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All Journal Jurnal Kedokteran Brawijaya Majalah Obat Tradisional MALIH PEDDAS Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento Electrices : Jurnal Otomasi Kelistrikan dan Energi Terbarukan Bioscientist : Jurnal Ilmiah Biologi JoMMiT : Jurnal Multi Media dan IT Solo Journal of Anesthesi, Pain and Critical Care Sciences of Pharmacy JPM-AKA SIMPLEX: Journal of Economic Management JI-KES (Jurnal Ilmu Kesehatan)
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Akademi Farmasi Samarinda, Samarinda, Kalimantan Timur
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Aktivitas Anti Jamur Fraksi Aktif Ekstrak Etanol Umbi Bawang Rambut (Allium Chinense G.Don) terhadap Jamur Candida Albicans Supomo, Supomo; Idriana, Idriana; Eka, Audinah; Indra, Indra; Huda, Miftahul; Warnida, Husnul
JI-KES (Jurnal Ilmu Kesehatan) Vol. 4 No. 2 (2021): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v4i2.188

Abstract

AbstrakTumbuhan umbi bawang rambut (Allium chinense G.Don) memiliki efek sebagai antijamur karena mengandung metabolit sekunder seperti flavanoid, alkaloid dan saponin. Tujuan penelitian ini adalah mengetahui aktivitas antijamur ekstrak umbi bawang rambut melalui proses fraksinasi menggunakan pelarut N-heksan, etil asetat, kloroform dan etanol-air. Penelitian yang dilakukan adalah penelitian eksperimental. Sampel yang digunakan adalah umbi bawang rambut yang diperoleh di kampung Kelasan kecamatann Sungai Payang Kutai Kartanegara. Penelitian ini menggunakan metode maserasi dengan pelarut etanol 70%, metode uji aktivitas antijamur berdasarkan metode difusi cakram terhadap jamur Candida albicans dengan konsentrasi 5%, 10%, 25%, dan 50%, dengan kontrol negatif DMSO 50%. Hasil penelitian menunjukkan bahwa semua fraksi dari ekstrak etanol umbi bawang rambut memiliki aktivitas antijamur. Aktivitas antijamur fraksi etil asetat memberikan daya hambat yang paling besar terhadap Candida albicans diantara fraksi lainnya. Kata kunci:  candida albicans; Allium chinense G. Don; antijamur; fraksi AbstractAllium chinense has an antifungal effect because it contains secondary metabolites such as flavonoids, alkaloids and saponins. The purpose of this research is to investigate the antifungal activity of Allium chinense extract through fractionation process using N-hexane solvent, ethyl acetate, chloroform and ethanol-water. The research is experimental research. Samples used are the Allium chinense found in  Kelasan Sungai Payang  Kutai Kartanegara. Using maseration method with 70% ethanol solvent, antifungal activity test method based on disc diffusion method on Candida albicans fungi with concentration of 5%, 10%, 25%, and 50%, with negative control of DMSO 50%. The results showed that all fractions of Allium chinense ethanol extract had antifungal activity. The antifungal activity of the ethyl acetate fraction provides the greatest resistance to Candida albicans among other fractions. Keywords:  candida albicans, allium chinense G. Don, antifungal, fraction
Uji Aktivitas Antibakteri EkstrakEtanol dan Fraksi Batang Kuning (Fibraurea Tinctoria Lour) terhadap Bakteri Escherichia coli dan Staphylococcus aureus Ariyanti, Lusi Mardika; Supomo, Supomo; Sa’adah, Hayatus; Syamsul, Eka Siswanto; Kintoko, Kintoko; Witasari, Hardi Astuti
JI-KES (Jurnal Ilmu Kesehatan) Vol. 5 No. 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.323

