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Effectiveness of golden sea cucumber (Stichopus hermanii) extract gel on increasing RANKL expression process modeling in post extraction tooth: Efektivitas gel ekstrak teripang emas (Stichopus hermanii) terhadap peningkatan ekspresi RANKL pada proses remodeling tulang pascapencabutan gigi Fachry, M. Faizal; Damayanti, Ike; Damoro, Probo; Jubhari, Eri Hendra; Thalib, Bahruddin; Mude, Acing Habibie
Makassar Dental Journal Vol. 14 No. 1 (2025): Volume 14 Issue 1 April 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i1.988

Socket preservation is a procedure in the tooth socket by inserting graft material so as to reduce bone and soft tissue loss after tooth extraction. Gold sea cucumber (S.hermanii) extract has been widely studied because it contains many bioactive compo-nents that can accelerate the post-extraction ossification process. Gold sea cucumber extract was made into gel preparations with concentrations of 0.8%, 1.6%, and 3.2%. The experimental animals were randomly divided into 4 groups. Immunohistoche-mical observation to see the increase in RANK-L expression after gel administration on day 14 after tooth extraction of guinea pigs. The mean levels of osteoclasts and RANKL were highest in the control group and lowest in the 3.2% group. The results of the one-way Anova test showed that there were significant differences between the four treatment groups (p<0.05). It was con-cluded that the administration of golden sea cucumber gel extract had an effect on the bone socket formation process. The most effective concentration of 3.2% was used in the process of socket bone formation.

The potential of marine sponge as a bone graft in the formation of bone regeneration: Potensi marine sponge sebagai bone graft dalam pembentukan regenerasi tulang Thalib, Al'qarama Mahardhika; Amin, Asmawati; Thalib, Bahruddin; Indriani, Lenni
Makassar Dental Journal Vol. 14 No. 1 (2025): Volume 14 Issue 1 April 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i1.1188

Bone graft is a tissue capable of promoting new bone formation, transplanted into damaged bone, either alone or in combination with other materials. From marine biodiversity, marine sponge can be one of the options as a biological material for bone graft uti-lisation. This review discusses the potential of marine sponge as bone graft in the formation of bone regeneration. Through sys-tematic review, articles were searched through PubMed, MDPI and Google Scholar databases and analysed. In total, 370 arti-cles were obtained from the initial search, but only 15 articles met the inclusion criteria, which showed the positive effect of ma-rine sponge in bone regeneration. It was concluded that marine sponge has great potential as a bone graft in the formation of bone regeneration, especially when combined with other biomaterials that have proven effective as graft materials.

Enhancing Diagnostic Precision: The Role of Specialized Head Coil MRI in Disc Displacement Diagnosis of Temporomandibular Joint Latief, Shofiyah; Murtala, Bachtiar; Thalib, Bahruddin; Muis, Mirna; Ilyas, Muhammad; Ruslin, Muhammad; Utama, Dharma; Bahar, Burhanuddin
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.208-221

Background: This study discusses the use of coil heads in Magnetic Resonance Imaging (MRI) technology to diagnose Temporomandibular Joint Disc Dislocation (TMJ). TMJ disc dislocation is a common condition of the temporomandibular joint that can hurt a person's jaw and make it difficult for them to open their mouth fully. This study sought to assess the effectiveness of MRI with coil heads performed in locating and diagnosing TMJ disc dislocations. Method: Analytic observational with cross-sectional design. A diagnostic test to assess the validity of MRI. Predictor analysis was performed using a multivariate logistic regression test. Result: This study shows disparities in the findings of MRI and RDC tests for detecting temporomandibular joint disc dislocations. Clinical complaints have a strong correlation with disc displacement on MRI and RDC. In the MRI, disc dislocation was significantly correlated with all panoramic examination factors. Only the impaction variable in RDC significantly influences disc dislocation. Asymmetrical condyle position on panoramic inspection and complaints present for more than a year on physical examination indicate disc dislocation. These findings imply that MRI is more effective at identifying displaced temporomandibular joint discs, leading to a more precise diagnosis. Conclusion: The diagnosis of TMJ disc dislocations often involves MRI with coil heads. Medical practitioners can more easily spot disc abnormalities or changes in position thanks to this technology, which offers an accurate and thorough image of the temporomandibular joint's anatomy

