Noor Wijayahadi
Department Of Pharmacology, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia

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Pengaruh Kadar Vitamin C dan Vitamin E Terhadap Peningkatan Kadar Bilirubin pada Neonatus Kamilah Budhi Rahardjani; Rifki Agung; Noor Wijayahadi
Sari Pediatri Vol 12, No 1 (2010)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (81.95 KB) | DOI: 10.14238/sp12.1.2010.30-5

Abstract

Latar belakang. Hiperbilirubinemia terjadi pada 25%-50% bayi baru lahir. Secara fisiologis bilirubinmeningkat mencapai puncak pada kadar 5-6 mg/dl pada hari 3-4 setelah kelahiran, penyebab terbanyakkarena hemolisis (75%) akibat pendeknya usia eritrosit fetus yang kemungkinan juga akibat paparan oksidan.Vitamin C dan E bersinergi melindungi eritrosit dari kerusakan oksidatif.Tujuan. Menganalisis pengaruh kadar vitamin C dan vitamin E terhadap kadar bilirubin pada neonatus.Metode. Desain penelitian ini cross sectional dengan subjek adalah 40 neonatus aterm sehat yang dirawat dibangsal rawat gabung RSUP Dr. Kariadi selama bulan Maret - Mei 2009. Dilakukan pemeriksaan vitaminC dengan metode Colorimetric Assay, vitamin E menggunakan metode Elisa (Immunoassay). Uji beda Mann-Whitney untuk mengetahui perbedaan kadar vitamin C dan vitamin E pada kedua kelompok peningkatanbilirubin. Uji bivariat dan multivariat regresi logistik untuk mengetahui pengaruh kadar vitamin C danvitamin E terhadap peningkatan kadar bilirubin.Hasil. Kadar vitamin C pada kelompok bilirubin meningkat (6,89±0,09) μg/ml dan tidak meningkat(7,18±0,28) μg/ml, vitamin E (0,19±0,03) μg/ml dan (0,23±0,01) μg/ml, terdapat perbedaan bermakna padakedua kelompok dengan nilai p=0,001. Pengaruh kadar vitamin C (OR 16,734, IK95% 2.976; 93.885),sedangkan vitamin E (OR 21, IK95% 3664;120.373) dengan p=0,001. Analisis multivariat menunjukkanterdapat peningkatan pengaruh kadar vitamin C (OR 21,674, IK95% 2.048; 229.324), vitamin E (OR26,734, IK95% 2.654; 269.260), p=0,001.Kesimpulan. Kadar vitamin C dan vitamin E di bawah normal mempunyai pengaruh lebih besar terhadappeningkatan kadar bilirubin. Kadar vitamin E di bawah normal mempunyai pengaruh lebih besar dibandingkadar vitamin C di bawah normal.
Korelasi Kadar Seng Serum dan Bangkitan Kejang Demam Iva-Yuana Iva-Yuana; Tjipta Bahtera; Noor Wijayahadi
Sari Pediatri Vol 12, No 3 (2010)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp12.3.2010.150-6

Abstract

Latar belakang. Kejang demam merupakan kelainan saraf tersering pada anak. Sekitar 2%-5% anak di bawahumur 5 tahun pernah mengalami kejang demam. Prognosis kejang demam baik, namun mengkhawatirkanorang tua. Penelitian tentang hubungan kadar seng serum dengan bangkitan kejang demam belum banyakdilakukan.Tujuan. Membuktikan korelasi kadar seng serum dan bangkitan kejang demam.Metode. Penelitian kasus kontrol dengan subyek penelitian anak berumur 3 bulan-5 tahun di RS Dr.Kariadipada April 2009–Maret 2010, kelompok kasus dengan bangkitan kejang demam dan kelompok kontroldengan demam tanpa kejang. Kadar seng serum diperiksa di laboratorium GAKI FK UNDIP denganmetode atomic absorption spectrophotometry. Data dianalisis dengan uji Chi-square, korelasi Spearman,dan analisis determinan.Hasil. Subyek penelitian 72 pasien, 36 kelompok kasus dan 36 kelompok kontrol. Rerata kadar seng kelompokkasus 111,73 􀁍g/mL dan kelompok kontrol 114,56 􀁍g/mL (p=0,33). Tidak terdapat korelasi antara kadarseng serum dengan bangkitan kejang demam (r=0.114;p>0,05). Analisis determinan menunjukkan urutanbesarnya kontribusi faktor genetik (0,548), infeksi berulang (0,493), riwayat penyulit kehamilan-persalinan(0,364), suhu (0,309), gangguan perkembangan otak (0.141), kadar seng serum (-0,102), umur (-0,041)dengan confusion matrix 81,9% untuk prediksi.Kesimpulan. Rerata kadar seng serum pada bangkitan kejang demam lebih rendah dibanding tanpa kejangdemam, namun tidak bermakna. Tidak terdapat korelasi antara kadar seng serum dengan bangkitan kejangdemam. Kadar seng serum bersama faktor genetik, infeksi berulang, penyulit dalam kehamilan maupunpersalinan, suhu badan, gangguan perkembangan otak, dan umur dapat digunakan sebagai prediktorbangkitan kejang demam meskipun memiliki peranan kecil.
Pengaruh Suplementasi Seng Terhadap Kejadian Pneumonia pada Penyakit Jantung Bawaan Pirau Kiri ke Kanan Elvi Suryati; Agus Priyatno; Noor Wijayahadi
Sari Pediatri Vol 16, No 4 (2014)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (88.075 KB) | DOI: 10.14238/sp16.4.2014.221-8

