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All Journal Jurnal Sain Veteriner Jurnal Medik Veteriner Vitek : Bidang Kedokteran Hewan Ovozoa: Journal of Animal Reproduction Indian Journal of Forensic Medicine & Toxicology journal of Basic Medical Veterinary MANDALIKA VETERINARY JOURNAL
Lita Rakhma Yustinasari
Department Of Veterinary Anatomy, Faculty Of Veterinary Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Neoplasia of the Nictitating Membrane in A Domestic Short- Haired Cat based on Cytology of Fine Needle Aspiration Fatimah Alaydrus; Lita Rakhma Yustinasari; Juliano Mwenda Ntoruru
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16858

Abstract

A 3-year-oldmaledomestic short-hairedcat was presented with the complain ofa dark red mass of thenictitating membrane of the right eyecovered most of the cornea, mucopurulent eye secret, lost appetite,medium dehydration, and cough. Physical examination was performed and showedhigh temperature (38,6°C).Ultrasonographic examination was not performed due to tool limitations. Cytologyof fine-needle aspirationmasses suggested an ophthalmic neoplasm with the characteristic of neutrophils infiltration, multinecluatedgiant cells, and cells having glanular cytoplasm.Enucleation bulbi was performed subsequentlyto exenterationthe eye and the contents of the orbit.
Management of Urolithiasis in Cat with Special Diets Steven Taufic Leo; Lita Rakhma Yustinasari; Juliano Mwenda Ntoruru
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17093

Abstract

Introduction: The current study is focused on the treatment of a cat with urolithiasis. The main goal is tohelp provide a greater understanding of how to treat the cat with special diets.Case Description: Struvite urolithiasis was found in a 3-year-old female domestic short-haired cat withthe complaint of straining for a week during urination. Ultrasonographs indicated the existence of twocalculi in the bladder that were also detected by radiographic examination (7 mm in diameter each). Bladderstones were getting smaller by dissolution diets therapy. In this case, the cat was treated by melox 1.5 mg/ml (dosage 0.1 mg/kgBW) for 14 days, tramadol for 28 days (2mg/kg BW) and also special diets (struvite).Conclusion: After a month treatment,the stones were almost cannot be seen radiographically. This reportdescribes a cat with urolithiasis case which was successfully treated with special diets for struvite withoutany surgery.
Mozart KV 448 Menurunkan Densitas dan Aktivitas Neuroglia Hipokampus Mencit (Mus musculus) Selama Stres Prenatal No. 416-KE Shelly Kusumarini; Lita Rakhma Yustinasari; Eka Pramystha Hestianah; Suryo Kuncorojati; Tutik Juniastuti
Jurnal Sain Veteriner Vol 35, No 1 (2017): Juni
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1258.378 KB) | DOI: 10.22146/jsv.29279

Abstract

The aim of this research was to explore the influence of Mozart KV 448 classical music therapy to the neuroglia cells of mice’s hippocampus that were exposed to stress during prenatal. This research were employing twenty female mices and twenty male mices. Female mices were estrus synchronized with PMSG and hCG then monomating to the males. Pregnant females were then divided into four groups (P0, P1, P2, P3). P0 was as control, P1 was treated by one minute forced swim test, P2 was treated by one minute forced swim test followed by thirtyminutes classical music Mozart KV 448 and P3 was treated by one minute forced swim test followed by sixty minutes classical music Mozart KV 448. This research was carried out for twenty-one days during gestation period. The neuroglia density result was analyzed using ANOVA and Duncan test. The neuroglia activity result wasanalyzed using Kruskal wallis test and Z test. The histology reading showed degradation of density and activity of hippocampus neuroglia.
Uji Aktivitas Antibakteri dari Ekstrak n-Heksana dan Kloroform Daun Sirsak (Annona muricate L.) Terhadap Pertumbuhan Bakteri Staphylococcus aureus Secara In Vitro Lake, Werenfridus Kono; Hamid, Iwan Sahrial; Saputro, Amung Logam; Plumeriastuti, Hani; Yustinasari, Lita Rakhma; Yunita, Maya Nurwartanti
Jurnal Medik Veteriner Vol. 2 No. 1 (2019): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.135 KB) | DOI: 10.20473/jmv.vol2.iss1.2019.60-65

