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All Journal Jurnal Ilmiah Farmasi Media Eksakta Medula MPI (Media Pharmaceutica Indonesiana) KOVALEN: Jurnal Riset Kimia Pharmascience Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kesehatan Bakti Tunas Husada Jurnal Penelitian Pendidikan IPA (JPPIPA) JPK: Jurnal Proteksi Kesehatan Jurnal Mandala Pengabdian Masyarakat Molekul: Jurnal Ilmiah Kimia Jurnal Kesehatan Bakti Tunas Husada Jurnal Pengabdian Farmasi dan Sains
Yonelian Yuyun
Jurusan Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Tadulako
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Aktivitas Antioksidan Ekstrak Etanol Daun dan Batang Etlingera comosa Endemik Sulawesi Tengah Menggunakan Metode ABTS Anugraini, Annisa Putri; Rasida; Maskur, Risda; Satriani; Razak, Abd Rahman; Yuyun, Yonelian
MPI (Media Pharmaceutica Indonesiana) Vol. 6 No. 2 (2024): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v6i2.6827

Abstract

Etlingera comosa adalah jenis tanaman yang unik dan baru ditemukan, berasal dari Tentena, Sulawesi Tengah. Meskipun diyakini bahwa genus Etlingera ini mengandung senyawa antioksidan, belum ada penelitian yang mendalam mengenai spesies Etlingera comosa. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi kandungan senyawa metabolit sekunder pada ekstrak etanol daun dan batang tanaman Etlingera comosa, serta mengidentifikasi aktivitas antioksidan yang terdapat pada ekstrak etanol daun dan batang Etlingera comosa. Penelitian ini menggunakan metode ABTS (2,2-azinobis 3-etilbenzotiazolin-6-sulfonat) untuk menentukan aktivitas antioksidan ekstrak etanol daun dan batang Etlingera comosa. Hasil dari penelitian menunjukkan bahwa ekstrak etanol tanaman Etlingera comosa pada bagian daun positif mengandung senyawa metabolit sekunder golongan flavonoid, alkaloid, steroid dan tanin. Sedangkan bagian batang positif mengandung senyawa metabolit sekunder golongan flavonoid, alkaloid, dan tanin. Aktivitas antioksidan ekstrak etanol tanaman Etlingera comosa berdasarkan nilai IC50 bagian daun sebesar 11,75 μg/ml sedangkan bagian batang sebesar 83,11 μg/ml. Penelitian ini menunjukkan bahwa ekstrak etanol daun dan batang Etlingera comosa mempunyai senyawa antioksidan serta memiliki aktivitas antioksidan. Etlingera comosa is a unique and newly discovered plant species endemic to Tentena, Central Sulawesi. Although the Etlingera genus is believed to contain antioxidant compounds, there has been no thorough research on the specific species Etlingera comosa. This study aims to investigate thephytochemical content of the ethanol extract from the leaves and stems of Etlingera comosa, as well as to evaluate its antioxidant activity. The research utilized the ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate)) method with UV-Vis spectroscopy, measuring at a wavelength of 751 nm to assess the antioxidant activity of the ethanol extract. The findings indicated that the ethanol extract from the leaves of Etlingera comosa tested positive for secondary metabolite compounds, including flavonoids, alkaloids, triterpenoids/steroids, and tannins. In contrast, the stems showed positive results for flavonoids, alkaloids, and tannins. The antioxidant activity was quantified using the IC50 value, 11.75 μg/ml for the leaf extract and 83.11 μg/ml for the stem extract. These results demonstrate that the ethanol extracts of both the leaves and stems of Etlingera comosa contain antioxidant compounds and exhibit antioxidant activity. Submitted: 09-09-2024, Revised: 26-11-2024, Accepted: 29-11-2024, Published regularly: December 2024
Pengaruh Media Perebusan Terhadap Komposisi Mineral Kerang Air Tawar Meti (Batissa violacea Lamarck, 1818): Boiling Media Effect on Mineral Composition of Meti Fresh Water Mussels (Batissa violacea Lamarck, 1818) Handayani, Kiki Rizki; Yuyun, Yonelian; Jamaluddin
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15199

