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All Journal MEDIA MEDIKA INDONESIANA JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Sari Pediatri Paediatrica Indonesiana Media Medika Muda Jurnal Health Sains
Noor Wijayahadi
Department Of Pharmacology, Faculty Of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Effect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy Type 1 Reaction Patients Putri, Syifa Nurisma; Mundhofir, Farmaditya Eka Putra; Yuniati, Renni; Wijayahadi, Noor; Nindita, Yora
Jurnal Health Sains Vol. 5 No. 6 (2024): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v5i6.1301

Abstract

Type 1 leprosy reaction / Reversal reaction (RR) is an inflammatory episode in existing leprosy lesions and aggravates the pain rate. Long-term therapy with steroids causes a variety of side effects, so an adjuvant therapy alternative is needed to alleviate steroid use. Curcuma longa rhizome extract has become an anti-inflammatory therapy choice in various previous inflammatory diseases. This study aims to determine the anti-inflammatory effect of Curcuma longa rhizome extract as an adjuvant therapy for reversal reaction patients by analyzing serum levels of IL-6 as a marker of inflammation. The pre and post-test randomized single-blinded controlled trial was conducted on two groups, namely control (RR patients with steroid therapy & placebo) and treatment (steroid therapy & Curcuma longa rhizome extract 1 gram/day). IL-6 serum levels were analyzed from sampling before and after the intervention for one month. The serum levels of IL-6 post-test in the control group were significantly higher than those of the pre-test. The treatment group showed lower serum levels of IL-6 post-test compared to pre-test, although there was no significant difference. Curcuma longa rhizome extract 1 gram/day for one month as adjuvant therapy for patients with type 1 leprosy reaction did not significantly reduce serum IL-6 levels.
Effects of Garcinia Mangostana Linn Pericarp Extract and Physical Exercise on Atheroembolic Histopathologic Features Kidney in Wistar Rats with Metabolic Syndrome Evangga Yudha Perdana; Ika Pawitra Miranti; Fathur Nur Kholis; Noor Wijayahadi; Andreas Arie Setiawan
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 13, No 2 (2024): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v13i2.42578

Abstract

Background: Renal atheroembolism is an under-recognized cause of renal failure. Atheroembolism is caused by cholesterol crystals from ulcerated atherosclerotic plaques and is influenced by inflammation and endothelial dysfunction. The formation of complicated atherosclerotic lesions is a prerequisite for the development of cholesterol crystal emboli. The exact incidence of atheroembolism remains unclear due to frequent underdiagnosis. In a previous report, the rate of embolism in the kidney among patients dying after surgery for acute atherosclerosis of the aorta was 77%. Non-pharmacological therapeutic management (such as diet and physical exercise) is an important factor in preventing and reducing the risk of atherogenesis. Prior research suggests that controlling body weight, primarily through physical exercise, is a critical factor in preventing and reducing the risk of atherogenesis, in addition to medication adherence and other therapeutic management alternatives. Another study found that mice with metabolic syndrome given Garcinia mangostana pericarp can reduce inflammatory cell infiltration, thereby reducing physiological symptoms, metabolic syndrome, liver disorders, and cardiovascular symptoms. The combination of physical exercise and metabolic supplements in the treatment was even able to significantly reduce atheroma plaque area as well as the incidence of plaque rupture, and prolong survival time. Objective: To investigate the effect of Garcinia Mangostana Linn Pericarp administration along with Physical Exercise on the histopathologic features of renal atheroembolism in Wistar rats with metabolic syndrome. Methods: This study is a true experimental study with research subjects in the form of male Rattus norvegicus Wistar rats which were randomly divided into 3 groups. All groups were induced metabolic syndrome through the administration of a diet similar to the "Western" purified atherogenic diet patent Envigo® formulated as a high fat diet (20 - 23% BW; 40 - 45% kcal from fat), saturated fatty acids (SFA >60% of total fatty acids), and drinking tap water ad libitum. However, in group K (no additional treatment), P1 (garcinia pericarp extract 800 mg / kg / day with physical exercise), and P2 (nanoemulsion garcinia pericarp extract 50 mg / kg / time of administration with physical exercise). Results: In the group treated with garcinia pericarp extract 800 mg/kg bw/day with physical exercise and the group with nanoemulsion 50 mg/kg bw/day with physical exercise, there were no fatty streaks, inflammation, and impaired myocyte coherence. There was 0-5% fibrous connective tissue, one layer of foam cell layer and myocyte-lipid, no cholesterol crystal embolism was found. Conclusion: The administration of Garcinia Mangostana Linn pericarp extract and/or nanoemulsion with physical exercise can have an effect on the histopathological picture of the kidneys of Wistar rats with metabolic syndrome, although there was no difference in effect between the two treatments.
Co-Authors Abdul Khanis Agus Priyatno Alfarizi, Rizki Anang M Legowo Andreas Arie Setiawan Andreas Arie Setiawan Andrew Johan Diniafelsa Wola Edwin Tohaga Elvi Suryati Erwin Kresnoadi Evangga Yudha Perdana Fairuz Azmila Purnomo Fathur Nur Kholis Fuadi Fuadi Hartantyo Hartantyo Ika Pawitra Miranti Indra Wijaya Iva-Yuana Iva-Yuana Kamilah Budhi Kamilah Budhi R Kamilah Budhi Rahardjani Ken Shinta Kis - Djamiatun Kusdalinah Kusdalinah Kusmadewi Eka Damayanti Meira Dewi Mochamad Ali Sobirin Muhammad Sholeh Kosim Mundhofir, Farmaditya Eka Putra Niken Puruhita Novi Angriyani Putri, Syifa Nurisma Rachmatu Bill M Rahmi - Wirman Rahmi Isma Asmara Putri Raya, Maxianus Kopong Renni Yuniati Rifki Agung Rina Pratiwi Rudy Handoyo Satrio Adi W Sulistiyati Bayu U Tjahjono Tjahjono Tjipta Bahtera Tjipta Bahtera Tjipta Bahtera Tun Paksi Sareharto Vega Karlowee Yora Nindita