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri daun sirsak terhadap Staphylococcus aureus. Ekstraksi diproses dengan metode maserasi terlebih dahulu dengan n-heksana kemudian kloroform. Aktivitas antibakteri diukur secara in vitro dengan menggunakan metode difusi agar menggunakan paperdisk. Aktivitas antibakteri diuji dengan analisis variansi (ANOVA) dengan nilai signifikansi 0,5% untuk mengetahui pengobatan mana yang memiliki efek atau berbeda secara signifikan dengan dosis masing-masing 300 mg/ml, 250 mg/ml, 200 mg/ml, 150 mg/ml, 100 mg/ml dan menghasilkan aktivitas antibakteri dengan zona hambat berturut-turut 16,70 mm; 14,05 mm; 11,45 mm; 9,85 mm; 3,00. Hasil pemeriksaan aktivitas antibakteri menunjukkan ekstrak n-heksana dan kloroform dapat menghambat pertumbuhan Staphylococcus aureus pada konsentrasi 250 mg / ml dengan diameter zona hambat 14,05 mm. Ekstrak dengan aktivitas tertinggi ditentukan konsentrasi hambat tumbuh minimum (MIC). Ekstrak kloroform daun sirsak dari bakteri Staphylococcus aureus yang berada pada konsentrasi 100 mg/ml dengan zona hambat 3,00 mm.
THE EFFECT OF POLYPROPYLENE PLASTIC RESIDUE ON HEATED PALM OIL AGAINST HISTOPATHOLOGICAL CHANGES OF SMALL INTESTINE ON MALE WHITE RAT (Rattus norvegicus) WISTAR STRAIN Amaris, Aulia Puspa; Yustinasari, Lita Rakhma; Legowo, Djoko; Plumeriastuti, Hani; Anwar, Chairul; Hidajati, Nove
Journal of Basic Medical Veterinary Vol. 8 No. 2 (2019): Journal of Basic Medical Veterinary, December 2019
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/.v8i2.20409

Abstract

This study was conducted to investigate the effect of polypropylene residue on heated palm oil against histopathological changes of small intestine on male white rat (Rattus norvegicus) wistar strain. Eighteen male white rats divided into three groups and were administered via peroral gavage with different treatments for five weeks. The treatment were Control (84 grams palm oil), P1 (84 grams palm oil with 2.3 grams plastic), and P2 (84 grams palm oil with 6.81 grams plastic). The histopathological changes of small intestine were examined by using Barthel Scoring method was analysed using Kruskal Wallis and continued with Mann-Whitney test. The result showed that were significant difference (p<0.05) between treatment groups. The worse damage of polypropylene plastic residue was 6.81 grams.
Porang (Amorphophallus oncophyllus) tuber extract improved the histopathological features of diabetic rat (Rattus norvegicus) testicles Dwi Puspa Sukma Viranda; Rochmah Kurnijasanti; Kadek Rachmawati; Iwan Sahrial Hamid; Pudji Srianto; Hani Plumeriastuti; Lita Rakhma Yustinasari
Ovozoa: Journal of Animal Reproduction Vol. 13 No. 1 (2024): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v13i1.2024.47-57

Abstract

This study aims to determine the effect of porang (Amorphophallus oncophyllus) tuber extract on the histopathological features of the testicle of alloxan induced rats (Rattus norvegicus). Thirty male rats were randomly divided into six groups. Rats in group C- were injected with distilled water, while rats in groups C+, T0, T1, T2, and T3 were injected with 120 mg/kg bw alloxan. Blood glucose was measured three days after alloxan injection. Rats in groups C- and C+ were then administered with 1% Na-CMC, whereas rats in groups T0, T1, T2, and T3 were then administered with 45mg/kg bw metformin, and 100, 200, and 400 mg/kg bw of porang tuber extract, respectively. All solution were given orally once every day for 14 days. Spermatogenic activity was assessed using the Johnsen scoring system and analyzed by Kruskal-Wallis, followed by the Mann-Whitney test. The diameter and epithelial thickness of the seminiferous tubule were measured using image raster software and analyzed using Anova followed by Duncan's test. The results showed that spermatogenesis score, diameter, and epithelial thickness of seminiferous tubule of group C+ were smaller (p <0.05) than group C-. Spermatogenesis scores of groups T0, T1, T2, and T3 were higher (p <0.05) than group C+. Seminiferous tubule diameter and epithelial thickness in groups T0, T1, and T2 were greater (p <0.05) than group C+. It could be concluded that porang tuber extract at a dose of 200 mg/kg bw improved the spermatogenesis score, diameter seminiferous tubule, and thickness of the epithelium of diabetic rats.
Effect of ethanolic extract of Moringa oleifera leaves on the number of spermatogenic cells and Leydig cells of gentamicin-induced rats Ngizzah, Nailul; Wurlina Wurlina; Poedji Hastutiek; Iwan Sahrial Hamid; Eka Pramyrtha Hestianah; Lita Rakhma Yustinasari
Ovozoa: Journal of Animal Reproduction Vol. 12 No. 2 (2023): Ovozoa: Journal of Animal Reproduction
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ovz.v12i2.2023.99-106

