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All Journal Jurnal Ilmiah Farmasi Natural Science: Journal of Science and Technology Journal of Mathematical and Fundamental Sciences JURNAL PENGABDIAN KEPADA MASYARAKAT INDONESIAN JOURNAL OF PHARMACY Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Molekul: Jurnal Ilmiah Kimia
Muhammad Sulaiman Zubair
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Palu 94118, Indonesia
Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
Screening of Antibacterial and Anticancer Activity of Soft Corals from Togean Islands, Indonesia Muhammad Sulaiman Zubair; Subehan Lallo; Rusmiyanti Rusmiyanti; Arsa Wahyu Nugrahani; Ibrahim Jantan
Indonesian Journal of Pharmacy Vol 29 No 4, 2018
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1388.045 KB) | DOI: 10.14499/indonesianjpharm29iss4pp173

Abstract

Soft corals (Octocorallia, Alcyonaceae) have been reported to possess diverse biological activities and unique structural chemistry. This study aims to screen the potential antibacterial and anticancer activity of some soft corals collected from Togean Islands, Central Sulawesi, Indonesia. They were Lobophytum sp, Sarcophyton sp, Sinularia sp 1, and Sinularia sp 2. All dried coral materials were extracted for 3 x 24 h by maceration method using methanol and then evaporated by rotary evaporator to obtain viscous extracts. The determination of antibacterial activity had been performed by well agar diffusion method against Staphylococcus aureus and Escherichia coli. Meanwhile, the cytotoxic activity was performed by MTT method, followed by apoptosis annexin V-FTIC assay agains. Identification for the presence of terpenoids was performed by vacuum p-anisaldehyde-sulphuric acid spraying reagent on thin layer chromatography (TLC). Sinularia sp2 extract have strongly inhibited S. aureus and E.coli with the diameter of inhibition range from 12.76mm and 17.86mm, respectively. Moreover, Sinularia sp2 extract possessed also cytotoxic activity against human breast adenocarcinoma (MCF-7) and colorectal carcinoma (HCT-116) with the IC50 of 46.807 and 47.186 μg/mL, respectively.  Extract Sinularia sp 1 was found to have strongest cytotoxicity on human colon colorectal carcinoma (HCT-116) with the IC50 of < 1.505 μg/mL. Annexin V-FTIC assay clearly exhibited that the apoptosis mechanism is proposed by the extracts of Sinularia sp1 and Sinularia sp 2. Terpenoids were identified on both  extracts suggesting for further purification and isolation for the bioactive terpenoid compounds. 
Co-Authors Agus Ritna Agustinus Widodo Ahmad Khumaidi Alfred Trisakti Alwiyah Mukaddas Alwiyah Mukaddas Andry Nur Hidayat Arba Pramundita Ramadani Arba, Muhammad Arfan Arfan Armini Syamsidi Arry Yanuar Asmiyenti Djaliasrin Djalil Asriana Sultan Daryono Hadi Tjahjono David Pakaya DEWI RISMAYANTI Evi Sulastri FIRMANITA DWIMURTI Hayati, Farida Ibrahim Jantan Ibrahim Jantan Ivan Julio Lubis, Siska Syahfitri Mohamed Ali Ghandourah Muhammad Arba Muhammad Yusran Musyahidah Musyahidah Nur Asita Nurlina Ibrahim Nurul Ambianti Poluan, Jesica Carine Ramdanil Ramdanil Rusmiyanti Rusmiyanti Saipul Maulana Sanang Nur Safitri Subehan Lallo Syariful Anam Walied Mohamed Alarif Yamin Yamin Yandi Syukri Yonelian Yuyun Yuliet Yuliet Yusriadi Yusriadi