Abstract

Abstrak Akar kuning (Fibraurea tinctoria Lour) merupakan tumbuhan khas yang dapat dijumpai di Kalimantan serta biasa dimanfaatkan oleh masyarakat setempat sebagai obat gatal, penyakit kuning dan diare. Salah satu senyawa kimia yang terkandung dalam akar kuning adalah berberin yang berpotensi memiliki khasiat sebagai antidiabetes, antivirus, antibakteri dan antiinflamasi. Penelitian ini bertujuan untuk  mengetahui potensi tumbuhan Akar Kuning (Fibraurea tinctoria Lour.) sebagai antibakteri terhadap bakteri Escherichia coli dan Staphylococcus aureus dengan menggunakan metode disc diffusion. Ekstrak etanol difraksinasi dengan menggunakan pelarut n-heksan dan etilasetat, ekstrak dan fraksi yang telah didapat ditimbang dengan konsentrasi 2,5%, 5% dan 10%. Kontrol positif yang digunakan yaitu amoxicillin dan DMSO sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ektrak etanol dan fraksi akar kuning (Fibraurea tinctoria Lour.) memiliki potensi untuk menghambat pertumbuhan bakteri. Aktivitas zona hambat terbesar yang terbentuk pada ekstrak etanol yaitu pada konsentrasi 10% dengan diameter zona hambat 9,18 mm terhadap bakteri Escherichia coli dan 12,16 mm terhadap bakteri Staphylococcus aureus sedangkan fraksi batang akar kuning yang memiliki aktivitas antibakteri paling kuat terhadap bakteri Escherichia coli dan Staphylococcus aureus yaitu fraksi sisa. Staphylococcus aureus memiliki sensitifitas lebih tinggi terhadap akar kuning (Fibraurea tinctoria Lour) dari pada bakteri Escherichia coli. Kata kunci  : antibakteri, akar kuning, berberin, Fibraurea tinctoria Lour. Abstract Akar kuning (Fibraurea tinctoria Lour.) is typically plant that can be found in Kalimantan usually used by local people as itch medicine, jaundice and diarrhea. Berberin, one of the chemical compounds contained in the akar kuning, berberin has the potential to act as an anti-diabetic, antiviral, antibacterial, and anti-inflammatory. This study aimed to determine the activity of akar kuning as an antibacterial against Escherichia coli and Staphylococcus aureus using the disc diffusion method. Ethanol extract are fractionated using n-Heksan and Etilasetat solvents, the obtained of extract and fraction are weighed to 2,5%, 5% and 10%. Positive control antibacterial used amoxicillin and DMSO as negative control. The results showed that ethanol extracts and fraction of akar kuning (Fibraurea tinctoria Lour.) are have potential to inhibited bacteria growth. The highest antibacterial activity that showed at 10% concentration of ethanol extract with diameter inhibition is 9,18 mm to Escherichia coli and 12,16 mm to Staphylococcus aureus while the fraction of akar kuning which has the stronger antibacterial activity to Escherichia coli and Staphylococcus aureus is the rest fraction. Staphylococcus aureus were more susceptible to akar kuning (Fibraurea tinctoria Lour.) extract and fraction than Escherichia coli.Keywords:           antibacterial, akar kuning, berberin, Fibraurea tinctoria Lour
Uji Aktivitas Antioksidan Ekstrak Baccaurea Lanceolata Fructus dengan Metode ABTS dan DPPH Rahman, Rauli Dimas Nur; Supomo, Supomo; Warnida, Husnul
JI-KES (Jurnal Ilmu Kesehatan) Vol. 6 No. 2 (2023): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/jikes.v6i2.546

