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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Nusantara Hasana Journal Jurnal Ilmiah Kesehatan Masyarakat Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Pengabdian Ilmu Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Ardhi: Jurnal Pengabdian dalam Negri Journal of Clinical Pharmacy and Pharmaceutical Science Galen: Jurnal Ilmu Farmasi dan Kesehatan Professional Evidence-based Research and Advances in Wellness and Treatment
Delladari Mayefis
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Penetapan Kadar Fenolik Total Ekstrak Daun Jotang (Sphagneticola Trilobata) Dengan Spektrofotometri UV-Vis Ghalib Syukrillah Syahputra; Delladari Mayefis; Tommy Julianto; Lyna Elvira
JURNAL RISET RUMPUN ILMU KESEHATAN Vol. 2 No. 1 (2023): April : Jurnal Riset Rumpun Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrikes.v2i1.2669

Abstract

Phenolic compounds are the largest group of compounds that act as natural antioxidants in plants. One of the plants that has the potential as a natural antioxidant is Jotang (Sphagneticola trilobata). This study aims to determine whether jotang leaf extract (Sphagneticola trilobata) has phenolic content and to determine the total phenolic content in jotang leaf extract (Sphagneticola trilobata). Jotang leaves were extracted by maceration method using methanol solvent. The method of determining total phenolic content was carried out using Folin-ciocaltaeu reagent because phenolic compounds can react with Folin-Ciocalteu to form a solution that can be measured absorbance. As a standard solution, gallic acid is used which is reacted with Folin-Ciocalteau reagent to produce a yellow color indicating that it contains phenolics, after which it is added with Na₂CO₃ solution as a base atmosphere giver. The phytochemical screening of jotang leaf extract showed positive results containing flavonoids, alkaloids, saponins, phenolic compounds, and triterpenoids. Determination of the wavelength of gallic acid obtained maximum 653 nm. The results showed that jotang leaf extract (Sphagneticola trilobata) has phenolic content and obtained total phenolic content of jotang leaf extract of 0.909 mg /g.
Uji Aktivitas Antibakteri Fraksi Ekstrak Daun Jotang (Sphagneticola trilobata L) terhadap Bakteri Eschericia coli Ghalib Syukrillah Syahputra; Ibnu Rusyd; Arie Vonikartika; Zahara Zahara; Eka Febriyanti; Delladari Mayefis
Journal Clinical Pharmacy and Pharmaceutical Science Vol. 4 No. 1 (2025): Journal of Clinical Pharmacy and Pharmaceutical Science
Publisher : Prodi D3 Farmasi Politeknik Katolik Mangunwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61740/jcp2s.v4i1.58

Abstract

Jotang (Sphagneticola trilobata) is a wild plant that has antibacterial potential. This study aims to determine the antibacterial activity of the n-hexane, ethyl acetate and methanol fractions of jotang leaf extract against Escherichia coli bacteria. Jotang leaves were extracted using methanol by maceration extraction method, followed by the fractionation stage using Liquid-Liquid Extraction method. The fractionation process uses n-hexane, ethyl acetate and methanol as solvents. Next step, each fraction was tested for antibacterial activity using the disc diffusion method. The concentrations of each fraction used were 200 µg/disc, 400 µg/disc, and 1000 µg/disc, positive control used chloramphenicol and negative control used DMSO 10%. The Result showed the most potential antibacterial activity of the active fraction from jotang leaves extract was the n-hexane fraction.
AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL DAUN GAHARU ( Aquilaria malaccensis Lamk ) PADA MENCIT PUTIH JANTAN ( Mus Musculus ) Delladari Mayefis; Cindy Octavia; Sri Hainil; Rury Trisa Utami; Desy Maniarti Gusmali; Hesti Marliza; Nurliyasman, Nurliyasman
Nusantara Hasana Journal Vol. 4 No. 12 (2025): Nusantara Hasana Journal, May 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v4i12.1413