Abstract

Latar belakang. Anak dengan penyakit jantung bawaan (PJB) pirau kiri ke kanan lebih mudah menderitapneumonia. Seng merupakan trace element yang berperan dalam sistem imunitas tubuh.Tujuan. Membuktikan pengaruh suplementasi seng dalam mencegah kejadian pneumonia pada anak PJBpirau kiri ke kanan.Metode. Dilakukan double blind randomized controlled trial pada anak PJB pirau kiri ke kanan usia 12–60bulan di Poliklinik Kardiologi Anak RS dr Kariadi. Subjek penelitian dibagi 2 kelompok yang mendapatsuplementasi seng 20 mg/hari dan plasebo, pemberian selama 2 minggu, selanjutnya dipantau selama 3bulan. Data kejadian pneumonia dikumpulkan melalui wawancara saat kontrol atau melalui telepon setiap2 minggu selama 3 bulan. Pemeriksaan antropometri dan laboratorium dilakukan sebelum dan sesudahsuplementasi. Analisis statistik dilakukan dengan uji chi-square dan Mann-Whitney.Hasil. Subjek 40 anak dengan PJB pirau kiri ke kanan didapatkan kejadian pneumonia pada kelompok seng(5%) lebih rendah dibanding plasebo (30%), perbedaan ini tidak berbeda bermakna. Episode pneumonialebih rendah pada kelompok seng 1 kali dibandingkan plasebo 1-2 kali selama 3 bulan pengamatan, tidakberbeda bermakna. Terdapat peningkatan kadar seng secara bermakna pada kelompok perlakuan dari median57,55 menjadi 72,42 mcg/dL dibandingkan plasebo 42,40 menjadi 52,85 mcg/dL (p=0,002). Terdapatperbedaan bermakna selisih peningkatan kadar seng pada kelompok seng 20 mcg/dL dibanding plasebo7,25 mcg/dL (p=0,004). Didapatkan manfaat suplementasi seng terhadap pencegahan pneumonia denganrelative risk reduction (RRR) 83%.Kesimpulan. Suplementasi seng menurunkan kejadian pneumonia pada anak PJB pirau kiri ke kanan.
Effect of Combination Songga-Wood-Stem (Strychnos ligustrina Blume) and Antimalaria-ACT on IL-10 Production of Malaria Kis - Djamiatun; Rahmi - Wirman; Noor - Wijayahadi
Journal of Biomedicine and Translational Research Vol 8, No 1 (2022): April 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v1i1.13906