Abstract

Abstrak Radikal bebas dapat menyebabkan kerusakan pada tubuh yang berlanjut kepada penyakit kronis seperti kanker, penyakit neurodegeneratif dan diabetes. Antioksidan merupakan suatu zat yang memiliki kemampuan untuk memperlambat proses oksidasi yang disebabkan radikal bebas. Ekstrak buah limpasu (Baccaurea lanceolata) memiliki kandungan senyawa flavonoid dan tannin. Metabolit sekunder seperti flavonoid dan tanin ini memiliki aktivitas antioksidan.  Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan ekstrak buah limpasu menggunakan metode ABTS (2,2-azinobis-3-Ethylbenzothiazoline-6-Sulfonic Acid) dan DPPH (1,1-difenil-2-pikrilhidrazil) melalui nilai IC50. Penelitian yang dilakukan bersifat eksperimental. Objek penelitian ini adalah aktivitas antioksidan dari metode ABTS dan DPPH. Konsentrasi ekstrak etanol buah limpasu diukur menggunakan spektrofotometri UV-Vis untuk mendapatkan persen inhibisi dari sampel. Persen inhibisi dimasukkan ke dalam persamaan regresi linear untuk mendapatkan nilai IC50 dari kedua metode uji. Berdasarkan hasil penelitian diperoleh nilai IC50 sebesar 721,19 ppm pada metode DPPH yang termasuk kategori antioksidan tidak aktif, sedangkan pada uji ABTS didapatkan nilai IC50 sebesar 118,70 ppm yang termasuk kategori antioksidan sedang. Keywords: antioksidan, buah limpasu, ABTS, DPPH, IC50    Abstract Free radicals can harm the body and cause chronic diseases such as cancer, neurodegenerative diseases, and diabetes. Antioxidants are substances that have the ability to slow the oxidation process caused by free radicals. Limpasu fruit extract (Baccaurea lanceolata) contains flavonoid and tannin. Flavonoids and tannins have antioxidant activity. The goal of this study was to determine the antioxidant activity of limpasu fruit extract using the ABTS (2,2-azinobis-3-ethylbenzothiazoline-6-sulfonic acid) and DPPH (1,1-diphenyl-2-picrylhydrazil) methods using the IC50 value. This study is an experiment. The antioxidant activity of the ABTS and DPPH methods is the focus of this study. Independent variables of this study were limpasu fruit extract with concentration of 100; 200; 300; 400 500 ppm in DPPH and 30; 40; 50; 60; 70 ppm in ABTS, dependent variable is the antioxidant activity of limpasu fruit extract. The concentration of limpasu fruit extract measured using UV-Vis spectrophotometry to obtain the inhibition percentage of sample. The inhibition percentage was then entered into a linear regression equation to calculate the IC50 value for both methods. According to the study's findings, the IC50 value in the DPPH method was 721.19 ppm, indicating that it was an inactive antioxidant, whereas the IC50 value in the ABTS test was 118.70 ppm, indicating that it was a moderate antioxidant. Keywords: antioxidants, limpasu fruit, ABTS, DPPH, IC50
Antioxidant activity of pumpkin leaf extract(Cucurbita moschata duch.) Using the dpph method Supriningrum, Risa; Khusnah, Miftahul Nabila; Supomo, Supomo
Jurnal Riset Kefarmasian Indonesia Vol. 8 No. 1 (2026): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v8i1.948

Abstract

Pumpkin leaves (Cucurbita moschata Duch.) have benefits as an antidiabetic agent, stomach protector, and can increase blood hemoglobin levels, thereby treating anemia. Pumpkin leaves contain vitamin A, vitamin B, carbohydrates, phosphorus, calcium, iron, vitamin C, and secondary metabolites that have antioxidant potential. The purpose of this study was to determine the antioxidant activity of yellow pumpkin leaf extract using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The research stages included plant identification, simplisia preparation, extraction by maceration with 95% ethanol solvent, phytochemical screening, and testing of antioxidant activity with DPPH free radicals and vitamin C as a comparison. The results of the antioxidant activity test of the ethanol extract of pumpkin leaves showed very strong antioxidant activity with an IC50 value of 24.29 ppm, and a vitamin C IC50 value as a comparison of 9.809 ppm.
PERBANDINGAN METODE EKSTRAKSI EKSTRAK UMBI BAWANG RAMBUT (Allium chinense G.Don.) MENGGUNAKAN PELARUT ETANOL 70% TERHADAP RENDEMEN DAN SKRINING FITOKIMIA Supomo, Supomo; Warnida, Husnul; Said, Bagus Moch
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.15

Abstract

Allium chinense are plants that contain bioactive compounds such as alkaloids, flavonoids, and saponins. The rendement of an extract may be affected by the extraction mentod used. This study aims to determine the effect of maseration and digestion extraction method on rendemen and identification of secondary metabolite in the extract of the hair onion bulbs. Research conducted is an experimental study. The samples used were hair bulbs obtained in Kota Bangun, East Kalimantan, extracted wiyh 2 extraction methods of maceration and digestion using ethanol 70% solvent and done as much as 3 times replication. Identification of secondary metabolite compounds was performed by phytochemical screening including test of alkaloids, flavonoids, saponins, tannins, and steroids. From the test data is processed by statistical analysis. The result of rendement with 3 times replikation of digesti mentod obtained by 20,02 gram, 19,03 gram, and 19,17 gram. While the maseration method obtained for 12,38 grams, 12,45 grams, and 15,91 grams. So there are differences between the results of the results of digestion mentod and maseration mentod. Based on phytochemical screening tets showed that the thick extract of hair onion bulbs contain compounds alkaloids, flavonoids, and saponins.
AKTIVITAS ANTIBAKTERI EKSTRAK AIR KULIT BAWANG MERAH (Allium cepa L.) TERHADAP BAKTERI Propionibacterium acnes Sa`adah, Hayatus; Supomo, Supomo; Musaenah, Musaenah
Jurnal Riset Kefarmasian Indonesia Vol. 2 No. 2 (2020): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v2i2.73

