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All Journal INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana E-Jurnal Udayana Medica Jurnal Kesehatan Jurnal Kesehatan Andalas Journal of Medicine and Health Indonesian Journal for Health Sciences (IJHS) Majalah Kedokteran Andalas ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Respirasi (JR) Bali Dermatology and Venereology Journal Physical Therapy Journal of Indonesia Bali Dermatology Venereology and Aesthetic Journal Journal of Medicine and Health
I G. P. Supadmanaba
Departemen Biokimia, Fakultas Kedokteran, Universitas Udayana, Denpasar, Bali, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Hubungan kejadian eating disorder dengan status gizi remaja putri di Denpasar, Bali Made Violin Weda Yani; Made Sindy Astri Pratiwi; Made Priska Arya Agustini; Putu Cintya Denny Yuliyatni; I Gede Putu Supadmanaba
Intisari Sains Medis Vol. 13 No. 3 (2022): (In Press 1 December 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/ism.v13i3.717

Abstract

Background: Nutrition problems in adolescents both malnutrition and overnutrition in Indonesia are quite high. Nutrition problems are multifactorial, but several previous studies have shown that eating behavior will interfere with eating disorders related to nutritional quality. This study aims to analyze the relationship between eating attitude and eating disorders on nutritional status in adolescent girls. Methods: This research design was cross sectional observation conducted at SMAN 1 Denpasar, Bali. The samples were 119 adolescent girls that were selected by simple random sampling. Assessment of eating behavior used the adolescent food habit checklist, and eating disorders were assessed by EAT-26 questionnaire. Results: The subjects were 119 adolescent girls. Most of them were 15 and 16 years old. There were 53.8% of subjects having unhealthy food behavior and 86.6% did not experience eating disorders. There were 75.6% of students having normal nutritional status, followed by thin, overweight, and obese respectively 3.4%, 15.1%, and 5.9%. There was a significant relationship between eating attitude with nutritional status of adolescent girls (p value = 0.04; PR (95% CI) = 2.15 (1.09-4.21)). There is also a significant relationship between eating disorder with nutritional status of adolescent girls (p value=0.01; PR (95% CI) = 2.45 (1.32-4.56)) Conclusion: This study found that eating behavior was not related to nutritional status. The condition of eating disorders has a significant relationship with adolescent nutritional disorders. Individuals with eating disorders have a greater risk of experiencing nutritional disorders than individuals without eating disorders.   Latar Belakang: Masalah gizi pada remaja baik undernutrition ataupun overnutrition di Indonesia cukuplah tinggi. Masalah gizi pada remaja bersifat multifaktorial, namun beberapa penelitian sebelumnya menunjukkan bahwa faktor perilaku makan yang tidak baik akan memicu eating disorder yang berhubungan dengan kualitas gizi remaja putri. Sejauh ini belum terdapat studi terkait hubungan eating disorder dengan status gizi remaja putri di Bali. penelitian ini bertujuan untuk menganalisis hubungan antara perilaku makan dan eating disorder terhadap status gizi pada remaja putri. Metode: Desain penelitian yaitu observasi cross sectional yang dilakukan di SMAN 1 Denpasar, Bali. Sampel berjumlah 119 orang remaja putri berusia 14-18 tahun yang dipilih dengan simple random sampling. Penilaian perilaku makan menggunakan the adolescent food habbit checklist, dan gangguan makan dinilai menggunakan kuesioner EAT-26. Hasil: Dari 119 subjek penelitian, dominasis siswi putri berusia 16 tahun. Sebanyak 53.8% remaja putri memiliki perilaku makanan yang tidak sehat dan 86.6% tidak mengalami eating disorder. Mayoritas siswi memiliki status gizi yang normal yaitu 75.6%, diikuti dengan status gizi kurus, gemuk, dan obesitas berturut-turut yaitu sebesar 3.4%, 15.1% dan 5.9%. Terdapat hubungan yang signifikan antara perilaku makan buruk dengan gangguan gizi (p value=0.049; PR(95%CI) = 0.52 (0.27-1.01)) dan terdapat pula hubungan yang signifikan antara eating disorder dengan gangguan gizi remaja putri (p value=0.01; PR (95% CI) = 2.45 (1.32-4.56)) Simpulan: Penelitian ini mendapatkan bahwa perilaku makan dan kondisi eating disorder memiliki hubungan signifikan dengan gangguan gizi remaja putri.  Individu dengan eating disorder memiliki risiko lebih besar mengalami gangguan gizi dibandingkan individu tanpa eating disorder.
Asosiasi Polimorfisme Gen MMP-7-181A>G Terhadap Risiko Kanker Kolorektal di RSUP Prof. Dr. I. G. N. G. Ngoerah Bali Chandra, Christian; Wihandani, Desak Made; Supadmanaba, I Gede Putu; Dewi, Ni Nyoman Ayu
E-Jurnal Medika Udayana Vol 13 No 5 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i05.P12

