Claim Missing Document
Check
Articles

Evaluation of pH Effect on Conformation of Protein Interaction E-Cadherin…ADTC5 Complex: Molecular Dynamic Simulation Royhanshah, Moch Freskha Fauzi; Anam, Khairul; Hudiyanti, Dwi; Siahaan, Parsaoran
Greensphere: Journal of Environmental Chemistry Vol 3, No 2 (2023): Volume 3 Issue 2 Tahun 2023
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/gjec.2023.20955

Abstract

Abstract. Blood Brain Barrier (BBB) is a barrier located in the brain that controls the delivery of peptide drug to the brain. The difficulties of delivering drugs through BBB is because of E-Cadherin…E-Cadherin interaction that prevent drugs to pass through. ADTC5 has shown positive results to improve drug delivery through the BBB by modulating E-Cadherin…E-Cadherin interaction. Conformation are one of the factors that can affect the modulation stability between E-Cadherin…ADTC5. To analyze the conformation and stability of E-Cadherin…ADTC5 complex throughout the simulation time with pH effect, Molecular Dynamic (MD) method was used to simulate the conformational changes. The results indicate that pH 7.4, E-Cadherin…ADTC5 is the most stable conformation, with the lowest maximum radius gyration value 28.906 Å and the lowest ΔG Binding -168.244 kJ/mol. In the other hand, the most unstable conformation can be seen at pH 2.4, indicated by the positive ΔG Binding values 51,802 kJ/mol, high RMSD average at 2.8 Å and high RMSF fluctuations on residues. 
RETRACTED ARTICLE: THE CORRELATION OF LEARNING INDEPENDENCE ATTITUDES AND STUDENT’S LEARNING ACHIEVEMENT ON PHYSICS LEARNING BASED-PORTFOLIO Saefullah, Asep; Siahaan, Parsaoran; Sari, Ika Mustika
Jurnal Penelitian dan Pembelajaran IPA Vol 3, No 1 (2017): Available Online in May 2017 (Web of Science Indexed)
Publisher : Department of Science Education, Universitas Sultan Ageng Tirtayasa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (279.935 KB) | DOI: 10.30870/jppi.v3i1.1741

Abstract

Abstract This study aimed to determine correlation between learning independence attitudes and student’s learning achievement. Type of this research is a correlation study to detect the connection of learning independence attitude’s variance in relation to learning achievement variance. This study used an attitude scale to measure the student’s learning independence attitude and objective multiple-choice questions to measure the student’s learning achievement. The results showed that  there is a positive correlation (unidirectional) and significant betweenthe learning independence attitude and learning achievement. This means that the better student’s learning independence attitude, it will be the better students learning achievement. The attitude of learning independence contributed to 40.96% of students learning achievement.  Keywords: Learning Independence Attitude, Learning Achievement.
Junior High School Students Scientific Argumentation Skills on Conventional Biotechnology Materials Friska, Reski Ivon; Siahaan, Parsaoran; Hendayana, Sumar
Journal of Educational Sciences Vol 6, No 1: January 2022
Publisher : Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (726.613 KB) | DOI: 10.31258/jes.6.1.p.143-157

Abstract

Argumentation skills are included as an important features for critical thinking that need to be trained to students. Being involved in argumentation leads students to be able to put forward arguments that are supported by data and scientific reasoning. The purpose of this study was to analyze students' scientific argumentation skills on biotechnology material using the Argument-Driven Inquiry (ADI) model. The method in this study used a qualitative descriptive method. Students' scientific argumentation skills during the learning process were analyzed from transcripts of audio recordings and learning videos known as Transcript Based Lesson Analysis (TBLA). The results of this study indicate that learning with the Argument-Driven Inquiry (ADI) model can build students' scientific argumentation skills. The six categories of social negotiation have been identified from student conversations when involved in scientific arguments, but are still dominated by the idea construction components, namely information seeking and elaboration. Meanwhile, the components of criticism of ideas including challenging, supporting, rejecting and defending are not often used by students. This is due to the limited knowledge of students about the material and the low understanding of epistemic arguments where they are not accustomed to using scientific evidence to support their claims.
Junior High School Students' Scientific Argumentation Skills on Conventional Biotechnology Materials Friska, Reski Ivon; Siahaan, Parsaoran; Hendayana, Sumar
Journal of Educational Sciences Vol 6. No. 1. January 2022
Publisher : FKIP-Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jes.6.1.p.146-160

