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All Journal Tropical Medicine Journal Jurnal Ilmu Kedokteran (Journal of Medical Science) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Molucca Medica Indonesian Journal of Pharmacology and Therapy

Jarir At Thobari

Department Of Pharmacology And Therapy, Faculty Of Medicine, Public Health And Nursing, Gadjah Mada University, Yogyakarta, 55281, Indonesia

Author-ID : 403107

Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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The influence of proton pump inhibitors on the effect of clopidogrel on the risk of recurrent ischemic stroke Endang Mahati; Jarir Atthobari; . Ngatidjan
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 2 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Patients surviving with a stroke have an increased risk for recurrent stroke. Clopidogrel iswidely used to prevent recurrent stroke. However, clopidogrel may cause gastrointestinalbleeding (GIB). Therefore, proton pump inhibitors (PPIs) is recommended to reduce theside effect of clopidogrel. Unfortunately, these both drugs are metabolized in the liverby the same enzyme i.e. cytochrome P4502C19 (CYP219) that may reduce the effectof clopidogrel. The aim of this study was to evaluate the influence of PPIs on the effectof clopidogrel in the prevention of recurrent stroke. It was a hospital-based case controlstudy conducted in Bethesda Private Hospital, Yogyakarta involving 392 patients withrecurrent stroke as cases and 784 patients with first-ever stroke as controls. The exposureof PPIs during clopidogrel therapy on both cases and controls groups were recordedfrom prescription records for at least six months before index date. The duration of PPIsexposure were categorized as current expoure (less than two months before the indexdate) and recent exposure (2-6 months before the index date). The result showed therewas no influence of PPIs exposure on the effect of clopidogrel on the risk of recurrentischemic stroke (OR: 1.00; 95% CI: 0.56-1.79). Moreover, the current use of PPIs andclopidogrel could decrease the risk of recurrent ischemic stroke (OR: 0.04; 95% CI:0.01-0.41). In conclusion, there is no association between PPI exposure and the risk ofrecurrent stroke in patients receiving clopidogrel.

Severity and treatment level of acute gastroenteritis with rotavirus in children under 5 years in INDONESIA Fatma Othman Gdara; Jarir At Thobari; Yati Soenarto
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 1 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Rotavirus diarrhea causing gastroenteritis in children under five years is an importantissue that urgently needs to be addressed globally. Delay in management of rotavirusdiarrhea can be fatal. Diagnostic tool for detecting rotavirus is, therefore, needed.However, until now the gold standard diagnostic tools are expensive, often not availableand affordable in health care settings. The aim of the study was to compare the Vesikariclinical severity score of rotavirus-positive with rotavirus-negative in hospitalized childrenwith acute gastroenteritis. Furthermore, the difference of the level of treatment betweenrotavirus-positive with rotavirus-negative was also evaluated. This was a cross sectionalstudy that using secondary data from medical records of five general teaching hospital inIndonesia. Subjects were children aged <5 years with acute watery diarrhea admitted tothe hospital. Statistical analysis used was chi square test, U-Mann Whitney, and KruskalWallis. The results showed that the patient with rotavirus positive have higher dehydration(80.2%) compared to rotavirus negative (70%). The severity level of clinical feature washigher in diarrhea due to rotavirus positive than non rotavirus (11.47± 2.89 vs 10.41± 2.70; p<0.000). The level of treatment was higher in rotavirus positive. The majorityhad treatment plan C (47.7%) higher than plan B and A (45.6% and 30.9%; p<0.050).This was opposite with patient with rotavirus negative that majority had treatment inplan A (69.1%) higher than plan B and C (54.4% and 52.3%) (p<0.001). In conclusion,the severity of gastroentrities in children under 5 years using vesikari score are higher indiarrhea due to rotavirus positive than non rotavirus. The treatment level plan C is higherthan plan B and A in diarrhea due to rotavirus. This is opposite with non rotavirus majorityhave treatment in plan A higher than plan B and C.

