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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL KIMIA SAINS DAN APLIKASI Teknotan: Jurnal Industri Teknologi Pertanian Jurnal Ilmu Kimia Universitas Brawijaya Bulletin of Chemical Reaction Engineering & Catalysis Journal of Innovation and Applied Technology Jurnal Pembangunan dan Alam Lestari Natural B The Journal of Pure and Applied Chemistry Research Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry Indonesian Food Science and TechnologyJournal Media Akuakultur Makara Journal of Science Bulletin of Chemical Reaction Engineering & Catalysis
Siti Mariyah Ulfa
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, Brawijaya University, Jl. Veteran, Malang 65145, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Education Engineering Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Other

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Journal : Indonesian Food Science and TechnologyJournal

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Microencapsulation by Spray drying of Cosmos caudatus Kunth. Extracts Using Gum Arabic: Influencing Factors and Controlled Release Zahara, Izaz Aqeiluz; Sutrisno, Sutrisno; Ulfa, Siti Mariyah; Safitri, Anna
Indonesian Food Science and Technology Journal Vol. 8 No. 1 (2024): Volume 8 Number 1, December 2024 |IFSTJ|
Publisher : Department of Technology of Agricultural product (THP) Jambi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/ifstj.v8i1.32818

Abstract

Advanced drug delivery systems are required due to the increasing advancement in science and technology, with a common example being microencapsulation. This system is affected by the manufacturing conditions and slow release of bioactive compounds inside microcapsule. In general, phytochemicals in the edible plant, Cosmos caudatus Kunth, specifically flavonoids, offer several health benefits but are susceptible to degradation which reduces biological activities. Therefore, this study aimed to encapsulate extract using spray drying method, which can be used as wall material in Gum Arabic. Microencapsulated product was also tested for biological activities. The effect of microcapsule production was investigated, including the concentration of wall material and the stirring speed. Furthermore, the optimal conditions of microcapsule were selected based on the highest encapsulation efficiency. The results showed that a concentration of 4% (w/v) Gum Arabic and a stirring speed of 800 rpm were the optimal conditions, leading to a percentage release of 71.87%. Microcapsule under these conditions produced an IC50 value of 55.09 ± 0.57 ug/mL as an inhibitor of alpha-amylase enzyme. The characterization by scanning electron microscope (SEM) showed spherical forms with a mean diameter of 152.00 um. The bioactive substance in microcapsule was released at pH 2.2 and pH 7.4 for 30 to 120 min, with a percentage release of 38.05% and 95.14%, respectively. In conclusion, this study confirmed that microencapsulation played a crucial role in the development of plant extract with retained biological functions.
Co-Authors A.A. Ketut Agung Cahyawan W Adam Mahfud Ade Cintyia Sally Al zamzami, Ilham Misbakudin Alma Miranda Amaniyah, Amaniyah Amin, Abd Aziz Amini, Helda Wika Andi Kurniawan Andi Kurniawan Anggayasti, Wresti L. Anjani, Ryzki Martha Arda Rista Lestari Caterina Widya Astutik Chairulita Putri Kusumaningsih Dinia Rizqi Dwijayanti Dwi Susanti, Yogita Ayu Edi Priyo Utomo Edi Priyo Utomo Edi Priyo Utomo Efani, Anton Eka Novitasari Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah Esya, Firdausy Amalina Fadlilah, Lilik Nur Fath Dwisari Fatma, Aliya Galisong, Ridwan Danuarta Grahadi, Rahmat Gunawan, Firza Rajasa Hapsari, Febriyana Rizky Helda Wika Amini Hermanto, Feri Eko Hidayatul Mustafidah Hideki Okamoto Hideki Okamoto Iftitah, Elvina Dhiaul Indah Nur Pramesti Inra Sari Kamila, Fairuz Sarah Karimah Karimah Kyosuke Satake Kyosuke Satake Lisa Aulia, Lisa Listianingsih, Lia Lukman Hakim Lutfi Ni’matus Salamah Luthfia Ayu Dhea Maharani Pertiwi Koentjoro Mahfuzh Huda Masruri Masruri Masruri Masruri Masruri Moehammad, Khibar Syiar Moh. Farid Rahman Mohammad Elham Firdaus Mohammad Farid Rahman Mohammad Farid Rahman Momodou Salieu Sowe Momodou Salieu Sowe Nashi Widodo Nisa', Khibrun Nur Ikhtiarini Nuraini Uswatun Chasana Pangesti, Laras Pramudia, Zulkisam Pratama, Safreno Panggih Pratiwi, Rahmania Tulus Setya Prihartini, Dita Puspitasari, Rizka Dwitya Rachmat Triandi Tjahjanto Rizka Fauzia Ohorella Rizqi Alima Fabri, Ahmad Rosyadah, Nuraini Safitri, Anna Salamah, Lutfi Ni’matus Suratmo, Suratmo SUTRISNO Sutrisno, Sutrisno Utomo, Edi Priyo Wardani, Eris Agustin Warsito Warsito Warsito Warsito Widia Edy Kuncoro Widodo Widodo Widyananda, Muhammad Hermawan Yanuar, Adi Tiya Yosua Yosua Yulistian, Dhoni Prielananta Yusnawan, Eriyanto Yusuf Hendrawan Zahara, Izaz Aqeiluz