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All Journal FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASIMED (JFM) Indonesia Natural Research Pharmaceutical Journal (INRPJ) Berdikari : Jurnal Pengabdian kepada Masyarakat Pharmacy Action Journal Sciences of Pharmacy PANDAWA : Jurnal Pengabdian kepada Masyarakat
Theodorus Rexa Handoyo
Fakultas Farmasi, Universitas Sanata Dharma
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Effect of Tween 80 and Span 80 Surfactants Systems on the Malus domestica Emulsions for Anti-Cutibacterium acnes Handoyo, Theodorus Rexa; Resmi, Juniar Kalpika; Hutabarat, Rahmi; Guanse, Yovi
Sciences of Pharmacy Volume 5 Issue 1
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0501526

Abstract

Red apple (Malus domestica) extract, rich in hydrophobic quercetin, was formulated into oil-in-water (O/W) emulsion using a 22 factorial design to evaluate Tween 80 (8-10 g) and Span 80 (2-4 g) concentrations, targeting pH (4.5-6.0), transmittance (90-100%), and viscosity (10-2000 cPs). Design-Expert® 13 analysis identified formulations F1, FA, and FAB within acceptable physical property ranges, with all red apple emulsions exhibiting O/W type, skin-compatible pH (5.20-5.48), high transmittance, and suitable viscosity. Freeze-thaw cycling (3 cycles, -15/25°C) and centrifugation showed physical stability with non-significant changes for F1 (p > 0.05). The agar well diffusion assay was performed on F1 (n = 3), which exhibited optimal physical parameters and met stability criteria, revealing Cutibacterium acnes inhibition zones up to 22.7 ± 0.577 mm. Thus, F1 emerges as a promising nanoemulsion candidate demonstrating antibacterial activity against acne-causing bacteria.
Co-Authors Alaina, Hawwin Alfinur, Muhammad Anggarini, Yulianti Arbah, Windy Annisa Asha, Asha Azzahra, Taysa Zifa Chelsia Devina Maryanto Djohansah, Violetta Elza Reihana Fitriani Fitriani Go Andrew Purnomo Guanse, Yovi Hanim, Abra Uzri Harahap, Chairunnisa Hasbullah, Zahra Rahmawati Herlina, Dwi Irawati, Juwita Isfani, Delia Karina Karina Michael Raharja Gani Opur, Hamka George Marly Hairil Purwati Purwati Putri, Zaskia Fahmi Rahmi Hutabarat Resmi, Juniar Kalpika Ria Anggraeni Sagala, Zuraida Sianipar, Rahul Rafles Simatupang, Angel Maria Sulawati, Iggit Supit, Tesalonica Maria Victoria, Brigita Wibawa, Wahyu Setya Zahira, Rayzha Firya