Abstract

Inflammation is a complex response that occurs in blood vessel tissue due to external or internal stimuli. One plant that is known to have anti-inflammatory properties is agarwood leaves (Aquilaria malaccensis Lam). This study aims to evaluate the effect of ethanol extract from gaharu leaves on anti-inflammatory activity in male white mice (Mus musculus) and to determine the most effective dose. The experimental animals were divided into five groups, including a control group that received Na CMC and diclofenac sodium. Inflammation induction was carried out through injection of egg white solution, and measurements were carried out periodically for six hours. The analysis results showed that a dose of 300 mg/KgBW of agarwood leaf extract provided the most significant anti-inflammatory effect compared to lower doses. 100 mg/kgBB and 200 mg/kgBB
UJI AKTIVITAS ANTIBAKTERI DARI EKSTRAK ETANOL DAUN MANGKOKAN (Polyscias Scutellaria) TERHADAP BAKTERI Bacillus cereus DAN Shigella dysentriae Sri Hainil; Rury Trisa Utami; Delladari Mayefis; Nurul Asiqin
Nusantara Hasana Journal Vol. 5 No. 5 (2025): Nusantara Hasana Journal, October 2025
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i5.1710

Abstract

Mangkokan leaves (Polyscias scutellaria) are medicinal plants believed to treat the digestive tract, such as diarrhea, and abdominal pain, to use it by drinking a decoction of Mangkokan leaves as a traditional medicine. This study aims to determine the antibacterial activity of ethanol extract of Polyscias scutellaria leaves in inhibiting the growth of Bacillus cereus and Shigella dysentriae bacteria. The active compounds in Mangkokan leaves contain alkaloids, saponins, phenolics, and steroids. These ingredients can function as antibacterial. This study was carried out by maceration method using 96% ethanol solvent, and the viscous extract obtained tested to see the inhibition in Bacillus cereus and Shigella dysenteriae bacteria using the disc paper diffusion method with concentrations of 25%, 50%, 75%, and 100%. The positive control was chloramphenicol 30 μg/disk, and the negative control was DMSO 5% (Dimethylsulfoxide). The test results showed that Mangkokan leaf ethanol extract had antibacterial activity against Bacillus cereus bacteria with a (moderate) inhibitory response at a concentration of 100% of 7.96 mm. In comparison, Shigella dysentriae has an inhibitory response (moderate) at a concentration of 100% of 7.68 mm
Uji Aktivitas Ekstrak Etanol Daun Beriang (Ploiarium elegans korth ) Secara In Vivo sebagai Antidiabetes pada Mencit Putih Jantan (Mus Musculus) Rina Yunita; Delladari Mayefis; Aprilya Sri Rachmayanti
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 1 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i1.116

Abstract

Diabetes melitus merupakan suatu keadaan dimana gula darah dalam keadaan tinggi atau diatas normal dan perlahan namun pasti akan merusak jaringan dalam tubuh jika tidak ditangani secara tepat. Salah satu tumbuhan yang berpotensi untuk pengobatan tradisional sebagai antidiabetes adalah Beriang (Ploiarium elegans korth). Senyawa yang terkandung dalam daun beriang adalah alkaloid, flavonoid, tannin, saponin dan triterpenoid. Tujuan penelitian ini untuk mengetahui pengaruh pemberian ekstrak etanol daun Beriang (Ploiarium elegans korth) dalam menurunkan kadar glukosa darah pada mencit putih jantan (Mus musculus). Metode yang digunakan dalam pengujian aktivitas antidiabetes ialah tes toleransi glukosa dengan mengamati aktivitas penurunan kadar glukosa pada mencit putih Jantan (Mus musculus) dengan dosis 100 mg/kg BB, 200 mg/kg BB, dan 300 mg/kg BB yang di induksi aloksan. Hasil penelitian ini menunjukkan bahwa daun Beriang memiliki aktivitas menurunkan kadar glukosa darah pada mencit hiperglikemia dengan rata-rata persentase dosis ekstrak daun Beriang 100 mg/kgBB yaitu 30,18%, 200 mg/kgBB yaitu 35,32%, dan 300 mg/kgBB yaitu 54,57%. Dari hasil tersebut dapat dikatakan bahwa pemberian ekstrak etanol daun beriang dapat menurunkan kadar glukosa darah secara signifikan yang ditunjukkan oleh hewan uji mencit.
The Influence of Interpersonal Communication, Professionalism and Competence on The Monitoring System and Hospital Paramedic Performance at Dr. H. Soewondo Kendal Regional Hospital Anindita Paramastuti Azuma; Hindyah Ike Suhariati; Raden Roro Ratuningrum Anggorodiputro; Delladari Mayefis; Nelwetis
Professional Evidence-based Research and Advances in Wellness and Treatment Vol. 2 No. 2 (2025): April, 2025
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/perawat.v2i2.141