Abstract

Propionibacterium acnes is one of the causes of acne. Shallot peels contain flavonoids, tannins, and saponins which potentially have antibacterial activity. The purpose of this study was to determine whether the water extracts of shallot peels have antibacterial activity against Propionibacterium acnes and determine the concentration which can inhibit the growth of bacteria Propionibacterium acnes. This research is an experimental study. The research stage begins with the extraction of shallot peels using in the foundation. Antibacterial activity was tested using the diffusion method with the Cup-plate technique. Propionibacterium acnes used as a sample of bacteria, with extract concentrations of 5%, 10%, 20%, and 40%. Positive controls used are clindamycin 150 mg and negative controls were used dimethyl sulfoxide 1% (v / v). Data were analyzed with a statistical test of the Kolmogorov-Smirnov method. The measurement results inhibition zone of shallot peels water extract with a concentration of 5%, 10%, 20%, and 40% of the bacteria Propionibacterium acnes sequentially by 12.8 mm, 13 mm, 14.33 mm and 15.50 mm in the strong category. The measurements of bacterial growth inhibition zone were statistically analyzed with the Kruskal-Wallis method gained 0,053 results indicating that the test has a significant effect (P > 0.05) with a decision that means that there is no significant difference between all concentrations.
Optimization Of Tablet Formulation of Ethanol Extract of Basin (Ocimum basilicum L.) As Antioxidant with Variations of Pregelatinized Starch and Explotab Sa`adah, Hayatus; Sya’diyah, Halimatus; Ansyory, Achmad Kadri; Supomo, Supomo
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12621

Abstract

Background: Basil (Ocimum basilicum L.) is recognized as a rich botanical source of secondary metabolites that exhibit notable antioxidant properties.Objective: The present investigation sought to examine how variations in disintegrant type and proportion—specifically pregelatinized starch and Explotab—influenced the physical characteristics and antioxidant capacity of tablets prepared from basil leaf ethanol extract.Methods: Three distinct formulations were developed based on differing pregelatinized starch-to-Explotab ratios: Formula I (0:1), Formula II (1:1), and Formula III (1:0). All prepared tablets underwent comprehensive physical evaluation and stability assessment, while antioxidant potential was quantified through the DPPH radical scavenging method. The formulation optimization process employed the Simplex Lattice Design (SLD) methodology executed via Design-Expert® version 13 software.Results: Experimental findings demonstrated that the ratio variation between pregelatinized starch and Explotab exerted measurable effects on both granule and tablet physical attributes. Specifically, pregelatinized starch was found to predominantly elevate bulk density, weight uniformity, and disintegration time, whereas Explotab exhibited a stronger regulatory influence over moisture content, flow rate, Carr’s index, and tablet friability. The optimal formulation was identified as containing 6.72% pregelatinized starch combined with 1.27% Explotab. Notably, all three formulations demonstrated very strong antioxidant activity, with IC₅₀ values spanning from 33.78 to 39.52 ppm. One-way ANOVA statistical evaluation revealed no significant interformulation differences (p > 0.05).Conclusion: The collective data supports the conclusion that a strategic combination of pregelatinized starch and Explotab yields basil extract tablets with satisfactory physical quality alongside preserved antioxidant efficacy.
Physico-Chemical Characterisation and Determination of Luteolin Content of Pidada merah (Sonneratia Caseolaris L) Leaf Extract Syamsul, Eka Siswanto; Lestari, Dwi; Dachriyanus, Dachriyanus; Supomo, Supomo
Sciences of Pharmacy Volume 5 Issue 2
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501579

