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All Journal PROSIDING SEMINAR NASIONAL Jurnal Kedokteran Brawijaya Jurnal Gizi dan Pangan Soedirman (JGPS) Jurnal Serambi Abdimas Mandala of Health : A Scientific Journal Medical and Health Journal Linggamas: Jurnal Pengabdian Masyarakat Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research)
Viva Ratih Bening Ati
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Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Ethanolic Extract of Butterfly Pea Flower (Clitoria ternatea L.) as an Antifungal and Antibiofilm Agent Against Candida albicans ATCC 10231 Setiawati Setiawati; Carrissa Alifia; Nia Krisniawati; Viva Ratih Bening Ati; M.M Rudi Prihatno
Medical and Health Journal Vol 6 No 1 (2026): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.6.1.22442

Abstract

Candida albicans is the leading cause of fungal infections worldwide, with mortality rates reaching up to 60%. Biofilm formation by C. albicans makes infections more difficult to treat and increases resistance to antifungal agents. The ethanolic extract of butterfly pea flower (Clitoria ternatea L.) has potential as an antifungal and antibiofilm agent, making it a promising alternative treatment. This study aimed to determine the antifungal and antibiofilm activity of butterfly pea flower ethanolic extract against C. albicans ATCC 10231. The research employed a true experimental method with a post-test only control group design. The antifungal assay used the microdilution method to determine the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC), while the antibiofilm assay used the Microtiter Plate Assay to determine MBIC50 and MBRC50. The concentrations tested were 5, 10, 20, 40, and 80 mg/mL, with fluconazole 6.25 µg/mL as the positive control. The results showed an MFC value at 20 mg/mL. The MBIC50 and MBRC50 values were both at 10 mg/mL, with inhibition and reduction percentages of 72.28% and 65.18%, respectively. The ethanolic extract of butterfly pea flower exhibited better antifungal and antibiofilm activity than the positive control fluconazole at 6.25 µg/mL. The ethanolic extract of butterfly pea flower has the potential to be developed as an antifungal and antibiofilm agent.
Co-Authors Afifah Afifah Alfi Muntafiah Andi Suriyanti Ardinas, Shinta Prima Bestari, Gita Carrissa Alifia Diah Krisnansari Fadhilah, Synta Haqqul Fajar Wahyu Pribadi Gumilas, Nur Signa Aini Hajid Rahmadianto Mardihusodo, Hajid Rahmadianto Harini, Ika Murti Hevatio, Dufvan Hidayat Sulistyo Khusnul Muflikhah Kinanti, Luhung Sekar M.M Rudi Prihatno Muhammad Afif Munawir, Azzah Azizah Nafiisah, Nafiisah Nia Krisniawati Panuntun, Hilmi Puguh Pratama, Tisna Sendy Pristika, Alya Sainal Edi Kamal Setiawati - Setiawati Setiawati Siti Munfiah Susiana Candrawati Sutrisno, Sutrisno Tamad, Fatiha Sri Utami Thianti Sylviningrum Wahyudin Wahyudin Wahyudin Wahyudin Widiartini, Catharina Widodo, Azzahra Wuri Widyasari, Ailsya Inaayah Putri Wisesa, Sindhu Wulandari, Leni Zahra, Rafika Zufiah Zufiah