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All Journal Medula Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Respirasi (JR) Jurnal Aisyah : Jurnal Ilmu Kesehatan JK Unila (Jurnal Kedokteran Universitas Lampung) Mamangan Social Science Journal
Adityo Wibowo, Adityo
Bagian Fisiologi, Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary

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Hubungan Kadar Bromotyrosine Urin Dengan Terapi Montelukast, Beclometasone/Formoterol, Dan Kombinasi Selama 3 Bulan Pada Pasien Asma Di Klinik Harum Melati Pringsewu Pinaka Baladika, Dimas Trend; Soeprihatini Soemarwoto, Retno Ariza; Mustofa, Syazili; Yunus, Faisal; Ekawati, Diyan; Wibowo, Adityo
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 7 (2025): Volume 12 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i7.20239

Abstract

Bromotyrosine urin memiliki banyak keuntungan sebagai biomarker potensial penyakit asma mengingat stabilitasnya dan pengumpulan sampel urin yang bersifat non-invasif. Dalam manajemen tatalaksana asma leukotriene receptor antagonist (LTRA) merupakan obat alternatif lini pertama setelah kortikosteroid inhalasi. Penelitian ini bertujuan untuk mengetahui hubungan kadar bromotyrosine urin dengan terapi montelukast selama 3 bulan. Penelitian ini melibatkan 82 pasien berusia antara 6-65 tahun dari Klinik Harum Melati, Pringsewu dari bulan Mei – Desember 2023. Dilakukan uji spirometri, urin, differential count sebelum dan setelah terapi 3 bulan, diklasifikasikan derajat obstruksi ringan (n= 66) dan sedang-berat (n=6) serta pasien non-asma untuk kontrol (n= 10). Hanya 28 pasien yang datang untuk evaluasi setelah 3 bulan terapi. Pasien dibagi menjadi 3 kelompok, yaitu kelompok terapi montelukast (n=14), beclometason/formoterol (n=5), dan kombinasi montelukast dan beclometason/formoterol (n=9). Kadar bromotyrosine urin penderita asma secara bermakna lebih tinggi dibandingkan dengan kontrol (154.11 ng/ml vs 11,87 ng/ml, p= 0,000). Tidak terdapat perbedaan bermakna kadar bromotyrosine urin setelah terapi montelukast (104.24 ng/ml vs 40.79 ng/ml, p=0,433) dan setelah terapi beclometason/formoterol (136,25 ng/ml vs 33,20 ng/ml, p= 0,345. Terjadi penurunan kadar bromotyrosine urin yang bermakna pada kelompok setelah terapi kombinasi montelukast dan beclometasone/formoterol (39.63 ng/ml vs 11.13 ng/ml) (95% CI 3.90-42.43, p= 0.028). Hasil penelitian menunjukkan pasien asma memiliki kadar bromotyrosine urin jauh lebih tinggi dibandingkan dengan non-asma. Kadar bromotyrosine urin menurun secara bermakna setelah terapi kombinasi (montelukast dan beclometason/formoterol) selama 3 bulan.
EFFECTIVENESS OF TRIPLE THERAPY WITH SINGLE AND MULTIPLE INHALERS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE Soemarwoto, Retno Ariza; Putri, Maharani; Meirissa, Tria; Yunus, Faisal; Aryana, Wayan Ferly; Wibowo, Adityo; Oktobiannobel, Jordy
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3050