Abstract

This study aimed to determine the effect of the administration of ethanolic extract of Moringa oleifera leaves on the number of spermatogenic and Leydig cells of gentamicin-induced rats (Rattus norvegicus). This study used 25 white male rats divided randomly into five groups. The rats were injected with Gentamicin 5 mg/kg bw/day subcutaneously for 14 days, except for the negative control group (NCG). During the next 14 days, the rats were given oral moringa leaf extract of 200, 316, and 500 mg/kg bw/day respectively for E200, E316, and E500 groups. The data were analyzed with one-way ANOVA followed by Duncan's test. The results showed that the number of spermatogonia, spermatocytes, and spermatids in NCG was higher (p <0.05) than in the other groups. The number of spermatogonia, spermatocytes, and spermatids in the E316 group was higher (p <0.05) than in PCG. The number of spermatogonia in the E500 group was higher (p <0.05) than in the E316 group, but the number of spermatocytes and spermatids in the E316 group was similar (p >0.05) to the E500 group. The number of PCG Leydig cells was the smallest (p <0.05) compared to the other groups. The administration of Moringa leaves extract in the E200 and E316 groups increased (p <0.05) the number of Leydig cells compared to PCG. The number of Leydig PCG cells in the E500 group was not significantly different (p >0.05) from that of the NCG. It could be concluded that administration of Moringa oleifera leaves extract restored the number of spermatogenic and Leydig cells of gentamicin-induced rats.
Antibiotic Resistance of Escherichia coli Bacteria in Cattle: Challenges to Food Self-Sufficiency in Indonesia Alfiana Laili Dwi Agustin; Novarina Sulsia Ista'In Ningtyas; Lita Rakhma Yustinasari; Agus Widodo; I Putu Cahyadi Putra
Mandalika Veterinary Journal Vol. 6 No. 1 (2026): APRIL
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/mvj.v6i1.18753

Abstract

Antimicrobial resistance (AMR) in the livestock sector, particularly in cattle farming in Indonesia, requires special attention as it is a rather concerning public health issue. The irrational use of antibiotics for therapy, prophylaxis, or as growth promoters has contributed to the increasing presence of resistant bacteria in beef and dairy cattle. The main challenges in controlling AMR include the lack of regulation on antibiotic use in the field, limited diagnostic facilities, low farmer awareness, and suboptimal national surveillance programs. This review synthesizes findings on the incidence of antibiotic resistance in Escherichia coli (E. coli) bacteria isolated from cattle in Indonesia. Various studies have shown that E. coli isolates from cattle in Indonesia have exhibited resistance to important antibiotics, including tetracycline, penicillin, and several β-lactam antibiotics. The presence of these resistant bacteria not only affects the effectiveness of veterinary treatments but also has the potential to transfer to humans through the food chain, direct contact, and environmental contamination. Based on these findings, control efforts need to be conducted in an integrated manner through a One Health approach, including improving farm biosecurity, strengthening antibiotic use policies, educating farmers, and developing a consistent, nationally standardized AMR surveillance program. The surveillance results from research data on E. coli bacterial resistance in Indonesia can be used to significantly reduce the risk of the spread of antibiotic resistance from the cattle sector to humans.
In Silico Evaluation of Physalis angulata Secondary Metabolites as Potential QcrB Inhibitors in Mycobacterium tuberculosis and Mycobacterium bovis  Zahir Thoriq -; Lia Puspitasari; Lita Rakhma Yustinasari; Suryo Kuncorojakti; Tarshan Sharma Suresh
VITEK : Bidang Kedokteran Hewan Vol. 16 No. 1 (2026): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/b51bvx32

