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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Mutiara Medika: Jurnal Kedokteran dan Kesehatan The Indonesian Biomedical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Journal of Global Pharma Technology Indonesian Journal of Biomedicine and Clinical Sciences
Usi Sukorini
Departement Of Clinical Pathology And Medical Laboratory, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Turnaround time for the provision of packed red cells (PRC) and factors affecting their achievements in the Blood Transfusion Unit of Dr. Sardjito General Hospital, Yogyakarta Kaslam, Surawijaya Bakhtiar; Sukorini, Usi; Triyono, Teguh
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 3 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005503202304

Abstract

Turnaround time (TAT) is defined as the time it takes since request/sample is received at the blood bank until blood is cross-matched/reserved and available for transfusion. Turnround time prolongation affects patient care and satisfaction. This study aimed to evaluate TAT for the provision of packed red cells (PRC) at the Blood Transfusion Unit of Dr. Sardjito General Hospital, Yogyakarta, analyze factors affected in TAT prolongation, and provide solution the prolongation.  It was an analytical descriptive study with a qualitative design, by calculating the time since receipt of the PRC request at the Blood Transfusion Unit or since blood collection from donors until data input of the crossmatch results in Dr. Sardjito General Hospital management information system (SIMETRIS) completed. Moreover, the  delay in the provision of PRC at the Blood Transfusion Unit was also analyzed. There were 3 (1.5%) of 200 ER samples that met TAT for the provision of the PRC, which was 30 min after receipt of the request at the Blood Transfusion Unit in cito conditions. There were 20 (10%) of 200 samples from the wards that met TAT for the provision of the PRC, which was 2 h after receipt of the request at the Blood Transfusion Unit if the blood stock was available. There were 55 (27.5%) of 200 samples from the wards that met TAT for the provision of the PRC, which was 4 h after the blood was collected from the donor. TAT for the provision of the PRC at the Blood Transfusion for the available blood stock group was 179.08 (67.2 – 396.27) min, replacement blood donor group was 485.38 (126.43 – 910.68) min, and cito group was 121.29 (27.68 – 421.38) min. In conclusion, there is TAT prolongation of PRC provision at the Blood Transfusion Unit of Dr. Sardjito General Hospital.
Correlation between type of surgery and incidence of postoperative venous thromboembolism (VTE) Supomo; Budi Mulyono; Usi Sukorini; Adika Zhulhi Arjana; Tandean Tommy Novenanto
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 01 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i01.11888

Abstract

Venous thromboembolism (VTE) is a significant complication in patients after undergoing major surgery. The type of surgery is believed correlated with the incidence of VTE. This study aimed to evaluate the correlation between type of surgery and incidence of VTE among patients who underwent major surgery. It was a retrospective study conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of patients who underwent major surgery and were diagnosed with VTE between 2016 and 2020. Patients were grouped by surgery type, and length of stay (LoS). All caused deaths were also analyzed. Among 29,120 patients who underwent major surgery, 76 (0.26%) experienced VTE with females patients accounting for 75%. The mean age of the patients was 55 yr. All VTE cases had the mean LoS of 25 d. The highest proportion of patients who experienced VTE were patients who underwent tumor removal (67.0%) followed by trauma patients (18.4%). A significant difference in the incidence of mortality between the surgical groups was reported (p = 0.02). Post-cardiology had the highest risk of mortality (OR=7.46; 95% CI: 0.322 - 172.61) while age had the lowest risk of mortality (OR=1.01; 95% CI: 0.953 - 1.071). In conclusion, surgery type is correlated with the incidence of VTE. Surgery due to cancer and trauma has a higher risk of VTE compared to the others.
Laboratory findings of postoperative venous thromboembolism (VTE) in Dr. Sardjito General Hospital, Yogyakarta Supomo; Mulyono, Budi; Sukorini, Usi; Arjana, Adika Zhulhi; Novenanto, Tandean Tommy
Indonesian Journal of Biomedicine and Clinical Sciences Vol 56 No 2 (2024)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v56i2.13627

