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All Journal JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Majalah Obat Tradisional Journal of Islamic Pharmacy Jurnal Wiyata : Penelitian Sains dan Kesehatan Jurnal Biologi Tropis AL-HAYAT: Journal of Biology and Applied Biology Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Stannum : Jurnal Sains dan Terapan Kimia Spizaetus: Jurnal Biologi dan Pendidikan Biologi Bioscientist : Jurnal Ilmiah Biologi Jurnal Jeumpa IJCR (Indonesian Journal of Chemical Research) BIOTROPIC
Atiqoh Zummah
UIN Sunan Ampel Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Silent Killers: The Alarming Impact of Microplastics Polystyrene on Catfish Liver Health Suhardi, Haidar Rafli Putra; Moch Irfan Hadi; Atiqoh Zummah
JURNAL KESEHATAN LINGKUNGAN Vol. 17 No. 2 (2025): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v17i2.2025.177-186

Abstract

Introduction: The presence of microplastics in the bodies of living things has become a matter of concern. One example is the widespread use of polystyrene microplastics, which have been widely used by industry even medical products. Styrene bonds and Benzyl Carbon in polystyrene have been identified as potential sources of free radical formation. Upon decomposition, these bonds release dissolved organic carbon, which has been identified as a significant contributor to chemical pollution. Methods: This study aims to determine the effect of microplastic polystyrene in experimental research (MP-PS measuring +0.5 mm) on catfish Clarias gariepinus with concentrations of 1, 1.5, 2, 2.5, 3 mg (K1-K5) for one month on fish liver histopathology. Histopathological observation of fish liver using parrafin method and statistical analysis using SPSS was tested using Anova. Results and Discussion: As determined by the analysis of variance (ANOVA) statistical test (P>0.05), it showed that MP-PS had a significant effect on liver damage in catfish, resulting in the most severe liver damage and the least damage depending on the amount of MP-PS given to the fish. Additional data were obtained in the form of liver tissue abnormalities. Conclusion: The toxicological effects of polystyrene microplastics (MP-PS) on catfish liver health, demonstrating a dose-dependent relationship. Higher MP-PS concentrations led to severe histopathological damage, including several types of liver cell abnormalities. These findings emphasize the urgent need for stricter regulations on microplastic pollution, as its unregulated production threatens aquatic ecosystems and public health.
Identification of Microplastics Content in Sediment, Water and Digestive Channel of Milkfish (Chanos chanos) in Sidoarjo Pond Sanabila, Annisa Inda; Hadi, Moch Irfan; Zummah, Atiqoh
Al-Hayat: Journal of Biology and Applied Biology Vol. 5 No. 1 (2022)
Publisher : Fakultas Sains dan Teknologi, UIN Walisongo Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21580/ah.v5i1.12295

Abstract

Microplastics are a form of new pollution that the Indonesian people are not aware of. The factors for the entry of microplastics into pond waters are water sources, anthropogenic activities, and pond cleanliness. The purpose of this study was to determine the abundance of microplastics, the color and shape of microplastics, and the types of microplastic polymers found in sediment, water, and the digestive tract of milkfish (Chanos chanos) in Sidoarjo ponds. The average abundance of microplastics in sediment samples obtained from semi-intensive ponds is 300 particles per 50 grams, while the sediment samples from traditional ponds are 613 particles per 50 grams. The average abundance of microplastics in the semi-intensive pond water samples was 2.1 particles per 20 liters and in traditional ponds was 2.3 particles per 20 liters. The average abundance of microplastics in the milkfish (Chanos chanos) samples from the Semi-Intensive Pond was as many as 6 particles per tail, while the Traditional Pond had 9.5 particles per tail. In this study, four colors of microplastics were found, namely blue, black, red, and transparent, while the microplastics obtained were fiber, fragment, and filament. The types of microplastic polymers encountered in this study were dominated by polyamide or nylon polymers. In sediment samples from both ponds, we found the presence of Polyamide or Nylon polymers, namely Polystyrene and Polyamide or Nylon, and in the digestive tract of milkfish (Chanos chanos), namely Polyamide or Nylon.
Exploring Potential Aquaculture-Immunostimulant-Peptides Derived from Chlorella sorokiniana Safitri, Nur Maulida; Violando, Wiga Alif; Suhermanto, Achmad; Rizkiah, Riza; Mukhaimin, Iman; Ramli, Taufik Hadi; Puspitasari, Asthervina Widyastami; Zummah, Atiqoh
Jurnal Biologi Tropis Vol. 24 No. 3 (2024): July - September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i3.7585