Abstract

Background: Colorectal cancer is the third most diagnosed cancer worldwide and ranks second as the cause of cancer-related mortality. Matrix Metalloproteinase (MMP) enzymes are known to be closely associated with the carcinogenesis of colorectal cancer. The MMP-7-181A>G polymorphism has been previously linked to the risk of various types of cancer. However, the association of the MMP-7-181A>G polymorphism with the risk of colorectal cancer has not been investigated in Indonesia. Objective: This study aims to determine the relationship between the MMP-7-181A>G polymorphism and the risk of colorectal cancer. Methods: Polymerase chain reaction (PCR) followed by Sanger sequencing was employed to obtain genotype data from 26 cases and 26 controls. Univariate and bivariate statistical analyses were conducted to determine the association of MMP-7-181A>G polymorphism to the risk of colorectal cancer by evaluating obtained Odds Ratio (OR) and p-values. Results: The distribution of the AG and GG variants in the case group was 23.1% and 3.8%, respectively. Meanwhile, the distribution of the AG and GG variants in the control group was 15.4% and 0%. Data analysis shows an insignificant increase in colorectal cancer risk in genotypes with the G allele (OR=2.02, 95% CI: 0.51-8.00, p=0.308). Conclusion: The study suggests that the MMP-7-181A>G polymorphism cannot be directly associated with colorectal cancer risk, emphasizing the need to consider multiple interactions with other MMP gene polymorphisms. Further investigations into direct associations of this polymorphism with MMP-7 expression levels in colorectal cancer lesions could help give a clearer understanding of genetic risk factors in colorectal cancer.
Potensi Kombinasi Naringenin-Liposom Sebagai Anti-Viral dan Anti-Fibrotik dalam Penatalaksanaan Hepatitis C Anjani, Ida AyuWidya; Artha, I Wayan Windi; Purwaningrum, Ni Made Ari; Wiranata, Sinta; Supadmanaba, I Gede Putu; Wihandani, Desak Made
Jurnal Kesehatan Andalas Vol. 9 No. 2 (2020): Online June 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1280

Abstract

Penatalaksanaan hepatitis C yang umum diberikan di Indonesia adalah terapi kombinasi Peg-IFNα dan RBV, namun terapi tersebut mempunyai efek samping seperti depresi, hipotiroidisme, memperlambat motorik, risiko kardiovaskular tinggi, dan lain sebagainya. Berdasarkan hal tersebut, maka dibutuhkan alternatif yang dapat meminimalisir efek samping yang ditimbulkan dalam penatalaksanaan hepatitis C, salah satunya menggunakan bahan herbal naringenin. Naringenin adalah flavanon alami yang diketahui memiliki efek hepatoprotektif sebagai anti-viral dan anti-fibrotik pada penatalaksanaan hepatitis C.  Metode penulisan yang digunakan dalam karya tulis ilmiah ini adalah metode kajian pustaka. Data yang digunakan berasal dari beberapa sumber literatur yang relevan dan sesuai dengan topik masalah yang dibahas. Naringenin berpotensi sebagai modalitas anti-viral dan anti-fibrotik pada penatalaksanaan hepatitis C. Sebagai anti-viral, naringenin mampu menghambat sekresi virus hepatitis C sebanyak 80% melalui penghambatan aktivitas MTP, ACAT2, dan HMGR. Sebagai anti-fibrotik, naringenin mampu menghambat jalur NF-kB dan TGF-β Smad3, tetapi naringenin memiliki bioavailabilitas dan solubilitas yang rendah, sehingga penyerapannya hanya sebesar 15%. Enkapsulasi naringenin dengan liposom dapat meningkatkan jumlah serapannya pada tubuh, meningkatkan waktu paruh, meningkatkan konsentrasi obat di plasma, serta mudah terkonsentrasi di hati.Kata kunci: hepatitis C, naringenin, liposom, anti-viral, anti-fibrotik 
Kombinasi Nanopartikel Cisplatin-Withaferin Berbasis PEGylated Liposome Sebagai Terapi Alternatif Kanker Ovarium Made VW Yani; Ida Ayu W Anjani; I Gede S Narayana; Desak M Wihandani; I Gede P Supadmanaba
Journal of Medicine and Health Vol 2 No 5 (2020)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v2i5.1129

