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All Journal Journal of Food and Pharmaceutical Science Alchemy : Journal of Chemistry SAINSTIS Indonesian Journal of Cancer Chemoprevention Erudio: Journal of Educational Innovation Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Pharmascience Journal of Islamic Pharmacy Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Majalah Kesehatan FKUB FITOFARMAKA: Jurnal Ilmiah Farmasi Farmasis: Jurnal Sains Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry
Arief Suryadinata
Universitas Islam Negeri Maulana Malik Ibrahim Malang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health

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Journal : Journal of Islamic Pharmacy

 1 
ACTIVITY OF ETHYL ACETATE EXTRACT FROM Chrysophyllum cainito L. LEAVES IN DECREASING BLOOD SUGAR LEVEL IN MALE WISTAR RATS Arrijal, Imam Malikul Hadi; Ma'arif, Burhan; Suryadinata, Arief
Journal of Islamic Pharmacy Vol 3, No 1 (2018): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v3i1.4996

Abstract

The high morbidity or mortality due to diabetes mellitus becomes the world health problem. That fact encourages the study about antidiabetes drugs from natural material especially plants. This study aims to analyze the effect of ethyl acetate extract from Chrysophyllum cainito L. leaves in decreasing of blood sugar level of alloxan-induced male male wistar rats. This research is considered as experimental research with pre and post test randomized controlled group design. The experimental animals in this study were 25 male male wistar rats divided into 5 treatment groups, treatment with CMC-Na (negative control), metformin with the dose of 9 mg/200gBW (positive control), and leaves extract C. cainito dose 25; 50; 75 mg/kgBW. All treatment groups had significant decrease of blood sugar levels at 7, 10 and 14 day observations with p 0.05. While in the day 3 had insignificant decrease of blood sugar level with p 0.05. Every C. cainito leaves extract doses group have the ability to decrease sugar blood level better than negative control, but still below positif control. The optimum dose in decreasing sugar blood level in this study is 75 mg/kg BW.
Kajian Efek Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr) sebagai Antikanker Muti'ah, Roihatul; Listiyana, Anik; Nafisa, Belia Bima; Suryadinata, Arief
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9778

Abstract

Dayak onion (Eleutherine palmifolia (L.) Merr) is a typical plant in Central Kalimantan. This plant has been passed down for generations by Indonesian people for various treatments. The potential of dayak onions that have various pharmacological activities needs to be increased in their use as modern medicinal ingredients. The purpose of this literature study is to review the various uses, the secondary metabolites content, and the action mechanism as an anticancer both in vitro, in vivo, and in silico. The results of this literature study show that traditionally the Indonesian people use the bulbs for the treatment of breast cancer, colon cancer, hypertension, diabetes mellitus, stroke, fever, dysuria, intestinal inflammation, dysentery, boils, cysts, prostate, lowering cholesterol and triglycerides, breastfeeding and sexual disorders. In the empiric treatment of cancer, this plant is used by drying the bulbs and chewing it. Dayak onion bulbs (Eleutherine palmifolia (L.) Merr) are known to contain flavonoid compounds wich isoliquiritigenin, polyphenols group wich oxyresveratrol and naphtoquinon group, and its derivatives such as elecanacine, eleutherine, eleutherol, eleutherinol, eleutherinon, eleuthoside B, eletherinoside A which has anti-cancer activity. Pre-clinical studies with in vitro and in vivo mechanism showed that dayak onion bulbs (Eleutherine palmifolia (L.) Merr) extracts have pharmacological activities, which are anti-cancer that can inhibit cell signaling through apoptosis and cell cycle arrest. Also, the mechanism of in silico showed anti-cancer activity from the inhibition of VHR receptors, BCL-2 receptors, VEGFR-2 receptors and alpha estrogen receptors (ERα).
Analisis Kandungan Logam Berat Cd, Hg, dan Pb Daun Semanggi (Marsilea crenata Presl.) di Desa Semen, Kecamatan Pagu, Kabupaten Kediri Ma'arif, Burhan; Muti'ah, Roihatul; Suryadinata, Arief; Nashichuddin, Ach; Karawid, Galih Elsy
Journal of Islamic Pharmacy Vol 5, No 2 (2020): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v5i2.9356