Abstract

Argumentation skills include important features for critical thinking that need to be trained to students. Being involved in argumentation leads students to be able to put forward arguments that are supported by data and scientific reasoning, argue with each other to consider the truth of alternative arguments so as to obtain an agreement that can be accounted for. The purpose of this study was to analyze students' scientific argumentation skills on biotechnology material using the Argument-Driven Inquiry (ADI) model. The method used in this study is a qualitative descriptive method. Students' scientific argumentation skills during the learning process were analyzed from transcripts of audio recordings and learning videos known as Transcript Based Lesson Analysis (TBLA). The results of this study indicate that learning with the Argument-Driven Inquiry (ADI) model can build students' scientific argumentation skills. The six categories of social negotiation have been identified from student conversations when involved in scientific arguments, but are still dominated by the idea construction components, namely information seeking and elaboration. Meanwhile, the components of criticism of ideas including challenging, supporting, rejecting and defending are not often used by students. This is due to the limited knowledge of students about the material and the low understanding of epistemic arguments where they are not accustomed to using scientific evidence to support their claims.
Kitosan sebagai Bahan Dasar Drug Delivery: Studi Interaksi antara Segmen Dimer Kitosan dengan Dipeptida Ac-AD-NH2 dan Ac-PV-NH2 secara Komputasi AB-Initio Imelda F. Saragih; Parsaoran Siahaan
Jurnal Kimia Sains dan Aplikasi Vol 17, No 2 (2014): Volume 17 Issue 2 Year 2014
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (865.868 KB) | DOI: 10.14710/jksa.17.2.58-64

Abstract

Telah dilakukan penelitian tentang optimasi dan interaksi antara molekul dipeptida dan dimer kitosan. Penelitian ini bertujuan untuk mempelajari pembukaan pada junction antar sel yang dilakukan dengan cara memodulasi peptida penyusun khaderinnya. Junction antar sel tersusun atas khaderin-khaderin yang terikat pada membran sel atau disebut dengan istilah trans-membran. Peptida yang digunakan berasal dari sekuens ADT-6 (Ac-ADTPPV-NH2) yaitu Ac-AD-NH2 dan Ac-PV-NH2. Penelitian ini dilakukan dengan metode kuantum ab initio pada tingkat teori dan basis set HF/6-31 G(d,p). Hasil penelitian menunjukkan energi potensial interaksi yang lebih stabil yaitu interaksi dimer kitosan dengan Ac-AD-NH2 konfigurasi 1 sebesar -78,1168 kJ mol-1 Ǻ sedangkan interaksi dimer kitosan dengan Ac-AD-NH2 konfigurasi 2 sebesar -68,6297 kJ mol-1. Segmen dimer kitosan dengan Ac-PV-NH2 konfigurasi 1 yang memiliki energi potensial interaksi sebesar -21,6289 kJ mol-1 sedangkan segmen dimer kitosan dengan Ac-PV-NH2 konfigurasi 2 yang memiliki energi potensial interaksi sebesar -57,6373 kJ mol-1. Kesimpulan adalah interaksi yang lebih stabil antara segmen dimer kitosan dengan peptida Ac-AD-NH2 dan Ac-PV-NH2 terjadi pada konfigurasi 1 dan 2. Aplikasi ke depannya, energi interaksi ini dapat digunakan untuk memprediksikan pelepasan peptida dari kitosan.
Introduction, connection, application, reflection, and extension (ICARE) learning model: The impact on students’ collaboration and communication skills Siahaan, Parsaoran; Dewi, Ermawati; Suhendi, Endi
Jurnal Ilmiah Pendidikan Fisika Al-Biruni Vol 9 No 1 (2020): Jurnal Ilmiah Pendidikan Fisika Al-Biruni
Publisher : Universitas Islam Negeri Raden Intan Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24042/jipfalbiruni.v9i1.5547

