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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Medical Laboratory Technology Journal Indonesian Journal of Community Services Journal of Holistics and Health Sciences (JHHS) Asian Journal of Health and Applied Sciences Gema Lingkungan Kesehatan Indonesian Journal of Medical and Pharmaceutical Science
Joko Wahyu Wibowo
Bagian Gizi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)
Humanities Biochemistry, Genetics & Molecular Biology Chemistry Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Upaya Peningkatan Kepatuhan Minum Obat Hipertensi melalui Edukasi dan Pemeriksaan Kesehatan bagi Warga Karangroto Genuk Yafie, Ahmad Arif; Fatikhasari, Amalia Nurazima; Sulistyowati, Dian; Pradana, Febry Annan; Wulandari, Fitri; Tianka, Inge Elsa; Putri, Maharani Aulia; Hanfin, Zayyina Chamaladina; Wibowo, Joko Wahyu; Soegeng, Purwito; Suparmi, Suparmi
Indonesian Journal of Community Services Vol 7, No 1 (2025): May 2025
Publisher : LPPM Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijocs.7.1.1-8

Abstract

Hipertensi atau tekanan darah tinggi merupakan salah satu penyakit tidak menular dimana tekanan darah sistolik ≥ 140 mmHg dan atau tekanan darah diastolik ≥ 90 mmHg. Hipertensi jika tidak ditangani akan menyebabkan penyakit vaskuler seperti stroke, retinopati, kerusakan ginjal, pembengkakan jantung, dan penyakit jantung koroner. Tujuan kegiatan pengabdian masyarakat (PkM) ini adalah untuk meningkatkan pengetahuan dan kepatuhan minum obat penderita hipertensi di RW 13, Kelurahan Karangroto, Genuk, Semarang melalui edukasi atau penyuluhan dan pemeriksaan kesehatan. Kegiatan PkM meliputi tahap persiapan berupa survei Program Indonesia Sehat Pendekatan Keluarga (PIS-PK) dan musyawarah masyarakat kelurahan dan pre test. Pelaksanaan PkM meliputi senam bersama, penyuluhan tentang kepatuhan minum obat hipertens, pemeriksaan tekanan darah dan glukosa darah. Hasil evaluasi menunjukkan bahwa tingkat pengetahuan dan sikap terhadap kepatuhan minum obat hipertensi mengalami peningkatan secara signifikan (p <0.005) dibandingkan dengan sebelum PkM. Edukasi dan pemeriksaan kesehatan bermanfaat sebagai upaya meningkatkan kepatuhan minum obat hipertensi sehingga diharapkan dapat menurunkan risiko komplikasi pada penderita.Hypertension, or high blood pressure, is a non-communicable disease where systolic blood pressure is ≥ 140 mmHg and/or diastolic blood pressure is ≥ 90 mmHg. If hypertension is not treated, it will cause vascular diseases such as stroke, retinopathy, kidney damage, heart swelling, and coronary heart disease. This community service activity (PkM) aims to increase knowledge and compliance with taking medication for hypertension sufferers in RW 13, Karangroto Village, Genuk, and Semarang through education, counseling, and health checks. PkM activities include the preparatory stage in the form of a Family Approach Healthy Indonesia Program (PIS-PK) survey and village community deliberations and pre-tests. Implementation of PkM includes group exercise and education about compliance with taking medication for hypertension, blood pressure, and blood glucose checks. The evaluation results show that knowledge and attitudes towards adherence to hypertension medication have increased significantly (p <0.005) compared to before PkM. Education and health checks are useful as an effort to improve compliance with taking hypertension medication, so it is hoped that they can reduce the risk of complications in sufferers.
Effect of Turmeric Ethanol Extract (Curcuma Longa Linn) on IL-6, IL-10 Levels and Skin Moisture Anggraeni, Gilda Putri; Sumarawati, Titiek; Chodidjah; Wibowo, Joko Wahyu; Zulaikah, Siti Thomas; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.330

Abstract

Ultraviolet B (UVB) radiation is known to induce skin damage, including erythema, roughness, sagging, wrinkles, and reduced skin moisture, contributing to premature aging. Turmeric (Curcuma longa Linn.) contains curcumin, an active compound with potent anti-inflammatory properties. This study investigated the effect of turmeric ethanol extract on IL-6 and IL-10 levels, as well as skin moisture, in UVB-exposed rats. A total of 24 Wistar rats were randomly divided into four groups: healthy controls (K1), UVB-exposed without treatment (K2), UVB-exposed treated with turmeric ethanol extract at 100 mg/kg BW (K3), and 200 mg/kg BW (K4). The extract was administered orally for 14 days. IL-6 and IL-10 levels were measured using ELISA, and skin moisture was assessed macroscopically. Statistical analysis was performed using one-way ANOVA. Rats in groups K2, K3, and K4 exhibited very dry skin, redness, visible wrinkles, and peeling following UVB exposure. IL-6 levels were significantly lower in treated groups, with the lowest levels observed in K4 (1.85 ± 0.24 ng/L), compared to K1 (4.36 ± 0.75 ng/L) and K2 (4.46 ± 0.74 ng/L) (p = 0.000). IL-10 levels increased in the treated groups, notably in K3 (376.48 ± 78.24 pg/mL) and K4 (351.06 ± 78.24 pg/mL), compared to K1 (285.34 ± 45.54 pg/mL) and K2 (306.89 ± 45.54 pg/mL) (p = 0.001). These findings suggest that oral administration of turmeric ethanol extract modulates inflammatory responses by reducing IL-6 and enhancing IL-10 in UVB-exposed skin, although significant dryness persists.
Penambahan Vitamin A Meningkatkan Kapasitas Antioksidan Air Kelapa Muda : Studi Eksperimental pada Tikus yang dipapar Asap Rokok Harum Sari, Stefani; Ratnawati; Wibowo, Joko Wahyu
Indonesian Journal of Medical and Pharmaceutical Science Vol. 1 No. 1 (2022)
Publisher : Sultan Agung Islamic University of Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v1i1.6

