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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Kesehatan Masyarakat Indonesia Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) Journal of Maternal and Child Health JSFK (Jurnal Sains Farmasi & Klinis) JFIOnline 2-TRIK: TUNAS-TUNAS RISET KESEHATAN Medical and Health Science Journal PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Inovasi Farmasi Indonesia Jurnal Farmasi dan Sains Indonesia (JFSI) MAHESA : Malahayati Health Student Journal Jurnal Sains dan Kesehatan Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rika Yulia
Faculty of Pharmacy, University of Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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ANALISIS PENGGUNAAN ANTIBIOTIK PADA PASIEN BEDAH Ningtyas, Widia; Herawati, Fauna; Yulia, Rika
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.42655

Abstract

Penggunaan antibiotik profilaksis pada bedah SC/sectio caesarea, histerektomi, dan kuretage penting untuk mencegah infeksi daerah operasi (IDO). Penelitian ini bertujuan menganalisis penggunaan antibiotik, kesesuaian dengan PPAB Kemkes 2021, dan asosiasi faktor risiko terhadap IDO di RS Islam Surabaya. Penelitian observasional analitik ini menggunakan data rekam medis retrospektif dari 273 pasien. Hasilnya menunjukkan profil penggunaan antibiotik cefazolin dominan pada ketiga prosedur (97-100%), dengan dosis ganda 2 gram. Analisis kuantitatif ATC/DDD tertinggi pada Agustus 2024 (DDD cefazolin 36, DDD cefadroxil 24,5), dengan DU90% pada segmen cefazolin dan cefadroxil. Kesesuaian dengan PPAB Kemkes 2021 mencapai 93,5-95% pada SC dan histerektomi. Usia, komorbiditas, jenis, dosis, dan lama pemberian antibiotik profilaksis tidak ada asosiasi dengan Kejadian IDO (p>0,01). Skor ASA, lama pembedahan, lama rawat inap menunjukkan adanya asosiasi dengan kejadian IDO (p<0,01). Penelitian ini memberikan gambaran penting tentang penggunaan antibiotik profilaksis pada bedah obstetri dan ginekologi di RS Islam Surabaya, menyoroti perlunya peningkatan kesesuaian dengan pedoman dan identifikasi faktor risiko IDO.
Analisis Penggunaan Antibiotik pada Pasien COVID-19 di Rumah Sakit “X” Malang Mardianto, Rudy; Yulia, Rika; Herawati, Fauna
2-TRIK: TUNAS-TUNAS RISET KESEHATAN Vol 12, No 2 (2022): Mei 2022
Publisher : FORUM ILMIAH KESEHATAN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/2trik12202