Enhancing Diagnostic Precision: The Role of Specialized Head Coil MRI in Disc Displacement Diagnosis of Temporomandibular Joint Latief, Shofiyah; Murtala, Bachtiar; Thalib, Bahruddin; Muis, Mirna; Ilyas, Muhammad; Ruslin, Muhammad; Utama, Dharma; Bahar, Burhanuddin
Odonto : Dental Journal Vol 12, No 2 (2025): August 2025
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.12.2.208-221

Background: This study discusses the use of coil heads in Magnetic Resonance Imaging (MRI) technology to diagnose Temporomandibular Joint Disc Dislocation (TMJ). TMJ disc dislocation is a common condition of the temporomandibular joint that can hurt a person's jaw and make it difficult for them to open their mouth fully. This study sought to assess the effectiveness of MRI with coil heads performed in locating and diagnosing TMJ disc dislocations. Method: Analytic observational with cross-sectional design. A diagnostic test to assess the validity of MRI. Predictor analysis was performed using a multivariate logistic regression test. Result: This study shows disparities in the findings of MRI and RDC tests for detecting temporomandibular joint disc dislocations. Clinical complaints have a strong correlation with disc displacement on MRI and RDC. In the MRI, disc dislocation was significantly correlated with all panoramic examination factors. Only the impaction variable in RDC significantly influences disc dislocation. Asymmetrical condyle position on panoramic inspection and complaints present for more than a year on physical examination indicate disc dislocation. These findings imply that MRI is more effective at identifying displaced temporomandibular joint discs, leading to a more precise diagnosis. Conclusion: The diagnosis of TMJ disc dislocations often involves MRI with coil heads. Medical practitioners can more easily spot disc abnormalities or changes in position thanks to this technology, which offers an accurate and thorough image of the temporomandibular joint's anatomy

Potential of Stichopus hermanni as a scaffold material in dental tissue engineering: Potensi Stichopus hermanni sebagai bahan penyangga dalam rekayasa jaringan gigi Amin, Asmawati; Thalib, Alqarama Mahardhika; Thalib, Bahruddin; Fauzan, Muhammad Fadil; Sambara, Eser Suryanti
Makassar Dental Journal Vol. 14 No. 3 (2025): Volume 14 Issue 3 December 2025
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35856/mdj.v14i3.1398

This article evaluates Stichopus hermanni as a scaffold for dental tissue engineering, focusing on biocompatibility, osteogenesis, angiogenesis, and immunomodulation. A systematic literature was conducted through PubMed/MEDLINE, Scopus, ScienceDi- rect, Google Scholar, and national databases. Studies were selected using the PICOS framework, covering both in vitro and in vivo research. The results showed that S.hermanni-based scaffolds, either alone or in combination with hydroxyapatite or chito-san, exhibited high biocompatibility, non-toxicity, increased osteogenic markers (CD44, IL-10, osteocalcin, bFGF), angiogenesis, and woven bone formation. This scaffold also reduced osteoclast activity through immunomodulatory effects. It was concluded that S.hermanni has strong potential as a biomaterial scaffold in dental tissue engineering, supporting the safe and effective re-generation of hard and soft tissues.