Abstract

Introduction: Exacerbations of chronic obstructive pulmonary disease (COPD) contribute to 3 million annual deaths worldwide. Triple therapy (ICS + LABA + LAMA) helps reduce symptoms and exacerbation risk.Objective: To assess the effectiveness and clinical response of single versus multiple inhaler therapy in managing COPD.Methods: A pre-post study was conducted on two groups of COPD patients over 8 weeks. Group 1 (n=47) used a single inhaler, while Group 2 (n=45) used multiple inhalers. Outcomes were measured using the mMRC scale, blood eosinophil levels, and spirometry at weeks 2 and 8.Results: The single-inhaler group significantly reduced mMRC scores, with a median decrease from 4.00 to 2.00 (p0.05). Eosinophil levels also decreased significantly in both groups, with a larger reduction in the single-inhaler group (p0.05). Lung function improved in both groups, but no significant differences were found (p0.05) in terms of time or between-group comparisons.Conclusion: Single-inhaler therapy reduced dyspnea and eosinophil levels more effectively than multiple inhalers. The effectiveness of single inhalers may be attributed to higher adherence due to ease of use. 
PERANAN KURVA DISOSIASI KARBON DIOKSIDA PADA PROSES PERNAFASAN : KAJIAN PUSTAKA Rusmini, Hetti; Lyanda, Apri; Hendarto, Gatot Sudiro; wibowo, adityo; Saputra, Tetra Arya; Morfi, Chicy Widia; Azka, Laisa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 8 (2025): Volume 12 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i8.22216

Abstract

Karbon dioksida (CO₂) merupakan produk akhir metabolisme aerobik yang memiliki peran vital dalam fisiologi pernapasan dan keseimbangan asam-basa tubuh. Artikel tinjauan ini membahas mekanisme pertukaran CO₂ mulai dari difusi alveolar, transportasi dalam darah (terlarut, sebagai bikarbonat, dan terikat hemoglobin), hingga kurva disosiasi CO₂. Efek Bohr dan Haldane dijelaskan sebagai mekanisme adaptif yang mendukung efisiensi pengangkutan gas respirasi. Selain proses fisiologis normal, artikel ini juga mengulas kondisi patologis yang mengganggu pertukaran CO₂, seperti hipoventilasi, gangguan ventilasi-perfusi, dan difusi terbatas. Pemahaman yang mendalam mengenai dinamika CO₂ memiliki implikasi klinis penting, khususnya dalam penatalaksanaan penyakit seperti PPOK, asma, dan ARDS. Dengan pendekatan ilmiah yang humanis, artikel ini bertujuan memperkuat pemahaman tenaga medis dan pembaca umum terhadap peran esensial CO₂ dalam menjaga homeostasis dan kehidupan.
Indwelling Pleural Catheter in Recurrent Pleural Effusion Due To Congestive Heart Failure: A Case Report Saputra, Tetra Arya; Wibowo, Adityo
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 9 (2025): Volume 12 Nomor 9
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i9.20318

Abstract

Pleural effusion commonly appears in congestive heart failure (CHF), caused by raised pulmonary capillary pressure and impaired lymphatic drainage, often resulting in respiratory distress and reduced quality of life. This case report presents the use of an indwelling pleural catheter (IPC) for recurrent pleural effusion in CHF unresponsive to standard therapy. A 42-year-old man with acute decompensated CHF and bilateral pleural effusions presented with worsened dyspnea. Initial thoracentesis and diuretic therapy failed to resolve the effusion, leading to IPC placement for ongoing drainage. IPC insertion resulted in marked symptom improvement, effective fluid management, and shorter hospital stay. The patient was able to continue outpatient care and experienced no major complications. This case demonstrates that IPCs can provide safe and effective symptom control in CHF-related pleural effusions when conventional treatment is inadequate. Individualized strategies, including the use of IPC, may enhance quality of life and reduce hospitalizations in patients with effusions caused by heart failure.
Co-Authors Andreas Makmur, Andreas Apri Lyanda Aryana, Wayan Ferly Azka, Laisa Ekawati, Diyan Faisal Yunus Febrihartati, Isura Gatot Sudiro Hendarto, Gatot Sudiro Gozali, Achmad Indriani, Sri Indah Jordy Oktobiannobel Meirissa, Tria Morfi, Chicy Widia Pinaka Baladika, Dimas Trend Putri, Maharani Rusmini, Hetti Saputra, Tetra Arya Saputra, Tito Tri Simatupang, Elvando Tunggul Mauliate SL, I Made Afryan Soemarwoto, Retno Ariza Soeprihatini Soemarwoto, Retno Ariza Syazili Mustofa Wiwit Ade Fidiawati Zakiah Zakiah