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Uji Karakteristik Fisik dan Aktivitas Antioksidan Sediaan Face Mist Berbasis Ekstrak Daun Tapak Dara (Catharanthus roseus L.) Yani' Qoriati; Akhmad Al-bari; Nawafila Februyani
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 2 (2026): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i2.40081

Kulit rentan mengalami kerusakan yang diakibatkan paparan radikal bebas yang dapat mengakibatkan stres oksidatif dan penuaan dini sehingga diperlukan antioksidan dalam sediaan topikal. Salah satu tanaman yang memiliki potensi antioksidan alami yaitu tapak dara (Catharanthus roseus L.) karena mengandung flavonoid, fenolik, dan alkaloid. Penelitian ini bertujuan untuk formulasi ekstrak daun tapak dara pada sediaan face mist dengan menguji karakteristik fisik dan tingkat aktivitas antioksidannya. Ekstrak didapat dengan ekstraksi ultrasonik menggunakan pelarut etanol 70% dan diformulasikan dalam tiga konsentrasi ekstrak yaitu 0,5, 1, dan 1,5 gram. Evaluasi meliputi uji organoleptik, pH, daya semprot, waktu kering, homogenitas, kelembapan kulit, bobot jenis, viskositas, dan aktivitas antioksidan metode DPPH. Hasil penelitian menunjukkan seluruh formula memenuhi persyaratan sediaan face mist dengan pH 4,6–5,0, daya semprot 5,3–7 cm, waktu kering kurang dari 5 menit, dan homogen. Formula F3 memberikan peningkatan kelembapan kulit tertinggi sebesar 60% serta aktivitas antioksidan terbaik dengan nilai IC50 108,10 ppm. Penelitian ini menunjukkan bahwa peningkatan konsentrasi ekstrak tapak dara meningkatkan aktivitas antioksidan sediaan face mist.

Physical Education Students' Perceptions Of The Use Of Supplements And Drugs In The World Of Sports Olivia Dwi Cahyani; Nawafila Februyani; Ria indah Kusuma Pitaloka
International Journal of Education and Learning Vol. 1 No. 1 (2025): Vol 1 No 1 June 2025
Publisher : Badan Usaha Milik Desa Berkaho Pungpungan

Show Abstract | Download Original | Original Source | Check in Google Scholar

The use of supplements and medications in the world of sports has become an increasingly prominent issue, including among Physical Education students. A lack of proper understanding regarding the content, benefits, and risks of these substances can lead to dangerous misconceptions in sports practice. This study aims to examine the perceptions of Physical Education students at Nahdlatul Ulama Sunan Giri University regarding the use of supplements and medications in sports, as well as the factors that influence those perceptions. The research employs a descriptive qualitative approach with a field study method. Data were collected through in-depth interviews, observations, and documentation involving six purposively selected informants. The results show that students tend to be permissive toward the use of supplements and morally reject the use of medications; however, their understanding remains limited in terms of scientific and regulatory aspects. Factors influencing their perceptions include personal experience, peer influence, social media, and the limited coverage of the topic in academic courses. These findings highlight the need to strengthen the curriculum and health education to foster critical understanding and responsible attitudes regarding the use of performance-enhancing substances in sports.

Formulasi dan Karakterisasi Jamu Serbuk Instan Tinospora crispa dan Citrus aurantifolia dengan Eksipien Taste Masking Rosyfiana Syafi'i Salma; Nawafila Februyani; Abdul Basith
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1673

Tinospora crispa has a strong bitter taste that can limit palatability. Bitter sensation is detected by taste receptors distributed across the tongue and may be prominent in the posterior tongue, where circumvallate papillae contain numerous taste buds. Citrus aurantifolia may modify this sensory profile. This study aimed to formulate an instant herbal powder containing Tinospora crispa and Citrus aurantifolia with graded maltodextrin-sucrose ratios and to evaluate its initial physical and sensory characteristics. Three formulas containing 20-40% maltodextrin and 45-65% sucrose were prepared in triplicate. Organoleptic properties, visual homogeneity, flow properties, moisture content, dissolution time, pH, and exploratory hedonic responses from seven untrained panelists were evaluated. Physical data were analyzed using one-way ANOVA and Tukey HSD, while sensory data were analyzed using the Friedman and Wilcoxon signed-rank tests with Bonferroni correction. All formulas were fine, visually homogeneous powders with a pH of 5 and moisture content of 2.50-3.67%. The excipient ratio significantly affected angle of repose and moisture content. Global differences were found for taste and overall acceptance, but no pairwise comparison remained significant after correction. F1 had the lowest moisture content, F2 the lowest angle of repose and fastest descriptive dissolution time, and F3 the fastest flow time and highest descriptive taste and overall-acceptance scores. Overall, no single formulation was superior across all physical parameters. However, F3 demonstrated the most favorable overall performance, particularly in the sensory evaluation, indicating its potential for further development.

