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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung AcTion: Aceh Nutrition Journal Indonesian Journal of Medicine Indonesian Journal of Community Services Journal of Holistics and Health Sciences (JHHS) Asian Journal of Health and Applied Sciences Gema Lingkungan Kesehatan
Joko Wahyu Wibowo
Bagian Gizi Fakultas Kedokteran Universitas Islam Sultan Agung (UNISSULA)
Humanities Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Effect of Nigella sativa on Growth and IGF-1 levels in Rats Prenatally Exposed to Pesticides Wibowo, Joko Wahyu; Fasitasari, Minidian; Yuniarti, Heny; Tanry, Selvina
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3862

Abstract

Nigella sativa contains antioxidants and can potentially improve growth disorders due to prenatal pesticide exposure. Pesticides affect the work of thyroid hormone, insulin, and Insulin-like Growth Factor that play essential roles in the growth and development processes. This study aimed to determine the effect of Nigella sativa supplementation on body weight and IGF-1 levels in mice, with a history of pesticide exposure in the womb. This study was conducted from October 14, 2023 to December 1, 2023 at the laboratory of the Center for Food and Nutrition Studies, Inter-University Center, Gajah Mada University, Indonesia. This experimental study used a cohort design and involved 20 pregnant female rats as the experimental animals. These rats were divided into several groups: K0 (control group with standard feed), K1 (group exposed to pesticides during pregnancy),  and P1 and P2 (group exposed to pesticides. Followed by 10.8 mg/200gBW/day and 21.6 mg/ 200 gBW/day of Nigella sativa after birth, respectively). The pesticide dose used was 10 mg/200gBW/day orally. Anthropometric examinations was conducted at birth, and on day 7, day 14, day 21, and day 28. The examination of IGF-1 levels was performed on day 28 using the ELISA method. Results showed that the mean birth weights (g) of the rats by group were as follows: K0:6.09±0.12; K1:4.03±0.03, P1:4.03±0.02 P2:4.05±0.03. On day 28, the mean body weights (g) were as follows: K0:104.0±1.79; K1:65.17±1.47; P1:92.17 ± 3.19; and P2:102.00±1.41. The mean IGF-1 level (pg/mL) were as follows: K0:23.76±0.68; K1:9.03±0.24, P1:14.94±0.37; and P2:19.51±0.56. The ANOVA test presented a p-value of <0.001. Hence, Nigella sativa supplementation after birth significantly affects body weight and IGF-1 levels in rat model of prenatally exposed to pesticides.
Upaya Peningkatan Kepatuhan Minum Obat Hipertensi melalui Edukasi dan Pemeriksaan Kesehatan bagi Warga Karangroto Genuk Yafie, Ahmad Arif; Fatikhasari, Amalia Nurazima; Sulistyowati, Dian; Pradana, Febry Annan; Wulandari, Fitri; Tianka, Inge Elsa; Putri, Maharani Aulia; Hanfin, Zayyina Chamaladina; Wibowo, Joko Wahyu; Soegeng, Purwito; Suparmi, Suparmi
Indonesian Journal of Community Services Vol 7, No 1 (2025): May 2025
Publisher : LPPM Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijocs.7.1.1-8