Abstract

This research aims were to analyzed mineral composition of fresh and processed meti freshwater mussels (Batissa violacea Lamarck,1818) and to know the effect of boiling media on the mineral composition with various added boiling media conditions that are water, NaCl 1%, and acetic acid 0.5%. Mineral compositions were tested with microwave digestion and Inductively Coupled Plasma Mass Spectrometry (ICP-MS) method. Mineral composition of fresh mussel were consisted of calcium (Ca) 10412 mg/kg, cobalt (Co) 0,182 mg/kg, copper (Cu) 3,54 mg/kg, magnesium (Mg) 345 mg/kg, mangan (Mn) 13,6 mg/kg, phosphor (P) 7753 mg/kg, potassium (K) 1163 mg/kg, sodium (Na) 291 mg/kg, and zinc (Zn) 44,2 mg/kg. The results of research on freshwater mussels in boiling media of water, NaCl 1%, and acetic acid 0.5% gave effect on the levels of minerals of calcium (Ca), magnesium (Mg), phosphor (P), potassium (K), sodium (Na ), cobalt (Co), copper (Cu), mangan (Mn) and there is no effect on the levels of zinc (Zn).
Docking Study of Naphthalene Compounds from Eleutherine Bulbosa as Antidiabetic Agents on Multiple Receptors Anam, Syariful; Yuyun, Yonelian; Yusriadi, Yusriadi; Sultan, Asriana; Pakaya, David; Maulana, Saipul; Zubair, Muhammad Sulaiman
Molekul Vol 20 No 1 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.1.10942

Abstract

ABSTRACT. Diabetes Mellitus is a severe disease to the world health community; it is estimated that 700 million people worldwide will suffer from it. The approach taken to this disease includes improving lifestyle and pharmacological therapy. Recent pharmacological therapeutic approaches include inhibiting the α-glucosidase enzyme, the dipeptidyl peptidase 4 (DPP-4) enzyme, and the sodium-glucose co-transporter-2 (SGLT-2) protein. This research aims to conduct a docking study on three naphthalene compounds from Eleutherine bulbosa against three receptors: α-glucosidase, the DPP-4, and the SGLT-2 protein. The methods used are protein structure preparation, docking protocol validation, preparation of E. bulbosa test ligand structures, and molecule docking for test compounds. Validation was carried out by calculating the Root Mean Square Deviation (RMSD) values using PyMOL software; the results showed that the RMSD value of native ligands was <2Å. Molecular docking of the test compounds was conducted using Autodock Vina 1.2.3 ver 2020. Eleutherinoside A showed the highest binding against the α-glucosidase and DPP-4 protein. Eleuthoside B has the most increased binding to SGLT-2 protein. The research concluded that three naphthalene compounds from E. bulbosa can be used as an antidiabetic agent. Keywords: Antidiabetic; Docking study; Eleutherine bulbosa; Naphthalene; α-glucosidase; DPP-4; SGLT-2
Phenolic content, flavonoid, and antioxidant activity of Etlingera comosa Ardiyani and Ardi leaf extract endemic to Central Sulawesi Rasida; Anugraini, Annisa Putri; Satriani; Maskur, Risda; Widodo, Agustinus; Yuyun, Yonelian
Jurnal Ilmiah Farmasi Vol. 21 No. 2 (2025): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol21.iss2.art3

