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PENGARUH JENIS IKAN TERHADAP RENDEMEN PEMBUATAN GELATIN DARI IKAN DAN KARAKTERISTIK GELATINNYA Agustini, Tri Winarni; Widayat, W; Suzery, Meiny; Darmanto, YS; Mubarak, Iqbal
Indonesia Journal of Halal Vol.2 (2) 2019
Publisher : Pusat Kajian Halal Undip

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.403 KB) | DOI: 10.14710/halal.v2i2.7342

Abstract

Gelatin merupakan protein sederhana dari hasil hidrolisis kolagen yang dapat berubah bentuk sol ke bentuk gel secara reversible. Indonesia masih melakukan import dari negara Australia, China, Jerman, Jepang, dan Perancis. Import gelatin pada tahun 2014 mencapai 601.681 Kg. Gelatin mayoritas di produksi dari bahan baku kulit babi (46%), kulit sapi (29,4%), daging dan tulang babi (23,1%). Gelatin yang dibuat dengan katalis asam maka digolongkan dalam gelatin tipe A. Penelitian bertujuan untuk menghasilkan gelatin yang halal dengan bahan baku dari berbagai produk-produk perikanan. Secara khusus dikaji dari 3 jenis ikan yaitu ikan nila, ikan pari dan ikan kakap merah. Percobaan dilakukan proses pembuatan gelatin dengan tahap degreasing (pemisahan), demineralisasi (perendaman asam sitrat), ekstraksi (dilakukan perendaman aquadest diatas kompor), pengeringan (pengeringan pada oven). Hasil penelitian menunjukkan bahwa studi karakteristik bahan baku berupa kadar air, rendemen, kekuatan gel, viskositas, pH, uji organoleptik sangat beragam.
Analisis Aktivitas Antiglikasi pada Berbagai Konsentrasi Ekstrak Etanol dari Produk Fermentasi Daun Matoa Putri, Adhina Choiri; Suzery, Meiny; Aminin, Agustin L.N.
Greensphere: Journal of Environmental Chemistry Vol 3, No 2 (2023): Volume 3 Issue 2 Tahun 2023
Publisher : Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/gjec.2023.21369

Abstract

Penyebab penyakit degeneratif salah satunya disebabkan oleh kondisi penurunan fungsi organ dalam tubuh yang dapat ditandai dari kerusakan struktur protein. Reaksi glikasi protein yang menghasilkan produk amadori mengarah pada pembentukan AGEs (Advanced Glycation End Products) yang bersifat radikal. Senyawa antiglikasi memiliki potensi menghambat kerusakan protein lebih lanjut. Metode solid state fermentation (SSF) menggunakan Aspergillus niger dapat menghasilkan enzim yang melimpah, yang berkontribusi terhadap degradasi makromolekul dan mampu meningkatkan bioaktivitasnya. Penelitian ini berfokus pada penentuan aktivitas antiglikasi produk fermentasi daun matoa. Variasi konsentrasi pada pengujian aktivitas antiglikasi dilakukan pada konsentrasi 50 hingga 1000 ppm. Data menunjukkan persen inhibisi produk fermentasi lebih rendah dibanding produk non-fermentasi. Semakin tinggi konsentrasi yang digunakan maka semakin tinggi persen inhibisinya. Variasi konsentrasi menunjukkan adanya pengaruh yang signifikan terhadap penurunan aktivitas antiglikasi (p<0,05). Aktivitas antiglikasi daun matoa sebelum dan sesudah fermentasi masuk dalam kategori sedang (medium).
Application of Bioinformatics Analysis to Identify Important Pathways and Hub Genes in Breast Cancer Affected by HER-2 Tjipta, Arya; Hermansyah, Dedy; Suzery, Meiny; Cahyono, Bambang; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.11

Abstract

Human epidermal growth factor receptor 2 (HER-2) is used as a marker for the diagnosis and prognosis of breast cancer. However, the molecular mechanisms involving HER2 in breast cancer require further study. Herein, we used the bioinformatics approaches to identify important pathways and hub genes in breast cancer affected by HER-2. The results showed that HER-2 is highly expressed in ovarian cancer and is closely related to the overall survival and progression-free survival of breast cancer. A total of 3014 downregulated genes and 4121 upregulated genes were identified under Gene Expression Omnibus (GEO) database with the GEO2R tool. Among them, the top 10 hub genes including CCNB1, KIF11, BUB1B, TOP2A, ASPM, MAD2L1, BUB1, RRM2, EGFR, and FN1 demonstrated by connectivity degree in the protein-protein interaction (PPI) network were screened out. In Kaplan–Meier plotter survival analysis, the overexpression of CCNB1, EGFR, MAD2L1, ASPM, and RRM2 were shown to be associated with an unfavourable prognosis in HER-2 positive breast cancer patients. In conclusion, we have identified important signalling pathways involving HER-2 that affect breast cancer. These findings could provide new insights outlining mechanisms involving HER-2 gene expression in breast cancer and provides a rationale for the novel treatment of breast cancer.
Analisis Pemahaman UMKM di Kota Semarang terhadap Kebijakan Produk Halal Widayat, Widayat; Suzery, Meiny; Ardianto, Hendra Try
Jurnal Riptek Vol 16, No 2 (2022)
Publisher : Badan Riset dan Inovasi Daerah Kota Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (573.591 KB) | DOI: 10.35475/riptek.v16i2.170

Abstract

The COVID-19 pandemic has had a significant economic impact. The second Sustainable Development Goals are eliminating hunger, achieving food security and good nutrition. The Government of Indonesia has carried out and implemented Law Number 33 of 2014 concerning Guarantees for Halal Products, since 2019. Indonesia is targeting to become the Center for Halal Food Products in the world in 2024. Micro, Small and Medium Enterprises (MSMEs) have a very important role in the Indonesian economy given their great potential in increasing public welfare. The number of MSMEs in Indonesia reached 64.2 million with a contribution to the gross domestic product (GDP) of 61.07% or 8,573.89 trillion. MSMEs are able to absorb 97% of the total workforce and are able to collect up to 60.42% of total investment in Indonesia. To achieve the government's target to become the center of world halal products and continue to contribute to the Indonesian economy, MSMEs have problems in terms of halal certification. This requires intensive study. The Semarang City Government already has Regional Regulation Number 1 of 2021 concerning halal food products. Local governments have an obligation to protect the public from consuming food and beverages that are not guaranteed to be halal. This research is a qualitative research where the respondents used are MSME actors spread across the city of Semarang. The number of MSMEs in Seamarang City until March 2022 was recorded at 23,984 business actors. This study aims to identify problems related to halal certification for MSMEs, understanding, willingness and increasing understanding and willingness in halal certification. The results the profile of MSMEs in Semarang City is Micro Industry and do not have Business License Codes /Nomor Ijin Berusaha (NIB). The MSMEs do not understand about policy Halal Certificate Product about 84%. They don’t also understand about SIHALAL and self-declare / Sertifikasi Halal Gratis respectively 90% and 72%.