Abstract

Ovarian cancer is one of the major health problems in gynecology worldwide. Globocan 2012 data shows that ovarian cancer occurs in 239.000 cases, and is placed fourth as the most malignancy occurred in Indonesia. So far, cisplatin is the most effective therapeutic agent, but the high dosage of administration often caused side effects. A new alternative therapy to overcome the problems by using withaferin-A and nanoparticle PEGylated liposome. WFA has the potential effect to reduce cisplatin resistance but has low bioavailability thus, it needs to be encapsulated. This review’s goal is to depict the potency of withaferin-A, cisplatin, and PEGylated liposome combination as a therapeutic agent to treat ovarian cancer. The combination of Cisplatin-Withaferin PEGylated Liposome is constructed by the modified thin lipid film hydration method then administered orally. This combination suppresses 70-80% of the ovarian cancer cell growth in vivo and inhibits NGFR from binding to TRKA, prevents cell migration as much as 50%. Nano-Cisferin-Liposome, inhibits migration of ovarian cancer cell significantly through ?-catenin signaling through ALDH1 that disturb the spheroid formation, and increase apoptosis event as much 70-80% by increasing ROS production up to 2,5 times. Thus, Nano-Cisferin-Liposome (NCL) has potential as a therapeutic agent for treating ovarian cancer. Keywords: Cisplatin; Ovarian Cancer; PEGylated Liposome; Withaferin A
Emerging Role of Precision Medicine in Diagnosis and Treatment of Chronic Respiratory Disease Wesnawa, Made Agustya Darma Putra; Asmara, Oke Dimas; Supadmanaba, I Gede Putu
Jurnal Respirasi Vol. 10 No. 1 (2024): January 2024
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v10-I.1.2024.85-92

Abstract

Precision medicine is the current approach to managing chronic respiratory diseases, especially asthma and chronic obstructive pulmonary disease (COPD). It involves the evaluation of genetic, environmental, and lifestyle variations for each patient. It requires valid and specific biomarkers obtained through genetic studies, biomolecular technology, and omics-based technology to determine targeted therapies. Asthma and COPD have heterogeneous clinical phenotype variations, and giving one standard treatment for asthma and COPD may not necessarily provide the same effectiveness to other patients. The endotype, a specific molecular mechanism in disease pathogenesis, is essential in phenotype variation. The role of precision medicine in asthma and COPD is to determine endotypes through specific biomarkers and to provide specific targeted therapy for achieving personalized treatment in each patient. The application of precision medicine not only provides precise diagnosis and treatment but also enables early detection in individuals at risk and prevention of progression and exacerbation in asthma and COPD.
Focus on the dabrafenib, vemurafenib, and trametinib in the clinical outcome of melanoma: A systematic review and meta-analysis Ida Ayu Widya Anjani; Anak Agung Bagus Putra Indrakusuma; I Gede Krisna Arim Sadeva; Putri Ayu Wulandari; Luh Made Mas Rusyanti; Prima Sanjiwani Saraswati Sudarsa; I Gede Putu Supadmanaba; Desak Made Wihandani
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 3 No. 2 (December 2020)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/myphje28