Abstract

Background: The recently identified plant species Etlingera comosa Ardiyani & Ardi is endemic to Tentena, Central Sulawesi, where it thrives both terrestrially and as an epiphyte. Nevertheless, the antioxidant activities of E. comosa have yet to be investigated, although other Etlingera species are recognized for their antioxidant components. Objective: This work aims to evaluate the antioxidant capabilities of E. comosa leaf extract using the Ferric Reducing Antioxidant Power (FRAP) assay, subsequently determining the total phenolic and flavonoid content. Method: The leaf extract was prepared through maceration with 96% ethanol. The FRAP method was employed to assess antioxidant activity, whereas the Folin-Ciocalteu method was utilized to quantify total phenolic content. The aluminum chloride colorimetric technique was employed to determine the total flavonoid content. Result: The results indicated that the extract exhibited robust antioxidant activities, with an EC₅₀ value of 9.94 µg/mL, whereas vitamin C, serving as the positive control, demonstrated an EC₅₀ value of 3.50 µg/mL. The extract comprised 18.86 mg GAE per 100 mg of extract for total phenolics and 3.31 mg QE per 100 mg of extract for total flavonoids. Conclusion: The antioxidant capacity of E. comosa leaf extract is significant, rendering it a promising subject for further pharmacological investigation.
Pelatihan Pembuatan Teh Herbal Daun Kelor Untuk Meningkatkan Daya Tahan Tubuh Di Desa Tosale Zubair, M. Sulaiman; Musnina, Wa Ode Sitti; Widodo, Agustinus; Zainal, Amalia Purnama; Jamaluddin, Jamaluddin; Yuyun, Yonelian
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.348

Abstract

Kelor (Moringa oleifera Lamk.) merupakan tanaman yang bisa tumbuh dengan cepat, berumur panjang, berbunga sepanjang tahun, dan tahan dengan kondisi panas ekstrim. Kelor memiliki senyawa antioksidan seperti flavonoid, asam askorbat, karotenoid dan fenolat. Berdasarkan kandungannya tersebut kelor memiliki banyak manfaat, namun pemanfaatan kelor oleh ibu PKK di Desa Tosale masih sebatas sebagai bahan sayuran. Fokus utama program pengabdian ini adalah memberikan sosialisasi dan pelatihan baik secara teori maupun praktik dalam pembuatan teh herbal daun kelor menjadi bubuk minuman teh dalam upaya meningkatkan daya tahan tubuh. Metode kegiatan ini yakni metode PRA, yakni melibatkan masyarakat dalam proses kegiatan yang dibagi menjadi beberapa tahapan diantaranya: (1) Sosialisasi persiapan kegiatan, (2) Pretest, (3) Penyampaian materi cara pengolahan teh (4) Pelatihan dan demonstrasi pembuatan teh daun kelor dan (5) Evaluasi keberhasilan kegiatan pengabdian yang dilakukan. Sosialisasi persiapan kegiatan dilakukan sebelum pelaksanaan kegiatan yakni dengan melakukan koordinasi dengan Kepala Desa Tosale. Sebelum melakukan kegiatan pengabdian peserta dalam hal ini ibu PKK diberikan pretest untuk mengetahui pemahaman masyarakat terkait teh kelor serta cara pembuatannya. Berdasarkan hasil pretest secara umum ibu PKK sudah mendengar dan melihat produk teh kelor melalui media sosial namun belum mengetahui cara pembuatannya. Melalui kegiatan ini ibu-ibu PKK secara langsung mengikuti tahapan pembuatan teh kelor dan mencoba menyeduh teh hasil buatan mereka. Berdasarkan hasil evalusi, secara keseluruhan ibu-ibu PKK dapat mengikuti pelatihan dengan baik, melakukan diskusi dengan tim pengabdi sembari mempraktekkan cara pembuatan teh kelor.
Edukasi Pengenalan Apoteker Cilik dan DAGUSIBU Pada Siswa SDN 4 di Desa Bahomoleo Kecamatan Bungku Tengah Kabupaten Morowali Ismail, Ihwan; Khaerati, Khildah; Yuliet, Yuliet; Yuyun, Yonelian
JURNAL PENGABDIAN FARMASI DAN SAINS Vol. 2 No. 2 (2024): April 2024
Publisher : Jurusan Farmasi FMIPA Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/jpsf.2024.v2.i2.17099