The effect of the implementation of evidence-based drug formulary on antibacterial use in a private hospital at Tanjung Enim, Sumatera Selatan, Indonesia Erna Kristin; Dwi Indria Anggraini; Jarir At Thobari; Alfi Yasmina
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 1 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The increase of drug expenditure in the hospital has facilitated the implementation of an evidence-based drug formulary. The aim of this study was to assess the change in antibacterial use after the implementation of an evidence-based drug formulary in a private hospital at Tanjung Enim, Sumatera Selatan, Indonesia. This study used a pre-posttest design. Drug use data in the period before (2010-2011) and after (2012-2013) the formulary implementation were extracted from the hospital medical records. The drug use in the hospital before and after the implementation was compared using t-test and chi-square test, with the significance level of 0.05. Average number of drugs prescribed per prescription after the implementation was similar with that before the implementation (4.4 vs 4.6; p > 0.05). However, the proportion of generic drugs prescribed increased significantly after the formulary implementation (17.0% vs 52.7%; p < 0.05). Moreover, it was still significantly increased when the analysis was conducted only for antibacterial drugs (25.9% vs 72.0%; p < 0.05). Average drug cost per prescription was 34% lower after the intervention (p < 0.05), and the average cost for antibacterial drug was also decreased (26%). The use of antibacterial drugs was significantly decreased after the intervention (12.5% vs 6.9%; p < 0.05). The most often antibacterial drugs prescribed before the interventions were beta-lactams and macrolides; while quinolones were more increasingly used after the intervention. In conclusion, the implementation of evidence-based hospital drug formulary in a private hospital at Tanjung Enim, Sumatera Selatan significantly increase generic drug use and decreased antibacterial use and average drug cost per prescription. Key words : drug formulary – prescribing pattern – generic drug – antibacterial – private hospital

Convalescent plasma for COVID-19: A reasonable option for the pandemic based on both scientific and practical point of views Mardiah Suci Hardianti; Syahru Agung Setiawan; David Dwi Putera; Teguh Triyono; Jarir At Thobari; Johan Kurnianda
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 3 (2020): Special Issue: COVID-19
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Convalescent plasma treatment has become a promising adjunctive option to treat COVID-19. Several case reports consistently supported the feasibility of this approach by showing the safety and improvements of clinical and laboratory aspects from the treated patients. However, more clinical trials are still required to establish the definitive statement about its potential effectiveness. We review the scientific basis for the application of convalescent plasma in COVID-19 to understand its potentials better. We also cover the potential risks and benefits for this treatment in order to be more selective and careful when preparing and deciding to apply this approach. Lastly, we summarize any important points to monitor after the administration of this treatment to prioritize safety and measure the effectiveness of the treatment.

Improving Knowledge, Attitude, and Perception towards Childhood Diarrhea Using Interactive Discussion in Kulon Progo Community Jarir At Thobari; Wahyu Damayanti; Asal Wahyuni Erlin Mulyadi; Jonathan Hasian Haposan; Annisa Setiyaningrum; Shofya Indraguna; Sutarman S; Nailatul Arifah; Anggit Dewi Rahayu; Faridatun Khasanah; Al Razi Sena; Yati Soenaro
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 7, No 2 (2021): June
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Introduction: Diarrhea is still a leading cause of death in the world in children, especially in children under 5 years. Diarrhea is a contagious disease with relatively high morbidity and mortality rates. Rotavirus is a cause of diarrhea in children and is a very important public health problem in both developed and developing countries. Parents' knowledge is one of the causes of diarrhea due to parents' ignorance of the causes of diarrhea, how diarrhea is transmitted and how to prevent diarrhea.Methods: This explanatory mixed qantitative-qualitative method with a quasi experimental design study to determine the effect of interactive discussion on changes in knowledge, attitudes, and perceptions towards the prevention and management of childhood diarrhea among mothers and children living in the area of The Ash-Shiddiqiyah Orphanage located in Central Sremo, Hargowilis, Kokap, Kulon Progo Regency, Yogyakarta.Results: The activities were conducted on November 29th, 2020 with 67 participants consisting of 54 children and 13 mothers from the area. The questionnaire results showed that the posttest scores in all sections (knowledge, attitudes, and perceptions) were significantly higher compared to the the pretest scores. There were increment of 1.33 points in knowledge (p<0.001), 0.5 points in attitudes (p<0.001), 0.4 points in perception (p<0.05), and 0.76 points in overall scores (p<0.001). Interviewees agreed that the intervention has been properly conducted with clear delivery, easy to understand for both adults and children, and ability to two-way communication. Technology utilization might help the understanding of the audience. Besides, a small group discussion in the session may benefit the participants to ask more confidently compared to asking in the middle of large group due to shame.Conclusion: Interactive discussion could be used to improve knowledge, atittude and perception towards childhood diarrhea. The delivery of interactive discussion using simple language for targetted population, adoption of small group discussion and technology utilization might help the effectiveness of the intervention. Further study is needed to identify effective ways to promote the childhood diarrhea management and prevention in community.