Abstract

Semanggi (Marsilea crenata Presl.) berpotensi untuk diolah menjadi produk obat herbal karena khasiat yang dimilikinya. Namun, tanaman semanggi (Marsilea crenata Presl.) memiliki kemampuan fitoremediasi sehingga berdampak pada penimbunan logam berat yang berbahaya untuk kesehatan tubuh. Penelitian ini dilakukan untuk mengetahui kandungan logam berat Cd, Hg dan Pb pada daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) untuk dibandingkan dengan Perka BPOM No. 12 tahun 2014 terkait batas logam berat untuk simplisia. Metode yang digunakan yaitu menggunakan Atomic Absorption Spectroscopy (AAS) pada sampel simplisia daun tanaman semanggi dan juga sampel tanah sebagai pembanding. Dari hasil pengujian sampel simplisia daun semanggi di Kabupaten Kediri (Desa Semen, Kecamatan Pagu) terdapat (Cd) dengan kadar 4,16 ppm. Hasil ini menunjukkan tidak memenuhi standar Perka BPOM No. 12 tahun 2014 karena melewati batas minimum Cd sebesar ≤ 0,3 ppm.
Analisis Efektivitas Biaya Terapi Kombinasi Insulin dengan Obat Antidiabetes Oral pada Pasien Rawat Jalan Penderita Diabetes Melitus Tipe 2 di RSUD dr. Soehadi Prijonegoro Sragen Daffa Dhiya Ulhaq; Yen Yen Ari Indrawijaya; Arief Suryadinata
Journal of Islamic Pharmacy Vol 7, No 2 (2022): J. Islamic. Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v7i2.16376

Abstract

Diabetes melitus tipe 2 (DM 2) adalah penyakit kronis menahun karena resistensi insulin atau akibat dari berkurangnya sekresi insulin oleh sel beta pankreas. Pengobatan DM 2 berupa terapi oral dan insulin. Cost-Effectiveness Analysis adalah metode analisis untuk mengambil keputusan alternatif terbaik dari terapi yang digunakan. Tujuan penelitian ini mengetahui efektivitas biaya terapi kombinasi insulin dengan antidiabetes oral (ADO) pada pasien rawat jalan di RSUD dr. Soehadi Prijonegoro Sragen tahun 2021. Metode penelitian ini non-eksperimental deskriptif dengan pengambilan data secara retrospektif. Data yang diambil yaitu data rekam medis pasien rawat jalan DM 2 di RSUD dr. Soehadi Prijonegoro Sragen tahun 2021. Parameter yang digunakan yaitu kadar gula darah puasa (GDP) dan biaya medis langsung meliputi biaya pendaftaran, biaya jasa dokter, biaya obat, dan biaya laboratorium. Pasien yang memenuhi kriteria inklusi sebanyak 49 pasien. Terdapat 5 macam kombinasi obat antidiabetes yang diberikan kepada pasien yaitu insulin + ADO (61,22%), insulin + 2 ADO (8,16%), 2 insulin + ADO (14,28%), 2 insulin + 2 ADO (4,08%), dan insulin + 3 ADO (4,08%). Efektivitas terapi dilihat dari jumlah GDP normal dibagi jumlah total pemeriksaan GDP dikali 100%. Efektivitas terapi tertinggi 100% dan terendah 0%. Biaya medis langsung tertinggi Rp. 1.066.520,- dengan terapi Apidra + Sansulin + Metformin + Pioglitazone. Terapi antidiabetes dengan biaya rendah dan paling efektif yaitu terapi dengan ACER terendah dan ICER negatif yaitu terapi Sansulin + Metformin dengan ACER sebesar Rp. 4.320,- dan ICER sebesar Rp. -13,381,-.
Co-Authors AA Sudharmawan, AA Abdul Hakim Abdul Wafi Ach. Nashichuddin Ahmad, Ananda Rizkia Azizah Akyunul Jannah Almay Abidzar Elpasha Ami Fini Faqiha Amrulloh, Muhammad Firman Anik Listiyana Arrijal, Imam Malikul Hadi Artabah Begum Fauziyah Begum Fauziyah Briliana, Malich Septi Diajeng Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma'arif Burhan Ma’arif Chamlah Ayatillah Daffa Dhiya Ulhaq Denis Dewi Annisa, Dewi Diana Candra Dewi Fahrul Rizki Faisal Akhmal Muslikh Fina Luthfiana Fitria Rahma Fauzia Fitrotun Nasikhatul Maslakhah Fransiska Rosari Dewi Fuadi, Muhammad Nauval Nadhirul Hening Laswati Putra Indradewa, Rhian Janaloka, Nandana Adyuta Karawid, Galih Elsy M. Yogi Riyantama Isjoni Ma'arif , Burhan Ma'arif, Burhan Ma'arif, Burhan Mangestuti Agil Meilina Ratna Dianti Muhammad Afif Muhammad Amiruddin Muti'ah, Roihatul Mutiah, Roihatul Nafisa, Belia Bima Ni Nyoman Sri Budayanti Novia Maulina Nurani, Prasasti Swara Nurwijayanti Pradita Fiqlyanur Isna Primadana Qonita, Kesimira Rani Azzahara Risma Aprinda Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Roihatul Mutiah Sholekhah, Syafirda Arma'atu Suryanto Suryanto Tanaya Jati Dharma Dewi Ulfah, Jauza Wirda Anggraini Wirda Anggraini Yen Yen Ari Indrawijaya