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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Kesehatan Masyarakat Indonesia Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) Journal of Maternal and Child Health JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Medical and Health Science Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Inovasi Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) MAHESA : Malahayati Health Student Journal Jurnal Sains dan Kesehatan Al-muhajirin : Jurnal Pendidikan Islam Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rika Yulia
Faculty of Pharmacy, University of Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Efek Glycine max Varietas Anjasmoro terhadap Kadar Timbal dan Malondialdehid pada Mencit Terintoksikasi Timbal Yulia, Rika; Karina, Lidya; Veronica, .; Christyaningsih, Juliana
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 1 (2014)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.933 KB)

Abstract

The objective of this research is investigating the effect of Glycine max Anjasmoro variety to mice with lead intoxication by measuring the levels of Pb in mice's (Mus musculus) blood and MDA in mice's liver and kidney strain BALB/C by using the thiobarbituric acid reactive substance (TBARS) assay. Research carried out by using 20 mice strain BALB/C that were randomly divided into four groups of five mice including negative control, positive control, treatment, and reference. All groups except positive control were intoxicated with lead in a dose of 25 mg/kg body weight for the duration of seven days. One gram of Glycine max has been given to the treatment group and positive control. There after 64 mg/kg body weight of vitamin has been given to the reference group. The results showed that Glycine max Anjasmoro varieties was significantly decrease the levels of lead in mice's blood and also reduce the levels of MDA in the liver and kidney although the results were not significant.Keywords : Glycine max Anjasmoro variety, lead, malondialdehyde, vitamin C, Mus musculus
Ekspresi dan Kadar GABA pada Palatum Sekunder Mencit Prenatal dengan Paparan Diazepam di Periode Organogenesis Yulia, Rika; Kuntoro, Kuntoro; Santoso, Heru; Darmanto, Wim
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 4 (2015)
Publisher : Indonesian Research Gateway

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Abstract

Penelitian ini bertujuan menganalisis perubahan ekspresi dan kadar Neurotransmitter Gamma-aminobutyric acid (GABA) pada palatum mencit prenatal, yang terpapar diazepam di periode organogenesis. Paparan diazepam di periode organogenesis menyebabkan tidak terjadinya penyatuan lempeng palatum  sehingga terjadi celah palatum. GABA berperan dalam pembentukkan palatum. Duapuluh tujuh (27) ekor mencit (Mus musculus) betina, bunting, yang sudah diketahui umur dan berat badannya digunakan dalam penelitian ini. hewan coba dibagi menjadi tiga (3) kelompok : kelompok kontrol, diberi aquades, kelompok uji I diberi injeksi diazepam 8 mg/kg/BB dan kelompok uji II diberi injeksi diazepam 16 mg/kg/BB setiap hari. Pemberian secara intraperitonial di periode organogénesis, yaitu gestasi hari ke 9 sampai 15. Hasil pemeriksaan imunohistokimia, tidak terjadi peningkatan jumlah sel yang mengekspresikan GABA, tapi pemeriksaan kadar menggunakan Elisa Reader, memperlihatkan terjadinya peningkatan kadar GABA pada kelompok uji. Análisis hasil menunjukkan bahwa paparan diazepam di periode organogénesis menyebabkan terjadinya peningkatan kadar GABA jaringan palatum pada mencit prenatal yang mengalami celah palatum.
Ekspresi dan Kadar GABA pada Palatum Sekunder Mencit Prenatal dengan Paparan Diazepam di Periode Organogenesis Yulia, Rika; Kuntoro, Kuntoro; Santoso, Heru; Darmanto, Wim
Jurnal Farmasi Indonesia Vol 7, No 4 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v7i4.213

Abstract

Penelitian ini bertujuan menganalisis perubahan ekspresi dan kadar Neurotransmitter Gamma-aminobutyric acid (GABA) pada palatum mencit prenatal, yang terpapar diazepam di periode organogenesis. Paparan diazepam di periode organogenesis menyebabkan tidak terjadinya penyatuan lempeng palatum  sehingga terjadi celah palatum. GABA berperan dalam pembentukkan palatum. Duapuluh tujuh (27) ekor mencit (Mus musculus) betina, bunting, yang sudah diketahui umur dan berat badannya digunakan dalam penelitian ini. hewan coba dibagi menjadi tiga (3) kelompok : kelompok kontrol, diberi aquades, kelompok uji I diberi injeksi diazepam 8 mg/kg/BB dan kelompok uji II diberi injeksi diazepam 16 mg/kg/BB setiap hari. Pemberian secara intraperitonial di periode organogénesis, yaitu gestasi hari ke 9 sampai 15. Hasil pemeriksaan imunohistokimia, tidak terjadi peningkatan jumlah sel yang mengekspresikan GABA, tapi pemeriksaan kadar menggunakan Elisa Reader, memperlihatkan terjadinya peningkatan kadar GABA pada kelompok uji. Análisis hasil menunjukkan bahwa paparan diazepam di periode organogénesis menyebabkan terjadinya peningkatan kadar GABA jaringan palatum pada mencit prenatal yang mengalami celah palatum.
Efek Glycine max Varietas Anjasmoro terhadap Kadar Timbal dan Malondialdehid pada Mencit Terintoksikasi Timbal Yulia, Rika; Karina, Lidya; Veronica, .; Christyaningsih, Juliana
Jurnal Farmasi Indonesia Vol 7, No 1 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (473.933 KB) | DOI: 10.35617/jfi.v7i1.153

Abstract

The objective of this research is investigating the effect of Glycine max Anjasmoro variety to mice with lead intoxication by measuring the levels of Pb in mice's (Mus musculus) blood and MDA in mice's liver and kidney strain BALB/C by using the thiobarbituric acid reactive substance (TBARS) assay. Research carried out by using 20 mice strain BALB/C that were randomly divided into four groups of five mice including negative control, positive control, treatment, and reference. All groups except positive control were intoxicated with lead in a dose of 25 mg/kg body weight for the duration of seven days. One gram of Glycine max has been given to the treatment group and positive control. There after 64 mg/kg body weight of vitamin has been given to the reference group. The results showed that Glycine max Anjasmoro varieties was significantly decrease the levels of lead in mice's blood and also reduce the levels of MDA in the liver and kidney although the results were not significant.Keywords : Glycine max Anjasmoro variety, lead, malondialdehyde, vitamin C, Mus musculus
Co-Authors Abdul Kadir Aguslina Kirtishanti Alfarendra, Muhammad Daffa Binta, Jihan Darmanto, Wim Darmanto, Wim Darmawan Muttaqin Deisy, Deisy Eko Setiawan Fawandi Fuad Alkindi Fef Rukminingsih Halim, Steven V. Herawati, Fauna Heru Santoso Indrayanti, Mufida Irawati, Adinda Jaelani, Abdul K. Juliana Christyaningsih Karina, Lidya Karina, Lidya Kuntoro Kuntoro Kusuma, Meradiana Widya Lisa Aditama, Lisa Massey, Firdaus Kabiru Muliani, Nurlina Ningtyas, Widia Nuraini, April Octavia, Stefani Kartika Octavianty, Clara Paulina Maya Octasari Raden Mohamad Herdian Bhakti Setiasih Setiasih, Setiasih Tanayawati, Tri Tsamrotul Ilmi Tukan, Listiani Anggraeni Palang Veronica, . Veronica, . Viani, Ella Wattiheluw, Muhammad Hasan Wijaya, Afelia Mettania Wijono, Heru Wirda Anggraini Wiyono, Heru zumaroh, siti