PREDICTORS OF THE USE OF GASTROPROTECTIVE AGENTS IN PATIENTS USING NSAID IN YOGYAKARTA INDONESIA Ady Bagus Indrianto; Jarir At Thobari; Agung Endro Nugroho
Indonesian Journal of Pharmacy Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Non Steroid Anti-Inflammatory (NSAID) is one type of AntiInflammatory drug that is used to treat pain in patients of osteoarthritis (OA) and rheumatoid arthritis (RA). The use of NSAIDs can cause gastrointestinal side effects. To prevent the side effects, NSAIDs are prescribed in combination with gastroprotective agent (GPA). The aim of the study is to determine the factors considered in the GPA prescription by the doctors in patients who have risk factors for gastric disorder due to NSAIDs use. This study was performed using a cross-sectional observational design. The data were collected retrospectively during a period of January to December 2010. The subjects were OA and RA patients considering the inclusion and exclusion criteria. The data included patient characteristics (gender, age, occupation, payment method, the primary diagnosis), prescription of NSAID, prescription of GPA, history of gastrointestinal disease, NSAID prescription with corticosteroids, prescription with antiplatelet. The data were processed descriptively and quantitatively, and analyzed statistically using chi-square and log. regression with 95% Confidence Interval. The results showed that there were correlation between some predictor factors with prescription of gastroprotective agent. These factors were women patient, patient age of ≥ 65 years, oxicam prescribing, diclofenac sodium prescribing, prescribing >1 type of NSAIDs, prescription of NSAID concomitant with corticosteroids, prescription of NSAID concomitant with antiplatelet, patients with history of gastrointestinal, prescribing NSAIDs with duration of ≥ 3 months. Patient with a history of gastrointestinal disease was the most predictor influential factor, with OR (odds ratio) of 3.6 (95% CI: 2.79 - 4.66). Predictor factor of patients with a history of dyspepsia possessed the highest OR {OR=4,29 (CI 95%: 3.23–5.7)}. It means that patients with a history of dyspepsia prescribed NSAIDs would have greater risk of 4.29 times to get GPA prescription than patients without a history of dyspepsia. Prescribing NSAIDs > 1 DDD (defined daily dose) had p value of 0.777, which means there was no relationship between GPA prescription with NSAIDs > 1 DDD prescription.Key words: Gastroprotective Agent, Non-steroid anti-inflammatory, Osteoarthritis, Rheumatoid Arthritis

SOSIOKULTURAL MEMPENGARUHI KETIDAKPATUHAN TERAPI ANTIRETROVITAL PADA ODHIV DI MALUKU: QUALITATIVE STUDY Presli Glovrig Siahaya; Jarir At Thobari; Indwiani Astuti; Hari Agus Sanjoto
Molucca Medica VOLUME 14, NOMOR 2, OKTOBER 2021
Publisher : Pattimura University