Potensi Antidiabetes Teh Celup Ekstrak Tinospora crispa (L.) dan Stevia rebaudiana Menggunakan Teknik Co-Processing Granulasi Basah Alfiatul Khasanah; Nawafila Februyani; Atika Nirmala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1679

Introduction: Diabetes mellitus is a chronic metabolic disorder requiring practical herbal therapies with controlled physical quality. Tinospora crispa (L.) is known to possess antidiabetic potential through its alkaloid, flavonoid, and terpenoid constituents, while Stevia rebaudiana serves as a natural low-calorie sweetener and may offer additional metabolic benefits. This study aimed to evaluate the physical characteristics and antidiabetic potential of tea bags containing a combination of Tinospora crispa (L.) extract and Stevia rebaudiana powder prepared using wet-granulation co-processing technique. Methods: Three formulations were developed with varying concentrations of Tinospora crispa (L.) extract at 5%, 10%, and 15%. Extraction was performed using an ultrasonic-assisted method with 70% ethanol as solvent. Physical quality evaluation included moisture content, weight uniformity, brewing time, infusion pH, and homogeneity. An exploratory in vivo test was conducted on 15 alloxan-induced Swiss Webster mice (n=3 per group) over 7 days. Statistical analysis employed One-Way ANOVA followed by Tukey HSD test at α=0.05 significance level. Results: The extract yield was 39.07%. All formulations demonstrated homogeneity with uniform fill weight of 2 g per bag. Significant differences among formulations were observed in moisture content (*p*=0.001; η²=0.895), brewing time (*p*=0.006; η²=0.822), and infusion pH (*p*=0.031; η²=0.687). In the in vivo study, the positive control and all formulation groups showed a tendency toward decreasing blood glucose levels, whereas the negative control group exceeded the glucometer detection limit (>500 mg/dL) from day 5 to day 7. The formulation containing 10% extract (F2) demonstrated the largest descriptive reduction from 210.67 to 88.00 mg/dL (58.23%). Conclusion: Variations in Tinospora crispa (L.) extract concentration affected several physical quality parameters; however, no single formulation was superior across all tested parameters. The in vivo findings suggest a tendency toward antidiabetic activity, yet further studies with larger sample sizes, placebo controls, active compound standardization, and safety evaluations are required to confirm efficacy and elucidate the mechanism of action.

Pengaruh konsentrasi sediaan lotion tabir surya ekstrak daun kelor (Moringa oleifera lam.) dengan bleaching terhadap nilai SPF dan kelembapan kulit Farda Nur Aziziyah; Nawafila Februyani; Abdul Basith
JOURNAL OF Pharmacy and Tropical Issues Vol. 6 No. 4 (2026): August edition 2026
Publisher : Indonesian Public Health-Observer Information Forum (IPHORR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56922/pti.v6i4.4014

