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All Journal Bionatura Dentika Dental Journal ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Padjadjaran Journal of Dental Researchers and Students MDJ (Makassar Dental Journal) Makara Journal of Health Research Odonto dental journal Jurnal of Syiah Kuala Dentistry Society
Dewi Fatma Suniarti
Department Of Oral Biology, Faculty Of Dentistry, Universitas Indonesia, Jakarta 10430
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Ethyl acetate fractions of Cordyline fruticosa leaf: Chemical composition and cariogenic antimicrobial activity Alphianti, Likky Tiara; Bachtiar, Endang Winiati; Suniarti, Dewi Fatma; Fauziah, Eva
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.64444

Abstract

Introduction: Early childhood caries (ECC) is a prominent oral health problem, especially among low socioeconomic status (SES) groups. The development of herbal agents for caries prevention is essential due to the elevated costs and potential adverse effects linked to existing synthetic pharmaceuticals. Cordyline fruticosa (L.) A. Chev. (CF), prevalent in Indonesian rural regions, is an ornamental plant recognised for its medicinal properties, especially its antimicrobial efficacy. This study aimed to identify the chemical compounds in the ethyl acetate fraction of CF leaf extract and evaluate its antibacterial and antifungal activities against Streptococcus mutans (S. mutans) and Candida albicans (C. albicans), the main microorganisms associated with early childhood caries. Methods: This study used a laboratory experimental method. CF leaf extract was fractionated using ethyl acetate. Phytochemical and GC-MS screening were performed to identify secondary metabolites and chemical compounds. S. mutans and C. albicans were isolated from supragingival plaque samples of pediatric patients with severe ECC. The Minimum Inhibitory Concentration (MIC) was determined via serial dilution and ELISA spectrophotometry by comparing absorbance or optical density (OD) values before and after incubation.Results: Phytochemical screening confirmed the presence of phenolic compounds, flavonoids, tannins, and triterpenoids. GC-MS identified 4 chemical compounds, of which the largest peak area (73.88%) corresponding to 5-hydroxymethylfurfural. The MIC for S. mutans was 3.125% and 1.56% for C. albicans. Conclusion: The ethyl acetate fraction of the CF leaf extract exhibits antibacterial and antifungal properties and may function as a cariogenic antimicrobial agent.
Co-Authors Afifah Bambang Sutjiatmo, Afifah Bambang Amir, Lisa Rinanda Anggraeny Putri Sekar Palupi Bambang Pontjo Priosoeryanto Benny M. Soegiharto, Benny M. Boy M Bachtiar Endang Winiati Bachtiar Erik Idrus Euis Reni Yuslianti Eva Fauziah Febriana Setiawati Hartanti, Pratiwi Dwi Hartanto, Willy Hery Widijanto Komariah Komariah Latief, Benny Syariefsjah Lestari, Widya Lubis, Hilda Fitria Lubis, Septina Sabilla Meta Yunia Candra Nurtami Soedarsono Prasetyo, Sri Redjeki Pratiwi, Dwita Shanty Chairani Sri Utami Sri Utami Subarnbhesaj, Ajiravudh Sutjiatmo, Afifah B Yuniardini Septorini Wimardhani Yuslianti, Euis Reni