HIV merupakan permasalah global dengan angka kematian yang tinggi. Pengobatan paling efektif pada ODHIV hanyalah dengan terapi ARV. Tujuan utama dari terapi arv adalah untuk meningkatan kelangsungan hidup bebas penyakit dengan menekan replikasi HIV dan meningkatkan fungsi kekebalan. Ketidakpatuhan terhadap terapi ARV akan membeir dampak pada kegaggalan pengobatan. Kegagalan pengobatan pada ODHIV, menyebabkan penurunan CD4 dan infeksi opurtunitik. Tujuan penelitian ini untuk mengetahui bagaiman factor sosikultural dapat mempengaruhi ketidakpatuhan terapi ARV pada ODHIV di Maluku. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan studi kasus. Jumlah informan dalam penelitian ini sebanyak 12 informan, dengan menggunakan in-depth interview untuk memperoleh data. Analisis transkrip wawancara melalui koding, menentukan kategori, sub-tema dan tema. Hasil penelitian yang didapatkan stigma, diskriminasi dan tertutup dengan status HIV merupakan faktorsosial yang mempengaruhi ketidakpatuhan terapi ARV. Faktor prespsi ODHIV, bila HIV merupakan santet, sehingga ODHIV menggunakan cara lain untuk pengobatan. Faktor religious dapat mempengaruhi ketidakpatuhan terapi ARV. Faktor culture dapat mempengaruhi ketidakpatuhan terapi RV. Faktor pengobatan alternative dapat mempengaruhi ketidakpatuhan terapi ARV pada ODHIV. Kesimpulan dari penelitian ini factor sosiokultural yang mempengaruhi ketidakpatuhan teapi ARV yaitu factor social, factor presepsi, factor religious, factor culture dan faktor pengobtan alternative.

EVALUATION QUALITY OF LIFE OF TYPE 2 DIABETIC PATIENTS WITH ORAL ANTIDIABETIC THERAPY AT AMBULATORY CLINIC IN RSUP DR. SARDJITO Rafika Mutia Sari; Jarir At Thobari; Tri Murti Andayani
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 1, No 1
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.7

Type 2 Diabetes Mellitus is a chronic disease which can’t be healed totally. Therefore type 2 DM will affect the Health Related Quality of Life (HRQOL). The purpose of this study was to determinate the QOL of type 2 DM patients based on patient’s characteristics, drug groups, and therapy pattern (single versus combination therapy). This study was conducted in RSUP Dr. Sardjito Yogyakarta. This study is an analytical research with cross sectional design. Data collection was done by interview and review of patient’s medical records. Research’s subjects are ambulatory patient with type 2 DM who are threated with oral antidiabetic(s) and willing to fill the questionnaire. Total 227 total patients were included in this study. Quality of life was measured by Diabetes Quality of Life Clinical Trial Questionnaire (DQLCTQ). The analysis showed that gender, age, duration of DM, educational level, marital status and occupation affect the QOL. Patient taking metformin had 67.9 score, 67.7 for patient with acarbose therapy and patient taking sulfonylurea 67.6 score. Those differences were not significant (ANOVA test, p = 0.298). Patients taking single antidiabetic agent had 70.6, whereas those taking combination therapy had 67.6 score. Independent sample t‐test showed that those score have significant difference (p = 0.002). Linear regression analysis with enter method showed that QOL’s difference between single and combination therapy groups did affected by patient’s characteristics (p=0.049). Keywords : type 2 DM, ADO therapy, quality of life, DQLCTQ