Background: Ultraviolet (UV) radiation is one of the environmental factors that can cause various skin disorders, including erythema, hyperpigmentation, premature skin aging, and tissue damage due to the formation of free radicals. One of the most effective approaches to preventing the harmful effects of UV exposure is the use of sunscreen. Moringa oleifera Lam. leaves are known to contain flavonoids, which act as antioxidants and possess the ability to absorb UV radiation, making them a promising natural active ingredient for sunscreen formulations. Purpose: To determine the effect of varying concentrations of bleached (Moringa oleifera L.) leaf extract in a sunscreen lotion formulation on the Sun Protection Factor (SPF) value and skin moisture, and to identify the optimal extract concentration. Method: This study employed a true experimental design using a Completely Randomized Design (CRD). Moringa leaf extract was obtained via ultrasonic extraction using 96% ethanol as the solvent, followed by a bleaching process using activated charcoal. The extract was formulated into lotions at concentrations of 7.5% (F1), 10% (F2), and 12.5% (F3), alongside a lotion base without extract serving as the control (F0). Testing included physical evaluation of the formulations, determination of SPF values using a UV-Vis spectrophotometer, skin moisture assessment using a skin analyzer, irritation testing, and statistical analysis using One-Way ANOVA. Results: Varying concentrations of bleached (Moringa oleifera L.) leaf extract in sunscreen lotion formulations significantly influenced SPF values and skin moisture (p<0.05). The average SPF values for F0, F1, F2, and F3 were 2.66, 4.80, 6.45, and 7.18, respectively. Formula F3, containing a 12.5% extract concentration, yielded the highest SPF value falling into the extra protection category and demonstrated the greatest improvement in skin moisture compared to the other formulas. All formulas met physical evaluation requirements regarding organoleptic properties, homogeneity, pH, spreadability, and adhesiveness, and caused no skin irritation. Conclusion: The formula with a 12.5% extract concentration is the optimal formulation, as it yields the highest SPF value and offers the best skin-moisturizing capability, thereby showing potential for development into an effective and safe natural sunscreen. Keywords: Moringa Leaves; Skin Moisture; Sun Protection Factor (SPF); Sunscreen Lotion.

The Skrining dan Uji Penggolongan Fitokimia dengan Metode KLT pada Ekstrak Etanol Kemangi (Ocium basilicum L) dan Sereh Dapur (Cymbopogon ciratus) Shoffi Ajeng pratiwi; Nawafila Februyani; Abdul Basith
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 6 No. 2 (2023): Vol. 6, No.2, 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v6i2.50782

Tujuan dari penelitian ini untuk menentukan golongon senyawa fitokimia yang terkandung didalam ekstrak etanol kemangi (Ocimum basilicum L) dan sereh dapur (Cymbopogon ciratus) dan Untuk mengetahui hasil dari skrining dan uji penggolongan fitokimia dengan metode kromatografi KLT pada ekstrak etanol kemangi dan sereh dapur. Metode yang digunakan dalam penelitian ini adalah eksperimen laboratorium. Dengan jenis penelitian RAL (rancangan acak lengkap). Ocimum basilicum L dan Cymbopogon ciratus diekstraksi dengan metode maserasi dengan pelarut etanol 96%. Selanjutnya di uji skrining fitokimia meliputi flavonoid, alkoloid, tanin, saponin dan steroid dan di uji KLT meliputi jumlah noda, warna noda dan nilai Rf pada plat KLT. Hasil uji skrining fitokimia pada ekstrak etanol daun kemangi menunjukan hasil positif flavonoid, alkoloid tanin dan steroid sedangkan pada ekstrak etanol rimpang sereh dapur menunjukan positif flavonoid, alkoloid dan steroid. Hasil dari metode KLT ekstrak etanol kemangi adalah jenis senyawa flavonoid yang terikat yaitu flavonon tanpa 5-OH bebas dan flavonon dengan 3-OH bebas dan memiliki atau tidak memiliki 5-OH bebas, dan alkaloid jenis nikotin, dan jenis tanin terkondensasi dan memiliki kadar steroid 1,246%. Sedangkan pada ekstrak etanol sereh dapur mengandung flavonoid yang terikat yaitu flavonon tanpa 5-OH bebas dan flavonon dengan 3-OH bebas dan memiliki atau tidak memiliki 5-OH bebas, dan alkaloid jenis nikotin, dan dengan kadar steroid 1,024%

FORMULASI SEDIAAN SIRUP OBAT BATUK MUKOLITIK EKSTRAK SERAI DAPUR (Cymbopogon citratus) DAN KEMANGI (Ocimum basilicum) Yuni Puji Rahayu; Nawafila Februyani; Moh. Mu'alliful Ilmi
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol. 6 No. 2 (2023): Vol. 6, No.2, 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pmj.v6i2.50789

Salah satu penyakit yang paling sering dialami oleh masyarakat Indonesia adalah batuk sebanyak 9.975 kasus. Penelitian ini bertujuan untuk mengetahui apakah serai dapur dan kemangi dapat diformulasikan menjadi sediaan sirup obat batuk mukolitik dan mengetahui konsentrasi terbaik dari formulasi sirup tersebut. Penelitian ini termasuk penelitian kuantitatif dengan desain true experimental dan RAL. Berdasarkan hasil penelitian serai dapur dan kemangi dapat diformulasikan menjadi sirup obat batuk mukolitik dengan tekstur kental, bau khas dengan warna kuning dan sudah homogen. Konsentrasi terbaik sediaan sirup obat pada pH 4 yaitu konsentrasi 1% sedangkan efektivitas mukolitik tertinggi dimiliki oleh sirup dengan konsentrasi 2% sebesar 81,03%. Kata kunci: Saponin, Serai dapur, Kemangi, Mukolitik

