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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Program Kreativitas Mahasiswa - Penelitian Journal of Islamic Pharmacy Science and Technology Indonesia Majalah Kesehatan FKUB Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Darmabakti : Junal Pengabdian dan Pemberdayaan Masyarakat Caring : Jurnal Pengabdian Masyarakat Tri Dharma Mandiri: Diseminasi dan Hilirisasi Riset Kepada Masyarakat (Jurnal Pengabdian Kepada Masyarakat) Jurnal Bioteknologi & Biosains Indonesia
VALENTINA YURINA
Program Studi Farmasi, Fakultas Kedokteran Universitas Brawijaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Science and Technology Indonesia

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Oral Immunization with Recombinant Lactococcus lactis and Retinoic Acid Boost Immune Response in Mice Nugroho, Inggil Cahyo; Amalia, Maulida Nisa; Juniardi, Muhamad Rizki; Marhendra, Eunike Berliana; Yanma, Nadifa Almira; Adianingsih, Oktavia Rahayu; Winarsih, Sri; Widodo, Nashi; Yurina, Valentina
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.55-64

Abstract

The COVID-19 vaccine is one of the most important approaches for preventing SARS-CoV-2 virus transmission and spread. Oral vaccines are a promising option for preventing SARS-CoV-2 infection because it can activate both the mucosal and cellular immune systems. Previous research has shown that administering oral and intranasal vaccines can induce an immune response in mice. The effectiveness of the SARS-CoV-2 oral vaccine was evaluated in this study by combining spike protein with a carrier of food-grade recombinant Lactococcus lactis bacteria and a retinoic acid adjuvant. Mice were divided into three groups: a negative control (no treatment), a positive control (L. lactis recombinant), and a third group (L. lactis recombinant plus 300 μg retinoic acid). The vaccines were given three times, with a three-week interval between each. The serum levels of IgG, IgA, and IgE were determined using the ELISA method at the end of the study. CD4 and CD8 cellswere detected using immunofluorescence. While not statistically significant, the results showed that the retinoic acid groups had the highest anti-spike antibody levels of the three groups. In comparison to the control group, CD4 and CD8 cells increased in the spleens of mice given retinoic acid. There was no difference in temperature or IgE levels between vaccinated and non-vaccinated mice, indicating that the vaccine caused no allergic reaction. This study’s findings suggest that retinoic acid adjuvant can stimulate the cellular and humoral immune system.
Anti-Photoaging Effects of Moisturizer and Serum Containing Andrographis paniculata, Syzygium aromaticum, and Pogostemon cablin: A Network Pharmacology, Molecular Docking, and in vivo Study Adianingsih, Oktavia Rahayu; Johan, Christopher Kuncoro; Widarson; Ravsanjani, Eurica Andriani Najwa; Sutiyono, Bershiella Amandari; Qurrotuain, Iffah; Yurina, Valentina; Puspita, Oktavia Eka; Widasmara, Dhelya; Saitama, Akbar; Hariyono, Didik
Science and Technology Indonesia Vol. 11 No. 1 (2026): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.1.19-34

Abstract

Ultraviolet-B (UVB)-induced photoaging accelerates collagen degradation, disrupts dermal structure, and compromises epidermal integrity. Natural extracts, such as Andrographis paniculata, Syzygium aromaticum, and Pogostemon cablin demonstrated antioxidant and anti-aging properties to mitigate these damages. This study investigated the protective effects of serum and moisturizer containing A. paniculata extract, S. aromaticum oil, and P. cablin oil on UVB-induced photoaging rats, by integrating network pharmacology and in vivo experiment. Compounds and photoaging-associated targets were retrieved through online databases. Enrichment analyses were performed using Metascape. Protein-protein interaction (PPI) construction and herbs-compounds-targets-pathways disease network were performed using STRING and Cytoscape 3.10.0, respectively, followed by molecular docking. An in vivo study was conducted to evaluate epidermal thickness, collagen density, and dermo-epidermal junction (DEJ) structure. Eleven key phytoconstituents and twelve core targets were identified in anti-photoaging molecular mechanisms using network pharmacology. Molecular docking analysis revealed that 7-O-methylwogonin demonstrated favorable binding against ten photoaging-associated targets. KEGG enrichment analysis showed potential inflammation processes inhibition, including photocarcinogenesis, AGE-RAGE signaling pathway, and TNF-α expression. Furthermore, treatment with serum, moisturizer, or combination of both significantly reduced epidermal thickening and enhanced collagen density compared to the UVB-exposed only group. Although no significant difference was observed in DEJ interdigitation index across groups, treated groups exhibited a trend towards better preservation of DEJ structure relative to the UVB group. In summary, serum and moisturizer containing A. paniculata, S. aromaticum, and P. cablin extracts demonstrated potential anti-photoaging effects by reducing epidermal thickness and preserving collagen density in UVB-exposed rats. These findings support these botanical-based formulations potential as effective anti-aging skincare.
Co-Authors Achmad Rudijanto Alvan Febrian Shalas Amalia, Maulida Nisa Anggita Rosiana Putri Anggita Rosiana Putri Angi Nurkhairina, Angi Anita Puspa Widiyana Ardina Pramesti Putri, Ardina Pramesti Bachtiar Rifai Pratita Ihsan Bachtiar Rifai Pratita Ihsan Dhelya Widasmara Diah Royani Meisani Didik Hariyono Ema Pristi Yunita, Ema Pristi Eva Putri Arfiani Fredo Tamara, Fredo Ihsan, Bachtiar Rifai Pratita Johan, Christopher Kuncoro Juniardi, Muhamad Rizki Kesuma, Suryanata Kusworini Handono Luthfi Ahmad Muchlashi Marhendra, Eunike Berliana Megasari, Suci Muchlashi, Luthfi Ahmad Nabila Ayu Safitri, Nabila Ayu Nashi Widodo Nugroho, Inggil Cahyo Oktavia Eka Puspita Oktavia Eka Puspita, Oktavia Eka Oktavia Rahayu A, Oktavia Rahayu Oktavia Rahayu Adianingsih Poejiani, Soeyati Qurrotuain, Iffah Ravsanjani, Eurica Andriani Najwa Saitama, Akbar Sri Winarsih Sutiyono, Bershiella Amandari Tamara Gusti Ebtavanny Thoha Muhajir Albaar, Thoha Muhajir Tri Yudani Mardining Raras Widarson Yanma, Nadifa Almira