Abstract

Malaria is one of the deadliest infectious diseases in the world. Artemisinin-Based-Combination-Therapy (ACT) an antimalaria recommended by WHO, is starting to experience resistance in Asia. Meanwhile the natural-product-immunoprotective and antimalaria-effect may benefice for malaria. Objective of this study was to determine the effect of combination of ethanolic-extract from Songga-wood-stem (EESWS) and ACT on IL-10, a protective-cytokine against malaria-immunopathology. This experimental-study used post-test-only-randomized-controlled-group-design. The thirty-Swiss-webster-mice were grouped into 5 groups. The one-group of healthy-mice (K1), and the four-groups infected with Plasmodium berghei ANKA (PbA) which were untreated-K2-group, ACT-treated-K3-group, EESWS-treated-P1-group, and EESWS-ACT-combination-treated-P2-group. IL-10-level of stimulated-splenocytes-culture was examined by ELISA-method. Data-analysis-used was One-Way-Anova-Welch-test and Post-hoc Games-Howell. P1 and P2-groups had higher IL-10-levels than K1 (p=0.038). Groups of P1 and P2 showed lower IL-10-levels than K3 (p=0.001). IL-10-level of P2-group was not different than P1 (p=0.135). The conclusion is the EEWS or EESWS-ACT-combination-therapy restrains the increase-splenic-IL-10-production above normal value in the healing phase of malaria infection.
The Effect of Black Garlic (Allium sativum Linn) on Cardiac and Aortic Histopathology in Experimental Studies in Obesity Rats Andreas Arie Setiawan; Fairuz Azmila Purnomo; Vega Karlowee; Noor Wijayahadi
Journal of Biomedicine and Translational Research Vol 7, No 2 (2021): August 2021
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v7i2.11686

Abstract

ABSTRACTBackground: Obesity is a disorder or disease characterized by the accumulation of excess fat in the body due to an imbalance in energy intake that is used for a long time. Accumulation of fat can reduce adiponectin, causing cardiac hypertrophy, endothelial vasodilation, and other cardiovascular diseases. Black garlic have high antioxidants in the form of S-Allylcysteine(SAC) which functions to increase adiponectin. Objective: To determine the effect of Black garlic on the histopathological picture of the heart and aorta of obese rats. Methods: This study was an experimental study with a randomized post-test only design with control group design with 5 groups of male white rats Sprague Dawley (Rattus novergicus) fed High Fat Fructose. Diet (HFFD) enriched with 1.25% cholesterol and 0.5% cholic acid for 8 weeks and was given black garlic intervention at doses of 450 mg / 200BW, 900mg / 200BW and 1350mg200 / BW for 4 weeks. Results: Giving black garlic significantly reduced body weight of rats (p = 0.001), and the results did not significantly reduce heart weight (p = 0.147), aortic weight (p = 0.061), histopathological changes in heart wall thickness (p = 0.423) and aortic wall thickness (p = 0.802). The effective doses of black garlic in this study were 450 mg / 200 grams BW, 900 mg / 200 grams rat BW and 1350 mg / 200 grams BW of rats. The optimal dose is 900 mg / 200 grams BW. Conclusion: Black garlic gave a significant reduction in body weight of rats and no significant reduction in heart weight, aortic weight, cardiac and aortic histopathological features. 
Prognostic factors for success in the Kangaroo Mother Care method for low birth weight babies Rina Pratiwi; Muhammad Sholeh Kosim; Noor Wijayahadi
Paediatrica Indonesiana Vol 55 No 3 (2015): May 2015
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.134 KB) | DOI: 10.14238/pi55.3.2015.142-6