Abstract

Chlorella sorokiniana is a microalgae with an outstanding nutritional profile and numerous therapeutic substances that can be used as an immunostimulant, including in aquaculture. This research aimed to investigate and characterize peptides isolated from C. sorokiniana protein using TCA digestion and hydrolyzed enzymatically with trypsin. Peptides were then subsequently identified using Tandem LC-MS/MS and Mascot Distiller. Results showed that the percentage of pure protein yield following TCA digestion was 54.66%, and 12 peptides with lengths ranging from 7 to 23 sequences were discovered after trypsin digestion. These peptides originated from various enzymes and chloroplast proteins, including protein synthesis elongation factor TU, photosystem I iron-sulfur center, photosystem II 43 kDa, Ycf4, ATP-dependent zinc metalloprotease FtsH homolog, nitrate reductase, chloroplastic glucose-6-phospate dehydrogenase, and ATP synthase CF1 alpha chain. These findings demonstrated that C. sorokiniana might serve as a source of immunostimulant peptides and proteins, particularly for aquaculture biota.
Pengendalian Hama Bemisia tabaci pada Tanaman Melon Varietas Golden Langkawi melalui Modifikasi Warna dan Ketinggian Perangkap Dellita Sari, Nurriza Dwi; Bahri, Saiful; Pribadi, Eko Teguh; Manan, Abdul; Zummah, Atiqoh
Spizaetus: Jurnal Biologi dan Pendidikan Biologi Vol 5 No 2 (2024): Spizaetus: Jurnal Biologi dan Pendidikan Biologi
Publisher : Program Studi Pendidikan Biologi, FKIP, Universitas Nusa Nipa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55241/spibio.v5i2.379

Abstract

Buah melon (Cucumis melo L.) kaya nutrisi, namun produksinya rentan terhadap serangan hama seperti kutu kebul. Penggunaan perangkap likat menjadi solusi alternatif untuk mengendalikan hama tersebut tanpa terlalu mengandalkan insektisida sintetik. Penelitian ini secara mendalam mengevaluasi tingkat kerusakan yang ditimbulkan oleh serangan hama kutu kebul (Bemisia tabaci) terhadap tanaman melon, sekaligus menguji efektivitas perangkap lengket dengan memvariasikan warna (hijau, kuning, coklat, putih) dan tinggi (antara 50 hingga 200 cm). Eksperimen dilakukan di dalam rumah kaca dengan menerapkan Rancangan Acak Lengkap faktorial karena kondisi lingkungan yang tidak seragam. Hasil penelitian menunjukkan bahwa perangkap lengket berwarna kuning mampu secara efisien mengurangi populasi kutu kebul hingga mencapai 6.307 individu. Meskipun demikian, penyesuaian tinggi perangkap tidak memberikan pengaruh signifikan (Sig=0,061) terhadap pengurangan populasi kutu kebul, namun tinggi perangkap ternyata dipengaruhi oleh pertumbuhan tanaman. Meskipun perangkap kuning terbukti efektif dalam lingkungan yang seragam, analisis Two-Way ANOVA mengungkap nilai Signifikansi yang menunjukkan hasil yang lebih kompleks. Variabel abiotik seperti iklim, cahaya, dan kelembapan ternyata memegang peran penting dalam memengaruhi efikasi perangkap. Penelitian ini memberikan wawasan mendalam tentang strategi pemilihan perangkap lengket untuk mengendalikan populasi kutu kebul pada tanaman melon, sambil menyoroti pentingnya mempertimbangkan faktor lingkungan dalam pengembangan strategi pengendalian hama yang efektif.
Potensi Tumbuhan Melati Air (Echinodorus radicans) Terhadap Penurunan Kadar Timbal (Pb) dan Tembaga (Cu) Pada Limbah Cair Home Industry Batik di Desa Sendang Kabupaten Lamongan Fatiha, Irssa Intan; Firdhausi, Nirmala Fitria; Zummah, Atiqoh
Bioscientist : Jurnal Ilmiah Biologi Vol. 13 No. 1 (2025): March
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v13i1.14892