Formulasi dan Karakterisasi Jamu Serbuk Instan Tinospora crispa dan Citrus aurantifolia dengan Eksipien Taste Masking Rosyfiana Syafi'i Salma; Nawafila Februyani; Abdul Basith
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1673

Tinospora crispa has a strong bitter taste that can limit palatability. Bitter sensation is detected by taste receptors distributed across the tongue and may be prominent in the posterior tongue, where circumvallate papillae contain numerous taste buds. Citrus aurantifolia may modify this sensory profile. This study aimed to formulate an instant herbal powder containing Tinospora crispa and Citrus aurantifolia with graded maltodextrin-sucrose ratios and to evaluate its initial physical and sensory characteristics. Three formulas containing 20-40% maltodextrin and 45-65% sucrose were prepared in triplicate. Organoleptic properties, visual homogeneity, flow properties, moisture content, dissolution time, pH, and exploratory hedonic responses from seven untrained panelists were evaluated. Physical data were analyzed using one-way ANOVA and Tukey HSD, while sensory data were analyzed using the Friedman and Wilcoxon signed-rank tests with Bonferroni correction. All formulas were fine, visually homogeneous powders with a pH of 5 and moisture content of 2.50-3.67%. The excipient ratio significantly affected angle of repose and moisture content. Global differences were found for taste and overall acceptance, but no pairwise comparison remained significant after correction. F1 had the lowest moisture content, F2 the lowest angle of repose and fastest descriptive dissolution time, and F3 the fastest flow time and highest descriptive taste and overall-acceptance scores. Overall, no single formulation was superior across all physical parameters. However, F3 demonstrated the most favorable overall performance, particularly in the sensory evaluation, indicating its potential for further development.

Potensi Antidiabetes Teh Celup Ekstrak Tinospora crispa (L.) dan Stevia rebaudiana Menggunakan Teknik Co-Processing Granulasi Basah Alfiatul Khasanah; Nawafila Februyani; Atika Nirmala
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 3 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i3.1679

Introduction: Diabetes mellitus is a chronic metabolic disorder requiring practical herbal therapies with controlled physical quality. Tinospora crispa (L.) is known to possess antidiabetic potential through its alkaloid, flavonoid, and terpenoid constituents, while Stevia rebaudiana serves as a natural low-calorie sweetener and may offer additional metabolic benefits. This study aimed to evaluate the physical characteristics and antidiabetic potential of tea bags containing a combination of Tinospora crispa (L.) extract and Stevia rebaudiana powder prepared using wet-granulation co-processing technique. Methods: Three formulations were developed with varying concentrations of Tinospora crispa (L.) extract at 5%, 10%, and 15%. Extraction was performed using an ultrasonic-assisted method with 70% ethanol as solvent. Physical quality evaluation included moisture content, weight uniformity, brewing time, infusion pH, and homogeneity. An exploratory in vivo test was conducted on 15 alloxan-induced Swiss Webster mice (n=3 per group) over 7 days. Statistical analysis employed One-Way ANOVA followed by Tukey HSD test at α=0.05 significance level. Results: The extract yield was 39.07%. All formulations demonstrated homogeneity with uniform fill weight of 2 g per bag. Significant differences among formulations were observed in moisture content (*p*=0.001; η²=0.895), brewing time (*p*=0.006; η²=0.822), and infusion pH (*p*=0.031; η²=0.687). In the in vivo study, the positive control and all formulation groups showed a tendency toward decreasing blood glucose levels, whereas the negative control group exceeded the glucometer detection limit (>500 mg/dL) from day 5 to day 7. The formulation containing 10% extract (F2) demonstrated the largest descriptive reduction from 210.67 to 88.00 mg/dL (58.23%). Conclusion: Variations in Tinospora crispa (L.) extract concentration affected several physical quality parameters; however, no single formulation was superior across all tested parameters. The in vivo findings suggest a tendency toward antidiabetic activity, yet further studies with larger sample sizes, placebo controls, active compound standardization, and safety evaluations are required to confirm efficacy and elucidate the mechanism of action.

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