Abstract

Background: Melanoma is the most severe lethal skin cancer, affecting melanin producer cells (melanocytes). Surgery is the most common treatment, whereas, for the advanced stage, the development of treatment is recommended. BRAF (Dabrafenib and Vemurafenib) inhibitor or MEK inhibitor (Trametinib) is the most frequently targeted melanoma therapy due to more than 80% of patients with positive BRAF mutation. In this review, those treatments will be investigated systematically to identify their clinical outcome. Method: This systematic literature review (SLR) was performed from Cochrane, Science Direct, Google Scholar, and Pubmed. Cochrane Risk-of-Bias Tool RoB2 is used to assess RCT studies and New-castle Ottawa Scale Assessment to assess cohort studies by three different assessors. Data analysis was carried out by using Review Manager (RevMan 5.4). Heterogenicity test was assessed by I2 and Chi2 statistic Result: There are 20 studies used in this article (13 RCT and seven cohorts). The overall survival (OS) and progression-free survival (PFS) of the survey that using targeted therapy (vemurafenib, trametinib, or dabrafenib) compare other treatments (chemotherapy, immunotherapy, etc.) showed risk ratio (RR) was 1.12 (95%CI 1.07,1.17; I2=100%; p<0,00001). The OS and PFS with monotherapy compare of vemurafenib, trametinib, or dabrafenib with combination therapy showed RR was 1.09 (95%CI.06,1.13; I2=99%; p<0,00001). Conclusion: BRAF and MEK targeted therapy has a good prognosis for a patient with a positive BRAF gene mutation and could be combined with other treatments for better clinical outcomes rather than monotherapy.
Integrating simulation, role-play, and technology in physiotherapy education: A narrative review on teaching methods for patient education Manuaba, Ida Bagus Amertha Putra; Yani, Made Violin Weda; Indrakusuma, Anak Agung Bagus Putra; Dewi, Ketut Liana Arya; Wulandari, Putri Ayu; Mahadipaka K.A, Ngurah Arya T.; Sasmitha, Ni Luh Ayu; Supadmanaba, I Gede Putu
Physical Therapy Journal of Indonesia Vol. 7 No. 1 (2026): Inpress January-June 2026
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v7i1.399

Abstract

Physiotherapists play a crucial role in patient education, as effective communication and educational strategies directly influence treatment adherence, functional outcomes, patient satisfaction, and trust in healthcare services. The increasing global burden of musculoskeletal and neurological disorders has intensified the demand for physiotherapy services, emphasizing the need for graduates who are not only clinically competent but also proficient in patient-centered education. This narrative review aims to synthesize evidence from 2015 to 2025 regarding the integration of simulation, role-play, and educational technology in physiotherapy education, with a particular focus on teaching methods that enhance patient education competencies. Relevant peer-reviewed literature was identified from major academic databases, including PubMed, Scopus, and Google Scholar, and analyzed thematically to examine educational outcomes related to communication skills, learner engagement, confidence, empathy, and clinical preparedness. The findings indicate that simulation-based learning and structured role-play provide safe and experiential environments for students to practice patient communication and education, while technology-enhanced approaches such as virtual simulations and digital learning platforms offer scalable and flexible learning opportunities. Collectively, these methods demonstrate consistent benefits in improving students’ ability to deliver clear, structured, and empathetic patient education, thereby supporting readiness for clinical practice. Integrating simulation, role-play, and technology within physiotherapy curricula represents a strategic approach to strengthening patient education competencies and preparing graduates to deliver high-quality, patient-centered, and trusted physiotherapy care in response to contemporary healthcare demands.
Co-Authors Agung Bagus S. Satyarsa Anak Agung Bagus Putra Indrakusuma Anak Agung Bagus Putra Indrakusuma Anjani, Ida AyuWidya Arim Sadeva, I Gede Krisna Artha, I Wayan Windi Asmara, Oke Dimas Christian Chandra Desak Made Wihandani Dewi, Ketut Liana Arya F. N. Anggreini Gede Andry Nicolas Andry Nicolas I Gede Krisna Arim Sadeva I Gede Krisna Arim Sadeva I Gede S Narayana I Gede Wikania Wira Wiguna I Gusti Ayu Stiti Sadvika I W. Sudarsa I Wayan Windi Artha I. B. T. Wibawa-Manuaba Ida Ayu W Anjani Ida Ayu Widya Anjani Ida Ayu Widya Anjani Ida AyuWidya Anjani Ida Bagus Amertha Putra Manuaba Indrakusuma, Anak Agung Bagus Putra Luh Made Mas Rusyanti Luh Made Mas Rusyati Made Priska Arya Agustini Made Sindy Astri Pratiwi Made Violin Weda Yani Made VW Yani Mahadipaka K.A, Ngurah Arya T. Ni Made Ari Purwaningrum Ni Nyoman Ayu Dewi Ni Putu Sri Indrani Remitha PAT Adiputra Prima Saraswati Sanjiwani Sudarsa Purwaningrum, Ni Made Ari Putri Ayu Wulandari Putri Ayu Wulandari Putri Ayu Wulandari, Putri Ayu Putu Anda Tusta Adiputra Putu Cintya Denny Yuliyatni Putu Gupta Arya Gumilang R. Saraswati Sasmitha, Ni Luh Ayu Sinta Wiranata Wesnawa, Made Agustya Darma Putra Widya Anjani, Ida Ayu Wiranata, Sinta Yani, Made Violin Weda