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All Journal Jambura Journal of Health Sciences and Research Jurnal Dunia Farmasi JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Multidisiplin Sahombu Ranah Research : Journal of Multidisciplinary Research and Development Journal of Pharmaceutical and Sciences. Journal of Innovative and Creativity
Razoki Razoki
Program Studi Sarjana Farmasi Klinis Universitas Prima Indonesia
Agriculture, Biological Sciences & Forestry Arts Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Other

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EVALUASI FORMULASI SEDIAAN MIKROENKAPSULASI EKSTRAK ETANOL DAUN MINDI (Melia Azedarach L.) Casey Dola Rebeca br Pinem; Razoki Razoki; Erida Novriani
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2203

Abstract

Microencapsulation is a technology used to protect active ingredients from environmental influences and enhance their stability. This study aimed to evaluate the formulation of microencapsulated ethanol extract of mindi leaves (Melia azedarach L.), which possesses pharmacological activities as an antioxidant, antibacterial, and antidiabetic agent. The extraction of mindi leaves was performed using the maceration method with 80% ethanol, yielding a 10.4% extract. Microencapsulation was prepared using sodium alginate and chitosan as coating materials, with three different extract concentrations (0.25%, 0.5%, and 0.75%). Formulation evaluation included moisture content testing, stability testing using cycling test, and floating test on rat gastric mucosa. The results showed that moisture content ranged from 0.37% to 0.63%, with the 0.75% formulation having the lowest moisture content (0.37%). Stability testing over six cycles demonstrated that all formulations remained stable without significant changes in color, texture, and shape. The floating test showed a lag time of less than 2 minutes for all formulations with floating time ranging from 3 to 6 hours, where the 0.25% concentration exhibited the longest floating time (6 hours). It can be concluded that microencapsulation technology successfully produced mindi leaf ethanol extract preparations with stable characteristics, low moisture content, and good floating capability, making it potential as an oral drug delivery system.
Evaluation of Microencapsulated Preparation Formulation of Ethanol Extract of Moringa Leaves (Moringa Oleifera) Nazla Deswita Siregar; Razoki Razoki; Refi Ikhtiari
Jurnal Multidisiplin Sahombu Vol. 6 No. 01 (2026): Jurnal Multidisiplin Sahombu, January 2026
Publisher : Sean Institute

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Abstract

Indonesia has abundant natural resources, one of which is the moringa plant (Moringa oleifera), known as “The Miracle Tree” due to its high nutritional content and pharmacological properties as an antioxidant, antimicrobial, and anti-inflammatory agent. This study aims to formulate ethanol extract of moringa leaves into microencapsulated preparations to improve the stability of active compounds and protect the active ingredients from stomach acid. The extract was obtained through maceration using 96% ethanol solvent with a yield of 24.42%. The characterization of the crude drug met the Indonesian Herbal Pharmacopoeia standards, and phytochemical screening showed the presence of alkaloids, flavonoids, triterpenoids, steroids, and tannins. The microencapsulation formulation was made using a combination of sodium alginate polymer and chitosan coating with CaCl2 hardening agent in four different extract concentrations. The evaluation of the preparations included stability testing (cycling test), moisture content testing, and buoyancy testing (floating). The stability test results showed that the preparation remained organoleptically stable without significant physical changes during 6 cycles. All formulas met the <5% moisture content requirement, with the 0.75% concentration formula (F4) having the lowest moisture content of 0.26%. In the adhesion test using rat gastric mucosa, the preparation showed good mucoadhesive ability, where the interaction of chitosan in an acidic environment prolonged the retention time of the microcapsules in the stomach. This study concluded that microencapsulation of moringa leaf extract has great potential as a stable and effective drug delivery system.
Co-Authors Asyrun Alkhaira Lubis Casey Dola Rebeca br Pinem Cindy Kurnia Sari Cindy Ronaldo Munthe Elfia Neswita Elfia Neswita Elfia Neswita Elfia Neswita Elfia Neswita Elfia Neswita Enni Halimahtussa’diyah Pakpahan Erida Novriani Erida Novriani Erida Novriani etha tesalonika tamba IKHTIARI, REFI Khansa Sabira Muhammad Yunus Nazla Deswita Siregar Nerly Juli Pranita Simanjuntak Novitaria Br Sembiring Novitaria Br Sembiring Novitaria Br. Sembiring Nur Afni Br. Ritonga Reh Malem br Karo Reh Malem Br Karo Rezki Sari Harahap Ruth Gaby Syahanaya Butar-Butar vira rusliza Yogi Andriansyah