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All Journal Reaktor SAINS DAN MATEMATIKA JURNAL KIMIA SAINS DAN APLIKASI Jurnal Ilmu Lingkungan Alchemy : Journal of Chemistry Indonesian Journal of Cancer Chemoprevention Jurnal Riset Kimia Alchemy Jurnal Penelitian Kimia Indonesian Journal of Chemical Science Chimica et Natura Acta Akta Kimia Indonesia Indonesia Journal of Halal Molekul: Jurnal Ilmiah Kimia Journal of Telenursing (JOTING) International Journal Of Science, Technology & Management (IJSTM) Greensphere: Journal of Environmental Chemistry Prosiding Seminar Nasional Universitas Serambi Mekkah Jurnal Riptek International Journal of Cell and Biomedical Science
Meiny Suzery
Department Of Chemistry, Diponegoro University, Jl. Prof. Soedarto, Kampus Undip Tembalang, Semarang 50275
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Social Sciences Transportation Other

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Application of Bioinformatics Analysis to Identify Important Pathways and Hub Genes in Breast Cancer Affected by HER-2 Tjipta, Arya; Hermansyah, Dedy; Suzery, Meiny; Cahyono, Bambang; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.11

Abstract

Human epidermal growth factor receptor 2 (HER-2) is used as a marker for the diagnosis and prognosis of breast cancer. However, the molecular mechanisms involving HER2 in breast cancer require further study. Herein, we used the bioinformatics approaches to identify important pathways and hub genes in breast cancer affected by HER-2. The results showed that HER-2 is highly expressed in ovarian cancer and is closely related to the overall survival and progression-free survival of breast cancer. A total of 3014 downregulated genes and 4121 upregulated genes were identified under Gene Expression Omnibus (GEO) database with the GEO2R tool. Among them, the top 10 hub genes including CCNB1, KIF11, BUB1B, TOP2A, ASPM, MAD2L1, BUB1, RRM2, EGFR, and FN1 demonstrated by connectivity degree in the protein-protein interaction (PPI) network were screened out. In Kaplan–Meier plotter survival analysis, the overexpression of CCNB1, EGFR, MAD2L1, ASPM, and RRM2 were shown to be associated with an unfavourable prognosis in HER-2 positive breast cancer patients. In conclusion, we have identified important signalling pathways involving HER-2 that affect breast cancer. These findings could provide new insights outlining mechanisms involving HER-2 gene expression in breast cancer and provides a rationale for the novel treatment of breast cancer.
Analisis Pemahaman UMKM di Kota Semarang terhadap Kebijakan Produk Halal Widayat, Widayat; Suzery, Meiny; Ardianto, Hendra Try
Jurnal Riptek Vol 16, No 2 (2022)
Publisher : Badan Riset dan Inovasi Daerah Kota Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (573.591 KB) | DOI: 10.35475/riptek.v16i2.170

Abstract

The COVID-19 pandemic has had a significant economic impact. The second Sustainable Development Goals are eliminating hunger, achieving food security and good nutrition. The Government of Indonesia has carried out and implemented Law Number 33 of 2014 concerning Guarantees for Halal Products, since 2019. Indonesia is targeting to become the Center for Halal Food Products in the world in 2024. Micro, Small and Medium Enterprises (MSMEs) have a very important role in the Indonesian economy given their great potential in increasing public welfare. The number of MSMEs in Indonesia reached 64.2 million with a contribution to the gross domestic product (GDP) of 61.07% or 8,573.89 trillion. MSMEs are able to absorb 97% of the total workforce and are able to collect up to 60.42% of total investment in Indonesia. To achieve the government's target to become the center of world halal products and continue to contribute to the Indonesian economy, MSMEs have problems in terms of halal certification. This requires intensive study. The Semarang City Government already has Regional Regulation Number 1 of 2021 concerning halal food products. Local governments have an obligation to protect the public from consuming food and beverages that are not guaranteed to be halal. This research is a qualitative research where the respondents used are MSME actors spread across the city of Semarang. The number of MSMEs in Seamarang City until March 2022 was recorded at 23,984 business actors. This study aims to identify problems related to halal certification for MSMEs, understanding, willingness and increasing understanding and willingness in halal certification. The results the profile of MSMEs in Semarang City is Micro Industry and do not have Business License Codes /Nomor Ijin Berusaha (NIB). The MSMEs do not understand about policy Halal Certificate Product about 84%. They don’t also understand about SIHALAL and self-declare / Sertifikasi Halal Gratis respectively 90% and 72%.
Nanoenkapsulasi Hiptolida dari Hyptis pectinata (L.) Poit dengan Kitosan, Pektin, dan TPP menggunakan Metode Koaservasi Kompleks Nur'aini, Luthfiah Putri; Cahyono, Bambang; Wibowa, Pratama Jujur; Suzery, Meiny
Chimica et Natura Acta Vol 12, No 2 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n2.50657

