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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal JSIKA Dental Journal (Majalah Kedokteran Gigi) Indonesian Journal of Dental Medicine BERNAS: Jurnal Pengabdian Kepada Masyarakat Indian Journal of Forensic Medicine & Toxicology Jurnal Abdi Masyarakat Indonesia Jurnal Sistem Informasi Universitas Dinamika
Tania Saskianti
Departemen Ilmu Kedokteran Gigi Anak, Fakultas Kedokteran Gigi, Universitas Airlangga, Surabaya, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Languange, Linguistic, Communication & Media Mathematics Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Viability and adhesion of osteoblast and fibroblast cells on polymethyl methacrylatehydroxyapatite composite scaffold Wardhani, Karina Kusuma; Roestamadji, Retno Indrawati; Kanawa, Masami; Saskianti, Tania; Basar, Erin Imaniar; Kardikadewi, Varellia Awang Wangi
Indonesian Journal of Dental Medicine Vol. 9 No. 1 (2026): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v9i1.2026.30-36

Abstract

Introduction: Polymethyl methacrylate (PMMA) and hydroxyapatite (HA) composites are emerging bone graft candidates, combining mechanical stability with osteoconductivity. PMMA contributes to structural strength and handling properties, while HA enhances bioactivity and bone tissue interaction. Prior to clinical use, biocompatibility toward both hard tissue–related cells (osteoblasts) and soft tissue–related cells (fibroblasts) must be established. Purpose: This study aimed to analyze the cell viability and adhesion of osteoblast (hFOB) and fibroblast (BHK-21) cells on a PMMA-HA composite with a 20:80 ratio. Methods: PMMA-HA composite (20:80) scaffolds were synthesized using the freeze-drying method to obtain a porous structure. Cell viability was evaluated using an indirect contact method with the MTT assay after 24 hours of incubation. Surface topography and cell adhesion morphology were analyzed using Scanning Electron Microscopy (SEM). Results: The MTT assay revealed cell viability percentages of 82.55% for hFOB cells and 88.14% for BHK-21 cells, indicating favorable cellular responses to the PMMA-HA composite. SEM analysis demonstrated that the scaffold possessed a rough, irregular, and porous surface. Cell adhesion analysis showed distinct morphological responses: hFOB cells exhibited a spherical morphology adapting to micropores, while BHK-21 cells displayed extensive spreading with flattened morphology and filopodia extensions. Conclusion: The PMMA-HA composite met biocompatibility standards, showing cell viability above 70% according to ISO 10993-5. The scaffold supported cell adhesion with specific morphological adaptations for both cell lines, indicating that the PMMA-HA composite is non-cytotoxic and a potential candidate for bone graft applications.
Physiological alterations in the oral microbiome: A scoping review Ohara, Masaru; Puteri, Mega Moeharyono; Kagami, Hideaki; Kazaoka, Yoshiaki; Saskianti, Tania
Dental Journal (Majalah Kedokteran Gigi) Vol. 59 No. 2 (2026): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v59.i2.p178-184

Abstract

Background: The oral cavity contains more than 774 species of microorganisms, which are collectively referred to as the oral microbiome. Oral microorganisms and their hosts maintain harmonious relations to coexist. Although there are many reviews on the relationship between oral diseases and oral microbiome composition, few articles describe the timing and causes of alterations in the oral microbiome of healthy individuals, particularly those due to lifestyle changes. Purpose: This review aims to identify factors related to physiological alterations in the oral microbiome of healthy individuals due to lifestyle changes, excluding disease-associated dysbiosis. Review: A literature search was performed using PubMed, Latin American and Caribbean Health Sciences Literature, Scientific Electronic Library Online, and Wiley online databases for the period of 2014–2024. Using the keywords ([oral microbiome change] AND [oral microbiome alteration]) AND (geographic, ethnic, culture, or lifestyle), 17 articles matched the inclusion and exclusion criteria for this study. Physiological microbiome alterations were categorized into three groups: (a) the historical change of the oral microbiome from ancient to modern lifestyles, (b) the dynamics of the oral microbiome over short periods due to current lifestyle changes, and (c) oral microbiome alterations during developmental stages. Conclusion: This review identified representative factors related to physiological alterations in the oral microbiome, including ancient–modern lifestyle changes, immigration, and childhood development. These three factors may assist physicians in distinguishing between dysbiosis and physiological change. Because time-course study designs make it easier to understand individual changes, researchers recommend utilizing longitudinal study methods.
Co-Authors Adinda Putri Ainayah, Aulia Nuur Ali Taqwim Amalia Wimarizky Aprillia, Zita Ardianti Maartrina Dewi Audrey, Natasha Winona Az Zahra, Alivy Aulia Azzahra, Syaina Basar, Erin Imaniar Berliana Ayu Prawesti Permatasari Bonardo, Barnabas Devi Oktaviani, Paramita Dewina Marsha Larasati Dimas Prasetianto Wicaksono Ernestine Harta, Putu Harlia Gilang Rasuna Sabdho Wening Hartman Tanzil Ichyana, Devalna Siwi Irfan, Mochammad Irma Josefina Savitri Irmawati Irmawati Iwan Dewanto, Iwan Jusak Irawan Jusak Irawan Kagami, Hideaki Kanawa Misami Kanawa, Masami Kardikadewi, Varellia Awang Wangi Kato, Yukio Kazaoka, Yoshiaki Limbri, Stephanie Clara Marks, Luc A. M. Marzuqi, Naila Masyithah Masyithah, Masyithah Maulidina Nabilah Tasyakuranti Mega Moeharyono Puteri Meidy Damayanti Merlynike Leo, Leviena Michael Josef Kridanto Kamadjaja Misami, Kanawa Mochammad Irfan Mohd Dom, Tuti Ningseh Nadira Jasmin Nelwan, Sindy Cornelia Octavia, Alfini Ohara, Masaru Prawati Nuraini Rafie Wahyu Purnomo Ramadhani, Karina Retno Indrawati Roestamadji Retno Pudji Rahayu Rizki Amalia Salwa Alya Putri Satiti Kuntari Savitri, Agil Torresia Nirwanasari Seno Pradopo Soegeng Wahluyo, Soegeng Sudarsono, Wahyudi Tri Wijayanti Puspitasari Udijanto Tedjosasongko Udijanto Tedjosasongko Vitasari, Niken Rahma Wardhani, Karina Kusuma Yukio Kato