Abstract

Background Low birth weight (LBW) is closely related to neonatal morbidity and mortality. Management of LBW infants in developing countries remains limited, due to the low availability of incubators. The Kangaroo Mother Care (KMC) method has been shown to be effective for newborns, especially LBW infants, in which skin-to-skin contact may be conducive for infants’ weight gain, thermoregulation, and heart rate stability.Objective To determine the prognostic factors for KMC success in LBW babies.Methods This cohort study included LBW infants at Dr. Kariadi General Government Hospital, Semarang, by a consecutive sampling method. Success of KMC was assessed by infant weight gain, as well as stabilization of temperature, heart rate, and respiration. Prognostic factors for KMC success that we assessed were birth weight, gestational age, KMC duration, age at KMC onset and maternal education level. Statistical analyses used were Chi-square and relative risk (RR) tests.Results Of 40 LBW infants, 24 were successful in KMC. Birth weight ≥ 1500 grams (RR 0.4; 95%CI 0.23 to 0.73; P=0.001)], gestational age ≥ 34 weeks (RR 0.94; 95%CI 0.46 to 1.89; P=1.00), KMC duration ≥ 65 minutes (RR 1.44; 95%CI 0.76 to 2.75; P= 0.215), high maternal education level (RR 1.25; 95%CI 0.76 to 2.04; P=0.408), and age at KMC onset >10 days (RR 2.69; 95%CI 1.14 to 6.32; P=0.003), were factors that related to the successful of KMC.Conclusion Age at KMC onset > 10 days was a prognostic factor for KMC success in low birth weight babies.
PENGARUH LATIHAN AEROBIK AKUT TERHADAP PENINGKATAN FUNGSI EKSEKUTIF YANG DIUKUR DENGAN STROOP COLOUR WORD TEST DAN TRAIL MAKING TEST PART B PADA ANAK SEKOLAH DASAR Rahmi Isma Asmara Putri; Rudy Handoyo; Noor Wijayahadi
Media Medika Muda Vol 2, No 3 (2017)
Publisher : Faculty of Medicine Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar Belakang: : Fungsi eksekutif merupakan bagian dari kognitif yang berperan penting dalam proses pembelajaran dan prestasi akademis anak, oleh karena itu penelitian ini bertujuan untuk mengetahui pengaruh latihan aerobik akut terhadap peningkatan fungsi eksekutif anak sekolah dasar usia 9-12 tahun yang diukur dengan Stroop Colour Word Test dan Trail Making Test part BMetode: Penelitian klnis eksperimental dengan randomized pre dan post controlled group design.Hasil: Pada kelompok perlakuan terdapat peningkatan yang bermakna pada skor stroop CW dari 2,2955±0,34235 menit menjadi 1,5795±0,29062 menit (p<0,001) dan pada skor TMT-B dari 32,6320±3,92685 detik menjadi 25,7435±4,63849 detik (p<0,001). Terdapat perbedaan yang bermakna selisih pretest-postest skor Stroop CW (p<0,001) dan TMT-B (p=0.037) pada kelompok perlakuan dibanding kelompok kontrol.Simpulan: Latihan aerobik akut dapat meningkatkan skor uji fungsi eksekutif Stroop CW dan TMT-B. Kata kunci: Aerobik akut, fungsi eksekutif, Stroop CW, TMT-B
EFEK REMOTE ISCHEMIC PRECONDITIONING TERHADAP LUAS KEMATIAN OTOT JANTUNG TIKUS WISTAR PASCA INFARK MIOKARD YANG DIINDUKSI ISOPROTERENOL Rachmatu Bill M; Novi Angriyani; Noor Wijayahadi; Sulistiyati Bayu U; Satrio Adi W
Media Medika Muda Vol 2, No 2 (2017)
Publisher : Faculty of Medicine Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (251.259 KB)

Abstract

Latar Belakang : Infark miokard adalah salah satu penyakit yang paling banyak menyebabkan kematian. Infark miokard dapat terjadi karena adanya iskemi berkepanjangan pada otot jantung. Baku emas indikator terjadinya infark miokard adalah pemeriksaan histopatologi. Terdapat suatu iskemi singkat dan sementara suatu organ sebelum infark miokard yang dapat melindungi otot jantung dari kerusakan yang disebut RIPC.Tujuan : Mengetahui efek RIPC terhadap luas kematian otot jantung tikus pasca infark miokard yang diinduksi isoproterenol.Metode : Penelitian eksperimental murni dengan rancangan randomized posttest only control group design. Sampel sebanyak 21 ekor tikus wistar jantan yang dibagi menjadi 3 kelompok yaitu kelompok kontrol, kelompok perlakuan RIPC 3x5 menit, dan kelompok perlakuan RIPC 3x15 menit. Ketiga kelompok tersebut diinjeksi dengan isoproterenol untuk menginduksi infark miokard. Luas kematian otot jantung tikus wistar diukur menggunakan pemeriksaan histopatologi. Uji statistik menggunakan Uji Mann Whitney-U.Hasil : Skoring luas kematian otot jantung rerata pada kelompok kontrol sebesar 4,0000, kelompok perlakuan RIPC 3x5 menit sebesar 2,8957, dan kelompok perlakuan RIPC 3x15 menit sebesar 1,3714. Uji Mann Whitney-U perbedaan bermakna pada luas kematian otot jantung tikus Wistar pada kelompok kontrol dan kelompok perlakuan RIPC 3x5 menit(p=0,025) serta terdapat perbedaan bermakna antara luas kematian otot jantung tikus Wistar pada kelompok kontrol dan kelompok perlakuan RIPC 3x15 menit(p=0,001).Kesimpulan : Terdapat perbedaan luas kematian otot jantung antara tikus wistar yang diberi perlakuan RIPC 3x5 menit (P1) dan RIPC 3x15 menit (P2) dengan yang tidak diberi perlakuan RIPC (K). Kata kunci: RIPC, Infark Miokard, Isoproterenol
Toxicity, Side Effects, and Furosemide Interactions in Therapy of Heart Failure Patients (Systematic Review) Diniafelsa Wola; Noor Wijayahadi; Mochamad Ali Sobirin; Erwin Kresnoadi
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 4 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i3.33706