Abstract

Venous thromboembolism (VTE) is a significant risk, especially for older individuals. Indonesian studies found 37.1% VTE incidence in bedridden patients over 40 and 2.1% in major surgeries. Surgery, like hip fractures, raises the risk temporarily. Diagnosis relies on tests like ultrasound with Doppler, Wells score, and neutrophil-to-lymphocyte ratio (NLR). This study aimed to evaluate the laboratory findings of postoperative VTE. A retrospective analysis was conducted in Dr. Sardjito General Hospital, Yogyakarta using medical record data of VTE patients who underwent major surgery. The laboratory data, including complete blood count characteristics for every month for three months after postsurgery and DVT presentation when it occurred on the diagnostic day were collected. In total of 27 patients involved in this study, VTE cases were more common in digestive (41.2%) and obstetric gynecology surgeries (29.4%) for females, and nervous (44.4%) and cardiovascular surgeries (22.2%) for males. Females had a higher prevalence of Well Score ≥3 (82.4% vs 40%; p=0.058) and longer VTE therapy durations (65.50 ± 46.51 vs 39.60 ± 41.04 d; p=0.172). Males had more unilateral VTE occurrences (90.9 vs 56.3%; p=0.070) and a higher proportion of total occlusion cases (60 vs 37.5%; p=0.422). NLR exhibited a significant decrease from the 1st to the 2nd month (10.52 vs 3.64; p=0.009), followed by an insignificant increase in the 3rd month (3.64 vs 3.98; p=0.878). Notably, NLR trended downward in the 2nd month examination. In conclusion, VTE occurs in 0.21% of postoperative patients, with the highest incidence observed in post-gynecological surgery patients. The NLR can serve as a diagnostic tool for VTE in extremities, as an elevated NLR indicates the presence of a more proximal thrombus.
The Role of Fibrin Monomer Compared to D-dimer and CRP in Determining COVID-19 Severity Iriani, Anggraini; Sukorini, Usi; Fatina, Marsya Kaila; Aflah, Naja F; Aiman, Sarah A; Gemilang, Rizka K; Kamelia, Telly
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 30 No. 2 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v30i2.2110

Abstract

Fibrin Monomer (FM), as a product of thrombin activity in cleaving fibrinogen, can be used as an early marker of thrombotic events in COVID-19 patients. D-dimer is a commonly used marker of hemostasis as a product of plasmin activity in cleaving polymeric fibrin. D-dimer is often used to help decide whether to initiate anticoagulant administration. This study aims to know whether FM can be used as a marker for thrombotic events such as D-dimer in COVID-19 patients; CRP levels were also examined to determine how inflammation affected the two hemostatic indicators. A total of 93 patients were confirmed with COVID-19 by PCR. The median (min-max) FM in the severe stage was 4.53 (2.26-58.20)ug/mL, whereas, in the mild-moderate stage, it was 4.21 (2.19-32.35 ug/mL. There are significant differences in median D-dimer levels in severe stages to mild-moderate, respectively 0.46 (0.14–7.58) and 0.7890, and ages. The level of FM that can be used to differentiate the severe stage  is > 4.46 ug/mL (sensitivity 56.3%, specificity 58.0%) as in the D-dimer level is > 0.58 ug/mL ((sensitivity 75.0%, specificity 65.2%). There is a moderate positive correlation between fibrin monomer and D-dimer, a weak positive correlation between D-dimer and CRP, and no correlation between FM and CRP. This study concludes that the FM median level is higher in severe COVID-19 than in D-dimer. Fibrin monomer levels have a positive correlation with D-dimer. Fibrin Monomer levels are not affected by CRP.  
Co-Authors . Setyawati Adang Muhammad Gugun Adang Muhammad Gugun, Adang Muhammad Adika Zhulhi Arjana Aflah, Naja F Agus Supartoto Aiman, Sarah A Anak Agung Wiradewi Lestari Andri Christianalusi Andriani Tri Susilowati Angela Nurini Agni Anggraini Iriani Anik Ika Winarni Annisa Ginar Indrarsi Arlan Prabowo Budi Mulyono Diannisa Ikarumi Erlina Erlina Fatina, Marsya Kaila Fenty Fenty Fridawati, Veronica Gemilang, Rizka K Handoyo Pramusinto Hans Vrielink Harina Salim I Nyoman G Sudana Indrarsi, Annisa Ginar Ira Puspitawati Isti Setijorini Wulandari Kaslam, Surawijaya Bakhtiar Linda Rosita Luz Maria GBW Muhammad Juffrie Mulyono, Budi Natalia Christina Angsana Ni Kadek Mulyantari Ni Luh Putu Widhyasti Novenanto, Tandean Tommy Osman Sianipar Pratiwi Herowati Purbosari Purbosari Rahmat Dani Satria Riat El Khair Riswan Hadi Kusuma Rizki A. Gumilang Rizto Wisuda Senuari Rosmeri Handayani Rukmono Siswishanto Setyawati Setyawati Setyawati Setyawati Shanti Ika Sari Sianny Herawati Siti Muchayat Purnamaningsih Sri Mulatsih Suhardjo Prawiroranu Supomo Surawijaya Bakhtiar Kaslam Tandean Tommy Novenanto Tatang Talka Gani Teguh Triyono Teguh Triyono Teguh Triyono Telly Kamelia Tri Ratnaningsih Tri Ratnaningsih Tri Wahyu Widayanti Umi S. Intansari Veronica Fridawati Windarwati Windarwati