Abstract

This study aims to determine the potential of water jasmine plants for optimal absorption time, reduction of heavy metal levels of Pb and Cu in Sendang batik liquid waste, and to observe plant morphology. This study uses an experimental method with a one-factor Completely Randomized Design (CRD) and four repetitions, resulting in 16 experimental plots. Heavy metal testing uses an Atomic Absorption Spectrophotometer (AAS). The results showed that (1) on days 9, 12, 15, and 18 of exposure, the decrease in Pb heavy metal levels was 3.71, 2.65, 0.80, and 0. 14 ppm, heavy metal Cu levels decreased consecutively by 4.09, 2.85, 0.31 and 0.26 ppm. (2) The average absorption rate of heavy metal Pb at exposure times of 9, 12, 15, and 18 consecutive days was 0.8, 0.14, 0.24 and 0.23 ppm, respectively, and the heavy metal Cu was 0.23, 0.28, 0.40 and 0. 33 ppm. (3) Morphological changes, namely the appearance of 2-3 new shoots for each treatment, the stems drooping slightly, the leaves changing color to yellow to brownish and brown spots throughout the treatment and on the 18th day one of the leaves died. (4) The initial results of the statistical test for Pb and Cu metals have a sig value of >0.05, where the data is normally distributed and homogeneous. (5) In the One Way Anova test results, sig = 0.000˂0.05 or there is an effect of exposure time and the post hoc Pb test results are ˂0.05 while some Cu metals are ˃0.05.
In Silico Study of Pomegranate Peel Polyphenols as Breast Anticancer Ummah, Khoirotul; Zummah, Atiqoh
Stannum : Jurnal Sains dan Terapan Kimia Vol 6 No 1 (2024): April 2024
Publisher : Department of Chemistry - Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jstk.v6i1.4817

Abstract

Breast cancer is one of the causes of women’s death. Estrogen-α receptors are one of the targets for breast cancer treatment because it plays a role in cancer cell proliferation. Several studies have stated that Flavonoid compounds have high activity in inhibiting the growth of breast cancer cells. This study aims to inhibit polyphenolic compounds in pomegranate peel (gallic acid, cafeic acid, ellagic acid, and chlorogenic acid) against estrogen receptors-α through molecular docking. The 3D structures of the polyphenolic compounds were obtained from the PubChem database and the estrogen-α receptors from the Protein Data Base. Molecular docking simulations were carried out using AutoDock Vina and supporting software such as Biovia Discovery Studio Client 4.1, AutoDockTools 1.5.6, PyMOL, and LigPlot. The results showed that the four polyphenolic compounds had a better potential to inhibit estrogen-α receptors than tamoxifen. The inhibitory potential is evidenced by the low affinity of ligand-protein binding energy (approximately -5.4 to -9.0 kcal/mol). The phenol group of polyphenolic compounds can strengthen the ligand-protein interactions through hydrogen bonds with the active site of ER-ꭤ proteins. Hydrophobic and π-π stacking interactions between polyphenolic and the active site of proteins also support the inhibition potential of polyphenolic compounds. The conclusion is that the polyphenolic compounds in pomegranate peel have the potential as breast anticancers.
Penentuan Tipe Inhibisi Senyawa Analog Kurkumin CA2 terhadap Enzim α-Glukosidase dari Beras Lapuk Atiqoh Zummah; Endang Astuti; Bambang Purwono
Biotropic : The Journal of Tropical Biology Vol. 7 No. 2 (2023): Biotropic, Volume 7 Nomor 2, 2023
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29080/biotropic.v7i2.1952

Abstract

Diabetes is a health problem that exists throughout the world, especially in Indonesia. Based on data compiled from the International Diabetes Federation (IDF) in 2017, people with diabetes in Indonesia reached 10.3 million people, and if not handled properly it is suspected that there will be an increase to 21.3 million people in 2030. Curcumin analog compounds can used for the treatment of diabetes by inhibiting the enzyme α-glucosidase. The curcumin analog compound used in this study was synthesized from 4 methoxybenzaldehyde with cyclopentanone which was then called the CA2 compound. The α-glucosidase enzyme used in this study was obtained through extraction of weathered rice with an optimum pH of 4.5 and the enzyme extract fraction used was fraction II which had the highest activity compared to fractions I and III. The results showed that the values of the kinetic parameters Km and Vmax of the extracted α-glucosidase enzyme were 1.53 mM and 0.03 U/mL, respectively. The Km kinetic parameter value changed to 1.66 Mm while the Vmax value did not change when the α-glucosidase enzyme was inhibited by CA2 compound, so that the type of inhibition shown by CA2 compound was competitive.
Co-Authors Abdul Manan Ainida, Anya Hayyu Andini, Eka Andini San Putri Annisa Inda Sanabila Bambang Purwono Dellita Sari, Nurriza Dwi Eko Teguh Pribadi Endang Astuti Esti Tyastirin Fatiha, Irssa Intan Irul Hidayati Khoirotul Ummah Moch. Irfan Hadi Mukhaimin, Iman Nirmala Fitria Firdhausi Nur Maulida Safitri Prima Retno Wikandari Puspitasari, Asthervina Widyastami Rahma Diyan Martha Rahmah, Firda Maghfiratur Ramli, Taufik Hadi Rani, Titis Eka Rizkiah, Riza Sa'adah, Nafiatus Safarina, Nourma Saiful Bahri Saiful Bahri Sanabila, Annisa Inda Seftianingrum, Bella Suhardi, Haidar Rafli Putra Suhermanto, Achmad Ummah, Khoirotul Wiga Alif Violando Zahro, Dea Ma'rifatul