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All Journal Journal of Food and Pharmaceutical Science Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Sains dan Komunitas Jurnal Biodjati Majalah Farmaseutik JFIOnline Journal of Food and Pharmaceutical Sciences
Nunung Yuniarti
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Effect of aspirin on pi-class of rat kidney glutathione S-transferase activity Yuniarti, Nunung; Martono, Sudibyo; A.M., Supardjan
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 2, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (171.919 KB) | DOI: 10.14499/indonesianjpharm0iss0pp87-93

Abstract

The nonsteroids antiinflammatory compounds like curcumin and its analogues, indomethacine, and sulfasalazin have been reported to have an inhibitory effect on GST activity on an in vitro study. The aim of this research is to find out the effect of aspirin on pi-class of rat kidney GST activity in vitro using ethacrynic acid (EA) as a specific substrate for its GST class.Glutathione activity can be measured by conjugating GSH and EA catalyzed with GST. The product can be measured spectrophotometrically to result in a rate (Δ absorption/min). With the same method, aspirin was added as an inhibitor. Decreasing conjugation product indicated that there was an inhibitory activity of aspirin.The aspirin inhibitory activity using EA and CDNB (1-chloro-2,4-dinitrobenzene) as substrates are 9,090% (Extrapolated IC50 6665,03 μM) and 14,087% (Extrapolated IC50 4102,0 μM), respectively. These results have shown that aspirin can not inhibit pi-class of rat kidney cytosolic GST activity using EA and CDNB (1-chloro-2,4-dinitrobenzene) as substrates.Key words: aspirin, GSTP, kidney.
Co-Authors Ardiana Wati, Anas Ardiningtyas, Bondan Arko Jatmiko Wicaksono, Arko Jatmiko Azizah, Ulfah Laily Cici Darsih Devi, Dwitya Devi Nurlistyo Ika Puspitasari Ilham Perdana Marlyn Dian Laksitorini, Marlyn Dian Nur Hidayah, Arifatu Puji Astuti Retno Murwanti Rina Nur Maulawati, Rina Nur Ririn Suharsanti, Ririn Subagus Wahyuono Sudibyo Martono Supardjan A.M., Supardjan SUWIJIYO PRAMONO Wulandari, Febri Yance Anas