Abstract

Antimicrobial resistance in Mycobacterium tuberculosis and Mycobacterium bovis remains a major challenge in human and veterinary medicine, emphasizing the importance of identifying novel therapeutic compounds. This study aimed to predict the most promising secondary metabolite of Physalis angulata as a quinol–cytochrome c reductase subunit B (QcrB) inhibitor using an in silico approach. Sequence alignment of QcrB proteins from M. tuberculosis and M. bovis demonstrated complete sequence identity, indicating that compounds targeting QcrB in M. tuberculosis may exhibit comparable binding behavior toward QcrB in M. bovis. Among 51 identified metabolites, nine satisfied drug-likeness and safety criteria and underwent molecular docking analysis. Docking simulations predicted that four metabolites occupied the QcrB binding pocket, with withaphysanolide A exhibiting the most favorable interaction profile based on predicted binding free energy and correspondence with reference residues. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) analysis predicted favorable pharmacokinetic and safety-related characteristics for withaphysanolide A. However, these findings should be interpreted in light of several limitations, including the use of rigid docking and the absence of molecular dynamics simulations. Collectively, the results suggest that withaphysanolide A may represent a promising QcrB inhibitor candidate for further investigation, although in vitro and in vivo validation remains necessary.
A comperhensive review: Antimicrobial Resistance in Indonesia One Health Challenge Ranto Bayu Damanik; Alfiana Laili Dwi Agustin; Agus Widodo; Eka Pramyrtha Hestianah; Danti Nur Indiastuti; Ratna Damayanti; Kuncoro Puguh Santoso; Boedi Setiawan; Rahmi Sugihartuti; Vivi Oktaviana; Rury Mega Wahyuni; Lita Rakhma Yustinasari
VITEK : Bidang Kedokteran Hewan Vol. 16 No. 1 (2026): VITEK-Bidang Kedokteran Hewan
Publisher : Fakultas Kedokteran Hewan Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/3svevz51

Abstract

Antimicrobial resistance has become a major global health concern affecting humans, animals, and the environment. The increasing occurrence of antibiotic resistant bacteria threatens the effectiveness of antimicrobial therapy and poses serious public health risks. This review aims to describe the occurrence and distribution of antimicrobial resistant Escherichia coli across humans, animals, wildlife, and environmental sources using a One Health perspective. A literature review approach was conducted by collecting scientific articles published between 2015 and 2025 from international and national databases including PubMed, Scopus, and Google Scholar. Articles were selected based on relevance to antimicrobial resistance in Escherichia coli within human, animal, and environmental contexts. The reviewed studies indicate that Escherichia coli isolates frequently show resistance to commonly used antibiotics such as ampicillin, tetracycline, fluoroquinolones, and third generation cephalosporins. Multidrug resistant strains and extended spectrum beta lactamase producing bacteria have been reported in clinical samples, livestock, companion animals, wildlife, and environmental samples including wastewater and river water. These findings highlight the interconnected nature of antimicrobial resistance transmission between humans, animals, and the environment. Integrated surveillance and responsible antibiotic use are essential to control the spread of antimicrobial resistance through the One Health approach
Co-Authors Agus Widodo Alfiana Laili Dwi Agustin Alfiana Laili Dwi Agustin Amaris, Aulia Puspa Boedi Setiawan Chairul Anwar Dwi Puspa Sukma Viranda Eka Pramyrtha Hestianah Eka Pramyrtha Hestianah Eka Pramystha Hestianah Fatimah Alaydrus Hani Plumeriastuti I Putu Cahyadi Putra Indiastuti, Danti Nur Iwan Sahrial Hamid Iwan Sahrial Hamid Juliano Mwenda Ntoruru Kadek Rachmawati Kuncoro Puguh Santoso Kuncorojakti, Suryo Kusumaningrum, Putri Anggraheni Kusumarini, Shelly Lake, Werenfridus Kono Legowo, Djoko Lia Puspitasari Ngizzah, Nailul Novarina Sulsia Ista'In Ningtyas Nove Hidajati Poedji Hastutiek Pudji Srianto Rahmi Sugihartuti Ranto Bayu Damanik Ratna Damayanti Rochmah Kurnijasanti Rury Mega Wahyuni Santoso, Kuncoro Puguh Saputro, Amung Logam Steven Taufic Leo Suryo Kuncorojati Tarshan Sharma Suresh Tutik Juniastuti Vivi Oktaviana Wurlina, W Yunita, Maya Nurwartanti Zahir Thoriq -