Abstract

Pharmacists are pharmaceutical graduates who have completed pharmacy education and have taken the pharmacist oath, carrying out pharmaceutical work including the manufacturing, quality control of pharmaceutical preparations, security, procurement, storage, distribution, or dispensing of drugs, drug management, prescription drug services, drug information services, as well as drug development, drug substances, and traditional medicines. Currently, the empowerment of health education programs and health services at an early age, especially at the elementary school level, has begun to develop. Children need to receive a lot of information about various professions to increase their insights and stimulate their learning spirit. Based on this, education activities of Junior Pharmacists (Apoteker Cilik) and DAGUSIBU (acronym for Obtaining, Using, Storing, and Disposing of drugs properly) were conducted for elementary school students to introduce the pharmacist profession and educate them on obtaining, using, storing, and disposing of drugs properly. The education was conducted for 5th and 6th-grade students at SDN 4 Bungku Tengah, Morowali, Central Sulawesi, involving 60 students. The method of this activity was through PowerPoint presentations, selection of speakers and materials for Junior Pharmacists and DAGUSIBU, and evaluation of education through question and answer sessions on the material. The evaluation results showed a positive outcome, namely an increase in knowledge about the pharmacist profession and proper drug DAGUSIBU.
The Effect of Adsorbents on the Quality of Refined Eel Fish (Anguilla marmorata [Q.] Gaimard) Oil as a Raw Material for Pharmaceutical Preparations Jamaluddin; Yuliet; Musnina, Wa Ode S.; Yuyun, Yonelian; Shaldan, Syahna; Malasugi, S.; Arta, Putri A.; Putri, Gina N.; Maryani, Adetya; Haq, Muhammad F.; Lakahoro, Syamsul; Firman, Nurul Awwaliyah P.; Al-Amri, Siti B.; Amelia, Sinta; Hasanuddin, Asriani; Serdiati, Novalina; Nilawati, Jusri
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9806

Abstract

Eel fish (Anguilla marmorata (Q.) Gaimard) oil is a valuable source of health-promoting unsaturated fatty acids. Adsorbent selection during the bleaching stage of fish oil purification can significantly impact the final product quality.  This study aimed to evaluate the impact of different adsorbents on the quality of refined eel fish (Anguilla marmorata (Q.) Gaimard) oil. Eel fish oil was extracted using Soxhlet extraction with diethyl ether and purified through degumming, neutralization, and bleaching stages. Various adsorbents (bentonite, magnesol XL, and zeolite) were employed at different concentrations (1% bentonite, 3% magnesol XL, and 5% & 10% zeolite activated by acid and base) to remove impurities. The refined oils were analyzed for physical, chemical, and microbiological properties. Results showed that all adsorbents effectively improved the quality of eel fish oil, meeting most International Fish Oil Standard (IFOS) and Indonesian National Standard (SNI - 8467:2018) criteria. However, density and iodine values were below the specified limits. Microbiological analysis confirmed the absence of contamination, but lead levels exceeded the permissible standard.
Co-Authors Agustinus Widodo Al-Amri, Siti B. Amelia, Sinta Andi Riesti Angelin Peuru Anugraini, Annisa Putri Arta, Putri A. Asriana Sultan Asriani Hasanuddin Ceria Arun Venagaya David Pakaya Firman, Nurul Awwaliyah P. Haq, Muhammad F. Ismail, Ihwan Jamaluddin Jamaluddin Jamaluddin Jumriana Akhyar Jusri Nilawati Khildah Khaerati Kiki Rizki Handayani Lakahoro, Syamsul Ma'rifah Ma'rifah Malasugi, S. Maryani, Adetya Maskur, Risda Muhammad Sulaiman Zubair Musnina, Wa Ode S. Na'im, Muh Novalina Serdiati Nugraha, Faisal Nurlina Ibrahim Putri, Gina N. Randa Wulaisfan Rasida Razak, Abd Rahman Saipul Maulana Satriani Seprililianti Seprililianti Shaldan, Syahna Sri Sulistiana Syariful Anam Vini Mandasari Wa Ode Sitti Musnina Yuliet Yuliet Yusriadi Yusriadi Zainal, Amalia Purnama Zubair, M. Sulaiman