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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat (ABDIRA) Journal of Innovation Research and Knowledge Jurnal Farmasi Indonesia Journal of Research in Pharmacy and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan
Annisa Farida Muti
Universitas Pembangunan Nasional Veteran Jakarta
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Journal : Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)

 1 
Lipase Enzyme Inhibitory Activity of Jombang Leaves Extract (Taraxacum officinale F.H. Wigg): Aktivitas Penghambatan Enzim Lipase Ekstrak Daun Jombang (Taraxacum officinale F.H. Wigg) Secara In Vitro Muti, Annisa Farida; Adia, Risa; Rifkia, Via; Pradana, Dhigna Luthfiyani Citra
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 1 (2024): (March 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i1.16454

Abstract

Background: Obesity is a condition that occurs due to an imbalance between energy intake and expenditure. Lipase enzymes play an important role in the process of fat metabolism, making it a target in obesity treatment strategies. Jombang plant has been used for generations as an alternative treatment for various diseases. The main content of secondary metabolite compounds in jombang plants are phenolics, flavonoids, terpenoids, and alkaloids. Objective: This study was conducted to determine the activity and potential inhibition of jombang plant (Taraxacum officinale F.H. Wigg.) against lipase enzyme in vitro. Materials and Methods: The phytochemical screening was determined by a color change reaction with certain reagents, while total phenolic content was carried out using Folin-Ciocalteau reagent spectrophotometrically. The inhibitory activity of 96% ethanol extract of jombang leaves as well as orlistat as positive control was measured by titration method and using olive oil substrate. The extract concentrations used were 125 ppm, 250 ppm, and 500 ppm. Results: Jombang leaf extract contains alkaloid, phenolic, flavonoid and terpenoid compounds qualitatively. Determination of total phenolic content in 96% ethanol extract of jombang leaves was obtained at 12.69 ± 0.91 mgGAE/g. The highest percentage of inhibition was found at a concentration of 500 ppm which amounted to 103.85%. The difference in the percentage of inhibition in all groups showed no significant difference (Sig>0.05). Conclusion: This study shows that jombang leaf extract is able to inhibit lipase enzyme activity with the highest percentage of inhibition was 103,85%.
Synergistic Effect Antibacterial Activity of The Combination of Andaliman (Zanthoxylum acanthopodium DC) Fruit Essential Oil and Erythromycin against Streptococcus mutans and Streptococcus pyogenes : Efek Sinergisme Aktivitas Antibakteri Kombinasi Minyak Atsiri Buah Andaliman (Zanthoxylum acanthopodium DC) dan Eritromisin terhadap Streptococcus mutans dan Streptococcus pyogenes Situmorang, Vania Clarissha; Rahmi, Eldiza Puji; Pradana, Dhigna Luthfiyani Citra; Septama, Abdi Wira; Muti, Annisa Farida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16977

Abstract

Background: The concept of synergism is one of the approaches taken to combat the problems related to antibiotic resistance. Objectives: The goal of this study was to determine the synergistic effect of the antibacterial activity of a combination of essential oil of Zanthoxylum acanthopodium DC fruit and erythromycin against Streptococcus mutans and Streptococcus pyogenes. Methods: The broth microdilution assay was used to determine the Minimum Inhibitory Concentration (MIC) of Z. acanthpodium DC fruit essential oil and erythromycin. The synergistic effects were assessed using the checkerboard method. Results: MIC value of Z. acanthopodium DC fruit essential oil against both bacteria was 2500 mg/mL. The combination of Z. acanthopodium DC fruit essential oil and erythromycin had a synergistic effect against S. mutans and S. pyogenes with fractional inhibitory concentration index (FICI) values of 0.375 and 0.0872, respectively. Conclusions: These results suggest that a combination of herbal plants and conventional antibiotics could be used as an alternative therapy for bacterial infections.
Analysis of Potential Drug-drug Interactions in Liver Cirrhosis Patients: Analisis Interaksi Obat-obat Potensial pada Pasien Sirosis Hati Muti, Annisa Farida; Anindya, Chanica
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15148

Abstract

Background: Patients with liver cirrhosis are at a high risk of drug interactions due to the use of multi-drug combination regimens. Objectives: This study analyzed potential drug-drug interactions in the liver cirrhosis patients at Gatot Soebroto Army Hospital, Jakarta in 2016. Material and Methods: This study employed an observational-cross sectional design with retrospective data collection of liver cirrhosis patients' medical records. The data of potential drug-drug interactions were identified using Drug Interaction Facts 2012 including the mechanism type, the severity and the onset of drug interactions. Results: As many as 88% of the liver cirrhosis patients experienced potential drug-drug interactions with a total of 35 cases. The highest proportions of the cases were found in the pharmacokinetic mechanism by approximately 25 cases (71.43%), minor severity comprising 29 cases (82.86%) and rapid onset by 19 cases (54.29%). The highest potential drug-drug interactions were furosemide-propranolol combination in 16 cases (45.72%). Conclusions: The high incidence of potential drug interactions in patients with liver cirrhosis requires high vigilance and close monitoring of all health professionals in achieving optimal therapeutic outcomes for the patients.
Co-Authors Abdi Wira Septama Adia, Risa Afdhal Raziq Hanania Alhaque, Nitya Fithra Salsabila Alya Andina Dasuki Anggita Cahya Ningrum Anggita Virginia Naulina Manurung Anindya, Chanica Asri Yani Deskia Amanda Fitriyani Dhigna Luthfiyani Citra Pradana Dian Mega Sugiyarto Emma Rahmawati Emma Rahmawati Fatimah Azzahra Hany Yusmaini Kharazi Farand Vitonova Moh. Benny Perdana Nafis Ikhwana Nasyia Qaanita Nasywa Dwi Ayu Nurul Octavia Pritha Maya Savitri Rahmawati, Emma Rahmi, Eldiza Puji Ramdhan, Zeashafa Zafira Refdanita Refdanita Revina, Rika Rifkia, Via Roqayyah Ryan Herardi Salma Ika Rahmadani Sister Sianturi Situmorang, Vania Clarissha Sukardiman Tirta Fitri Aryani Veronica Anggelita Putri Yanti Harjono Hadiwiardjo