Abstract

Background: Furosemide as a diuretic loop is one of the main therapies given to heart failure patients with congestion, but in its use furosemide requires a lot of consideration related to toxicity, side effects, and drug interactions.Objective: To determine the toxicity, side effects and drug interactions of furosemide on heart failure patients.Methods: This research is a Systematic Review. Samples were obtained by searching for journals in the online databases of Pubmed, Scopus and Springer Link then adjusted to inclusion criteria and research questions. Data analysis was based on the PRISMA checklist, then searched for similarities and differences.Results: This study found the side effects of furosemide therapy in heart failure patients were: electrolyte disturbance such as: hyponatremia; hypokalemia; and hypomagnesemia, arrythmia, worsening renal function and worsening of AKI, hypotension, increase of plasma renin, and increased risk of fractures. No incidence of furosemid toxicity. The interaction of furosemide on heart failure patients may occur in several drugs like aspirin, digoxin, ACE-inhibitor, and bronchodilator.Conclusion: There is some side effect of furosemide and drug interactions occured in therapy of heart failure patients.Keywords: Furosemide, Toxicity, Side Effects, Interactions, Heart Failure.
Effects of Garcinia Mangostana Linn Pericarp Extract and Physical Exercise on Atheroembolic Histopathologic Features Kidney in Wistar Rats with Metabolic Syndrome Perdana, Evangga Yudha; Miranti, Ika Pawitra; Kholis, Fathur Nur; Wijayahadi, Noor; Setiawan, Andreas Arie
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42578

Abstract

Background: Renal atheroembolism is an under-recognized cause of renal failure. Atheroembolism is caused by cholesterol crystals from ulcerated atherosclerotic plaques and is influenced by inflammation and endothelial dysfunction. The formation of complicated atherosclerotic lesions is a prerequisite for the development of cholesterol crystal emboli. The exact incidence of atheroembolism remains unclear due to frequent underdiagnosis. In a previous report, the rate of embolism in the kidney among patients dying after surgery for acute atherosclerosis of the aorta was 77%. Non-pharmacological therapeutic management (such as diet and physical exercise) is an important factor in preventing and reducing the risk of atherogenesis. Prior research suggests that controlling body weight, primarily through physical exercise, is a critical factor in preventing and reducing the risk of atherogenesis, in addition to medication adherence and other therapeutic management alternatives. Another study found that mice with metabolic syndrome given Garcinia mangostana pericarp can reduce inflammatory cell infiltration, thereby reducing physiological symptoms, metabolic syndrome, liver disorders, and cardiovascular symptoms. The combination of physical exercise and metabolic supplements in the treatment was even able to significantly reduce atheroma plaque area as well as the incidence of plaque rupture, and prolong survival time. Objective: To investigate the effect of Garcinia Mangostana Linn Pericarp administration along with Physical Exercise on the histopathologic features of renal atheroembolism in Wistar rats with metabolic syndrome. Methods: This study is a true experimental study with research subjects in the form of male Rattus norvegicus Wistar rats which were randomly divided into 3 groups. All groups were induced metabolic syndrome through the administration of a diet similar to the "Western" purified atherogenic diet patent Envigo® formulated as a high fat diet (20 - 23% BW; 40 - 45% kcal from fat), saturated fatty acids (SFA >60% of total fatty acids), and drinking tap water ad libitum. However, in group K (no additional treatment), P1 (garcinia pericarp extract 800 mg / kg / day with physical exercise), and P2 (nanoemulsion garcinia pericarp extract 50 mg / kg / time of administration with physical exercise). Results: In the group treated with garcinia pericarp extract 800 mg/kg bw/day with physical exercise and the group with nanoemulsion 50 mg/kg bw/day with physical exercise, there were no fatty streaks, inflammation, and impaired myocyte coherence. There was 0-5% fibrous connective tissue, one layer of foam cell layer and myocyte-lipid, no cholesterol crystal embolism was found. Conclusion: The administration of Garcinia Mangostana Linn pericarp extract and/or nanoemulsion with physical exercise can have an effect on the histopathological picture of the kidneys of Wistar rats with metabolic syndrome, although there was no difference in effect between the two treatments.