A treatment of preventive prosthodontics telescopic overdenture: Perawatan prostodontik preventif dengan gigi tiruan teleskopik Muhammad Rifaldi Haeruddin; Bahruddin Thalib
Makassar Dental Journal Vol. 14 No. 2 (2025): Volume 14 Issue 2 August 2025
Publisher : Makassar Dental Journal PDGI Makassar

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Kehilangan seluruh gigi adalah kasus yang sangat sering dijumpai oleh dokter gigi, terutama pada pasien yang berusia lanjut. Pembuatan gigi tiruan menjadi opsi yang tepat untuk kasus kehilangan gigi. Pada situasi tersisa beberapa gigi alami, prostodontis menghadapi dilema dalam menentukan perawatan. Pada beberapa kasus, overdenture menjadi opsi perawatan yang menguntungkan. Berdasarkan filosofi dari prostodontik preventif, overdenture memiliki keuntungan jangka panjang dalam mempertahankan kinestesi dan tulang alveolar yang tersisa. Artikel ini memaparkan tentang perawatan rehabilitasi pada pasien dengan kondisi tersisa dua gigi alami pada rahang bawah menggunakan gigi tiruan lengkap teleskopik. Disimpulkan bahwa gigi tiruan teleskopik unggul pada aspek retensi, stabilitas, dukungan, dan psikologis pada pasien.

Full denture with conventional overdenture: Gigi tiruan lengkap dengan overdenture konvensional Probo Damoro Putro; Bahruddin Thalib
Makassar Dental Journal Vol. 12 No. 3 (2023): Volume 12 Issue 3 Desember 2023
Publisher : Makassar Dental Journal PDGI Makassar

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Pencabutan gigi merupakan alasan utama terjadinya resorpsi pada tulang alveolar. Overdenture memiliki beberapa manfaat pada perawatan prostodontik, antara lain menjaga tinggi alveolar ridge, meningkatkan stabilitas gigi tiruan, mempertahankan sensor proprioseptif, dan meningkatkan efisiensi pengunyahan. Artikel ini melaporkan penggunaan gigi tiruan lengkap dengan overdenture konvensional sebagai perawatan rehabilitasi edentulus parsialis pada rahang atas dan bawah. Seorang laki-laki berusia 70 tahun datang ke Departemen Prostodontik RSGM Unhas dengan keluhan sulit mengunyah makanan karena kehilangan sebagian gigi rahang atas dan bawah, pasien ingin dibuatkan gigi tiruan tanpa pencabutan gigi karena trauma pada pencabutan gigi sebelumnya. Disimpulkan bahwa penggunaan gigi tiruan lengkap dengan dua coping pada rahang atas dan bawah dapat meningkatkan retensi dan stabilitas pada penggunaan gigi tiruan overdenture.

Marine sponges as potential inhibitors of oral squamous cell carcinoma: Spons laut sebagai penghambat potensial karsinoma sel skuamosa oral Asmawati; Bahruddin Thalib; Alqarama M. Thalib; Sitti Jahadiyah; Linda
Makassar Dental Journal Vol. 12 No. 3 (2023): Volume 12 Issue 3 Desember 2023
Publisher : Makassar Dental Journal PDGI Makassar

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Ekstrak senyawa dari marine sponges mampu mencegah pertumbuhan sel kanker dengan cara mencegah perkembangbiakan sel ganas dengan menginduksi apoptosis melalui kondensasi kromatin atau fragmentasi DNA sehingga menghasilkan apoptosis sel kanker. Keadaan tersebut akhirnya memicu program kematian sel melalui peningkatan jalur apoptosis. Artikel ini dimaksudkan untuk mengetahui manfaat senyawa turunan marine sponges dalam menghambat perkembangan oral squamous cell carcinoma (OSCC). Beberapa senyawa bioaktif yang diproduksi dari marine sponges seperti manoalide, stellettin B, methanol extract T.swinhoi, ilimaquinon, stigmasterol meningkatkan stres oksidatif, menghasilkan stres oksidatif N-acetylcysteine, Mito-Tempo dan ZVAD sel kanker mulut, efek antiproliferasi pada sel kanker mulut, stres oksidatif mengatur peningkatan subG1, menghambat aktivasi caspase 3 dan 3/7, memicu stres ER yang lebih tinggi, sitotoksik yang kuat pada sel KB/C152 dibandingkan dengan sel Jurkat/E6-1, aktivasi mitogen-activated protein kinase yang berperan terhadap apoptosis dan kerusakan DNA pada sel kanker mulut menunjukkan bahwa sponge mengambat OSCC. Disimpulkan bahwa senyawa turunan marine sponges dapat berperan dalam apoptosis, antiproliferasi, sitotoksik pada sel kanker mulut sehingga berpotensi menghambat OSCC.