PENGUKURAN KUALITAS HIDUP PASIEN TUBERKULOSIS MENGGUNAKAN INSTRUMEN ST GEORGE RESPIRATORY QUESTIONNAIRE (SGRQ) DI YOGYAKARTA Hendrik Hendrik; Dyah Aryani Perwitasari; Ully Adhie Mulyani; Jarir At Thobari
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis. It typically affects the lungs but can affect other sites as well. TB disease could influence the TB patients’ quality of life such as psychology of health, physical function and the leading role in society. The purpose of this research is to measure the differed TB patients’ quality of life before and during the treatment using Indonesian version of St George Respiratory Questionnaire (SGRQ) instruments that have been validated. The research used a cross-sectional design conducted prospectively in 91 new patients diagnosed as lung TB in BP4 province of Yogyakarta in November 2013 until April 2015. Patients filled out the questionnaires, and its obtained Total Score values were analyzed with Friedman's test to understand the quality of life. The results from this research showed that the quality of life of TB patient before, and during the treatment differed significantly. The Total score on the first month treatment was 43.57% and the second until the sixth months treatment was 30.40%; 25.22%; 20.50%; 18.45% and 16.51% respectively (p<0.05). The worst of quality of life was occurred in the first month treatment as the initial period before the treatment and continues to improve until the sixth-month treatment. In conclusion, the quality of life TB patients’ before and during the treatment is more increasing. Key words: Tuberculosis, SGRQ, Quality of life.

Cost-Effectiveness of Antithrombotic Agents for STEMI Zulpadly, M Fiqri; Thobari, Jarir At; Dinarti, Lucia Kris
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.006073

In Indonesia, the prevalence of Acute Coronary Syndrome (ACS) continues to rise annually and remains high. Aspirin and adenosine diphosphate receptor inhibitors are recommended as part of the dual antiplatelet therapy that is recommended by the standard guidelines for managing ACS. Ticagrelor, a new treatment option for ACS, has been made available during the current period of Indonesia's National Health Insurance. Ticagrelor is more effective, but it costs more. Objective: In patients with ST-Elevation Myocardial Infarction (STEMI), the goal of this study was to compare how much ticagrelor and clopidogrel cost when compared to one another with relative ratio (RR) analysis and 95% confidence interval (CI) with p

Co-Authors A.A. Ketut Agung Cahyawan W Ady Bagus Indrianto Agung Endro Nugroho Al Razi Sena Alfi Yasmina Alfi Yasmina Anggit Dewi Rahayu Anggoro Budi Hartopo Annisa Setiyaningrum Anwar Santoso Asal Wahyuni Erlin Mulyadi Ave Olivia Rahman Bambang Irawan Chandra, Lukman Ade Christi Mambo David Dwi Putera Deva Bachtiar Dimas Pramita Nugraha Dwi Indria Anggraini Dyah Aryani Perwitasari Endang Mahati Erna Kristin Faridatun Khasanah Fatma Othman Gdara Guntur Benedict Hutadjulu Hari Agus Sanjoto Hendrik Hendrik Indwiani Astuti Iwan Dwiprahasto Iwan Dwiprahasto Iwan Dwiprahasto Johan Kurnianda Jonathan Hasian Haposan Lucia Kris Dinarti Luhur Pribadi Lukman Ade Chandra Maemonah, Maemonah Mardiah Suci Hardianti Mustofa Mustofa Nailatul Arifah Ngatidjan Ngatidjan Pompini Agustina Sitompul Pratiwi, Woro Rukmi Pratiwi, Woro Rukmi Rafika Mutia Sari Rita Suhadi Rizaldy Pinzon Rizki Amalia Gumilang Sari, Rafika Mutia Shofya Indraguna Siahaya, Presli Glovrig Sitti Rahmah Umniyati Sutarman S Syahru Agung Setiawan Teguh Triyono Togi Junice Hutadjulu Tri Asti Isnariani Tri Murti Andayani Tri Murti Andayani Trijayanti, Christiana Ully Adhie Mulyani Umi Sa'adatun Nikmah Wahyu Damayanti Yanri Wijayanti Subronto Yati Soenaro Yati Soenaro Yati Soenarto Yolanda Dyah Kartika Zulpadly, M Fiqri

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