Abstract

The performance of paramedics, especially nurses and midwives, is essential to the quality of hospital health services. This study aims to examine the influence of interpersonal communication, professionalism, and competence on the monitoring system and nurse performance at at Dr. H. Soewondo Kendal Regional Hospital. Using a quantitative approach with SEM-PLS and WarpPLS 5.0, data from 110 paramedics (92 nurses and 18 midwives) were analyzed. The results show that interpersonal communication, professionalism, and competence significantly influence the monitoring system (R² = 0.79), which in turn positively affects nurse performance (R² = 0.73). However, competence does not have a significant direct effect on performance without the mediation of the monitoring system. These findings suggest that improving internal factors along with an effective monitoring system can enhance overall paramedic performance and support hospital management in optimizing human resources.
Pengaruh Gel Kombinasi Ekstrakherba Pegagan (Centella Asiatica L. Urban) Dan Lidah Buaya (Aloe Vera) Terhadap Penyembuhan Luka Bakar Pada Mencit Putih Jantan Delladari Mayefis; Sri Hainil; Ni Putu Sugi Maharani
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 6 No. 2 (2019)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v6i2.5133

Abstract

Luka bakar merupakan kerusakan pada jaringan kulit yang disebabkan oleh benda panas, sengatan listrik, bahan kima ataupun radiasi. Herba pegagan dan lidah buaya merupakan tanaman yang dikenal mempunyai khasiat menyembuhkan luka bakar. Pegagan memiliki kandungan komponen bioaktif triterpenoid yaitu asiaticoside, madecassocide dan madeccasic acidyang dapat menyembuhkan luka bakar dan juga memperbaiki sel-sel kulit mati. Lidah buaya mengandung saponin, senyawa antrakuinon, vitamin C dan vitamin E sebagai antioksidan. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian gel kombinasi ekstrak herba pegagan dan lidah buaya terhadap penyembuhan luka bakar. Penelitian ini menggunakan metode ekperimental pada 25 ekor mencit putih jantan yang dibagi menjadi 5 kelompok. Kelompok kontrol positif diberikan Bioplacenton, kelompok kontrol negatif diberikan gel tanpa ekstrak dan 3 kelompok uji yang lain diberikan masing-masing gel kombinasi ekstrak herba pegagan dan lidah buaya konsentrasi 5%, 10% dan 15%.Pemberian gel dilakukan sebanyak dua kali sehari hingga luka bakar pada punggung mencit sembuh. Pengamatan meliputi rata-rata diameter luka bakar perhari dan persentase penyembuhannya. Hasil penyembuhan paling cepat ditunjukkan pada kelompok yang diberikan gel kombinasi konsentrasi 15% yaitu dalam waktu 10 hari. Hasil analisis statistik menggunakan uji ANOVA satu arah menunjukkan terdapat perbedaan signifikanantara rata-rata nilai persentase antar kelompok.
Co-Authors Andi Bunga Dahlia Anindita Paramastuti Azuma Aprilya Sri Rachmayanti Aria Juanda Arie Vonikartika Cindy Octavia Desy Maniarti Gusmali Diani Mega Sari Eka Febriyanti Faziyana Faziyana Ghalib Syukrillah Syahputra Ghiffari, Habibie Deswilyaz Habibie Deswilyaz Henny Rachdianti T S Hesti Marliza Hindyah Ike Suhariati Ibnu Rusyd Julianto, Tommy Lyna Elvira Meddo Lorenza Garnida Mega Sari, Diani Merry Ardini Nelwetis Ni Putu Sugi Maharani Nurlia Oktaviyanti Nurliyasman Nurliyasman Nurul Asiqin Oktasari Oktasari Raden Roro Ratuningrum Anggorodiputro RENI NOVIANTI Reny Haryani Rina Yunita Rury Trisa Utami Selawati Selawati Shinta Sari Dewi Sri Hainil Sri Hainil Suci Fitriani Sammulia Suhaera Suhaera Zahara Zahara