Abstract

Telah dilakukan enkapsulasi hiptolida dengan penyalut kitosan, pektin, dan tripolifosfat (TPP) menggunakan metode koaservasi kompleks. Proses enkapsulasi dibuat dalam bentuk empat formula: formula 1 kitosan (BM = 500 KDa) 1% dan pektin 0,05%; formula 2 kitosan (BM = 168 KDa) 1% dan pektin 0,05%; formula 3 kitosan (BM = 168 KDa) 1% dan pektin 0,05% yang disertai perlakuan sonikasi; formula 4 kitosan 0,04%, pektin 0,08%, dan TPP 0,01%. Karakterisasi ukuran partikel formula enkapsulasi menggunakan particle size analyzer (PSA), efisiensi enkapsulasi (EE) menggunakan spektrofotometer UV-Vis, dan interaksi gugus fungsi hiptolida dalam masing-masing formula menggunakan spektrometer Raman. Hasil karakterisasi ukuran partikel formula 1 diperoleh 111,885 µm, formula 2 sebesar 118,389 µm, formula 3 sebesar 118,388 µm, dan formula 4 yaitu 20,578 nm, dengan efisiensi enkapsulasi 97,801%. Berdasarkan penelitian yang telah dilakukan, disimpulkan bahwa formula 4 dengan komposisi kitosan 0,04%, pektin 0,08%, dan TPP 0,01% merupakan formula optimum enkapsulasi hiptolida yang mampu membentuk nanopartikel berukuran 20,578 nm.
Cytotoxic Activity of Hyptis Pectinate Extracts on MCF-7 Human Breast Cancer Cells Amalina, Nur Dina; Suzery, Meiny; Cahyono, Bambang
Indonesian Journal of Cancer Chemoprevention Vol 11, No 1 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss1pp1-6

Abstract

Hyptis pectinata (L.) poit, popularly known in the world as “comb bushmint” is a medicinal plant commonly used for the treatment of throat and skin inflammations, bacterial infection, pain and cancer. The objective of this research is to determine the cytotoxic and antiproliferative effect under Hyptis pectinata ethanolic extract (HPE) treatment on breast cancer cells. The effect HPE of on cytotoxicity was examined by MTT assay on MCF-7 breast cancer cells. This assay also used to determine cell proliferation over 3 days of treatment with 1.5 – 100 µg/mL HPE. HPE showed that exhibited cytotoxic effects with IC50 value of 30 µg/mL for 24 hours and changes the physiological morphology on MCF-7 cells. Interestingly, the treatment of HPE for 48 and 72 hours highly decreases cell viability on MCF-7 with dose and time-dependent manner compared to untreated cells. These results indicate that HPE has antiproliferative activities and maybe the potential to be developed as a natural chemotherapeutic agent.Keywords: Hyptis pectinata (L.) poit extract, cytotoxicity, antiproliferative, MCF-7 cells
Analysis of Total Phenolics, Flavonoids, and Antioxidant Activity of Cashew Leaf Extract (Anacardium occidentale L.) with Varying Ethanol Concentrations: Analisis Total Fenolik, Flavonoid, dan Aktivitas Antioksidan Ekstrak Daun Jambu Mete (Anacardium occidentale L.) dengan Variasi Konsentrasi Etanol Kurniasari, Risma; Suzery, Meiny; Cahyono, Bambang
Jurnal Riset Kimia Vol. 15 No. 2 (2024): September
Publisher : Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jrk.v15i2.735

