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All Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia JCPS (Journal of Current Pharmaceutical Sciences) Pharmaceutical Journal of Indonesia Cendekia Journal of Pharmacy Jurnal Pengabdian Kesehatan Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang Journal of Fundamental and Applied Pharmaceutical Science Abdimas Altruis: Jurnal Pengabdian Kepada Masyarakat Jurnal Pengabdian Masyarakat Sehati Jurnal Medika: Medika Journal of Tropical Pharmacy and Chemistry Journal of Pharmascience
Sri Hartati Yuliani
Sanata Dharma University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Optimasi Tween 80 dan Setil Alkohol pada Sediaan Hand Sanitizer Cream Ekstrak Pegagan (Centella asiatica (L.)) Sisna Sisna; Sri Hartati Yuliani
Journal of Pharmascience Vol. 10 No. 2 (2023): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v10i2.14755

Abstract

Pegagan (Centella asiatica (L.)) merupakan salah satu tanaman yang memiliki potensi antivirus dan aktivitas sebagai antibakteri. Ekstrak kering pegagan akan diformulasikan dalam sediaan hand sanitizer cream sebagai alternatif dari hand sanitizer berbasis alkohol. Penelitian ini bertujuan untuk mengetahui pengaruh tween 80 dan setil alkohol terhadap sifat fisik dan stabilitas hand sanitizer cream serta mendapatkan komposisi optimum dari tween 80 dan setil alkohol dengan sifat fisik dan stabilitas yang baik. Optimasi komposisi tween 80 dan setil alkohol dilakukan dengan metode desain faktorial pada dua faktor dan dua level menggunakan aplikasi Design Expert Version 13 (free trial). Data sifat fisik dan stabilitas berupa viskositas, daya sebar, pergeseran viskositas, dan pergeseran daya sebar akan dianalisis secara statistik dengan uji two-way ANOVA pada tingkat kepercayaan 95%. Overlay plot digunakan untuk menentukan area optimum dari tween 80 dan setil alkohol. Hasil uji kualitatif menunjukkan bahwa ekstrak pegagan mengandung senyawa triterpenoid. Tween 80 dan setil alkohol dapat memengaruhi viskositas secara signifikan, sedangkan interaksi antara tween 80 dan setil alkohol secara signifikan dapat memengaruhi pergeseran daya sebar. Area berwarna kuning yang didapatkan pada overlay plot merupakan area optimum untuk menghasilkan sediaan hand sanitizer cream dengan sifat fisik dan stabilitas yang memenuhi kriteria. Kata Kunci: Krim, Desain Faktorial, Hand Sanitizer, Optimasi, Pegagan Centella asiatica (L.) is one of the plants with antiviral potential and antibacterial activity. Centella asiatica (L.) dry extract would be formulated in hand sanitizer cream as an alternative to alcohol-based hand sanitizer. This research aimed to determine the effect of tween 80 and cetyl alcohol on hand sanitizer cream's physical properties and stability and obtained the optimum composition of tween 80 and cetyl alcohol with good physical properties and stability. The composition of tween 80 and cetyl alcohol was optimized using a factorial design method on two factors and two levels using the Design Expert Version 13 application (free trial). Viscosity and spreadability physical properties, viscosity and spreadability shift stability data will be analyzed statistically by a two-way ANOVA test at a 95% confidence level. The overlay plot determined the optimum tween 80 and cetyl alcohol composition. The qualitative test results showed that Centella asiatica (L.) extract contained triterpenoid compounds. Tween 80 and cetyl alcohol can significantly affect the viscosity, while the interaction between tween 80 and cetyl alcohol can significantly affect the spreadability shift. The yellow area obtained on the overlay plot is the optimum area to produce hand sanitizer cream preparations with physical properties and stability that meet the criteria.
Co-Authors Achmad Fudholi Adi, Antonius Iswara Agnes Mutiara Kurniawan Agustina Setiawati Ani, Ni Wayan Annabel, Evangeline Keisha Arini Safti Sandrapitaloka Arpan, Verdynant Augusto Ayaga Divadi Bernadetta Karina Sekar Maheswari Bertha Nathania Branitasandini, Adhika Branitasandini, Regina Epiphania Branitasandini, Regina Epiphania Adhika Christofori Maria Ratna Rini Nastiti Chusien, Adhita Wicaksaneng Naya Brena David Chandra Putra Desi Amroni Kasanah Dina Christin Ayuning Putri Dita Maria Virginia Elaina Elaina Elliora, Greata Elsa Irnandari Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Enade Perdana Istyastono Evy Fenny Veronica Felicia Satya Christania Florentinus Dika Octa Riswanto Fransiska Revana Restiana Gani, Michael Raharja Handika Immanuel Hede, Marry Grace Florensia Ignasius Adi Kurniawan Kerenhapukh, Miracle Kinanthi, Eleonora Galuh Windu Lestari, Fajar Sri Lewier, Bryan Melianus Agustinus Limianty, Angela Lu, Felisha Marchaban . Maria Faustina Sari Maria Ludya Pulung Maywan Hariono Melviya Sudianto Melynia Sintha Dewi Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Michael Raharja Gani Novela, Yuven Nugraha, Alvin Arya Nunung Yuniarti Paulus Unggul Wikan Prabandono Pebrianty, Sahara Petrus Damiani Tosan Aji Prita Patricia Radite Yogaswara reza eka putra Rini Dwiastuti Rini Dwiastuti Salainti, Madeleine Trisha Sara Septi Widayani Shirley Candra Kurniawan Sihombing, Meisyah Marito Sisna Sisna Sudianto, Melviya Suwijiyo Pramono Tahesa, Idola Zulfi Tasik, Sulistiana Tulung, Cindy Stevani Wandansari, Eustachia Diajeng Wardhani, Kresentia Ayu Kusuma Waskitha, Stephanus Satria Wira Wibowo, Safri Sekti Yulia Yulia YUMI RAHMADANI