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All Journal Jurnal Riset Kefarmasian Indonesia Lumbung Farmasi : Jurnal Ilmu Kefarmasian Parapemikir Jurnal Ilmiah Farmasi ISTA Online Technologi Journal Jurnal Pengabdian Ikifa Jurnal Farmasi Ikifa JIFTK (Jurnal Ilmu Farmasi Terapan dan Kesehatan)
Pra Panca Bayu Chandra
Sekolah Tinggi Ilmu Kesehatan IKIFA
Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health

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PEMANFAATAN VITAMIN C PADA EKSTRAK KULIT JERUK NIPIS (Citrus aurantifolia) UNTUK FORMULASI SEDIAAN SERUM WAJAH Isti Dwi Pruschia; Nurhasanah; Maharani; Pra Panca Bayu Chandra
Jurnal Farmasi IKIFA Vol. 5 No. 3 (2026): JURNAL FARMASI IKIFA VOL. 5 NO. 3 OKTOBER TAHUN 2026
Publisher : Sekolah Tinggi Ilmu Kesehatan IKIFA

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Abstract

Kulit jeruk nipis (Citrus aurantifolia) merupakan limbah pertanian yang kaya akan Vitamin C dan senyawa bioaktif seperti flavonoid yang berpotensi sebagai bahan aktif alami untuk perawatan kulit. Penelitian ini bertujuan untuk memformulasikan serum wajah dari ekstrak kulit jeruk nipis serta mengevaluasi karakteristik fisik, dan tingkat kesukaan sediaan. Penelitian bersifat eksperimental yang dilaksanakan di Laboratorium Universitas Mangku Wiyata periode Februari hingga Mei 2026. Ekstrak kulit jeruk nipis diperoleh melalui metode maserasi menggunakan etanol 96% (perbandingan 1:3) dengan rendemen 45%. Skrining fitokimia menunjukkan positif mengandung alkaloid, flavonoid, tanin, saponin, dan fenolik. Sediaan serum diformulasikan dalam tiga variasi yaitu F1 (10%), F2 (15%), dan F3 (20%) menggunakan basis karbopol. Hasil evaluasi menunjukkan seluruh formula memenuhi persyaratan standar: pH 4,62–6,02, viskositas 230-1150 cPs, daya sebar 5,3–6,8 cm, waktu kering kurang dari 5 menit, homogen, serta tidak menimbulkan iritasi. Uji hedonik menunjukkan tingkat kesukaan yang sangat suka, dengan Formula 3 (20%) cenderung paling disukai secara keseluruhan. Simpulan penelitian ini adalah ekstrak kulit jeruk nipis berpotensi digunakan sebagai bahan aktif alami dalam formulasi serum wajah yang aman dan stabil.
PENETAPAN KADAR FLAVONOID TOTAL EKSTRAK DAUN Litsea elliptica Blume Pra Panca Bayu Chandra; Indri Astuti Handayani
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.513

Abstract

Kalimantan Island is an area with forests that can be developed for potential results, especially in plants with medicinal properties for health. The medicinal properties of plants are the role of the secondary metabolites contained in them. One of them is Litsea, a plant that comes from the Lauraceae family with 45 genera and more than 2,000 species. Plants from this genus are widely used by the community as traditional medicine, especially Litsea elliptica. One of the secondary metabolite contents of Litsea elliptica is flavonoids. The aim of this research was to determine the flavonoid content of Litsea elliptica leaf extract. The extraction process was carried out by maceration with 96% ethanol solvent. The results of the maceration extraction are then carried out by evaporation until a thick extract is obtained. The total flavonoid content was determined using the Colorimetric-Aluminum Chloride Method with a UV-Vis spectrophotometric instrument, resulting in a total flavonoid content of Litsea elliptica leaf extract of 391.01 mg ± 0.27 mg. The conclusion of this research is that Litsea elliptica leaf extract has a flavonoid content of 0.39%
PROFIL JUMLAH NEOVASKULARISASI LUKA MENCIT HIPERGLIKEMIK YANG DIBERIKAN GEL EKSTRAK BUAH OKRA (Abelmoschus esculentus L.) Pra Panca Bayu Chandra; Nia Lisnawati; Yanthy Susanti
Jurnal Riset Kefarmasian Indonesia Vol. 6 No. 2 (2024): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v6i2.523