Abstract

Red pidada (Sonneratia caseolaris L.) leaves are used traditionally for skin care and other medicinal purposes. This study aimed to characterise the powdered leaf material and determine the luteolin content of the ethanolic leaf extract. Dried leaf powder was macerated with 95% ethanol. The powdered material was characterised by macroscopic and microscopic examination and by determining the water-soluble extractive value, ethanol-soluble extractive value, moisture content, total ash, and acid-insoluble ash. Metabolite profiling of the extract was performed using high-resolution liquid chromatography-mass spectrometry (HR-LCMS). Luteolin content was estimated by TLC-densitometry using silica gel 60 F254 plates and n-hexane: ethyl acetate (2:3) as the mobile phase. Macroscopically, the leaves were oval to elongated with rounded to blunt apices, entire margins, pinnate venation, and a dark-green colour. Microscopic examination showed upper and lower epidermal tissues, stomata, and vascular bundles. The powdered leaves had a bitter taste. The water-soluble and ethanol-soluble extractive values were 11% and 16%, respectively, while the moisture content, total ash, and acid-insoluble ash were 8.8%, 8.12%, and 0.47%. HR-LCMS generated 38 tentative database matches, including luteolin. Under the assay conditions used, TLC-densitometry showed an Rf value of 0.54 for luteolin and a mean measured luteolin amount of 3.849 µg. These findings provide baseline physicochemical and preliminary phytochemical data for the standardisation of Sonneratia caseolaris L leaf extract.
Outcome Comparison Between Insulin-Dependent and Non Insulin-Dependent Patients after Open Adult Cardiac Surgery Kurniawaty, Juni; Setianto, Budi Yuli; Supomo, Supomo; Widyastuti, Yunita; Ancilla, Cornelia; Boom, Cindy Elfira
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 3, No 1 (2023): April 2023
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v3i1.66306

Abstract

Background: Insulin-dependent diabetic patients usually have poor glycemic control and higher risk of complications than non-insulin-dependent diabetic patients. However, the difference in clinical outcomes between these two groups of patients who underwent open cardiac surgery was not established. Therefore, this study compares the short-term outcome of insulin vs non-insulin-dependent diabetic patients after open cardiac surgery in a large-scale study.Methods: The study design was a retrospective cohort. All adults who underwent open cardiac surgery between January 1st 2016-December 31st 2020 in 4 tertiary hospitals in Indonesia were included in the study. From a total of 4.931 samples included in the study, 3.753 patients were non-diabetic (Group I) and 1.178 were diabetic (Group II). Group II was divided into subgroup IIA (930 non-insulin-dependent) and subgroup IIB (248 insulin-dependent). The main outcome was in-hospital mortality of open cardiac surgery patients.Result: In-hospital mortality between group I and II had no significant difference (6.8% vs 5.7%; p = 0.188), as well as IIA and IIB (5.6% vs 6%; p = 0.782). Multivariate analysis demonstrated that diabetes did not increase mortality of open cardiac surgery (OR 0.665; p = 0.021). In-hospital mortality of subgroup IIB was higher than subgroup IIA, but insulin therapy did not increase the risk of in-hospital mortality (OR 1.259; p = 0.464).Conclusion: Both insulin-dependent and non-insulin-dependent diabetes mellitus were not the predictors of poor short-term outcomes for open adult cardiac surgery patients.
Co-Authors Ancilla, Cornelia Ansyory, Achmad Kadri Ariani, Novia Arief, Diana Ross Ariyanti, Lusi Mardika Basyar, Fredi Budi Yuli Setianto Cindy Elfira Boom Dachriyanus Dwi Lestari Eka Kumalasari Eka Siswanto Syamsul Eka, Audinah Febrianti, Dwi Rizki Hardi Astuti Witasari Hayatus Sa`adah Hayatus Sa`adah, Hayatus Idriana, Idriana Indra Indra Irhamsah, Muhammad Isananto Winursito, Isananto Juni Kurniawaty Muhdar Abubakar Djayanti Sari Khusnah, Miftahul Nabila Kintoko Kintoko M. Sholahuddin Mario Sarisky Dwi Ellianto Miftahul Huda Musaenah, Musaenah Muzakar Isa Niah, Rakhmadhan NUR KOMALASARI Putri, Sirly Afifah Rahman, Rauli Dimas Nur Ratri Retno Utami Risa Supriningrum RR. Ella Evrita Hestiandari Said, Bagus Moch Sandi, Dita Ayulia Dwi sapri sapri Sari, Desy Nur Indah Satwikanitya, Pani Siswanto, Eka Suhada, Bambang Suharto Suharto Suwarno, Yuli Sya’diyah, Halimatus Uma Fadzilia Arifin, Uma Fadzilia Utami, Hajar Dian Ventyrina, Ine Warnida, Husnul Wibowo, Midarto Dwi Wulandari, Dyah Tantri Yullia Sukawati, Yullia Yunita Widyastuti