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All Journal EKSAKTA: Journal of Sciences and Data Analysis Buletin Anatomi dan Fisiologi (Bulletin of Anatomy and Physiology) Biomolecular and Health Science Journal Best Journal (Biology Education, Sains and Technology) Indonesia Berdaya Indonesian Community Journal ABDI DAYA: Jurnal Pengabdian dan Pemberdayaan Masyarakat SWAGATI: Journal of Community Service Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Rofiatun Solekha
Biology Program, Faculty Of Science, Technology, And Education, Universitas Muhammadiyah Lamongan, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : Biomolecular and Health Science Journal

 1 
Immunomodulator Effect of Lemongrass Extract (Cymbopogon nardus L.) to Increase Immune Cells as a Precaution Against SARS-CoV-2 Putri Ayu Ika Setiyowati; Rofiatun Solekha; Sri Bintang Sahara Mahaputra Kusuma Negara; Reny Rosalina
Biomolecular and Health Science Journal Vol. 4 No. 2 (2021): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v4i2.26619

Abstract

Introduction: In humans, Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) can damage some tissue when the immune systems was decrease. Natural product from the plant often used to improve immune response against microorganism including virus. This study aimed to determine the potential antioxidant of lemongrass extract (C . nardus) with various dosage that can provide immunomodulatory effects and find an optimal dosage to be used.  Methods: The method used observasional analytic, using animal model of 30 male mice strain BALB/C, weight 25-30 gram, divided into 5 groups; the positive control group was given 0.05 mL of  0.05% CMC within 14 days, negative control group was given IMBOOST® tablet 200 mg/kg body weight (bw) within 14 days, treatment groups  were given C. nardus extract with various doses 50 mg/kg bw, 150 mg/kg bw, and 300 mg/kg bw.  In day 21 all group were injected with 0,2 ml of  pathogen bacterial (S. aureus). Blood samples were taken three times: 7th day, 14th day, and 21th day. Results: The results showed that lemongrass extract (C. nardus) was able to influence the leukocyte and lymphocytes count with significant different (p<0.05). The optimal dose is 150 mg/kg body weight. Conclusion: The antioxidant compounds that contain in the C. nardus extract have an ability to increasing the immune system in the dose 150 mg/kg bw , but in the dose 300 mg/kg bw became toxic that can make a skin injury or death in animal test.
Protective Effect of Lemongrass Extract (Cymbopogon nardus) on Spermatozoa Cells Induced by Lead Acetate Putri Ayu Ika Setiyowati; Rofiatun Solekha; Dwi Dianita Irawan; Reny Rosalina; Karin Alifia Rachmadani; Angella Ananda Saputra
Biomolecular and Health Science Journal Vol. 5 No. 1 (2022): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bhsj.v5i1.31450

Abstract

Introduction: Male infertility can be caused by many factors. One of which is environmental pollution such as lead acetate. Lead acetate exposure can increase Reactive Oxygen Species (ROS), affecting spermatozoa quality. Natural antioxidants and flavonoid on Lemongrass (C. nardus) have a great potential for protecting the male reproductive system. This study aimed to analyze the effect of giving various dosages of C. nardus extract on the sperm quality of mice. Methods: The Balb/C male mice were divided into five equal groups. The negative control group was injected with 0.01 ml Na-CMC 0.5% within 40 days, and the positive control group was injected with 0.01 ml lead acetate 7 mg/kg BW within 5 days, the treatment groups were injected by 0.01 ml lead acetate 7 mg/kg body weight within 5 days and continuously injected by 0.01 ml of C. nardus extract with various dosage 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW within 35 days. At the end of the experiment, mice were sacrificed, and sperm suspensions were collected from cauda epididymal to measure the morphology, concentration, and motility.Results: The results showed that giving C. nardus extract could repair morphology, concentration, and motility of spermatozoa with significantly different (p<0.05). The 25 mg/kg BW dose has a good protective effect. Conclusion: The C. nardus extract can repair the decreasing sperm quality caused by lead acetate exposure.
Co-Authors Abdul Majid Aisyah Hadi Ramadani Aisyah, Neelam Aji Naufal Syafiq Alfanani, Syafiq Aluisius Hery Pratono Angella Ananda Saputra Angella Ananda Syaputra Ayuni, Rieke Dwi A’in, Nur Khurotul Badriatul Musyarofah Badriatul Musyarofah Badriyatul Musyarofah Bagus Dwi Jauhari Bambang Budiarto, Bambang Chandra Tri uliana Sari Dimas Arya Nugraha Dini Ermavitalini Djumadi, Firman Rosjadi Djuwari Djuwari Dwi Dianita Irawan Dwi Zulianti Elliv Hidayatul Lailiyah Febianti Dwi Hapsari Fika Nur Fitriana Putri Bukhori Haibaturrahma, Nur Fatimah Azzahra Halma, emil Milhatul Maflahah Hariadi, Sugeng Hery Purnobasuki Husna, Etika Ziadana Al Idfi Setyaningrum, Idfi Karin Alifia Rachmadani Karin Alifia Rachmadani Karin Alifia Rachmadani Khakim, Arsanul Khoirin Nisa Laila Ainur Rohmah Lailatus Fitri Latifah, Indah Ttriwahyuni Lilis Maghfuroh Mahbubillah, M. Ainul Mintarti Ariani Mufti Ari Bianto Ni'matuzahroh Ni'matuzahroh Nisa, Salasun Nynda Ayu Nadira Savitri Nynda Ayu Nadira Savitri Rahayu , Anisa Esti Rahmahana, Ratna Syifa’a Rajamin, Irza Meingindra Putri Ramadhan, Muhammad Syahrur Reny Rosalina Salasun Nisah Setiyowati, Putri Ayu Ika Silvi Wasi’atul Af'idah Sri Bintang Sahara Mahaputra Kusumanegara Sundari, Made Siti Wulandari, Ayu Dewi Yaumi, Sri