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All Journal Sari Pediatri Paediatrica Indonesiana Syntax Literate: Jurnal Ilmiah Indonesia AcTion: Aceh Nutrition Journal Jurnal Ilmiah Mahasiswa Kedokteran Medisia AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Budapest International Research in Exact Sciences (BirEx Journal) Narra J The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Peradaban Journal of Religion and Society Narra X
Sulaiman Yusuf
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Transportation Other

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Journal : Narra J

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A choledochal cyst type IVa in a child treated with Roux-en-Y hepaticojejunostomy Yusuf, Sulaiman; Nuriyanto, Alivia R.; Nadia, Nurul; Muntadhar, Muntadhar; Muzakkir, Yumna; Susanti, Nurhayani D.; Al-shather, Zain; Harrika, Fenny
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.201

Abstract

A choledochal cyst is a bile duct anomaly that disrupts the transportation of bile from the liver to the gallbladder and small intestine. Choledochal cysts are rare, occurring in approximately one out of every 100,000 to 150,000 children in Western countries, with a girls-to-boys ratio of 4:1. Immediate surgery to excise the cyst and construct a biliary-enteric continuity is necessary to treat this condition. This case-report aimed to present a child with choledochal cyst type IVa who underwent a Roux-en-Y hepaticojejunostomy. A 3-year-11-month-old girl with an abdominal mass experienced jaundice, nausea, and vomiting over the past two years, which worsened in the last month. Abdominal ultrasonography indicated intrahepatic biliary dilatation. Abdominal computed tomography (CT) scan results confirmed a choledochal cyst type IVa, characterized by fusiform cyst dilatation at the bilateral intrahepatic bile duct, common hepatic duct, cystic duct, and common bile duct. The cyst exerted pressure on the pancreas and small intestine. Before the surgery, the patient was treated with ceftriaxone 100 mg/kg/day and gentamicin 5 mg/kg/day. Roux-en-Y hepaticojejunostomy was performed, involving the complete excision of the extrahepatic bile duct to reconstruct the biliary system. During the surgery, a retroperitoneal cyst measuring 20 cm x 10 cm with a volume of 200 cc was discovered. Following the surgery, the patient showed clinical improvement. Patient follow-ups indicated that no complications such as wound infection, acute pancreatitis, and the formation of pancreatic or biliary fistula occurred. This case highlights that Roux-en-Y hepaticojejunostomy proves to be an effective surgical approach for managing choledochal cyst type IVa in children, helping to prevent further complications.
Association between tumor necrosis factor-α gene polymorphism and interleukin-6 level with mortality of neonatal sepsis Darnifayanti, Darnifayanti; Akmal, Muslim; Nur, Syahrun; Yusuf, Sulaiman
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1234

Abstract

Sepsis is a systemic infection that significantly causes morbidity and mortality among neonates, which is associated with immature immune response. Variations in the tumor necrosis factor-alpha gene (TNF-α) -308G/A may be linked to neonatal sepsis mortality by modulating interleukins (ILs) involved in the immune response cascade, such as IL-6. The aim of this study was to investigate the association between TNF-α -308G/A gene variation and IL-6 level with mortality of neonatal sepsis. A cohort of 30 neonates diagnosed with clinical sepsis was recruited. Blood culture was performed for all patients and serum IL-6 levels were examined 24 hours after suspected sepsis. Genetic analysis of TNF-α single nucleotide polymorphisms (SNP) -308G/A was conducted using polymerase chain reaction and DNA sequencing. The association was assessed based on bivariate logistic regression. We found that 12 (40%) of 30 patients had blood culture-proven sepsis. Genotype of TNF-α -308G/A stratified of the patients was 56.7% for GA and 43.3% for GG. There were no AA variations found in this study. There was no significant association between the TNF-α -308 G/A genotype and mortality in neonatal sepsis (p=0.211). Similarly, the allelic model of TNF-α -308 gene had no association with mortality (p=0.325). Additionally, there was no association between serum IL-6 level and mortality in neonatal sepsis (p=0.253). In conclusion, SNP of TNF-α -308 gene and IL-6 level are not associated with mortality in neonatal sepsis.
Co-Authors Adrian, Riki Akbar, Zaki Al-shather, Zain Amna, Eka Yunita Anidar Anidar Anidar Anidar, Anidar Arqam, Abil Arsa, Iwan Sabardi Badriul Hegar Badriul Hegar Bakhtiar Bakhtiar Carolina, Infra Yunita Cut Zahara Phoenna Darnifayanti Darnifayanti Darnifayanti, Darnifayanti Dora Darussalam Dora Darussalam, Dora Fajri, Fauzan Feliatra Harrika, Fenny Hasan, Denny I. Herlina Dimiati, Herlina Heru Noviat Herdata Heru Noviat Herdata, Heru Noviat Intan Chaharunia Mulya Ismy, Jufitriani Isra Firmansyah, Isra Jufitriani Ismy Liza Salawati, Liza Maghfirah, Dhiyal Maharani, Cut R. Muliana, Cut Mulya Safri, Mulya Muntadhar, Muntadhar Muslim Akmal Muslim Muslim Muzakkir, Yumna Nadia, Nurul Nora Sovira, Nora Nuriyanto, Alivia R. Nurul Maghfirah Octavina Susanti Raihani, Rifa Ramadhan, Muhammad Haris Rusdi Andid Rusdi Andid, Rusdi Sari, Eva Devita Sentosa, Sukmawan F. Siti Hajar Sofia Sofia, Sofia Sri Rezeki Susanti, Nurhayani D. Syafruddin Haris Syafruddin Haris, Syafruddin Syahrun Nur T.M. Thaib Thaib, Teuku Muhammad