Abstract

Hipertensi atau tekanan darah tinggi merupakan salah satu penyakit tidak menular dimana tekanan darah sistolik ≥ 140 mmHg dan atau tekanan darah diastolik ≥ 90 mmHg. Hipertensi jika tidak ditangani akan menyebabkan penyakit vaskuler seperti stroke, retinopati, kerusakan ginjal, pembengkakan jantung, dan penyakit jantung koroner. Tujuan kegiatan pengabdian masyarakat (PkM) ini adalah untuk meningkatkan pengetahuan dan kepatuhan minum obat penderita hipertensi di RW 13, Kelurahan Karangroto, Genuk, Semarang melalui edukasi atau penyuluhan dan pemeriksaan kesehatan. Kegiatan PkM meliputi tahap persiapan berupa survei Program Indonesia Sehat Pendekatan Keluarga (PIS-PK) dan musyawarah masyarakat kelurahan dan pre test. Pelaksanaan PkM meliputi senam bersama, penyuluhan tentang kepatuhan minum obat hipertens, pemeriksaan tekanan darah dan glukosa darah. Hasil evaluasi menunjukkan bahwa tingkat pengetahuan dan sikap terhadap kepatuhan minum obat hipertensi mengalami peningkatan secara signifikan (p <0.005) dibandingkan dengan sebelum PkM. Edukasi dan pemeriksaan kesehatan bermanfaat sebagai upaya meningkatkan kepatuhan minum obat hipertensi sehingga diharapkan dapat menurunkan risiko komplikasi pada penderita.Hypertension, or high blood pressure, is a non-communicable disease where systolic blood pressure is ≥ 140 mmHg and/or diastolic blood pressure is ≥ 90 mmHg. If hypertension is not treated, it will cause vascular diseases such as stroke, retinopathy, kidney damage, heart swelling, and coronary heart disease. This community service activity (PkM) aims to increase knowledge and compliance with taking medication for hypertension sufferers in RW 13, Karangroto Village, Genuk, and Semarang through education, counseling, and health checks. PkM activities include the preparatory stage in the form of a Family Approach Healthy Indonesia Program (PIS-PK) survey and village community deliberations and pre-tests. Implementation of PkM includes group exercise and education about compliance with taking medication for hypertension, blood pressure, and blood glucose checks. The evaluation results show that knowledge and attitudes towards adherence to hypertension medication have increased significantly (p <0.005) compared to before PkM. Education and health checks are useful as an effort to improve compliance with taking hypertension medication, so it is hoped that they can reduce the risk of complications in sufferers.
The effect of butterfly pea flower (Clitoria ternatea) extract gel on TNF-α and caspase-3 expression in wound tissue of wistar rats Ninasara, Yulisa Afriani; Wibowo, Joko Wahyu; Isradji, Israhnanto
AcTion: Aceh Nutrition Journal Vol 10, No 2 (2025): June
Publisher : Department of Nutrition at the Health Polytechnic of Aceh, Ministry of Health

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/action.v10i2.2441

Abstract

Exposure to acute ultraviolet B (UVB) damages the skin through oxidative stress, inflammation, and apoptosis. UVB increases the production of reactive oxygen species (ROS), which damage cells and trigger inflammation by increasing TNF-α levels. Increased ROS and TNF-α levels activate caspase-3, which causes cellular apoptosis. This damage worsens skin conditions, triggers premature aging (photoaging), and increases the risk of skin cancer. In Indonesia, approximately 57,3% of the population is exposed to sunlight, with a prevalence of dry skin ranging from 50% to 80%, while photoaging contributes to approximately 80% of the adverse effects of skin aging. Clitoria ternatea contains bioactive compounds with antioxidant and anti-inflammatory properties that have the potential to suppress caspase-3 activation and prevent cell damage. This experimental study used a post-test-only control group design with a completely randomized design, involving male Wistar rats divided into four treatment groups (K1–K4). The study was conducted at the Chemistry Laboratory of IBL UNISSULA, with animal treatment at the Animal Experiment Laboratory of IBL UNISSULA and skin tissue sample analysis at the General Medical Laboratory of CITO Yogyakarta from December 2024 to February 2025. Clitoria ternatea extract gel was applied topically once a day for 7 days, followed by UVB exposure (160 mJ/cm²) for ±15 min per day. Skin tissue samples were collected 24 h after the last treatment with a 6 mm punch biopsy, and the expression of TNF-α and caspase-3 was analyzed using qRT-PCR. Data were tested using one-way analysis of variance (ANOVA). Results, the group given a 5% dose of gel (K3) showed a significant decrease in the expression of TNF-α (0,35±0,20) and caspase-3 (0,16±0,32) compared to other groups, while the 10% dose (K4) showed no significant difference. The conclusion, Clitoria ternatea extract gel at a 5% dose effectively reduced the expression of TNF-α and caspase-3 in the skin of UVB-exposed mice.
Effect of Turmeric Ethanol Extract (Curcuma Longa Linn) on IL-6, IL-10 Levels and Skin Moisture Anggraeni, Gilda Putri; Sumarawati, Titiek; Chodidjah; Wibowo, Joko Wahyu; Zulaikah, Siti Thomas; Trisnadi, Setyo
Gema Lingkungan Kesehatan Vol. 23 No. 3 (2025): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v23i3.330

