal remedies have been used traditionally in Indonesian culture for their potential anti-inflammatory properties. We utilize Portal Garuda as the primary database for searching herbs with anti-inflammatory activity using the keyword "anti-inflamasi”. The selected herbs discussed in this review include turmeric (Curcuma longa), ginger (Zingiber officinale), clove (Syzygium aromaticum), and cinnamon (Cinnamomum sp.). These herbs have been reported to possess anti-inflammatory effects through various mechanisms, such as inhibition of pro-inflammatory enzymes and cytokines, antioxidant activity, and modulation of immune responses. Moreover, these herbs have also demonstrated safety profiles in traditional use. However, further scientific research is needed to elucidate the specific bioactive compounds responsible for their anti-inflammatory effects and to determine the optimal dosages and formulations for therapeutic use. The exploration of Indonesian anti-inflammatory herbs could contribute to the development of natural and affordable options for managing inflammatory conditions, complementing conventional treatments, and promoting overall health and well-being.

Analysis of Lead Metal Levels in Vaname Shrimp (Litopenaus vannamei) in the Coastal Area of Pekalongan : Analisis Kadar Logam Timbal Pada Udang Vaname (Litopenaeus vannamei) Di Wilayah Pesisir Pekalongan Naila Izza Sabila; Achmad Vandian Nur; Khusna Santika Rahmasari; Eko Mugiyanto
BIO-EDU: Jurnal Pendidikan Biologi Vol. 10 No. 1 (2025): BIO-EDU: Jurnal Pendidikan Biologi - April 2025
Publisher : Jurusan Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Timor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32938/jbe.v10i1.7953

Vannamei shrimp is one of the fishery commodities with high economic potential, but vulnerable to heavy metal contamination due to environmental pollution. This study aims to analyze the content of heavy metal lead (Pb) in vannamei shrimp (Litopenaeus vannamei) in Pekalongan coastal area. Atomic Absorption Spectrophotometry (SSA) method was used to analyze Pb levels in shrimp samples with age variations of 40, 50, 60, and 70 days. The results showed that lead levels in all shrimp samples exceeded the threshold set by BPOM RI, which is 0.5 mg/Kg. The highest Pb level was found in 70-day-old shrimp with a concentration of 10.57 mg/Kg, while the lowest level was in 40-day-old shrimp at 3.40 mg/Kg. These results indicate the potential dangers of consuming vaname shrimp exposed to heavy metals for human health, so that mitigation measures against heavy metal pollution in the region are needed.

Evaluation of Physical Attributes and Efficacy of Lip Balm Formulated with Okra Fruit Extract (Abelmoschus esculentus (L.) Moench Fructus) Ana Yulyana; Alfioni Wulandari J.E; Saiful Bahri; Eko Mugiyanto
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7452

The okra fruit (A esculentus fructus) is renowned for its significant antioxidant properties, attributed to its rich content of bioactive compounds. Despite its high antioxidant activity, which has been extensively documented, its potential as a component in cosmetic formulations particularly lip balm preparation remains underutilized. This study seeks to address this gap by incorporating okra fruit extract into lip balm formulations and evaluating the resulting physical and functional attributes. Lip balm formulations were developed with three varying concentrations of Ethanol okra fruit extract: F1 (1%), F2 (3%), and F3 (5%). A series of comprehensive evaluations were conducted to assess the physical stability and performance of the lip balms, including organoleptic properties, homogeneity, pH, melting point, spreadability, and overall stability. Stability was monitored over a 28-day period at room temperature to simulate typical storage conditions. The antioxidant efficacy of the okra extract was quantified using the DPPH (1,1-diphenyl-2-picrylhydrazyl) assay, which yielded an IC50 value of 10.06 µg/ml, reflecting its potent free radical scavenging capacity. In comparison, the lip balm formulations demonstrated higher IC50 values, with Formulation I (FI) at 46.35 µg/ml, Formulation II (FII) at 40 µg/ml, and Formulation III (FIII) at 30.23 µg/ml, indicating a reduction in antioxidant activity in the formulated products compared to the pure extract.. The lip balm formulations exhibited a distinct okra aroma, smooth texture, and uniform color variations ranging from light brown (F1), brown (F2), to dark brown (F3). pH values ranged from 5.40 to 5.81, and melting points were between 49.6°C and 52.9°C, all within the acceptable range as per SNI 16-4769-1998 standards. ANOVA statistical analysis revealed no significant changes (p > 0.05) in melting point and spreadability over time. However, significant differences (p < 0.05) were noted in pH values, with further analysis indicating that formulations F2 and F3 differed significantly from F1 (p < 0.05). These results demonstrate that okra fruit extract not only enhances the antioxidant properties of lip balm but also maintains its stability and functionality, supporting its potential as a valuable ingredient in cosmetic formulations.

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