Antimicrobial and anti-inflammatory properties of methyl palmitate and hexadecenoid acid in oral diseases: Sifat antimikroba dan antiinflamasi metil palmitat dan asam heksadekenoat dalam penyakit mulut Amin, Asmawati; Thalib, Bahruddin; Djerman, Adilah Zahirah Fitri; Putri, Dian Mentari
Makassar Dental Journal Vol. 15 No. 1 (2026): Volume 15 Issue 1 April 2026
Publisher : Makassar Dental Journal PDGI Makassar

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Oral diseases such as periodontitis and mucositis involve microbial biofilms and immune system disorders. Marine-derived lipid compounds such as methyl palmitate (MP) and hexadecenoic acid (AHD) exhibit promising antimicrobial and anti-inflammatory properties. This review compiles current preclinical and clinical evidence on their mechanisms and therapeutic potential in oral diseases. A systematic search (2015–2025) through PubMed, Scopus, and Google Scholar was conducted using the PICOS framework, covering in vitro, animal, and clinical studies. Narrative synthesis was applied due to data variability. MP appears to reduce TNF-? and IL-1? by inhibiting NF-?B in macrophages and increasing IL-10. AHD decreases IL-6, IL-18, and MCP-1, promotes M2 polarisation, and disrupts biofilm. Both compounds are derived from marine sources such as fish oil and microalgae. It is concluded that MP and AHD have potential as adjunctive therapies for oral inflammation, although further clinical validation is essential.

Marine sponges as potential inhibitors of oral squamous cell carcinoma: Spons laut sebagai penghambat potensial karsinoma sel skuamosa oral Asmawati; Bahruddin Thalib; Alqarama M. Thalib; Sitti Jahadiyah; Linda
Makassar Dental Journal Vol. 12 No. 3 (2023): Volume 12 Issue 3 Desember 2023
Publisher : Makassar Dental Journal PDGI Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar

Ekstrak senyawa dari marine sponges mampu mencegah pertumbuhan sel kanker dengan cara mencegah perkembangbiakan sel ganas dengan menginduksi apoptosis melalui kondensasi kromatin atau fragmentasi DNA sehingga menghasilkan apoptosis sel kanker. Keadaan tersebut akhirnya memicu program kematian sel melalui peningkatan jalur apoptosis. Artikel ini dimaksudkan untuk mengetahui manfaat senyawa turunan marine sponges dalam menghambat perkembangan oral squamous cell carcinoma (OSCC). Beberapa senyawa bioaktif yang diproduksi dari marine sponges seperti manoalide, stellettin B, methanol extract T.swinhoi, ilimaquinon, stigmasterol meningkatkan stres oksidatif, menghasilkan stres oksidatif N-acetylcysteine, Mito-Tempo dan ZVAD sel kanker mulut, efek antiproliferasi pada sel kanker mulut, stres oksidatif mengatur peningkatan subG1, menghambat aktivasi caspase 3 dan 3/7, memicu stres ER yang lebih tinggi, sitotoksik yang kuat pada sel KB/C152 dibandingkan dengan sel Jurkat/E6-1, aktivasi mitogen-activated protein kinase yang berperan terhadap apoptosis dan kerusakan DNA pada sel kanker mulut menunjukkan bahwa sponge mengambat OSCC. Disimpulkan bahwa senyawa turunan marine sponges dapat berperan dalam apoptosis, antiproliferasi, sitotoksik pada sel kanker mulut sehingga berpotensi menghambat OSCC.

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