Abstract

Antibiotics are used to treat co-infection in COVID-19 patients during the pandemic. Research data show that cases of bacterial co-infection in COVID-19 patients are 5%. Uncontrolled use of antibiotics will accelerate bacterial resistance. Accurate selection of antibiotics, dosage, frequency of use and duration of administration are needed to avoid nosocomial infections of resistant bacteria and reduce treatment costs. The purpose of this study was to determine the quality of antibiotic use in COVID-19 patients at dr. Soepraoen Malang. This study is a retrospective descriptive with a cross-sectional approach. Data were obtained from medical records and drugs from pharmacy installations. The population is hospitalized patients with confirmed COVID-19. Samples were hospitalized patients with confirmed COVID-19 who met the inclusion and exclusion criteria. The sample size was 258 patients selected by purposive sampling method during October 2019 to March 2020. The results of the study were patients 46-55 years old = 41%, male patients = 64%, female = 36%; moderate disease degree = 17%, severe = 83%; patients recovered = 95%, died = 5%. Choice of antibiotics, iv azithromycin; levofloxacin iv; azithromycin p.o; levofloxacin p.o is 100%. Meropenem iv 86.05%; moxifloxacin p.o 14.37%; ceftriaxone iv 10.08%; cefixime p.o 3.49%; moxifloxacin iv 2.71%; cefotaxime iv 1.94%; cefadroxil p.o 0.39%; doxycycline p.o 0.39%. The accuracy of the dose of azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%, the accuracy of the frequency of use of azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%. The accuracy of the administration of iv azithromycin injection was 99.57%, levofloxacin iv 98.34%, azithromycin p.o. 89.29%; levofloxacin p.o 100%. The conclusion of this study is that the use of antibiotics in COVID-19 patients has met the correct 4 criteria, namely the right selection of drugs, the right dose, the right frequency of use and the right duration of administration.Keywords: COVID-19; antibiotics; 4 rightABSTRAK Antibiotik digunakan untuk mengatasi ko-infeksi pada pasien COVID-19 di masa pandemi. Data penelitian menunjukkan bahwa kasus ko-infeksi bakteri pada pasien COVID-19 adalah <5%. Penggunaan antibiotik yang tidak terkendali akan mempercepat resistensi bakteri. Ketepatan pemilihan antibiotik, dosis, frekuensi penggunaan serta lama pemberian, diperlukan untuk menghindari infeksi nosokomial bakteri resisten serta menurunkan biaya pengobatan. Tujuan penelitian ini adalah mengetahui kualitas penggunaan antibiotik pada pasien COVID-19 di rumah sakit dr. Soepraoen Malang. Penelitian ini adalah deskriptif retrospektif dengan pendekatan cross-sectional. Dta diperoleh dari rekam medis dan obat dari instalasi farmasi. Populasi adalah pasien rawat inap yang terkonfirmasi COVID-19. Sampel merupakan pasien rawat inap yang terkonfirmasi COVID-19 yang memenuhi kriteria inklusi dan eksklusi. Ukuran sampel adalah 258 pasien yang dipilih dengan metode purposive sampling selama bulan Oktober 2019 sampai Maret 2020. Hasil penelitian pasien 46-55 tahun = 41%,  pasien laki-laki = 64%, perempuan = 36%;  derajat penyakit sedang = 17%,  berat = 83%;  pasien sembuh = 95%, meninggal = 5%. Pemilihan antibiotik, azithromycin iv; levofloxacin iv; azithromycin p.o; levofloxacin p.o adalah 100%. Meropenem iv 86,05%; moxifloxacin p.o 14,37%; ceftriaxone iv 10,08%; cefixime p.o 3,49%; moxifloxacin iv 2,71%; cefotaxime iv 1,94%; cefadroxil p.o 0,39%; doxycycline p.o 0,39%. Ketepatan dosis azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%, ketepatan frekuensi penggunaan azithromycin (iv; p.o) 100%, levofloxacin (iv; p.o) 100%.  Ketepatan lama pemberian injeksi azithromycin iv 99,57%, levofloxacin iv 98,34%, azithromycin p.o 89,29%; levofloxacin p.o 100%. Kesimpulan penelitian ini adalah penggunaan antibiotik pada pasien COVID-19 telah memenuhi kriteria 4 tepat, yaitu tepat pemilihan obat, tepat dosis, tepat frekuensi penggunaan dan tepat lama pemberian.Kata kunci: COVID-19; antibiotik; 4 tepat
Correlation of Knowledge and Beliefs to Adherence with Antibiotic Use in Adult Patients at a Private Hospital in Sidoarjo Wattiheluw, Muhammad Hasan; Herawati, Fauna; Setiasih, Setiasih; Yulia, Rika
Kesmas Vol. 15, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Infectious diseases are one of the top ten causes of death in the world. Antibiotic therapy is administered for infectious diseases, but if bacteria are exposed to antibiotics continuously, then the bacteria are able to adapt to the medication, thereby resulting in antibiotic resistance. This condition results in an increase in mortality, long hospitalization period, and increased cost of antibiotic therapy and health services. Adherence to using antibiotics may be influenced by knowledge and beliefs about them. This study aimed to understand correlation between knowledge and belief with adherence to antibiotic use at a private hospital in Sidoarjo. This cross-sectional study, the data collected in three months period, was conducted with a questionnaire for assessment knowledge and belief. A pill count method was applied for assessment adherence to using antibiotics prescribed by doctors. The study results show that knowledge of the respondents was adequate for 76 people (69.7%), belief was adequate for 74 people (67.9%), and adherence to antibiotic use for 79 people (72%). Regression analysis showed that the variable that significantly influenced the adherence of patients in using antibiotics was perceived threat (p-value = 0,029). Sex, age, education, income, occupation, and marital status have no contribution to antibiotic knowledge, belief, and adherence.
Studi Penggunaan Kemoterapi pada Pasien Kanker Serviks di RSPAL Dr. Ramelan Surabaya: Study of the Use of Chemotherapy in Cervical Cancer Patients at RSPAL Dr. Ramelan Surabaya Tukan, Listiani Anggraeni Palang; Herawati, Fauna; Kirtishanti, Aguslina; Yulia, Rika; Octavia, Stefani Kartika
Jurnal Sains dan Kesehatan Vol. 6 No. 3 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i3.1801