Abstract

The 21st-Century skills are skills that must be possessed by students to compete in the era of globalization. The provisioning of these skills to students can go through the physics learning process at school. Introduction, Connection, Application, Reflection, and Extension (ICARE) learning model is one of the learning models that can be applied in Physics learning in high school to train students' skills in critical thinking, creative thinking, communication, and collaboration. The purpose of this study was to determine the improvement of communication and collaboration skills of students after applying the ICARE learning model. The research method used was quasi-experimental with a single-group interrupted time series design. The sample were high school students in one of the Karawang districts, consisting of 12 male students and 15 female students. During the learning activities, students will be given a worksheet with several different questions each meeting tailored to the material being studied, and the answer will be used as a source for analyzing their written communication skills. These questions lead students to be able to communicate the results of their experiments following scientific principles. Experimental activities conducted by students will be analyzed to measure their collaborative skills, and students' presentations will be used to measure their oral communication skills. The improvement of those three aspects was analyzed at each meeting. The results showed that the implementation of learning using the ICARE approach was able to improve the ability of students to collaborate with an average score of 7.87 at the first meeting to 15.93 at the second meeting. While the communication, especially report-writing skills of students, increased from the average of1.53 at the first meeting to 3.6 at the second meeting. The aspect of making presentation material increased from 1.67 to 3.17, and the aspect of oral presentation increased from 1.53 to 3.53 at the second meeting. Based on the results obtained, it can be concluded that students' communication and collaboration skills improve after the ICARE learning model implemented
Comprehensive Teaching Materials Based on Cognitive Conflict Strategies to Reduce Misconception of Calories for Junior High School Students Haryono, Heny Ekawati; Aini, Khafidhoh Nurul; Samsudin, Achmad; Siahaan, Parsaoran
Jurnal Pendidikan Fisika Vol. 9 No. 3 (2021): PENDIDIKAN FISIKA
Publisher : Universitas Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/jpf.v9i3.5224