Abstract

Ultraviolet B (UVB) radiation is known to induce skin damage, including erythema, roughness, sagging, wrinkles, and reduced skin moisture, contributing to premature aging. Turmeric (Curcuma longa Linn.) contains curcumin, an active compound with potent anti-inflammatory properties. This study investigated the effect of turmeric ethanol extract on IL-6 and IL-10 levels, as well as skin moisture, in UVB-exposed rats. A total of 24 Wistar rats were randomly divided into four groups: healthy controls (K1), UVB-exposed without treatment (K2), UVB-exposed treated with turmeric ethanol extract at 100 mg/kg BW (K3), and 200 mg/kg BW (K4). The extract was administered orally for 14 days. IL-6 and IL-10 levels were measured using ELISA, and skin moisture was assessed macroscopically. Statistical analysis was performed using one-way ANOVA. Rats in groups K2, K3, and K4 exhibited very dry skin, redness, visible wrinkles, and peeling following UVB exposure. IL-6 levels were significantly lower in treated groups, with the lowest levels observed in K4 (1.85 ± 0.24 ng/L), compared to K1 (4.36 ± 0.75 ng/L) and K2 (4.46 ± 0.74 ng/L) (p = 0.000). IL-10 levels increased in the treated groups, notably in K3 (376.48 ± 78.24 pg/mL) and K4 (351.06 ± 78.24 pg/mL), compared to K1 (285.34 ± 45.54 pg/mL) and K2 (306.89 ± 45.54 pg/mL) (p = 0.001). These findings suggest that oral administration of turmeric ethanol extract modulates inflammatory responses by reducing IL-6 and enhancing IL-10 in UVB-exposed skin, although significant dryness persists.
Community-based zinc supplementation for linear growth recovery in stunted under-five children in Indonesia Yuniarti, Heny; wibowo, Joko Wahyu; Purjaningsih, Shofi Khofsoftun
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2025): June 2025
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v16i1.47046

Abstract

Stunting remains a significant nutritional challenge in Indonesia and across Southeast Asia, with zinc deficiency identified as a contributing factor to impaired linear growth in early childhood. Zinc is critical for growth hormone synthesis, bone development, and immune regulation. Despite existing intervention programs, stunting prevalence in Indonesia remained at 19.8% in 2024. This study evaluated the effect of zinc supplementation on the linear growth of stunted children aged 0–5 years attending Bangetayu and Genuk Public Health Centres in Semarang. Employing an observational analytic design with a one-group pretest-posttest approach, 42 stunted toddlers received a daily oral dose of 20 mg zinc sulfate syrup for two months. Anthropometric measurements were recorded before and after the intervention, with paired T-tests applied to normally distributed data and Wilcoxon signed-rank tests to non-normal data. After two months of supplementation, 86% of the participants demonstrated improvements in both height and weight. The mean height increased from 79.9 cm to 81.0 cm (p < 0.001), while the mean weight increased from 9.28 kg to 9.74 kg (p < 0.001). These findings indicate that zinc supplementation significantly enhances linear growth among stunted toddlers. Consequently, integrating zinc supplementation into national nutrition intervention strategies could be pivotal in reducing early childhood stunting.
Co-Authors Anggraeni, Gilda Putri Athatsaniya, Mazaya Denta Chodidjah Danis Pertiwi Fatikhasari, Amalia Nurazima Fitri Wulandari Hanfin, Zayyina Chamaladina Israhnanto Isradji Maulidia, Meli Minidian Fasitasari Muhyi, Ahmad Ninasara, Yulisa Afriani Pradana, Febry Annan Purjaningsih, Shofi Khofsoftun Purwito Soegeng Putri, Maharani Aulia Setyo Trisnadi Shinta, Sopia Shofa Chasani Siti Thomas Zulaikhah Sri Priyantini Sulistyowati, Dian Suparmi Suparmi Tanry, Selvina Taufiqurrachman Nasihun Tianka, Inge Elsa Titiek Sumarawati Ulfah Dian Indrayani wibowo, subur Yafie, Ahmad Arif Yuniarifa, Conita Yuniarti, Heny Zulaikah, Siti Thomas