Abstract

Latar belakang: Stress oksidatif merupakan mekanisme jejas sel akibat paparan asap rokok. Suplementasi antioksidan berupa bahan makanan yang mengandung bioaktif maupun mikronutrien diharapkan mampu mencegah kerusakan sel dan memperbaiki kerusakan pada tingkat seluler. Vitamin A dan air kelapa muda berpotensi sebagai antioksidan untuk menurunkan tingkat stres oksidatif. Penelitian ini bertujuan untuk mengetahui kapasitas antioksidan kombinasi vitamin A dan air kelapa muda dalam menurunkan tingkat stres oksidatif akibat paparan asap rokok. Metode: Penelitian eksperimental dengan desain post test only control group, jumlah subyek penelitian 24 ekor tikus wistar jantan yang dibagi menjadi 4 kelompok secara acak. Kelompok 1 : pakan standar, kelompok 2 : pakan standar + paparan asap rokok, kelompok 3 : pakan standar + paparan asap rokok + air kelapa muda 8mL/ekor/hari, dan kelompok 4 mendapat pakan standar + paparan asap rokok+ air kelapa muda 8 mL/ ekor/hari+ vitamin A 108 IU/200 gBB/hari, Jenis pakan standar AD II sebanyak 20 g/ ekor/ hari, minum ad libitum. Lama penelitian 14 hari. Pemeriksaan kadar MDA dengan metode TBARS. Hasil: Rerata kadar MDA ( nmol/mL) kel. 1: 1,54 ± 0,21, kel. 2 : 9,77 ± 0,32, kel. 3: 3,77 ± 0,13, dan kel 4: 2,29 ± 0,34, setelah dilakukan uji anova didapatkan nilai p= 0,001. Kesimpulan: Terdapat perbedaan yang signifikan rerata kadar MDA kelompok tikus yang mendapat vitamin A dan air kelapa muda dibandingkan kelompok yang hanya air kelapa muda.
Effect of Butterfly Pea Flower (Clitoria ternatea L.) Gel on PDGF and IL-6 Expression in UVB-Exposed Wistar Rats Pratiwi, Desy Elia; Wibowo, Joko Wahyu; Isradji, Israhanto
Medical Laboratory Technology Journal Vol. 11 No. 2 (2025): December
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i2.660

Abstract

Ultraviolet-B (UV-B) exposure can trigger inflammation and inhibit skin regeneration by decreasing Platelet-Derived Growth Factor (PDGF) and increasing Interleukin-6 (IL-6). Butterfly Pea (Clitoria ternatea L.) is known for its antioxidant and anti-inflammatory properties, but its effectiveness as a topical gel has not been widely studied. This study aims to evaluate the effect of Butterfly Pea (Clitoria ternatea L) extract gel on IL-6 and PDGF expression in Wistar rats exposed to UVB. This study is an in vivo experimental study with a post-test-only control group design. A total of 20 Wistar rats (200–250 g) were divided into four groups consisting of 5 rats per group: K1 (healthy control), K2 (gel base + UV-B), K3 (5% Clitoria ternatea gel + UV-B), and K4 (10% Clitoria ternatea gel + UV-B). UV-B exposure was carried out for 20 minutes/day (160 mJ/cm²) for 7 days. PDGF and IL-6 expression were analyzed by RT-qPCR. Statistical tests using Shapiro-Wilk, Levene, Kruskal-Wallis for PDGF expression, and One-Way ANOVA for IL-6 expression. Studies have shown that PDGF expression did not show significant differences between groups (p=0.455), with an average expression of K1: 1.39±0.62, K2: 1.39±0.61, K3: 1.66±0.87, and K4: 1.52±1.88. IL-6 expression was also similar (p=0.663), an average of K1: 1.02±0.18, K2: 1.11±0.33, K3: 1.22±0.23, and K4: 1.16±0.26. Conclusion: Administration of Clitoria ternatea L. extract gel did not have a significant effect on PDGF and IL-6 expression in the skin of Wistar rats exposed to UVB light. Both 5% and 10% doses showed no significant difference in the expression of the two markers; further studies with larger sample sizes, longer treatment durations, and improved topical delivery systems are needed. are recommended to better evaluate its therapeutic potential.
Co-Authors Anggraeni, Gilda Putri Athatsaniya, Mazaya Denta Chodidjah Danis Pertiwi Fatikhasari, Amalia Nurazima Fitri Wulandari Hanfin, Zayyina Chamaladina Harum Sari, Stefani Isradji, Israhanto Minidian Fasitasari Muhyi, Ahmad Pradana, Febry Annan Pratiwi, Desy Elia Purwito Soegeng Putri, Maharani Aulia RATNAWATI Setyo Trisnadi Shinta, Sopia Shofa Chasani Siti Thomas Zulaikhah Sri Priyantini Sulistyowati, Dian Suparmi Suparmi Tanry, Selvina Taufiqurrachman Nasihun Tianka, Inge Elsa Titiek Sumarawati Ulfah Dian Indrayani wibowo, subur Yafie, Ahmad Arif Yuniarifa, Conita Yuniarti, Heny Zulaikah, Siti Thomas