Abstract

This study evaluated the effectiveness of various ethanol concentrations (50%, 70%, and 96%) in extracting bioactive compounds from cashew leaves (Anacardium occidentale). Parameters analyzed included total phenolics, total flavonoids, and antioxidant activity using the DPPH and H2O2 methods. The results showed that the 70% ethanol extract produced the highest total phenolic and flavonoid content as well as significant antioxidant activity compared to other ethanol concentrations. This study offers practical insights for pharmaceutical, cosmetic, and nutraceutical industries in selecting the optimal solvents for cashew leaf extraction. Additionally, the analysis showed that the 70% ethanol extract offered an optimal balance between extraction efficiency and antioxidant activity, making it the most efficient solvent for commercial use.
Effects of Temperature and Heating Time on Degradation and Antioxidant Activity of Anthocyanin from Roselle Petals (Hibiscus sabdariffa L.) Suzery, Meiny; Nudin, Burhan; Nurwahyu Bima, Damar; Cahyono, Bambang
International Journal of Science, Technology & Management Vol. 1 No. 4 (2020): November 2020
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v1i4.78

Abstract

The effects of temperature and heating time on the degradation and antioxidant activity of anthocyanin compounds from roselle petals (Hibiscus sabdariffa L.) have been evaluated from this research. The purpose of this study is to determine, the degradation and antioxidant activity of anthocyanin compounds on variations of temperature and heating time. In this study anthocyanin was extracted from roselle petals using ethanol solvent at 25oC. Then the anthocyanin extract obtained was dissolved into aqueous solution. The solution was then heated at 40oC, 60oC and 80oC for 60 minutes. The degradation of anthocyanin compounds was analyzed by calculating the total of anthocyanin contents, while the antioxidant activity was evaluated using the DPPH method. The results showed that Total Anthocyanin Content (TAC) from the extract solution before heating was 144.28 mg/L. Meanwhile the total value of anthocyanin in the 60 minutes after heating at 400C, 600C and 800C are 108.88 mg/L, 88.84 mg/L and 63.78 mg/L respectively. Heating at 80oC decreases antioxidant activity by increasing the IC50 value to 86.8 ppm higher than the conditions before heating. The increase of temperature and length of the heating process made the anthocyanin structure degraded. Degradation was indicated by the reduction of total anthocyanin content and the decrease of antioxidant activity.
Co-Authors . Widayat A.A. Ketut Agung Cahyawan W Agustini, Dewi Meliati Ahmad Ni’matullah, Albaari Al-Baarri, Ahmad Ni'matullah Al-Baarri, Ahmad Ni’matullah Amalina, Nur Dina Aminin, Agustin L.N. Bambang Cahyono Budianto, Irawan Arief Christiana Suci Prihatini Citra Agustina Isnaning Damar Nurwahyu Bima Dedy Hermansyah Dwi Hudiyanti Elvira Yunita Ely Kusniawati H Hadiyanto Hadiyanto Hadiyanto Hantoro Satriadi Hendarko, Sriani Hendra Try Ardianto Iqbal Mubarak Irawan Arif Budianto Ismiyarto Ismitarto Kurdianto Kurdianto Kurniasari, Risma M Cholid Djunaidi, M Cholid M. Cholid Djunaidi Maria Eka Patri Y Marini . Merry Gultom Nazli, Nazli Neni Susilaningsih Nike Rizky Prahesti, Nike Rizky Nudin, Burhan Nur'aini, Luthfiah Putri Priyosetyoko Priyosetyoko, Priyosetyoko Pusaka, Semerdanta Putri Pratiwi Putri, Adhina Choiri Raisi Aga Oktavi Sestri Bela Pratiwi Suhartono, Suhartono Sulistyowati Sulistyowati Suradi, Agus Sylvia Rahmi Putri Tjipta, Arya Tri Winarni Agustini Tri Winarni, Agustini Wibowa, Pratama Jujur Widayadi, Eko YS Darmanto Yuliyandjaja, John Philia Yusi Luluk, Rahmania Zainal Arifin Zhafran Hafizhki