Abstract

This study aimed to examine the gel activity of okra fruit extract (Abelmoschus esculentus L.) in mice with hyperglycemic conditions based on histopathological indicator parameters, namely the amount of neovascularization. Mus musculus strain male mice were hyperglycemic with STZ at a dose of 0.06 mg/gBW. Mice were divided into 8 groups (n=6). Group 1 (Non-DM Control), Group 2 (DM Control), Groups 3 to 8 (Test). The dose of glibenclamide was 5 mg/KgBW, the dose of okra fruit extract was 400 mg/KgBW and the dose of CMC Na was 5 mL/KgBW. Therapy was given once a day (oral and topical) for 15 days of therapy which was seen on days 0, 5, 11 and 15. The results of the study showed an increase in the number of neovascularizations on the 15th day of therapy in the test group compared to the control group. Administration of a combination of topical okra fruit extract gel with okra fruit extract orally for 15 days of therapy was able to increase the amount of neovascularization compared to administration without the combination or only orally. Administration of a combination of topical gel and oral okra fruit extract accelerated the wound healing process in hyperglycemic mice compared to non-combination administration. Management of fasting blood glucose levels has an effect on the success of the diabetic wound healing process.  
PENETAPAN KADAR RENDEMEN DAN FLAVONOID EKSTRAK DAUN KELOR (Moringa oleifera) SECARA SPEKTROFOTOMETRI UV-VIS Sabrina K Whardhani; Indri Astuti Handayani; Pricillya Maria Loimalitna; Pra Panca Bayu Chandra; Yulius Evan Christian
Jurnal Riset Kefarmasian Indonesia Vol. 7 No. 3 (2025): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/v7i3.773

Abstract

Moringa leaves (Moringa oleifera L.) are herbal plants known to contain bioactive compounds such as flavonoids and phenolics, which have potential as natural antioxidants and can be utilized in the development of herbal-based pharmaceutical preparations. This study aimed to determine the organoleptic characteristics and the total flavonoid content of 96% ethanol extract of Moringa leaves. The extraction process was carried out using the maceration method with 96% ethanol solvent on 1 kg of fresh Moringa leaves. The leaves were dried into simplicia powder weighing 126.22 g, then macerated for 3 days with stirring every 24 hours. The filtrate was evaporated using a rotary evaporator at 40°C to obtain a thick extract, yielding 7.01% with a native DER value of 14.26. The organoleptic characteristics showed that the extract had the typical odor of Moringa leaves, a bitter taste, and a greenish-brown color. The determination of flavonoid content was conducted using the aluminium chloride colorimetric method with quercetin as the standard, and measurements were performed at a maximum wavelength of 450 nm. The calibration curve showed a linear relationship between quercetin concentration and absorbance with the regression equation y = 0.0163x – 0.0789 and R² = 0.9986. The analysis results showed that the total flavonoid content of the 96% ethanol extract of Moringa leaves was 1203.78 ± 2.98 mg/100 g. With its high flavonoid content, Moringa leaf extract has the potential to be developed as a natural antioxidant in herbal-based pharmaceutical formulations.
Co-Authors Dede Komarudin Deni Rahmat Dian Ratih Laksmitawati Edo Gumelar Febri Hidayat Firda Alyaningsih In Rahmi Fatria Fajar Indri Astuti Handayani Indri Astuti Handayani Indri Astuti Handayani Isti Dwi Pruschia Ivan Santoso Ivan Santoso Lubna Naumi Salsabila Maharani Mega Efrilia Neina Febrina Nia Lisnawati Nurhasanah Nurul Novianti Pricillya Maria Loimalitna Pricillya Maria Loimalitna Pristiyantoro Rohima Robby Sabrina K Whardhani Senny Listy Kartika Falestin Wulan Sucianingrum Yanthy Susanti Yanthy Susanti Yulis Adriana Yulius Evan Christian Yulius Evan Christian