Abstract

Chemotherapy treatment is the most widely chosen method of treatment. The chemotherapy given not only shows effectiveness, but also has a detrimental impact on patients, namely side effects. The purpose of this study was to determine the profile of cancer patients based on stage, duration of cancer, family history of cervical cancer, and treatment cycles, determine the profile of drug use, determine the suitability of drug use, and determine side effects after administration of chemotherapy. This research is an observational study with the direction of data collection retrospectively. The research was conducted at RSPAL Dr. Ramelan Surabaya with research samples from the period August 2021 - September 2022. The results of the study with a sample of 101 samples, showed that the most results were 100% female and married sample, age range 46 - 55 years totaling 38.61%, last education level Elementary schools accounted for 34.65%, 100% payment with BPJS, Stadium IIIB was the largest stadium in the sample, namely 94.06%, the cycle that received the most samples was cycle III, which amounted to 30.69%. The suitability of the use of chemotherapy showed 100% according to the type, and 90.57% according to the dose. The most common side effect that appeared after chemotherapy was nausea with a total of 52.48%. Further research needs to be done using a prospective method to ensure the side effects that occur. Keywords:          Cervical Cancer, Chemotherapy, Suitability, Side effect   Abstrak Pengobatan kemoterapi merupakan metode pengobatan yang paling banyak dipilih. Kemoterapi yang diberikan tidak hanya menunjukkan efektivitas, namun juga memberikan dampak yang merugikan bagi pasien, yaitu efek samping. Tujuan penelitian ini adalah untuk mengetahui profil pasien kanker berdasarkan stadium, lama menderita kanker, riwayat keluarga yang mempunyai kanker serviks, dan siklus pengobatan, mengetahui profil penggunaan obat, mengetahui kesesuaian penggunaan obat, dan mengetahui efek samping setelah pemberian kemoterapi. Penelitian ini merupakan penelitian observational dengan arah pengambilan data secara retrospektif. Penelitian dilakukan di RSPAL Dr. Ramelan Surabaya dengan sampel penelitian dari periode Agustus 2021 – September 2022. Hasil penelitian dengan sampel berjumlah 101 sampel, menunjukkan hasil terbanyak adalah sampel 100% berjenis kelamin perempuan dan sudah menikah, rentang usia 46 – 55  tahun berjumlah 38,61%, tingkat pendidikan terakhir Sekolah Dasar berjumlah 34,65%, pembayaran 100% denga BPJS, Stadium IIIB merupakan stadium terbanyak pada sampel yaitu 94,06%, siklus yang diterima sampel terbanyak adalah siklus III yang berjumlah 30,69%. Kesesuaian penggunaan kemoterapi menunjukkan 100% sesuai jenis, dan 90.57% sesuai dosis. Efek samping terbanyak yang muncul setelah pemberian kemoterapi adalah mual dengan jumlah 52,48%. Penelitian lebih lanjut perlu dilakukan menggunakan metode prospektif untuk memastikan efek samping yang terjadi. Kata Kunci:         Kanker Serviks, Kemoterapi, Kesesuaian, efek samping
Co-Authors Abdul Kadir Aguslina Kirtishanti Alfarendra, Muhammad Daffa Darmanto, Wim Darmanto, Wim Darmawan Muttaqin Deisy, Deisy Eko Setiawan Fawandi Fuad Alkindi Halim, Steven V. Herawati, Fauna Heru Santoso Indrayanti, Mufida Irawati, Adinda Jaelani, Abdul K. Juliana Christyaningsih Karina, Lidya Karina, Lidya Kuntoro Kuntoro Kusuma, Meradiana Widya Lisa Aditama, Lisa Mardianto, Rudy Massey, Firdaus Kabiru Muliani, Nurlina Ningtyas, Widia Nuraini, April Octasari, Paulina Maya Octavia, Stefani Kartika Octavianty, Clara Rukminingsih, Fef Setiasih Setiasih, Setiasih Tanayawati, Tri Tsamrotul Ilmi Tukan, Listiani Anggraeni Palang Veronica, . Veronica, . Viani, Ella Wattiheluw, Muhammad Hasan Wijaya, Afelia Mettania Wijono, Heru Wirda Anggraini Wiyono, Heru