Abstract

Heat is a material that is close to everyday life. However, most students still have misconceptions about this material. Thus, teachers need to develop teaching materials that can reduce the misconception of heat material. One alternative is to use teaching materials with cognitive conflict strategies. The research aims to develop teaching materials that are able to reduce students' misconceptions about heat material. The development model used is the 4D model which consists of four stages, namely defining, designing, developing, and distributing. The teaching materials developed include lesson plans, textbooks, student worksheets, and tests. The subjects of the study were seventh-grade students in Lamongan regency which consisted of 10 state junior high schools and private junior high schools. The research instrument was a feasibility test sheet for teaching materials and a questionnaire to see students’ responses. Data collection techniques used the feasibility sheet of teaching materials and questionnaires. Therefore, the result shows that cognitive conflict-based teaching materials are appropriate to be used classroom with a score between 3.0 and 3.9 and a reliability coefficient value of more than 90%.  and can reduce misconceptions with a percentage reduction in misunderstandings from 10 junior high schools in the Lamongan regency ranging from 30.3 to 47.8 percent.
Using Non-Traditional Writing Task Strategy to Improve Cognitive Concept Mastery in Learning Science and Identify Self- Regulated Learning Ability Yanthi, Marchelia Dwi; Sinaga, Parlindungan; Siahaan, Parsaoran
Jurnal Pendidikan MIPA Vol 23, No 4 (2022): Jurnal Pendidikan MIPA
Publisher : FKIP Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The purpose of this study was to determine the effectiveness of writing task non�traditional strategies in improving students ' Concept mastery and to identify students' self�regulated learning profiles. The research method used was a quasi-experimental design with theresearch design Non-Equivalent Control Group Design. The population in this study were allstudents of class VIII at a junior high school in Bandung. The sample in this study consisted of64 students of class VIII at a junior high school in Bandung who were selected using apurposive sampling technique. The instruments used in this study were mastery of studentconcept tests and self-regulated learning questionnaires. The result of analysis using thepercentage of gain normalized showed that the strategy of writing task non-traditional was moreeffective in improving the mastery of student concepts. The result of descriptive analysis toobtain the self-regulated learning profile of students showed that in the experimental class andcontrol class were mostly in the moderate category. The relationship between mastery of studentconcepts and self-regulated learning profiles based on the results of the correlation test analysisclassified as low criteria.  Keywords: non-traditional writing tasks, concept mastery, self-regulated learning DOI: http://dx.doi.org/10.23960/jpmipa/v23i4.pp1561-1571
ICARE-U Learning Model to Improve Critical Thinking Skills of High School Students in Indonesia Yenni, Rozi Prima; Siahaan, Parsaoran; Suwarma, Irma Rahma
Jurnal Pendidikan MIPA Vol 23, No 2 (2022): Jurnal Pendidikan MIPA
Publisher : FKIP Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Critical thinking is one of the skills that are widely trained in the field of natural science studies. The study was conducted at a high school in the city of Padang to determine the effectiveness of ICARE-U learning (Introduction, Connection, Application, Reflection, Extension and Utility) on students' critical thinking skills in the matter of effort and energy. The research method used is pre-experimental with one group pretest posttest design. The research sample consisted of one class 10 high school as many as 31 people. Critical thinking skills are viewed from 5 aspects, namely elementary clarification, basic support, inference, advanced clarification, strategy and tactics. Based on the results of the n-gain on students' critical thinking skills with the ICARE-U learning model, a score of 0.4 was obtained. A score of 0.4 means that students' critical thinking skills before and after being given treatment have increased in the moderate category. Reviewing the critical thinking skills aspect, it is known that the advanced clarification aspect is still experiencing a low increase. Based on the results of hypothesis testing, it was found that the ICARE-U learning model was effectively used to improve students' critical thinking skills in the matter of effort and energy. Keywords: Critical thinking skils, ICARE-U learning model, work and energy. DOI: http://dx.doi.org/10.23960/jpmipa/v23i2.pp585-594
Development of Interactive e-Learning Media on Environmental Pollution using Prezi Farach, Nurul; Rahman, Taufik; Siahaan, Parsaoran
Jurnal Pendidikan MIPA Vol 23, No 2 (2022): Jurnal Pendidikan MIPA
Publisher : FKIP Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aims to develop an interactive learning media application based on Prezi. The methodology used in this study is the ADDIE method with a sample of class VII students. Data collection techniques were carried out through media experts and material experts including media and material expert validation questionnaires, student observation sheets, interview sheets, pretest-posttest sheets and response questionnaires. The results showed that the application of Prezi-based learning media had a media feasibility effect of 95% with very decent criteria and 95% on Prezi-based learning outcomes, with very good criteria. Student responses resulted in an average of 87% with very interesting criteria besides the results of the N-gain analysis of 0.73 which was included in the high category. effectively used in the learning process. Keywords: e-learning, interactive learning media, Prezi. DOI: http://dx.doi.org/10.23960/jpmipa/v23i2.pp554-568
Co-Authors A. Suhandi A.F.C Wijaya A.F.C. Wijaya Achmad Samsudin Ade Rahmani ADI YULANDI Agus Subagio Amsor, Amsor Anam, M. Khairul Anggi Hanif Setyadin Anugrah Ricky Wijaya Anugrah, Daru Seto Bagus ARIF HIDAYAT Asep Saefullah Atiatul Manna Ayub Indra Badri Rahmatulloh Bambang Cahyono Bani Amanullah Prasojo Bungaran David Simanjuntak Choiril Azmiyawati Cynthia L. Radiman Cynthia L. Radiman Desita Triana Dieter Ziessow Dieter Ziessow Diky Yopianto Dwi Hudiyanti Dwi Hudiyanti E. Suhendi Efendi, Ridwan Eka Liandari Endang Sawitri Endi Suhendi Ermawati Dewi Ermawati Dewi, Ermawati Farach, Nurul Febriani Sinambela Friska, Reski Ivon Fungky Iqlima Nasyidiah Gadis Argi Kiranti Hendri Widiyandari Heni Rusnayati Heny Ekawati Haryono Hildayani, Suci I Gusti Bagus Wiksuana Ida Kaniawati Ika Mustika Sari Imelda F. Saragih Isnaini Isnaini Isnaini Isnaini Khafidhoh Nurul Aini, Khafidhoh Nurul Khairul Anam KL Putri Laura Virdy Darmalim Liana Dewi Nuratikah Marchelia Dwi Yanthi Marlyn Dian Laksitorini Marlyn Dian Laksitorini Marta J. Sipangkar Mohd Hafiz Dzarfan Othman Mr Sumar Hendayana Muhamad A. Martoprawiro Muhamad A. Martoprawiro Muhammad Cholid Djunaidi Nadira Cahyaning Mentari Nanik Wijayanti Nastiti Nastiti Nia Kurniasih Nor Basid Adiwibawa Prasetya Nurbani, Anggita Repsi Nurwarrohman Andre Sasongko Parlindungan Sinaga Permono Adi Putro Purwanto, Purwanto Putra Habib Dhitareka Redemtus Heru Tjahjana Restina Septiani Retno Ariadi Lusiana Rikno Budiyanto Risda Destari Royhanshah, Moch Freskha Fauzi Sasmita, Dedi Sekar Kusuma Dewi Simanjuntak, Bungaran David Sri Haryanti Suci Hildayani Suci Zulaikha Hildayani Suhartana Suhartana Susanto Imam Rahayu Susanto Imam Rahayu Tantri Nevi Astuti Taufik Rahman Tri Endro Pranowo Tri Windarti Unang Purwana Ustera Octovindra Wiedyanto Vina Rilantinawati Vivitri Dewi Prasasty Wahyu Setiabudi Wawan Setiawan Wempie Gressangga Yanthi, Marchelia Dwi Yenni, Rozi Prima Yunina Surtiana